locus-tag class description HUT13_RS00010 ENOG4105C57 major facilitator superfamily HUT13_RS00060 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HUT13_RS00080 ENOG41088PD hydrolase HUT13_RS00085 ENOG4108FKH Transglycosylase SLT domain HUT13_RS00095 ENOG4105F1K Glutamine amidotransferase HUT13_RS00110 ENOG4105DKQ ROK family HUT13_RS00140 ENOG4105I1F Resistance protein HUT13_RS00145 ENOG4105DKQ ROK family HUT13_RS00155 ENOG4105C10 Electron transfer flavoprotein HUT13_RS00170 ENOG4105PSQ Acyl-transferase HUT13_RS00175 ENOG4105C5W Aldolase HUT13_RS00190 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT13_RS00215 ENOG4105M4P Tetr family transcriptional regulator HUT13_RS00235 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT13_RS00240 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT13_RS00255 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 HUT13_RS00315 ENOG4105TVJ transport system, permease HUT13_RS00320 ENOG4105DQ5 transport system permease protein HUT13_RS00365 ENOG4105CEY Amp-dependent synthetase and ligase HUT13_RS00370 ENOG4107258 Transcriptional regulator HUT13_RS00380 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT13_RS00385 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT13_RS00405 ENOG4105MXB limonene-12-epoxide hydrolase HUT13_RS00470 ENOG4105DRS transport system, permease HUT13_RS00475 ENOG4107R13 MMPL domain protein HUT13_RS00485 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT13_RS00520 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT13_RS00525 ENOG4105DRS transport system, permease HUT13_RS00530 ENOG4105CNT hydrolase family 2 HUT13_RS00545 ENOG4105CHR reductase HUT13_RS00550 ENOG4108JGH Tetr family transcriptional regulator HUT13_RS00575 ENOG4107ZED Uncharacterised protein family UPF0047 HUT13_RS00580 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS00585 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HUT13_RS00590 ENOG4105C9F isomerase HUT13_RS00600 ENOG4105DET Rhamnulokinase HUT13_RS00605 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HUT13_RS00615 ENOG41080R8 Conserved Protein HUT13_RS00625 ENOG4105CPC Aldo Keto reductase HUT13_RS00650 ENOG4105M6F mutator MutT protein HUT13_RS00665 ENOG4105BZ1 (ABC) transporter HUT13_RS00685 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS00690 ENOG4105C5I Dehydrogenase HUT13_RS00700 ENOG4108M1A Chitin-binding protein HUT13_RS00715 ENOG41066UM arsR family transcriptional regulator HUT13_RS00720 ENOG4105BZ1 (ABC) transporter HUT13_RS00725 ENOG4105BZ1 (ABC) transporter HUT13_RS00745 ENOG4105GWZ Roadblock lc7 family protein HUT13_RS00760 ENOG4105C0D helicase HUT13_RS00815 ENOG4105E2R ROK family HUT13_RS00820 ENOG4108RNG Permease of the drug metabolite transporter HUT13_RS00830 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUT13_RS00840 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS00855 ENOG4105E2R ROK family HUT13_RS00875 ENOG4105DEN Luciferase family HUT13_RS00880 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS00885 ENOG4105BZU Histidine kinase HUT13_RS00895 ENOG4108JQ7 (ABC) transporter HUT13_RS00905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS00920 ENOG4105I82 acetyl xylan esterase HUT13_RS00935 ENOG410719E cytochrome p450 HUT13_RS00960 ENOG4107SVN transposase HUT13_RS01010 ENOG4105CWX Alpha-1,2-mannosidase HUT13_RS01020 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HUT13_RS01025 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS01030 ENOG4105CV8 reductase HUT13_RS01095 ENOG4107QQG Dehydrogenase HUT13_RS01110 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT13_RS01145 ENOG4105D7W serine acetyltransferase HUT13_RS01150 ENOG4108594 Permease of the drug metabolite transporter HUT13_RS01155 ENOG4105CEY Amp-dependent synthetase and ligase HUT13_RS01165 ENOG4105S6R Iron-hydroxamate transporter permease subunit HUT13_RS01175 ENOG4105E0A ABC, transporter HUT13_RS01190 ENOG4105D9R oxidoreductase HUT13_RS01200 ENOG4105JSC dimethylmenaquinone methyltransferase HUT13_RS01205 ENOG4107258 Transcriptional regulator HUT13_RS01210 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HUT13_RS01235 ENOG4108KQ5 Integrase catalytic subunit HUT13_RS01245 ENOG4105EQK -acetyltransferase HUT13_RS01285 ENOG4105JXH GntR family transcriptional regulator HUT13_RS01310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS01330 ENOG4107T5V SNARE associated Golgi HUT13_RS01355 ENOG4105E1F short-chain dehydrogenase reductase HUT13_RS01395 ENOG4107DA6 Transcriptional regulator HUT13_RS01470 ENOG4105CGD Nad-dependent epimerase dehydratase HUT13_RS01475 ENOG4105D65 subunit l HUT13_RS01480 ENOG4105MKQ Monovalent cation H antiporter subunit C HUT13_RS01485 ENOG4108JPZ Monovalent cation H antiporter subunit D HUT13_RS01500 ENOG4105KJM monovalent cation h antiporter subunit g HUT13_RS01515 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT13_RS01550 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) HUT13_RS01555 ENOG4105CDH Citrulline--aspartate ligase HUT13_RS01560 ENOG4105BZU Histidine kinase HUT13_RS01565 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS01570 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS01575 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS01585 ENOG4105BZU Histidine kinase HUT13_RS01610 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HUT13_RS01620 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT13_RS01635 ENOG4107RCI amp-dependent synthetase and ligase HUT13_RS01640 ENOG4107EEY synthase HUT13_RS01645 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT13_RS01665 ENOG4108CCU Ribonucleotide-diphosphate reductase subunit beta HUT13_RS01735 ENOG4105D4B ABC, transporter HUT13_RS01745 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HUT13_RS01750 ENOG4105C2J ABC transporter HUT13_RS01765 ENOG4105CIK Amidinotransferase HUT13_RS01770 ENOG4105C8Y Acetylornithine aminotransferase HUT13_RS01790 ENOG4105C57 major facilitator superfamily HUT13_RS01830 ENOG4105C83 adenylosuccinate lyase HUT13_RS01835 ENOG4105DKQ ROK family HUT13_RS01840 ENOG4105FDP GntR family transcriptional regulator HUT13_RS01845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT13_RS01850 ENOG4108KPJ rna polymerase sigma factor HUT13_RS01865 ENOG4108PSK reductase HUT13_RS01870 ENOG4105EYH Exonuclease HUT13_RS01870 ENOG4105EYH Exonuclease HUT13_RS01875 ENOG4107RH8 nuclease SbcCD subunit D HUT13_RS01885 ENOG4105NBR Pectinesterase HUT13_RS01890 ENOG4108UZX fmn reductase HUT13_RS01895 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT13_RS01900 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HUT13_RS01905 ENOG4105K4P CoA-binding domain protein HUT13_RS01930 ENOG4107XBN GntR Family Transcriptional Regulator HUT13_RS01960 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT13_RS01965 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HUT13_RS01990 ENOG4108KQ5 Integrase catalytic subunit HUT13_RS02005 ENOG4105CNA YD repeat protein HUT13_RS02070 ENOG4105CXK mandelate racemase muconate lactonizing HUT13_RS02075 ENOG4105DRS transport system, permease HUT13_RS02090 ENOG4105EMF GntR family transcriptional regulator HUT13_RS02095 ENOG4105C6Z Gluconate HUT13_RS02110 ENOG4105CSW GntR family transcriptional regulator HUT13_RS02130 ENOG4107TIF Phenazine biosynthesis protein, PhzF family HUT13_RS02150 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HUT13_RS02160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HUT13_RS02190 ENOG4108R2U division initiation protein HUT13_RS02210 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HUT13_RS02220 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT13_RS02230 ENOG4105C1G acyl-Coa dehydrogenase HUT13_RS02260 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HUT13_RS02265 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase HUT13_RS02270 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HUT13_RS02275 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HUT13_RS02305 ENOG4105DKT Transcriptional regulator HUT13_RS02310 ENOG4105DJV ribulose-phosphate 3-epimerase HUT13_RS02320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HUT13_RS02340 ENOG4105VUF Transcriptional regulator HUT13_RS02350 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HUT13_RS02360 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HUT13_RS02365 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HUT13_RS02375 ENOG4105SKN orotidine 5''-phosphate decarboxylase HUT13_RS02380 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HUT13_RS02385 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HUT13_RS02390 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HUT13_RS02400 ENOG4105CD3 dihydroorotase HUT13_RS02405 ENOG4105CXT aspartate transcarbamylase HUT13_RS02410 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HUT13_RS02420 ENOG410803B Involved in the transcription termination process (By similarity) HUT13_RS02425 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HUT13_RS02430 ENOG4105DC7 peptidase M24 HUT13_RS02440 ENOG4105D49 3-dehydroquinate synthase HUT13_RS02445 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HUT13_RS02450 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HUT13_RS02455 ENOG4105E2X shikimate dehydrogenase HUT13_RS02465 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HUT13_RS02470 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT13_RS02490 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT13_RS02510 ENOG4105CUT histidyl-tRNA synthetase HUT13_RS02520 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) HUT13_RS02525 ENOG4105C99 atpase involved in dna repair HUT13_RS02530 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT13_RS02535 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HUT13_RS02540 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT13_RS02545 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT13_RS02555 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT13_RS02560 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HUT13_RS02565 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) HUT13_RS02570 ENOG4105CDY transcriptional regulatory protein HUT13_RS02575 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HUT13_RS02580 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HUT13_RS02590 ENOG4105E2K Glycosyl transferase (Group 1 HUT13_RS02595 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase HUT13_RS02615 ENOG4105C22 threonyL-tRNA synthetase HUT13_RS02625 ENOG4105KF0 sporulation and cell division protein, SsgA HUT13_RS02705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT13_RS02710 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT13_RS02725 ENOG4105D01 (LipO)protein HUT13_RS02730 ENOG4108UMI ABC transporter, permease HUT13_RS02735 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS02755 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HUT13_RS02760 ENOG4105CEY Amp-dependent synthetase and ligase HUT13_RS02780 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HUT13_RS02800 ENOG4105CH7 arginosuccinase HUT13_RS02810 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HUT13_RS02815 ENOG4105C8Y Acetylornithine aminotransferase HUT13_RS02820 ENOG4105CAS nag kinase HUT13_RS02825 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HUT13_RS02830 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HUT13_RS02840 ENOG4105PDP Short chain dehydrogenase HUT13_RS02860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT13_RS02865 ENOG4105T38 integral membrane protein HUT13_RS02915 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HUT13_RS02925 ENOG4105F32 YngK protein HUT13_RS02940 ENOG4105FDF Could be involved in DNA repair (By similarity) HUT13_RS02950 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HUT13_RS02955 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HUT13_RS02960 ENOG4105BZU Histidine kinase HUT13_RS02965 ENOG4108RWN rrna methyltransferase HUT13_RS02970 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HUT13_RS02975 ENOG41084BS 50S ribosomal protein L35 HUT13_RS02980 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HUT13_RS02990 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT13_RS03025 ENOG4105C26 Dehydrogenase HUT13_RS03035 ENOG41073TP transcriptional regulator HUT13_RS03040 ENOG4105C85 amino acid HUT13_RS03045 ENOG4108Z86 Glutamine amidotransferase HUT13_RS03050 ENOG4105HFS 5'-3' exonuclease HUT13_RS03060 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HUT13_RS03065 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT13_RS03080 ENOG4108FFZ Transcriptional regulator HUT13_RS03095 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) HUT13_RS03110 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT13_RS03115 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) HUT13_RS03120 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) HUT13_RS03125 ENOG4105E5F proteasome HUT13_RS03130 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) HUT13_RS03160 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS03165 ENOG4107URF beta-phospho-glucomutase HUT13_RS03170 ENOG4105C3R Methionine synthase HUT13_RS03175 ENOG4108K8U Glycerol operon regulatory protein HUT13_RS03180 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HUT13_RS03185 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HUT13_RS03200 ENOG4105C8N cysteinyl-tRNA synthetase HUT13_RS03220 ENOG4105DYW oxidoreductase HUT13_RS03225 ENOG4105CPC Aldo Keto reductase HUT13_RS03260 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT13_RS03275 ENOG4108MYR Secreted protein HUT13_RS03290 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS03300 ENOG4108M8W Monooxygenase HUT13_RS03310 ENOG4105C26 Dehydrogenase HUT13_RS03315 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HUT13_RS03330 ENOG4105C94 Transporter HUT13_RS03345 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS03390 ENOG4108762 serine threonine protein kinase HUT13_RS03405 ENOG4105KVH Transcriptional regulator HUT13_RS03420 ENOG4108UW5 maltose o-acetyltransferase HUT13_RS03425 ENOG4108RFG Tetr family transcriptional regulator HUT13_RS03435 ENOG4108IND Tetr family transcriptional regulator HUT13_RS03465 ENOG4105D7V transposase HUT13_RS03500 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS03510 ENOG4107U9B transcriptional regulator HUT13_RS03515 ENOG4107S2Z UPF0761 membrane protein HUT13_RS03525 ENOG4105VBF alkaline shock protein HUT13_RS03545 ENOG4108I69 Glycosyl transferases group 1 HUT13_RS03565 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS03575 ENOG41080UQ Transcriptional regulator HUT13_RS03580 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT13_RS03585 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN HUT13_RS03590 ENOG4107S91 Sodium hydrogen exchanger HUT13_RS03595 ENOG4108N23 SpoOM-related protein HUT13_RS03615 ENOG4105CJ1 ABC, transporter HUT13_RS03625 ENOG4107S91 Sodium hydrogen exchanger HUT13_RS03630 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT13_RS03640 ENOG4105DFD Na H antiporter HUT13_RS03645 ENOG4105C5Q Transcriptional regulator HUT13_RS03650 ENOG4105H3G oxidoreductase HUT13_RS03655 ENOG4105CHR reductase HUT13_RS03680 ENOG4108IV0 ABC, transporter HUT13_RS03685 ENOG4105C0Z ABC transporter HUT13_RS03695 ENOG4105C32 Amino acid ABC transporter (Permease) HUT13_RS03700 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HUT13_RS03725 ENOG4105D8V Glucose sorbosone dehydrogenase HUT13_RS03740 ENOG4105F1J Homogentisate 1,2-dioxygenase HUT13_RS03765 ENOG4106UW1 Major Facilitator superfamily HUT13_RS03805 ENOG4108D32 Methyltransferase HUT13_RS03845 ENOG4105CXK mandelate racemase muconate lactonizing HUT13_RS03850 ENOG4108UHU Aldolase HUT13_RS03855 ENOG4105D7K pfkb domain protein HUT13_RS03880 ENOG4105EUB pirin domain protein HUT13_RS03895 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS03900 ENOG4105CG3 alpha amylase, catalytic region HUT13_RS03905 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HUT13_RS03915 ENOG4108VGI doxx family HUT13_RS03920 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HUT13_RS03955 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) HUT13_RS03980 ENOG4108UQS dipeptidase HUT13_RS03995 ENOG4105GWZ Roadblock lc7 family protein HUT13_RS04075 ENOG4105D9P serine threonine protein kinase HUT13_RS04090 ENOG4108UHU Aldolase HUT13_RS04100 ENOG4105XPP Protein of unknown function (DUF1275) HUT13_RS04105 ENOG4105CMT Dihydroxyacetone kinase HUT13_RS04110 ENOG4108UTZ Dihydroxyacetone kinase HUT13_RS04140 ENOG4105ESN nucleotide-binding protein HUT13_RS04145 ENOG4105ESN nucleotide-binding protein HUT13_RS04145 ENOG4105ESN nucleotide-binding protein HUT13_RS04150 ENOG4106F1P AAA ATPase, central domain protein HUT13_RS04160 ENOG4105MVE transcriptional regulator HUT13_RS04170 ENOG4105C2M dna polymerase I HUT13_RS04175 ENOG4105XYF acetyltransferase HUT13_RS04180 ENOG41073TP transcriptional regulator HUT13_RS04190 ENOG4105Q70 HUT13_RS04200 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT13_RS04220 ENOG4107URF beta-phospho-glucomutase HUT13_RS04225 ENOG4105CJ1 ABC, transporter HUT13_RS04235 ENOG4105ENE Histidine kinase HUT13_RS04240 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS04245 ENOG4107SVN transposase HUT13_RS04255 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) HUT13_RS04265 ENOG4105CQM Urea amidohydrolase subunit alpha HUT13_RS04270 ENOG4105KI2 Urea amidohydrolase subunit beta HUT13_RS04275 ENOG4108YZ9 Urea amidohydrolase subunit gamma HUT13_RS04295 ENOG4106NMR serine protease HUT13_RS04300 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT13_RS04305 ENOG4105C1G acyl-Coa dehydrogenase HUT13_RS04310 ENOG4105C57 major facilitator superfamily HUT13_RS04315 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT13_RS04335 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HUT13_RS04345 ENOG4105CAT Cytidine monophosphate kinase HUT13_RS04355 ENOG4105FE9 pseudouridine synthase HUT13_RS04360 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HUT13_RS04365 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HUT13_RS04380 ENOG4105DCF alanine dehydrogenase HUT13_RS04390 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT13_RS04395 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HUT13_RS04400 ENOG4105BZP glycoside hydrolase 15-related HUT13_RS04410 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS04425 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HUT13_RS04430 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HUT13_RS04455 ENOG4105DSU hydrolase HUT13_RS04470 ENOG4105DUU IucA IucC family protein HUT13_RS04495 ENOG4108VX5 3-methyladenine DNA glycosylase HUT13_RS04505 ENOG4108V1U phospholipid-binding protein HUT13_RS04525 ENOG4105DKW ABC transporter HUT13_RS04545 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS04550 ENOG4105BZU Histidine kinase HUT13_RS04555 ENOG4105IDI abc transporter atp-binding protein HUT13_RS04560 ENOG4105EAC phosphoserine phosphatase HUT13_RS04575 ENOG4105DJ2 Major Facilitator Superfamily HUT13_RS04580 ENOG4107YCY Transcriptional regulator HUT13_RS04585 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HUT13_RS04590 ENOG4105CHR reductase HUT13_RS04615 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HUT13_RS04630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT13_RS04635 ENOG4107RZZ dna polymerase iii epsilon subunit HUT13_RS04675 ENOG4106YT9 Enoyl-CoA hydratase HUT13_RS04685 ENOG4105C5H ABC transporter HUT13_RS04720 ENOG4105NAF rna polymerase sigma factor HUT13_RS04730 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase HUT13_RS04740 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) HUT13_RS04745 ENOG4105EV8 ectoine hydroxylase HUT13_RS04775 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS04795 ENOG41069M3 Transcriptional regulator HUT13_RS04800 ENOG4108JGH Tetr family transcriptional regulator HUT13_RS04810 ENOG4105C7N Xanthine uracil vitamin C permease HUT13_RS04825 ENOG4105E9Z Nad-dependent epimerase dehydratase HUT13_RS04835 ENOG4108J20 pectate lyase HUT13_RS04850 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HUT13_RS04855 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS04865 ENOG4108JGH Tetr family transcriptional regulator HUT13_RS04870 ENOG4105C57 major facilitator superfamily HUT13_RS04885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT13_RS04895 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) HUT13_RS04900 ENOG410814C multidrug resistance protein HUT13_RS04910 ENOG4105VG1 fes assembly suf system protein HUT13_RS04915 ENOG4108UNV SUF system FeS assembly protein, NifU family HUT13_RS04920 ENOG4105C9B Cysteine desulfurase HUT13_RS04925 ENOG4105C3K feS assembly ATPase SufC HUT13_RS04935 ENOG4105JRK feS assembly protein SufD HUT13_RS04950 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS04955 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT13_RS04960 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT13_RS04970 ENOG4105DDC Oxidoreductase domain protein HUT13_RS04990 ENOG4107TK4 histidinol-phosphate phosphatase HUT13_RS04995 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HUT13_RS05010 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT13_RS05015 ENOG4105IIU Aminopeptidase HUT13_RS05020 ENOG4105CJ1 ABC, transporter HUT13_RS05030 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) HUT13_RS05045 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT13_RS05055 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HUT13_RS05070 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) HUT13_RS05075 ENOG4107QP8 phosphohexose isomerase HUT13_RS05090 ENOG4105CP7 Triose-phosphate isomerase HUT13_RS05095 ENOG4105BZA Phosphoglycerate kinase HUT13_RS05100 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HUT13_RS05105 ENOG4105CIE May be required for sporulation (By similarity) HUT13_RS05110 ENOG4105CHW UPF0052 protein HUT13_RS05115 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HUT13_RS05120 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HUT13_RS05135 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT13_RS05150 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HUT13_RS05155 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT13_RS05160 ENOG4105DR5 peptidase HUT13_RS05165 ENOG4105BZU Histidine kinase HUT13_RS05225 ENOG4105E2A Dehydrogenase HUT13_RS05245 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HUT13_RS05255 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HUT13_RS05275 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HUT13_RS05280 ENOG4108IV0 ABC, transporter HUT13_RS05285 ENOG4105C0Z ABC transporter HUT13_RS05290 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HUT13_RS05295 ENOG4105C32 Amino acid ABC transporter (Permease) HUT13_RS05360 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HUT13_RS05370 ENOG4108762 serine threonine protein kinase HUT13_RS05385 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT13_RS05390 ENOG4105XN3 extracellular solute-binding protein family 1 HUT13_RS05405 ENOG4105CBC glutamate synthase HUT13_RS05415 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HUT13_RS05435 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HUT13_RS05440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT13_RS05450 ENOG4105DK0 Indole-3-glycerol phosphate synthase HUT13_RS05470 ENOG4105CRQ synthase (Component I) HUT13_RS05475 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HUT13_RS05490 ENOG4107TDE lipolytic protein G-D-S-L family HUT13_RS05495 ENOG4105CX8 fg-gap repeat protein HUT13_RS05505 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HUT13_RS05510 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HUT13_RS05520 ENOG4105C5Q Transcriptional regulator HUT13_RS05535 ENOG4105E33 succinate dehydrogenase HUT13_RS05545 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HUT13_RS05575 ENOG4105CHR reductase HUT13_RS05580 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT13_RS05590 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HUT13_RS05600 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT13_RS05650 ENOG41064MX Tetr family transcriptional regulator HUT13_RS05655 ENOG41064MX Tetr family transcriptional regulator HUT13_RS05660 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HUT13_RS05665 ENOG4108176 endoribonuclease L-psp HUT13_RS05670 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HUT13_RS05675 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HUT13_RS05685 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HUT13_RS05690 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT13_RS05695 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HUT13_RS05705 ENOG4108Z66 YbaK ebsC protein HUT13_RS05750 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT13_RS05770 ENOG4105C0B DNA polymerase III (alpha subunit) HUT13_RS05805 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HUT13_RS05815 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HUT13_RS05820 ENOG4107VQS DivIVA family HUT13_RS05830 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HUT13_RS05835 ENOG4105DFA alanine racemase domain protein HUT13_RS05840 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HUT13_RS05845 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HUT13_RS05855 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HUT13_RS05865 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HUT13_RS05870 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HUT13_RS05875 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HUT13_RS05880 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HUT13_RS05885 ENOG4105CJN penicillin-binding protein HUT13_RS05895 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HUT13_RS05905 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT13_RS05925 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HUT13_RS05940 ENOG4105EWK phytoene HUT13_RS05955 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HUT13_RS05980 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HUT13_RS06000 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HUT13_RS06020 ENOG4108UQY Iron-storage protein HUT13_RS06030 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase HUT13_RS06095 ENOG4105DKQ ROK family HUT13_RS06105 ENOG4105D0U Arsenite-activated ATPase (ArsA) HUT13_RS06115 ENOG4105JNK Glycosyl transferase (Group 1 HUT13_RS06140 ENOG4108I0Q anthranilate phosphoribosyltransferase HUT13_RS06145 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HUT13_RS06150 ENOG4107EUI c reductase, iron-sulfur HUT13_RS06155 ENOG4107UDY cytochrome C HUT13_RS06160 ENOG4105CCU oxidase (Subunit III) HUT13_RS06170 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT13_RS06175 ENOG4105MCD Part of cytochrome c oxidase, its function is HUT13_RS06180 ENOG4105BZ9 Cytochrome C oxidase, subunit I HUT13_RS06185 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) HUT13_RS06190 ENOG4105C3J Cysteine desulfurase HUT13_RS06195 ENOG4107T4Z adenosine kinase HUT13_RS06210 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HUT13_RS06215 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS06220 ENOG4105BZU Histidine kinase HUT13_RS06240 ENOG4105C0H protease HUT13_RS06255 ENOG4108YZT Adenosylcobinamide kinase HUT13_RS06265 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HUT13_RS06280 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HUT13_RS06300 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT13_RS06330 ENOG4105EW9 transcriptional regulator AsnC family HUT13_RS06365 ENOG4105DTD Dehydrogenase HUT13_RS06390 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HUT13_RS06395 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HUT13_RS06435 ENOG4108KQ5 Integrase catalytic subunit HUT13_RS06450 ENOG4107R5B glutamine synthetase HUT13_RS06465 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS06485 ENOG4105CG3 alpha amylase, catalytic region HUT13_RS06490 ENOG4105EG2 ABC transporter, permease HUT13_RS06495 ENOG4105D56 permease protein HUT13_RS06500 ENOG4107FKK extracellular solute-binding protein family 1 HUT13_RS06515 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HUT13_RS06520 ENOG4105C5F glutamine synthetase HUT13_RS06550 ENOG4108X7A Terpene synthase metal-binding domain-containing protein HUT13_RS06560 ENOG4105D0M Protease HtpX homolog HUT13_RS06570 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HUT13_RS06620 ENOG4105CG3 alpha amylase, catalytic region HUT13_RS06625 ENOG4105CPC Aldo Keto reductase HUT13_RS06640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HUT13_RS06645 ENOG4105EHG Permease protein HUT13_RS06650 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS06655 ENOG4105D3Q Sugar transferase HUT13_RS06660 ENOG4105C30 Nad-dependent epimerase dehydratase HUT13_RS06665 ENOG4105C0K Gdp-mannose 4,6-dehydratase HUT13_RS06710 ENOG4105CHR reductase HUT13_RS06715 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) HUT13_RS06720 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS06755 ENOG4105FFM Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity) HUT13_RS06765 ENOG4105IIU Aminopeptidase HUT13_RS06785 ENOG4106CD9 glycosyl transferase group 1 HUT13_RS06795 ENOG4108KXM LysR family Transcriptional regulator HUT13_RS06800 ENOG4107AQZ Membrane HUT13_RS06815 ENOG4107S9F NmrA family HUT13_RS06825 ENOG4106A0S HUT13_RS06850 ENOG4105EW9 transcriptional regulator AsnC family HUT13_RS06870 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT13_RS06875 ENOG4105C2C drug resistance transporter, Bcr CflA HUT13_RS06880 ENOG4105DGI Alkaline phosphatase HUT13_RS06890 ENOG4107ZXU DSBA oxidoreductase HUT13_RS06920 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT13_RS06945 ENOG4105EMU Dehydrogenase HUT13_RS06955 ENOG4107XFJ UPF0246 protein HUT13_RS06970 ENOG4105EGD dinuclear metal center protein, YbgI family HUT13_RS06995 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS07000 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT13_RS07025 ENOG4107VXZ Hydrolase HUT13_RS07065 ENOG41064MX Tetr family transcriptional regulator HUT13_RS07110 ENOG4105DAX Pfam:DUF2983 HUT13_RS07165 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HUT13_RS07180 ENOG4105BZU Histidine kinase HUT13_RS07210 ENOG4105CPC Aldo Keto reductase HUT13_RS07215 ENOG4105VUF Transcriptional regulator HUT13_RS07225 ENOG4105C2W permease HUT13_RS07245 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT13_RS07250 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT13_RS07290 ENOG4107XEY Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT13_RS07295 ENOG4108KPJ rna polymerase sigma factor HUT13_RS07310 ENOG410645S MarR family Transcriptional regulator HUT13_RS07320 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HUT13_RS07325 ENOG4108IND Tetr family transcriptional regulator HUT13_RS07365 ENOG4106F60 Histidine kinase HUT13_RS07370 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT13_RS07375 ENOG4107WD8 ABC transporter, permease HUT13_RS07415 ENOG4105CXK mandelate racemase muconate lactonizing HUT13_RS07440 ENOG4108HWW ABC transporter HUT13_RS07445 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HUT13_RS07470 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS07480 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT13_RS07485 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HUT13_RS07490 ENOG4105J4Q Transcriptional regulator HUT13_RS07515 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT13_RS07520 ENOG4106F60 Histidine kinase HUT13_RS07525 ENOG4107SCK Monooxygenase HUT13_RS07560 ENOG4105F95 Monooxygenase HUT13_RS07580 ENOG4105C1G acyl-Coa dehydrogenase HUT13_RS07585 ENOG4107RCI amp-dependent synthetase and ligase HUT13_RS07610 ENOG4105VUN Transcriptional regulator HUT13_RS07635 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT13_RS07650 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HUT13_RS07665 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HUT13_RS07675 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HUT13_RS07715 ENOG4105FB2 class II Aldolase HUT13_RS07720 ENOG4105G63 Type III effector Hrp-dependent HUT13_RS07735 ENOG4105MVE transcriptional regulator HUT13_RS07740 ENOG4105CMG Carbohydrate kinase HUT13_RS07755 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HUT13_RS07765 ENOG4105C7K acetolactate synthase HUT13_RS07785 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HUT13_RS07800 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT13_RS07810 ENOG4105VF7 tolerance protein HUT13_RS07830 ENOG4107QZF nitrite reductase NADPH large subunit HUT13_RS07835 ENOG4107QZF nitrite reductase NADPH large subunit HUT13_RS07840 ENOG4107QZF nitrite reductase NADPH large subunit HUT13_RS07865 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) HUT13_RS07870 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS07885 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT13_RS07910 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT13_RS07915 ENOG4108V9W transcriptional regulatory protein HUT13_RS07925 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HUT13_RS07935 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HUT13_RS07950 ENOG4105E2R ROK family HUT13_RS07980 ENOG4108FN7 Aldo keto reductase HUT13_RS08000 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) HUT13_RS08010 ENOG4105FDK ABC transporter HUT13_RS08030 ENOG4105D9P serine threonine protein kinase HUT13_RS08035 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT13_RS08040 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HUT13_RS08050 ENOG4105KVH Transcriptional regulator HUT13_RS08075 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT13_RS08090 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT13_RS08095 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT13_RS08100 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HUT13_RS08120 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HUT13_RS08130 ENOG4108KPW sugar kinase HUT13_RS08135 ENOG4105F8D glycoside hydrolase family 4 HUT13_RS08140 ENOG4105DSG hydrolase family 43 HUT13_RS08145 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HUT13_RS08160 ENOG4105C8J )-transporter HUT13_RS08175 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT13_RS08180 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HUT13_RS08205 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HUT13_RS08210 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HUT13_RS08245 ENOG4105EPR degv family HUT13_RS08255 ENOG4105C8T Leucyl-tRNA synthetase HUT13_RS08270 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT13_RS08285 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HUT13_RS08295 ENOG4105D0M Protease HtpX homolog HUT13_RS08310 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HUT13_RS08320 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HUT13_RS08340 ENOG4108SHN Glycosyl transferase, family 2 HUT13_RS08355 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT13_RS08360 ENOG4105K46 50S ribosomal protein l27 HUT13_RS08365 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HUT13_RS08370 ENOG4105C03 ribonuclease HUT13_RS08380 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HUT13_RS08385 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HUT13_RS08390 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HUT13_RS08395 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HUT13_RS08420 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HUT13_RS08430 ENOG4108RZE Tetr family transcriptional regulator HUT13_RS08440 ENOG4105CX8 fg-gap repeat protein HUT13_RS08445 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HUT13_RS08450 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HUT13_RS08475 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS08490 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HUT13_RS08515 ENOG4105C5H ABC transporter HUT13_RS08520 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HUT13_RS08525 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HUT13_RS08530 ENOG4105F8V Hydrolase, tatD family HUT13_RS08560 ENOG4105EYF MMPL domain protein HUT13_RS08580 ENOG4107TB5 TRANSCRIPTIONal HUT13_RS08585 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT13_RS08590 ENOG41082SX arsR family transcriptional regulator HUT13_RS08595 ENOG4108Q5F Tetr family transcriptional regulator HUT13_RS08610 ENOG4105CGK Exodeoxyribonuclease III HUT13_RS08620 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT13_RS08625 ENOG4105E0S extracellular solute-binding protein family 1 HUT13_RS08635 ENOG4105DEN Luciferase family HUT13_RS08650 ENOG4105NRA 50s ribosomal protein l31 type b HUT13_RS08660 ENOG4105DQ5 transport system permease protein HUT13_RS08665 ENOG4105TVJ transport system, permease HUT13_RS08670 ENOG4105E0A ABC, transporter HUT13_RS08695 ENOG4105FDP GntR family transcriptional regulator HUT13_RS08700 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUT13_RS08705 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HUT13_RS08710 ENOG4105D8K carboxyl transferase HUT13_RS08715 ENOG4106A3M Cytochrome p-450 HUT13_RS08725 ENOG4105CIR epoxide hydrolase HUT13_RS08730 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HUT13_RS08775 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT13_RS08780 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HUT13_RS08790 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HUT13_RS08795 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase HUT13_RS08810 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) HUT13_RS08820 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HUT13_RS08825 ENOG4108ZHJ Organic hydroperoxide resistance protein HUT13_RS08830 ENOG4105K56 Transcriptional regulator HUT13_RS08845 ENOG4105KXX peptidase s58 dmpa HUT13_RS08855 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT13_RS08860 ENOG4105DM4 PTS System HUT13_RS08865 ENOG4105DE4 1-phosphofructokinase HUT13_RS08870 ENOG410804X Transcriptional regulator HUT13_RS08880 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HUT13_RS08885 ENOG41068KF Universal stress protein HUT13_RS08915 ENOG4105JXH GntR family transcriptional regulator HUT13_RS08920 ENOG4105DIA mandelate racemase muconate lactonizing HUT13_RS08940 ENOG4105CXK mandelate racemase muconate lactonizing HUT13_RS08950 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT13_RS08955 ENOG410801F ribosomal-protein-alanine acetyltransferase HUT13_RS08970 ENOG4108097 ATP-binding protein HUT13_RS08975 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HUT13_RS08980 ENOG4107QTJ carbohydrate kinase, YjeF related protein HUT13_RS08985 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HUT13_RS08990 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT13_RS08995 ENOG4105CS9 pantothenic acid kinase HUT13_RS09000 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HUT13_RS09005 ENOG4108UJD 30S ribosomal protein S9 HUT13_RS09010 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HUT13_RS09015 ENOG4105C5H ABC transporter HUT13_RS09055 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HUT13_RS09060 ENOG4108ZT0 50S ribosomal protein l17 HUT13_RS09065 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT13_RS09070 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HUT13_RS09075 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HUT13_RS09080 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HUT13_RS09085 ENOG41067V7 50S ribosomal protein L36 HUT13_RS09090 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HUT13_RS09100 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HUT13_RS09110 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HUT13_RS09115 ENOG410849U 50S ribosomal protein L30 HUT13_RS09120 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HUT13_RS09125 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HUT13_RS09130 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HUT13_RS09135 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HUT13_RS09140 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT13_RS09145 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HUT13_RS09150 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HUT13_RS09155 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HUT13_RS09160 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HUT13_RS09165 ENOG41082SA 50s ribosomal protein l29 HUT13_RS09170 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HUT13_RS09175 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HUT13_RS09180 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) HUT13_RS09185 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HUT13_RS09190 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HUT13_RS09195 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HUT13_RS09200 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HUT13_RS09205 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HUT13_RS09210 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HUT13_RS09215 ENOG4107QN1 sodium solute HUT13_RS09225 ENOG4105DY9 regulatoR HUT13_RS09230 ENOG4108HRK Histidine kinase HUT13_RS09240 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HUT13_RS09260 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HUT13_RS09265 ENOG4107QN1 sodium solute HUT13_RS09275 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HUT13_RS09280 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HUT13_RS09285 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HUT13_RS09290 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HUT13_RS09295 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT13_RS09300 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HUT13_RS09305 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HUT13_RS09310 ENOG4108VZM 50s ribosomal protein L10 HUT13_RS09320 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HUT13_RS09325 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HUT13_RS09330 ENOG4105CK2 sodium dicarboxylate symporter HUT13_RS09345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS09370 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HUT13_RS09375 ENOG410683Z Preprotein translocase SecE subunit HUT13_RS09400 ENOG4107R4N Cell wall formation (By similarity) HUT13_RS09420 ENOG410900P UPF0336 protein HUT13_RS09425 ENOG4105WDJ 50S ribosomal protein L33 HUT13_RS09460 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS09565 ENOG4108RWP Major Facilitator Superfamily protein HUT13_RS09590 ENOG4105CEY Amp-dependent synthetase and ligase HUT13_RS09595 ENOG4105WQI isochorismatase HUT13_RS09615 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT13_RS09620 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT13_RS09630 ENOG4105EHG Permease protein HUT13_RS09635 ENOG4105E0A ABC, transporter HUT13_RS09675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HUT13_RS09680 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HUT13_RS09695 ENOG4108VPT UPF0234 protein HUT13_RS09700 ENOG410901E Membrane HUT13_RS09705 ENOG4105D0M Protease HtpX homolog HUT13_RS09710 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09715 ENOG4105C8S subunit m HUT13_RS09725 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09735 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09740 ENOG4107QW0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT13_RS09745 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT13_RS09750 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09755 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT13_RS09775 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein HUT13_RS09780 ENOG4105DQU oxidoreductase, subunit beta HUT13_RS09835 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09845 ENOG4105D65 subunit l HUT13_RS09850 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09855 ENOG4105DF2 NADH dehydrogenase subunit j HUT13_RS09860 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09865 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) HUT13_RS09870 ENOG4108IEH NADH dehydrogenase subunit g HUT13_RS09875 ENOG4107QIZ NADH dehydrogenase HUT13_RS09885 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09890 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain HUT13_RS09895 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS09930 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS09945 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT13_RS09955 ENOG4105EV6 Pfam:DUF178 HUT13_RS09960 ENOG4105VEQ Cold shock protein HUT13_RS09985 ENOG4107QJT sodium dicarboxylate symporter HUT13_RS10000 ENOG4105DVY radical SAM domain protein HUT13_RS10010 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HUT13_RS10020 ENOG4105NDT Rhomboid family HUT13_RS10035 ENOG4108DT4 serine threonine protein kinase HUT13_RS10040 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HUT13_RS10075 ENOG4108762 serine threonine protein kinase HUT13_RS10155 ENOG41082SX arsR family transcriptional regulator HUT13_RS10175 ENOG4108IUW ABC transporter HUT13_RS10200 ENOG4105C01 Dihydroxy-acid dehydratase HUT13_RS10205 ENOG4108JWX HUT13_RS10210 ENOG4107R33 ppx gppa phosphatase HUT13_RS10220 ENOG4105CJ1 ABC, transporter HUT13_RS10225 ENOG4105EY0 Xylose isomerase domain protein TIM barrel HUT13_RS10230 ENOG4105U5Y Transcriptional regulator HUT13_RS10255 ENOG4105CNI cell division protein FtsW HUT13_RS10260 ENOG4105CJN penicillin-binding protein HUT13_RS10275 ENOG4105DFF Rod shape-determining protein mreb HUT13_RS10280 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HUT13_RS10290 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HUT13_RS10295 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT13_RS10335 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HUT13_RS10350 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT13_RS10355 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT13_RS10360 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT13_RS10365 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HUT13_RS10385 ENOG4108TGC Acyltransferase HUT13_RS10390 ENOG4105DR5 peptidase HUT13_RS10410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS10420 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT13_RS10435 ENOG4108YZG isomerase HUT13_RS10470 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HUT13_RS10475 ENOG4105MC2 DSBA oxidoreductase HUT13_RS10520 ENOG4105D8X mechanosensitive ion channel HUT13_RS10540 ENOG4107SMB hydrolase Family 5 HUT13_RS10550 ENOG4105CT1 (ABC) transporter HUT13_RS10585 ENOG4105CJ1 ABC, transporter HUT13_RS10635 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HUT13_RS10675 ENOG4105KVH Transcriptional regulator HUT13_RS10710 ENOG4108MP6 LysR family Transcriptional regulator HUT13_RS10735 ENOG4105CSU acyl-Coa dehydrogenase HUT13_RS10740 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT13_RS10750 ENOG4105CHR reductase HUT13_RS10770 ENOG41086VD Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HUT13_RS10775 ENOG4105C7K acetolactate synthase HUT13_RS10785 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT13_RS10795 ENOG4108ZXC Two component transcriptional regulator, luxr family HUT13_RS10805 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HUT13_RS10810 ENOG4107QJT sodium dicarboxylate symporter HUT13_RS10825 ENOG4107R13 MMPL domain protein HUT13_RS10830 ENOG4105CPQ Dehydrogenase HUT13_RS10845 ENOG4108Z6Z Transcriptional regulator HUT13_RS10850 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HUT13_RS10915 ENOG4105EC2 ftsk spoIIIe HUT13_RS10980 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT13_RS10995 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT13_RS11005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS11010 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT13_RS11030 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HUT13_RS11035 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HUT13_RS11040 ENOG4105EDK PfkB domain protein HUT13_RS11050 ENOG4105DH8 myo-inositol catabolism HUT13_RS11055 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HUT13_RS11060 ENOG4105C26 Dehydrogenase HUT13_RS11080 ENOG4105C7H Helicase, RecD TraA family HUT13_RS11115 ENOG4107S9F NmrA family HUT13_RS11120 ENOG4108X0B nad(p)h dehydrogenase (quinone) HUT13_RS11125 ENOG4105CN8 Transcriptional regulator HUT13_RS11135 ENOG4105CJN penicillin-binding protein HUT13_RS11145 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HUT13_RS11155 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) HUT13_RS11160 ENOG4105CAK Cell division ATP-binding protein ftsE HUT13_RS11175 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) HUT13_RS11180 ENOG4108QVN serine threonine protein kinase HUT13_RS11185 ENOG4108UGD Serine Threonine protein kinase HUT13_RS11200 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component HUT13_RS11205 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT13_RS11245 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS11250 ENOG4107RZX Teichoic acid biosynthesis protein HUT13_RS11255 ENOG4105K64 Glycosyl transferase, family 2 HUT13_RS11280 ENOG4105CFF transcriptional regulator HUT13_RS11290 ENOG4105CKK Glycosyl transferase, family 2 HUT13_RS11300 ENOG4107SJB teichoic acid biosynthesis HUT13_RS11305 ENOG4105CGN Glycosyl transferase (Group 1 HUT13_RS11325 ENOG4105C7I Dehydrogenase HUT13_RS11345 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT13_RS11350 ENOG4105T0Z Conserved Protein HUT13_RS11355 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS11360 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea HUT13_RS11370 ENOG4105G3P Lipoprotein lpqB HUT13_RS11375 ENOG4105BZU Histidine kinase HUT13_RS11380 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS11395 ENOG4108WQ6 secreted protein HUT13_RS11400 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HUT13_RS11440 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) HUT13_RS11445 ENOG4105EIP mannose-6-phosphate isomerase HUT13_RS11455 ENOG4105W49 UPF0434 protein HUT13_RS11480 ENOG4107RGC Glycosyl transferase, family 2 HUT13_RS11485 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT13_RS11500 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) HUT13_RS11520 ENOG4108KGH TRANSCRIPTIONal HUT13_RS11535 ENOG4108KGH TRANSCRIPTIONal HUT13_RS11560 ENOG4108S4H thioesterase Superfamily protein HUT13_RS11565 ENOG4108KGH TRANSCRIPTIONal HUT13_RS11570 ENOG4105C6Y Udp-glucose 6-dehydrogenase HUT13_RS11595 ENOG4105DR5 peptidase HUT13_RS11620 ENOG4105BZU Histidine kinase HUT13_RS11625 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS11640 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT13_RS11655 ENOG4105CI2 imidazolone-5-propionate hydrolase HUT13_RS11665 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HUT13_RS11670 ENOG4105CGP Urocanate hydratase HUT13_RS11675 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT13_RS11700 ENOG4105CHU acetyl-coa acetyltransferase HUT13_RS11715 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT13_RS11795 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT13_RS11800 ENOG4107RBB ABC transporter, permease HUT13_RS11805 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT13_RS11850 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HUT13_RS11855 ENOG4105MS9 Resuscitation-promoting factor HUT13_RS11870 ENOG4105BZU Histidine kinase HUT13_RS11880 ENOG4105D9P serine threonine protein kinase HUT13_RS11985 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HUT13_RS11995 ENOG4105CEN a g-specific adenine glycosylase HUT13_RS12015 ENOG4108KPJ rna polymerase sigma factor HUT13_RS12020 ENOG4105W1N transcriptional regulator HUT13_RS12025 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT13_RS12035 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT13_RS12080 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) HUT13_RS12090 ENOG4108IYU L-aspartate oxidase HUT13_RS12095 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HUT13_RS12105 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS12120 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HUT13_RS12150 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HUT13_RS12160 ENOG4108IJ8 ABC transporter HUT13_RS12165 ENOG4105E90 ABC transporter HUT13_RS12170 ENOG4105E90 ABC transporter HUT13_RS12190 ENOG4105EUJ GTP cyclohydrolase i HUT13_RS12205 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HUT13_RS12220 ENOG4105F0N pyrophosphate phospho-hydrolase HUT13_RS12235 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT13_RS12240 ENOG4108KPJ rna polymerase sigma factor HUT13_RS12295 ENOG4105DR5 peptidase HUT13_RS12300 ENOG41083TI Protein CrcB homolog HUT13_RS12305 ENOG4105KJJ Uncharacterized ACR, COG1993 HUT13_RS12310 ENOG41083YR Protein CrcB homolog HUT13_RS12350 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HUT13_RS12355 ENOG4105KDC 50s ribosomal protein l28 HUT13_RS12365 ENOG4105NRA 50s ribosomal protein l31 type b HUT13_RS12375 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT13_RS12435 ENOG4105ERH Fumarylacetoacetate hydrolase HUT13_RS12440 ENOG4108FN7 Aldo keto reductase HUT13_RS12460 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT13_RS12490 ENOG4105BZ1 (ABC) transporter HUT13_RS12505 ENOG4105DSE periplasmic solute binding protein HUT13_RS12515 ENOG4105CC5 ABC transporter HUT13_RS12520 ENOG4105DIK (ABC) transporter HUT13_RS12580 ENOG4105CHR reductase HUT13_RS12585 ENOG4105CPQ Dehydrogenase HUT13_RS12590 ENOG4105IJJ transcriptional regulator, crp fnr family HUT13_RS12620 ENOG4105C6E dna polymerase iii HUT13_RS12630 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HUT13_RS12635 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HUT13_RS12655 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT13_RS12670 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HUT13_RS12680 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for HUT13_RS12690 ENOG4105WN5 stage II sporulation protein HUT13_RS12695 ENOG4108I5C dEAD DEAH box helicase HUT13_RS12755 ENOG4105CHH sulfate transporter HUT13_RS12760 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HUT13_RS12770 ENOG4105D74 hydrolase HUT13_RS12785 ENOG4105DJ4 phosphatidylserine decarboxylase HUT13_RS12805 ENOG4105P8F nudix hydrolase HUT13_RS12820 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HUT13_RS12855 ENOG4105T16 Transcriptional regulator (AraC family) HUT13_RS12860 ENOG41068HZ 50S ribosomal protein L32 HUT13_RS12895 ENOG4105BZ4 penicillin-binding protein HUT13_RS12930 ENOG4105NAF rna polymerase sigma factor HUT13_RS12935 ENOG4105CFH Aspartokinase HUT13_RS12940 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) HUT13_RS12955 ENOG4107S5I aldo keto reductase HUT13_RS13015 ENOG4105M4P Tetr family transcriptional regulator HUT13_RS13020 ENOG4105CAT Cytidine monophosphate kinase HUT13_RS13030 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HUT13_RS13040 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HUT13_RS13045 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HUT13_RS13065 ENOG4107T65 Integrase HUT13_RS13070 ENOG4106CY5 excisionase HUT13_RS13085 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HUT13_RS13125 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT13_RS13220 ENOG4105CNN ABC, transporter HUT13_RS13225 ENOG4105C2J ABC transporter HUT13_RS13230 ENOG4105DKQ ROK family HUT13_RS13235 ENOG4105VEQ Cold shock protein HUT13_RS13250 ENOG4105NAF rna polymerase sigma factor HUT13_RS13265 ENOG4105CPC Aldo Keto reductase HUT13_RS13275 ENOG4107R13 MMPL domain protein HUT13_RS13295 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS13300 ENOG4105CX8 fg-gap repeat protein HUT13_RS13350 ENOG4106F1P AAA ATPase, central domain protein HUT13_RS13370 ENOG4105IIU Aminopeptidase HUT13_RS13385 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HUT13_RS13395 ENOG4108Z6B deaminase HUT13_RS13405 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT13_RS13410 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT13_RS13435 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HUT13_RS13460 ENOG4105CEY Amp-dependent synthetase and ligase HUT13_RS13465 ENOG4105NAF rna polymerase sigma factor HUT13_RS13515 ENOG4105C0H protease HUT13_RS13530 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HUT13_RS13545 ENOG4107T6F Xaa-Pro aminopeptidase HUT13_RS13570 ENOG4105NAF rna polymerase sigma factor HUT13_RS13600 ENOG41080T7 secreted protein HUT13_RS13605 ENOG4105JDN Copper resistance protein HUT13_RS13610 ENOG4105DBE peroxidase HUT13_RS13620 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HUT13_RS13625 ENOG410667J hydrolase HUT13_RS13655 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT13_RS13660 ENOG410667J hydrolase HUT13_RS13675 ENOG4107P2S Transcriptional regulator HUT13_RS13680 ENOG4105CIH Imidazole acetol-phosphate transaminase HUT13_RS13685 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT13_RS13690 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HUT13_RS13695 ENOG4108JJ9 ABC, transporter HUT13_RS13725 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HUT13_RS13740 ENOG4106048 Cupin 2, conserved barrel domain protein HUT13_RS13745 ENOG41082T9 Membrane HUT13_RS13750 ENOG4105KJF protein tyrosine phosphatase HUT13_RS13755 ENOG4105C28 cystathionine HUT13_RS13790 ENOG4105F27 Major Facilitator HUT13_RS13815 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT13_RS13825 ENOG4105C3M thioredoxin reductase HUT13_RS13830 ENOG4105CDU Replicative dna helicase HUT13_RS13840 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HUT13_RS13845 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HUT13_RS13850 ENOG4107YH6 single-stranded DNA-binding protein HUT13_RS13855 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) HUT13_RS13875 ENOG4105CZA synthase HUT13_RS13885 ENOG4105BZ4 penicillin-binding protein HUT13_RS13900 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HUT13_RS13930 ENOG4105C3M thioredoxin reductase HUT13_RS13935 ENOG4105K63 Thioredoxin HUT13_RS13945 ENOG4107QJE Chromosome Partitioning Protein HUT13_RS13950 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HUT13_RS13960 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HUT13_RS13965 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HUT13_RS13975 ENOG41084CH 50S ribosomal protein l34 HUT13_RS13985 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HUT13_RS13990 ENOG4108J5G 6-phosphogluconate dehydrogenase HUT13_RS13995 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HUT13_RS14000 ENOG4105K7N UPF0232 protein HUT13_RS14005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT13_RS14010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT13_RS14045 ENOG4108RN7 integral membrane protein HUT13_RS14050 ENOG4108U4N (sortase) family HUT13_RS14070 ENOG4105ZJT Cell division protein CrgA HUT13_RS14095 ENOG4105CJN penicillin-binding protein HUT13_RS14110 ENOG4105HZM Fha domain containing protein HUT13_RS14115 ENOG4105TV9 FHA Domain-Containing protein HUT13_RS14125 ENOG4107RCH Diaminopropionate ammonia-lyase HUT13_RS14140 ENOG4105D3Q Sugar transferase HUT13_RS14150 ENOG4105CJR Integral membrane protein (MviN HUT13_RS14160 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT13_RS14195 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT13_RS14200 ENOG4105KVH Transcriptional regulator HUT13_RS14210 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HUT13_RS14230 ENOG41080RH Thioredoxin HUT13_RS14260 ENOG4105C9M aspartyl-trna synthetase HUT13_RS14265 ENOG4105EUB pirin domain protein HUT13_RS14275 ENOG4105CSU acyl-Coa dehydrogenase HUT13_RS14320 ENOG4105EC2 ftsk spoIIIe HUT13_RS14330 ENOG4105DFM M18 family aminopeptidase HUT13_RS14340 ENOG4107QPV Serine Threonine protein kinase HUT13_RS14360 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HUT13_RS14365 ENOG4107258 Transcriptional regulator HUT13_RS14385 ENOG4105CPP Dehydrogenase, E1 component HUT13_RS14395 ENOG4108VC7 Protein of unknown function (DUF2587) HUT13_RS14405 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT13_RS14425 ENOG4107SVH Potassium channel protein HUT13_RS14430 ENOG4105CVM Molybdenum cofactor synthesis domain protein HUT13_RS14440 ENOG4108TKH Nitroreductase HUT13_RS14450 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HUT13_RS14455 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HUT13_RS14460 ENOG4105C7W Xanthine dehydrogenase HUT13_RS14465 ENOG4107QSN dihydrolipoamide acetyltransferase HUT13_RS14495 ENOG4108RZE Tetr family transcriptional regulator HUT13_RS14565 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HUT13_RS14570 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HUT13_RS14575 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HUT13_RS14580 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HUT13_RS14585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HUT13_RS14610 ENOG4107SM8 Adenylate Guanylate cyclase HUT13_RS14625 ENOG4105CHR reductase HUT13_RS14630 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS14655 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS14665 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HUT13_RS14670 ENOG4105CVK Glutamate decarboxylase HUT13_RS14710 ENOG4105E0A ABC, transporter HUT13_RS14715 ENOG4105EHG Permease protein HUT13_RS14740 ENOG41082YX Transcriptional regulator, arsr family HUT13_RS14860 ENOG4105DHP deoxycytidine triphosphate deaminase HUT13_RS14870 ENOG4105DF6 Fe-S oxidoreductase HUT13_RS14875 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT13_RS14885 ENOG4105CFG Acts as a chaperone (By similarity) HUT13_RS14890 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HUT13_RS14895 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HUT13_RS14900 ENOG4105KNI merR family transcriptional Regulator HUT13_RS14905 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT13_RS14910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS14920 ENOG410841Q phosphoesterase PA-phosphatase related protein HUT13_RS14940 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HUT13_RS14955 ENOG4108JQ7 (ABC) transporter HUT13_RS15000 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HUT13_RS15005 ENOG4107RCW fructose-bisphosphate aldolase HUT13_RS15015 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) HUT13_RS15050 ENOG41082VC UPF0145 protein HUT13_RS15070 ENOG4105DIM ABC transporter HUT13_RS15075 ENOG4105CIG ABC transporter HUT13_RS15090 ENOG4105EBR Carboxylesterase HUT13_RS15100 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HUT13_RS15125 ENOG4108V4B ThiJ pfpI HUT13_RS15130 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS15145 ENOG4105C12 Phosphoribosylglycinamide synthetase HUT13_RS15165 ENOG4105C8V SAICAR synthetase HUT13_RS15185 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS15225 ENOG410839H phosphoribosylformylglycinamidine synthase HUT13_RS15230 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HUT13_RS15235 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HUT13_RS15245 ENOG4108ZHR arsR family transcriptional regulator HUT13_RS15265 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT13_RS15305 ENOG4105CXB phosphoribosylaminoimidazole synthetase HUT13_RS15335 ENOG4105CQ7 ATP-dependent helicase HUT13_RS15365 ENOG4105VUN Transcriptional regulator HUT13_RS15385 ENOG4105FDP GntR family transcriptional regulator HUT13_RS15465 ENOG4107ZVI PhiRv2 prophage protein HUT13_RS15475 ENOG4105VTR Integrase HUT13_RS15490 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HUT13_RS15510 ENOG4105C1J atp-dependent rna helicase HUT13_RS15530 ENOG4105E4C Lytic transglycosylase catalytic HUT13_RS15540 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HUT13_RS15565 ENOG41067SE Tetr family transcriptional regulator HUT13_RS15595 ENOG4105DGU Histone deacetylase HUT13_RS15630 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HUT13_RS15635 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HUT13_RS15640 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HUT13_RS15645 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HUT13_RS15650 ENOG4105D52 delta-aminolevulinic acid dehydratase HUT13_RS15665 ENOG4106UW1 Major Facilitator superfamily HUT13_RS15675 ENOG4105CIR epoxide hydrolase HUT13_RS15680 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT13_RS15685 ENOG4105C75 arginyL-tRNA synthetase HUT13_RS15690 ENOG4105DK7 lysyl-tRNA synthetase HUT13_RS15700 ENOG4105CHH sulfate transporter HUT13_RS15735 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HUT13_RS15740 ENOG4108RH7 phosphoglycerate mutase HUT13_RS15745 ENOG4107ZT5 Thiol disulfide interchange protein HUT13_RS15750 ENOG4107QIV Cytochrome c biogenesis protein HUT13_RS15755 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) HUT13_RS15760 ENOG4105CRE cytochrome C HUT13_RS15770 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HUT13_RS15775 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HUT13_RS15800 ENOG4105E4C Lytic transglycosylase catalytic HUT13_RS15805 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HUT13_RS15820 ENOG4105VPX protein, conserved in bacteria HUT13_RS15835 ENOG4105E2Z phosphate ABC transporter (Permease HUT13_RS15840 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS15885 ENOG4105JXB ankyrin repeat-containing protein HUT13_RS15890 ENOG4105BZU Histidine kinase HUT13_RS15895 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS15900 ENOG4105C4M (Ubiquinol oxidase) subunit I HUT13_RS15910 ENOG4105EYF MMPL domain protein HUT13_RS15915 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HUT13_RS15920 ENOG4107YCY Transcriptional regulator HUT13_RS15930 ENOG4105HHS UPF0256 protein HUT13_RS15940 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HUT13_RS15960 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HUT13_RS15970 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HUT13_RS15980 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands HUT13_RS15985 ENOG4105PKJ carbohydrate binding HUT13_RS15990 ENOG4105KHC sulfurtransferase HUT13_RS16010 ENOG4107NHD transcriptional regulator HUT13_RS16015 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS16030 ENOG4105C0H protease HUT13_RS16045 ENOG4108Z4X TRANSCRIPTIONal HUT13_RS16060 ENOG4105CGH 5'-nucleotidase HUT13_RS16065 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT13_RS16070 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HUT13_RS16085 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT13_RS16090 ENOG4108YZJ Pfam:DUF2596 HUT13_RS16105 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS16125 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT13_RS16130 ENOG4105BZU Histidine kinase HUT13_RS16140 ENOG4105BZU Histidine kinase HUT13_RS16155 ENOG4108VJ1 Transcriptional regulator (CarD family HUT13_RS16160 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HUT13_RS16165 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HUT13_RS16175 ENOG4105C8N cysteinyl-tRNA synthetase HUT13_RS16180 ENOG4105C2N RNA methyltransferase TrmH family group 3 HUT13_RS16195 ENOG4108S0S Nucleotidyl transferase HUT13_RS16255 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HUT13_RS16320 ENOG4105BZU Histidine kinase HUT13_RS16330 ENOG4105CE4 GlcNAc 6-P deacetylase HUT13_RS16335 ENOG4105DKQ ROK family HUT13_RS16355 ENOG4108K4C ec 3.1.3.12 HUT13_RS16370 ENOG4105C3Q Glycosyl transferase, family 2 HUT13_RS16385 ENOG4105VEQ Cold shock protein HUT13_RS16395 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HUT13_RS16400 ENOG4106G6Q Transcriptional regulator HUT13_RS16420 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS16425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS16430 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HUT13_RS16440 ENOG4105E2Z phosphate ABC transporter (Permease HUT13_RS16445 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS16470 ENOG4105E4C Lytic transglycosylase catalytic HUT13_RS16490 ENOG4105CFI type iii restriction protein res subunit HUT13_RS16495 ENOG4105EEM helicase HUT13_RS16515 ENOG4108IMY Transcriptional regulator HUT13_RS16560 ENOG4105VEQ Cold shock protein HUT13_RS16565 ENOG4105E63 Pfam:DUF178 HUT13_RS16570 ENOG4108UIH futalosine nucleosidase HUT13_RS16580 ENOG4108N0W Major Facilitator superfamily HUT13_RS16615 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HUT13_RS16625 ENOG4105XMC MarR family Transcriptional regulator HUT13_RS16630 ENOG4107Y80 Major Facilitator superfamily HUT13_RS16645 ENOG4105CPC Aldo Keto reductase HUT13_RS16655 ENOG4105CPC Aldo Keto reductase HUT13_RS16685 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS16695 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HUT13_RS16735 ENOG4105CQB FAD linked oxidase domain protein HUT13_RS16825 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS16830 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HUT13_RS16835 ENOG4108SU4 UPF0309 protein HUT13_RS16885 ENOG4105C57 major facilitator superfamily HUT13_RS16930 ENOG4105H3G oxidoreductase HUT13_RS16940 ENOG4108762 serine threonine protein kinase HUT13_RS16970 ENOG4105F0K SARP family transcriptional regulator HUT13_RS16975 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) HUT13_RS16980 ENOG41065RQ ADP-ribosylation crystallin J1 HUT13_RS17000 ENOG4105DZ1 carboxypeptidase HUT13_RS17030 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT13_RS17045 ENOG4105EMU Dehydrogenase HUT13_RS17050 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) HUT13_RS17055 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS17060 ENOG4108MMM RNA Polymerase HUT13_RS17070 ENOG4107QVP Dehydrogenase HUT13_RS17080 ENOG4107QQG Dehydrogenase HUT13_RS17085 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HUT13_RS17090 ENOG4105D9P serine threonine protein kinase HUT13_RS17100 ENOG4105C26 Dehydrogenase HUT13_RS17115 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HUT13_RS17130 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS17165 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HUT13_RS17175 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT13_RS17185 ENOG4108Z4X TRANSCRIPTIONal HUT13_RS17190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT13_RS17230 ENOG4105CMV Succinyl-CoA synthetase subunit beta HUT13_RS17265 ENOG4105DC1 bifunctional purine biosynthesis protein purh HUT13_RS17285 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HUT13_RS17300 ENOG41067TZ transcriptional regulator, MarR family HUT13_RS17315 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HUT13_RS17330 ENOG4105C8Y Acetylornithine aminotransferase HUT13_RS17335 ENOG4105C31 Tryptophanyl-tRNA synthetase HUT13_RS17350 ENOG4105DZ1 carboxypeptidase HUT13_RS17355 ENOG4107RN3 metallophosphoesterase HUT13_RS17375 ENOG4105C0R drug resistance transporter emrb qaca subfamily HUT13_RS17380 ENOG4105CQB FAD linked oxidase domain protein HUT13_RS17385 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HUT13_RS17400 ENOG4105CHP RNA polymerase HUT13_RS17415 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT13_RS17425 ENOG4105C26 Dehydrogenase HUT13_RS17435 ENOG4108SV8 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) HUT13_RS17505 ENOG4105E2D ec 3.2.1.52 HUT13_RS17515 ENOG4105D5P Methylmalonyl-coA mutase HUT13_RS17545 ENOG4105F0R Cytidylyltransferase HUT13_RS17560 ENOG4107RM1 amidohydrolase HUT13_RS17565 ENOG4105DIH basic membrane HUT13_RS17570 ENOG4108JQ9 ABC transporter HUT13_RS17575 ENOG4105UIB (ABC) transporter HUT13_RS17595 ENOG4105CJW magnesium transporter HUT13_RS17605 ENOG4105C6F GntR Family Transcriptional Regulator HUT13_RS17610 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HUT13_RS17615 ENOG4105C6Z Gluconate HUT13_RS17655 ENOG4105C22 threonyL-tRNA synthetase HUT13_RS17660 ENOG4107SVN transposase HUT13_RS17675 ENOG4105D94 Major Facilitator Superfamily HUT13_RS17680 ENOG4107RSM transcriptional regulator HUT13_RS17685 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT13_RS17710 ENOG41065SU Two-component system sensor kinase HUT13_RS17715 ENOG4108KXV response regulator HUT13_RS17720 ENOG4105NAF rna polymerase sigma factor HUT13_RS17730 ENOG4105C26 Dehydrogenase HUT13_RS17735 ENOG4105C26 Dehydrogenase HUT13_RS17750 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain HUT13_RS17775 ENOG4108JIK carboxylase HUT13_RS17780 ENOG4107WR6 Maf-like protein HUT13_RS17810 ENOG4105D8K carboxyl transferase HUT13_RS17820 ENOG4108QER Adenylate cyclase HUT13_RS17825 ENOG4105E39 Enoyl-CoA hydratase HUT13_RS17835 ENOG4105KDM Diguanylate cyclase with gaf sensor HUT13_RS17840 ENOG4105C84 Histidine ammonia-lyase HUT13_RS17855 ENOG4107UBC ErfK ybiS ycfS ynhG family protein HUT13_RS17860 ENOG4105WBV Transcriptional regulator HUT13_RS17865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT13_RS17870 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HUT13_RS17880 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HUT13_RS17900 ENOG4105C7B Threonine dehydratase HUT13_RS17925 ENOG4105T1M mycothiol conjugate amidase mca HUT13_RS17935 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HUT13_RS17940 ENOG4105C7Z Conserved Protein HUT13_RS17950 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) HUT13_RS18035 ENOG4107QKZ Ompa motb domain protein HUT13_RS18050 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HUT13_RS18055 ENOG4108IAB Phoh family HUT13_RS18080 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT13_RS18100 ENOG4107TPY serine threonine protein kinase HUT13_RS18105 ENOG4107GFK fumarate HUT13_RS18110 ENOG4105C9Q fumarate hydratase class II HUT13_RS18125 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HUT13_RS18130 ENOG4105D3R alkyl hydroperoxide reductase HUT13_RS18170 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HUT13_RS18180 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HUT13_RS18185 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HUT13_RS18195 ENOG4105C3G gtp-binding protein HUT13_RS18235 ENOG4105CI3 gtp-binding protein typa HUT13_RS18240 ENOG4108J59 Extracellular solute-binding protein, family 5 HUT13_RS18245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT13_RS18250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS18260 ENOG4108JQ7 (ABC) transporter HUT13_RS18270 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT13_RS18275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS18280 ENOG4105C3U ABC transporter HUT13_RS18285 ENOG4108JQ7 (ABC) transporter HUT13_RS18320 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS18325 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) HUT13_RS18340 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) HUT13_RS18350 ENOG4108JQ7 (ABC) transporter HUT13_RS18355 ENOG4105C3U ABC transporter HUT13_RS18360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT13_RS18365 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT13_RS18370 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS18380 ENOG4108Z4U Ferredoxin HUT13_RS18415 ENOG4107R4C succinyl-diaminopimelate desuccinylase HUT13_RS18420 ENOG4108URH decarboxylase HUT13_RS18425 ENOG4105EEI dihydropteroate synthase HUT13_RS18435 ENOG4105CGU Enoyl-CoA hydratase HUT13_RS18450 ENOG4105DU6 RNA polymerase HUT13_RS18460 ENOG4105C0H protease HUT13_RS18465 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HUT13_RS18500 ENOG4105CGH 5'-nucleotidase HUT13_RS18510 ENOG4105DB7 PHP domain protein HUT13_RS18630 ENOG4105C4R Atp-dependent dna helicase HUT13_RS18750 ENOG41063PX domain protein HUT13_RS18760 ENOG4105DJZ UPF0182 protein HUT13_RS18790 ENOG4108IG5 Transcriptional regulator HUT13_RS18800 ENOG4107QX3 carboxylase HUT13_RS18810 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HUT13_RS18815 ENOG4105C1G acyl-Coa dehydrogenase HUT13_RS18830 ENOG4105J76 Periplasmic binding protein HUT13_RS18835 ENOG4105DQ5 transport system permease protein HUT13_RS18840 ENOG4105TVJ transport system, permease HUT13_RS18845 ENOG4105E0A ABC, transporter HUT13_RS18855 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT13_RS18870 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HUT13_RS18895 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HUT13_RS18900 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT13_RS18915 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HUT13_RS18925 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS18940 ENOG4107TK4 histidinol-phosphate phosphatase HUT13_RS18960 ENOG4105C29 acyl-CoA thioesterase HUT13_RS18970 ENOG4108XFF HUT13_RS19005 ENOG4105XUP Phage derived protein Gp49-like (DUF891) HUT13_RS19010 ENOG4106F59 XRE family Transcriptional regulator HUT13_RS19015 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HUT13_RS19025 ENOG4106NZI LysR family Transcriptional regulator HUT13_RS19035 ENOG41060NJ transcriptional regulator HUT13_RS19060 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT13_RS19085 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) HUT13_RS19100 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS19105 ENOG4105KVH Transcriptional regulator HUT13_RS19150 ENOG4108W6C Dehydrogenase HUT13_RS19155 ENOG4105E1F short-chain dehydrogenase reductase HUT13_RS19170 ENOG4107TXC Transcriptional regulator HUT13_RS19180 ENOG4107TPY serine threonine protein kinase HUT13_RS19185 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS19215 ENOG4105DQQ Major facilitator superfamily MFS_1 HUT13_RS19255 ENOG4107VWK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HUT13_RS19265 ENOG4106NZI LysR family Transcriptional regulator HUT13_RS19270 ENOG4105CAQ asparagine synthetase HUT13_RS19275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT13_RS19280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS19335 ENOG4108426 dNA-binding protein HUT13_RS19340 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT13_RS19345 ENOG4108UJU UPF0301 protein HUT13_RS19355 ENOG4105E2D ec 3.2.1.52 HUT13_RS19370 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT13_RS19380 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HUT13_RS19420 ENOG41063PX domain protein HUT13_RS19425 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT13_RS19435 ENOG4105KF0 sporulation and cell division protein, SsgA HUT13_RS19465 ENOG4108RWI nicotinamidase HUT13_RS19475 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) HUT13_RS19485 ENOG4105BZG amino acid carrier protein HUT13_RS19505 ENOG4105CNI cell division protein FtsW HUT13_RS19515 ENOG4108RQ5 Beta-lactamase domain-containing protein HUT13_RS19520 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HUT13_RS19525 ENOG41060NJ transcriptional regulator HUT13_RS19530 ENOG4105WEM extracellular solute-binding protein HUT13_RS19535 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HUT13_RS19540 ENOG4105DRS transport system, permease HUT13_RS19550 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HUT13_RS19580 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) HUT13_RS19585 ENOG4108JQC penicillin-binding protein 1A HUT13_RS19595 ENOG4106BRA Membrane HUT13_RS19665 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT13_RS19670 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HUT13_RS19685 ENOG4105BZU Histidine kinase HUT13_RS19720 ENOG4108ZM9 phosphoglycerate mutase HUT13_RS19750 ENOG4105BZU Histidine kinase HUT13_RS19775 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS19780 ENOG4105C3M thioredoxin reductase HUT13_RS19795 ENOG41065HY 1,4-beta-cellobiosidase HUT13_RS19800 ENOG4105CYP glycoside hydrolase, family HUT13_RS19810 ENOG41065HY 1,4-beta-cellobiosidase HUT13_RS19815 ENOG4108RAV Conserved protein HUT13_RS19820 ENOG4105EMN RNA polymerase sigma factor HUT13_RS19825 ENOG4105WMN AntiSigma factor HUT13_RS19830 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT13_RS19845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HUT13_RS19855 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT13_RS19865 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT13_RS19870 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT13_RS19880 ENOG4105D22 carbon starvation protein HUT13_RS19885 ENOG4105FDP GntR family transcriptional regulator HUT13_RS19905 ENOG4105D17 glycoside hydrolase, family 3 domain protein HUT13_RS19910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HUT13_RS19925 ENOG4105CBD Diacylglycerol kinase HUT13_RS19940 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HUT13_RS19945 ENOG4105K6H D-cysteine desulfhydrase HUT13_RS19970 ENOG4108VEQ Superoxide dismutase HUT13_RS19985 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT13_RS19990 ENOG4105C6K Malic enzyme HUT13_RS19995 ENOG4105E89 ABC transporter HUT13_RS20000 ENOG4108HW4 amino acid AbC transporter HUT13_RS20010 ENOG4106PGW Short-chain dehydrogenase reductase Sdr HUT13_RS20035 ENOG4105CB2 alcohol dehydrogenase HUT13_RS20040 ENOG4105JXH GntR family transcriptional regulator HUT13_RS20050 ENOG4105CMT Dihydroxyacetone kinase HUT13_RS20055 ENOG4107YVI ribose 5-phosphate isomerase HUT13_RS20060 ENOG4105CP7 Triose-phosphate isomerase HUT13_RS20065 ENOG4108KFM Xylose Isomerase Domain-Containing protein HUT13_RS20070 ENOG4106J7G oxidoreductase HUT13_RS20075 ENOG4105CV1 Transketolase (EC 2.2.1.1) HUT13_RS20085 ENOG4108SGK Tetr family transcriptional regulator HUT13_RS20090 ENOG4105E1F short-chain dehydrogenase reductase HUT13_RS20160 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HUT13_RS20200 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HUT13_RS20205 ENOG4105EB3 Histidine kinase HUT13_RS20210 ENOG4108PYU two-component system response regulator HUT13_RS20255 ENOG41060BG Tetr family transcriptional regulator HUT13_RS20265 ENOG4105DCG PHP domain protein HUT13_RS20285 ENOG4105D1K glutamate--cysteine ligase HUT13_RS20290 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process HUT13_RS20340 ENOG4107QRI Phosphoketolase HUT13_RS20345 ENOG4105CJQ hydrolase, family 31 HUT13_RS20355 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HUT13_RS20360 ENOG4105EWK phytoene HUT13_RS20380 ENOG4108ZJ4 polysaccharide deacetylase HUT13_RS20390 ENOG4105CFF transcriptional regulator HUT13_RS20400 ENOG4105CR4 methylisocitrate lyase HUT13_RS20420 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS20435 ENOG4106JUT Streptomycin 3''-adenylyltransferase HUT13_RS20445 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HUT13_RS20455 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HUT13_RS20475 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HUT13_RS20485 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HUT13_RS20490 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HUT13_RS20500 ENOG4108KGH TRANSCRIPTIONal HUT13_RS20505 ENOG4105VFB Binds the 23S rRNA (By similarity) HUT13_RS20510 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HUT13_RS20515 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HUT13_RS20545 ENOG4105ZA1 atp synthase HUT13_RS20550 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) HUT13_RS20555 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HUT13_RS20560 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HUT13_RS20565 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HUT13_RS20570 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HUT13_RS20575 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HUT13_RS20595 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS20600 ENOG4105BZU Histidine kinase HUT13_RS20605 ENOG4105IIP Membrane HUT13_RS20635 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HUT13_RS20650 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) HUT13_RS20675 ENOG4108YYH Nadph-dependent fmn reductase HUT13_RS20705 ENOG4105CJ1 ABC, transporter HUT13_RS20725 ENOG4105CHU acetyl-coa acetyltransferase HUT13_RS20740 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT13_RS20755 ENOG4105ECQ AraC Family Transcriptional Regulator HUT13_RS20760 ENOG4105DDN Pentapeptide repeat-containing protein HUT13_RS20770 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HUT13_RS20785 ENOG4105EMU Dehydrogenase HUT13_RS20805 ENOG4108Z6Z Transcriptional regulator HUT13_RS20860 ENOG4105EJ2 Transcriptional regulator HUT13_RS20915 ENOG4105EMN RNA polymerase sigma factor HUT13_RS20930 ENOG4105WX6 Membrane HUT13_RS20940 ENOG4105JZI cytochrome P450 HUT13_RS20950 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT13_RS20980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HUT13_RS20985 ENOG4105C6K Malic enzyme HUT13_RS20990 ENOG4105CTQ phosphohexokinase HUT13_RS21035 ENOG4105FBW Monooxygenase HUT13_RS21040 ENOG4105CPN adenine deaminase HUT13_RS21085 ENOG4108MRH transcriptional regulatory protein HUT13_RS21090 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HUT13_RS21095 ENOG4105C8P )-transporter HUT13_RS21100 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HUT13_RS21105 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) HUT13_RS21110 ENOG4105CG3 alpha amylase, catalytic region HUT13_RS21115 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) HUT13_RS21125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HUT13_RS21130 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HUT13_RS21135 ENOG4105C3U ABC transporter HUT13_RS21140 ENOG4108JQ7 (ABC) transporter HUT13_RS21145 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HUT13_RS21150 ENOG4105BZ1 (ABC) transporter HUT13_RS21155 ENOG4105BZ1 (ABC) transporter HUT13_RS21175 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HUT13_RS21220 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS21225 ENOG4105C6T cysteine synthase HUT13_RS21290 ENOG4105CJ1 ABC, transporter HUT13_RS21370 ENOG4105CJ1 ABC, transporter HUT13_RS21410 ENOG4105EJQ L-serine dehydratase HUT13_RS21415 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT13_RS21420 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HUT13_RS21425 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HUT13_RS21445 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction HUT13_RS21475 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HUT13_RS21480 ENOG4105VMP Transcriptional regulator HUT13_RS21505 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HUT13_RS21510 ENOG4105BZU Histidine kinase HUT13_RS21515 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT13_RS21520 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HUT13_RS21530 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HUT13_RS21540 ENOG4107SM8 Adenylate Guanylate cyclase HUT13_RS21555 ENOG4107SM8 Adenylate Guanylate cyclase HUT13_RS21560 ENOG4107SET aldo keto reductase HUT13_RS21580 ENOG4108ZP8 Acetolactate synthase small subunit HUT13_RS21585 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HUT13_RS21625 ENOG4105C26 Dehydrogenase HUT13_RS21635 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HUT13_RS21640 ENOG4105CM2 brancheD-chain amino acid aminotransferase HUT13_RS21645 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HUT13_RS21650 ENOG4105D8K carboxyl transferase HUT13_RS21670 ENOG4105GWZ Roadblock lc7 family protein HUT13_RS21690 ENOG4105GWZ Roadblock lc7 family protein HUT13_RS21705 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HUT13_RS21710 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HUT13_RS21760 ENOG41069M3 Transcriptional regulator HUT13_RS21765 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT13_RS21770 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HUT13_RS21780 ENOG4105K70 DNA-binding protein HUT13_RS21800 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HUT13_RS21805 ENOG4105CPF Cell wall formation (By similarity) HUT13_RS21830 ENOG4105DWF phosphomethylpyrimidine kinase HUT13_RS21835 ENOG4105VB9 50S ribosomal protein l28 HUT13_RS21840 ENOG4105DP4 dak2 domain fusion protein ylov HUT13_RS21865 ENOG4106H78 methyltransferase HUT13_RS21870 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HUT13_RS21885 ENOG41084BZ 50S ribosomal protein L32 HUT13_RS21890 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HUT13_RS21895 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HUT13_RS21900 ENOG4105K4I Scp-like extracellular HUT13_RS21905 ENOG4108375 Acylphosphatase (EC 3.6.1.7) HUT13_RS21950 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HUT13_RS21960 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) HUT13_RS21970 ENOG4105K5M 30s ribosomal protein S16 HUT13_RS21975 ENOG41082KU UPF0109 protein HUT13_RS21980 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HUT13_RS21985 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HUT13_RS21990 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HUT13_RS22005 ENOG4107QYR Signal peptidase i HUT13_RS22010 ENOG4107QYR Signal peptidase i HUT13_RS22025 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT13_RS22040 ENOG41080R2 UPF0102 protein HUT13_RS22045 ENOG4105CE9 30S ribosomal protein S2 HUT13_RS22050 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HUT13_RS22055 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HUT13_RS22060 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HUT13_RS22065 ENOG4105KNE Phosphatidate cytidylyltransferase HUT13_RS22155 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HUT13_RS22170 ENOG4108UCS ABC, transporter HUT13_RS22185 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HUT13_RS22190 ENOG4105C26 Dehydrogenase HUT13_RS22205 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HUT13_RS22210 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT13_RS22225 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HUT13_RS22245 ENOG4105G9B Transcriptional regulator HUT13_RS22280 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HUT13_RS22315 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HUT13_RS22320 ENOG4105DZP Membrane-associated zinc metalloprotease HUT13_RS22325 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HUT13_RS22330 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) HUT13_RS22335 ENOG41080E2 ribosomal-protein-alanine acetyltransferase HUT13_RS22340 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HUT13_RS22345 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase HUT13_RS22360 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) HUT13_RS22375 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HUT13_RS22385 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HUT13_RS22390 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HUT13_RS22420 ENOG4108T50 Protein of unknown function (DUF690) HUT13_RS22475 ENOG4105EC2 ftsk spoIIIe HUT13_RS22485 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HUT13_RS22490 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HUT13_RS22495 ENOG4105C1V Peptidase, M16 HUT13_RS22500 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HUT13_RS22525 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HUT13_RS22530 ENOG4105CN5 Metallo-Beta-Lactamase HUT13_RS22560 ENOG4105BZU Histidine kinase HUT13_RS22565 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase HUT13_RS22570 ENOG4107QZI cell division protein FtsK HUT13_RS22580 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HUT13_RS22590 ENOG4105CEV competence damage-inducible protein HUT13_RS22595 ENOG4105WBV Transcriptional regulator HUT13_RS22600 ENOG4107QRT dEAD DEAH box helicase HUT13_RS22610 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) HUT13_RS22620 ENOG4107SCK Monooxygenase HUT13_RS22625 ENOG4105DRP amino acid AbC transporter HUT13_RS22630 ENOG4108Q1T ABC transporter HUT13_RS22635 ENOG4107UBR Extracellular solute-binding protein family 3 HUT13_RS22640 ENOG4105CDA abc transporter atp-binding protein HUT13_RS22645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS22665 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HUT13_RS22690 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HUT13_RS22700 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HUT13_RS22705 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HUT13_RS22710 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HUT13_RS22725 ENOG4105FKQ transcriptional regulator HUT13_RS22745 ENOG4105DRS transport system, permease HUT13_RS22750 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HUT13_RS22780 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HUT13_RS22785 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HUT13_RS22790 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HUT13_RS22805 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HUT13_RS22810 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HUT13_RS22815 ENOG4105C9U ATP-dependent DNA helicase RecQ HUT13_RS22830 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS22835 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HUT13_RS22850 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT13_RS22860 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HUT13_RS22875 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS22880 ENOG410849S phosphocarrier protein (HPr) HUT13_RS22900 ENOG4107W53 thymidine kinase HUT13_RS22920 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HUT13_RS22935 ENOG4105F44 Two component transcriptional regulator, winged helix family HUT13_RS22940 ENOG4106F60 Histidine kinase HUT13_RS22955 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HUT13_RS22995 ENOG4107VEG TrkA-N domain protein HUT13_RS23000 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HUT13_RS23010 ENOG4105VEQ Cold shock protein HUT13_RS23015 ENOG4105C1J atp-dependent rna helicase HUT13_RS23025 ENOG4105F0K SARP family transcriptional regulator HUT13_RS23060 ENOG4105EC2 ftsk spoIIIe HUT13_RS23100 ENOG4107QK5 Homocysteine s-methyltransferase HUT13_RS23105 ENOG4108JNI Alpha beta hydrolase HUT13_RS23125 ENOG4105DBV ornithine carbamoyltransferase HUT13_RS23130 ENOG4105CEU Arginine dihydrolase HUT13_RS23170 ENOG4105EYF MMPL domain protein HUT13_RS23210 ENOG4108VWQ crispr-associated protein HUT13_RS23225 ENOG4105PWE CRISPR-associated protein cas2 HUT13_RS23230 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HUT13_RS23235 ENOG4107QM5 aconitate hydratase HUT13_RS23255 ENOG4105E2R ROK family HUT13_RS23265 ENOG4105C2J ABC transporter HUT13_RS23270 ENOG4108HWW ABC transporter HUT13_RS23275 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HUT13_RS23285 ENOG4108KGH TRANSCRIPTIONal HUT13_RS23295 ENOG4105CHU acetyl-coa acetyltransferase HUT13_RS23315 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HUT13_RS23320 ENOG4105C1Q protoporphyrinogen oxidase HUT13_RS23325 ENOG4107JTW chlorite dismutase HUT13_RS23330 ENOG4105CSR polyphosphate kinase 2 HUT13_RS23350 ENOG4105DFU Cell wall formation (By similarity) HUT13_RS23355 ENOG4105E0X reductase HUT13_RS23360 ENOG4108U3T pfkb domain protein HUT13_RS23365 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT13_RS23385 ENOG4108UW8 fha domain-containing protein HUT13_RS23420 ENOG4105E8G Major facilitator Superfamily HUT13_RS23430 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HUT13_RS23445 ENOG4107NHD transcriptional regulator HUT13_RS23455 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HUT13_RS23460 ENOG4108IY8 ABC, transporter HUT13_RS23485 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HUT13_RS23495 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HUT13_RS23505 ENOG4105CSU acyl-Coa dehydrogenase HUT13_RS23520 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HUT13_RS23525 ENOG410905P Pyridoxamine 5-phosphate HUT13_RS23555 ENOG4105DRR Transcriptional regulator, GntR family HUT13_RS23570 ENOG4108K8K Transcriptional regulator HUT13_RS23585 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HUT13_RS23625 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) HUT13_RS23640 ENOG4107R9S Malate synthase HUT13_RS23655 ENOG4105J4Q Transcriptional regulator HUT13_RS23665 ENOG4105DHG Allantoate amidinohydrolase HUT13_RS23695 ENOG41062B0 ABC transporter, permease HUT13_RS23700 ENOG4105C2J ABC transporter HUT13_RS23705 ENOG4105DKQ ROK family HUT13_RS23715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS23730 ENOG4105BZW Glycerate kinase HUT13_RS23735 ENOG4105C94 Transporter HUT13_RS23745 ENOG4105ECY inositol monophosphatase HUT13_RS23775 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) HUT13_RS23790 ENOG4105C3M thioredoxin reductase HUT13_RS23805 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS23825 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HUT13_RS23855 ENOG4105E0A ABC, transporter HUT13_RS23860 ENOG4105EHG Permease protein HUT13_RS23875 ENOG4105CC5 ABC transporter HUT13_RS23890 ENOG4105DSE periplasmic solute binding protein HUT13_RS23905 ENOG4105CKI cobalamin synthesis protein HUT13_RS23925 ENOG4105DGA Diaminopimelate dehydrogenase HUT13_RS23935 ENOG4105C0W non-ribosomal peptide synthetase HUT13_RS23940 ENOG4105C0W non-ribosomal peptide synthetase HUT13_RS23945 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HUT13_RS23955 ENOG4105DEF Extracellular solute-binding protein, family 5 HUT13_RS23970 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS24000 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS24100 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS24120 ENOG4105C8Y Acetylornithine aminotransferase HUT13_RS24145 ENOG4105CGK Exodeoxyribonuclease III HUT13_RS24160 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme HUT13_RS24165 ENOG4105CI0 Citrate lyase HUT13_RS24185 ENOG4105PAD Hydrolase HUT13_RS24205 ENOG4105KME endoribonuclease L-psp HUT13_RS24240 ENOG4108Q50 Histidine kinase HUT13_RS24245 ENOG4108ME1 Peptidase M55 D-aminopeptidase HUT13_RS24250 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HUT13_RS24275 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HUT13_RS24320 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component HUT13_RS24325 ENOG4105CPQ Dehydrogenase HUT13_RS24335 ENOG4105EBM Alpha Beta Hydrolase Fold protein HUT13_RS24345 ENOG4105GFG DUF218 domain HUT13_RS24350 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS24395 ENOG4105CHJ isochorismatase hydrolase HUT13_RS24405 ENOG410842T Pterin carbinolamine dehydratase HUT13_RS24430 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HUT13_RS24440 ENOG4105CVP deoxyribo-dipyrimidine photolyase HUT13_RS24445 ENOG4105RNG membrane HUT13_RS24450 ENOG4105K6V RNA polymerase HUT13_RS24455 ENOG4105CV8 reductase HUT13_RS24460 ENOG4105DHU Bile acid HUT13_RS24465 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HUT13_RS24505 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HUT13_RS24510 ENOG4105CHF Glutathione S-transferase HUT13_RS24550 ENOG4105C0B DNA polymerase III (alpha subunit) HUT13_RS24560 ENOG4105QE3 oxidoreductase HUT13_RS24580 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HUT13_RS24585 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HUT13_RS24590 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS24600 ENOG4105DRS transport system, permease HUT13_RS24610 ENOG4105C4C beta-galactosidase HUT13_RS24620 ENOG410829K Lysine exporter protein (Lyse ygga) HUT13_RS24655 ENOG4105BZ1 (ABC) transporter HUT13_RS24680 ENOG4105DJB Major Facilitator Superfamily HUT13_RS24685 ENOG4105EYF MMPL domain protein HUT13_RS24700 ENOG4108K8S endonuclease I HUT13_RS24705 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HUT13_RS24720 ENOG4105BZ1 (ABC) transporter HUT13_RS24730 ENOG4108KPJ rna polymerase sigma factor HUT13_RS24740 ENOG4108HWW ABC transporter HUT13_RS24745 ENOG4105C2J ABC transporter HUT13_RS24750 ENOG4105DFW ABC transporter HUT13_RS24755 ENOG4107TB6 phosphoglycerate mutase HUT13_RS24765 ENOG4105CMG Carbohydrate kinase HUT13_RS24770 ENOG4105CMG Carbohydrate kinase HUT13_RS24780 ENOG4107S46 esterase, PHB depolymerase HUT13_RS24785 ENOG41086D8 Transcriptional regulator HUT13_RS24800 ENOG4105WH1 Two component transcriptional regulator luxr family HUT13_RS24805 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HUT13_RS24835 ENOG4105CIG ABC transporter HUT13_RS24885 ENOG4105KTE polyketide synthesis cyclase HUT13_RS24895 ENOG4105CZS beta-ketoacyl synthase HUT13_RS24945 ENOG4107V9E glucose-1-phosphate thymidylyltransferase HUT13_RS24990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HUT13_RS25040 ENOG4108XNA Gas vesicle HUT13_RS25050 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT13_RS25075 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HUT13_RS25080 ENOG4108IAJ Nad-dependent epimerase dehydratase HUT13_RS25095 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HUT13_RS25100 ENOG4105DKP glycosyl transferase, family 9 HUT13_RS25110 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HUT13_RS25115 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HUT13_RS25120 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HUT13_RS25140 ENOG4108R85 Short chain dehydrogenase HUT13_RS25150 ENOG4105DIA mandelate racemase muconate lactonizing HUT13_RS25160 ENOG4105CQB FAD linked oxidase domain protein HUT13_RS25165 ENOG4105CH6 catalase HUT13_RS25175 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein HUT13_RS25195 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone HUT13_RS25200 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT13_RS25210 ENOG4105F38 ABC transporter, permease HUT13_RS25215 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HUT13_RS25220 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HUT13_RS25230 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HUT13_RS25235 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin HUT13_RS25250 ENOG4108RVA ribokinase HUT13_RS25275 ENOG4108TCJ secreted hydrolase HUT13_RS25350 ENOG4106A3M Cytochrome p-450 HUT13_RS25360 ENOG4105WKW Pfam:DUF1458 HUT13_RS25365 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HUT13_RS25370 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HUT13_RS25375 ENOG4105C9B Cysteine desulfurase HUT13_RS25395 ENOG4105ECR NmrA family HUT13_RS25400 ENOG4105KVH Transcriptional regulator HUT13_RS25415 ENOG4105EYF MMPL domain protein HUT13_RS25420 ENOG4105BZM domain protein HUT13_RS25430 ENOG4105BZ1 (ABC) transporter HUT13_RS25440 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HUT13_RS25465 ENOG4108MDK Dehydrogenase HUT13_RS25485 ENOG4105EY8 ABC transporter HUT13_RS25490 ENOG4105FBD synthase HUT13_RS25500 ENOG4107S11 squalene-associated FAD-dependent desaturase HUT13_RS25535 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HUT13_RS25540 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HUT13_RS25560 ENOG4105E0Y RtcB Protein HUT13_RS25570 ENOG4105DKQ ROK family HUT13_RS25620 ENOG4105CJQ hydrolase, family 31 HUT13_RS25630 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HUT13_RS25645 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS25650 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HUT13_RS25655 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HUT13_RS25660 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HUT13_RS25670 ENOG4105DQE DNA ligase HUT13_RS25680 ENOG4105K59 histidine triad (HIT) protein HUT13_RS25685 ENOG4107S2E monooxygenase HUT13_RS25690 ENOG4106T9R serine protease HUT13_RS25705 ENOG41065KQ synthase HUT13_RS25720 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HUT13_RS25730 ENOG4105C3U ABC transporter HUT13_RS25745 ENOG4105ETE Transcriptional regulator (LacI family HUT13_RS25775 ENOG4105DEN Luciferase family HUT13_RS25780 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HUT13_RS25830 ENOG4105DDV Transcriptional regulator (LacI family HUT13_RS25845 ENOG4105DRS transport system, permease HUT13_RS25850 ENOG4105DQE DNA ligase HUT13_RS25860 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HUT13_RS25875 ENOG4105KVH Transcriptional regulator HUT13_RS25895 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein HUT13_RS25900 ENOG4105E0A ABC, transporter HUT13_RS25905 ENOG4105TVJ transport system, permease HUT13_RS25910 ENOG4105DQ5 transport system permease protein HUT13_RS25920 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase HUT13_RS26030 ENOG4107SCK Monooxygenase HUT13_RS26045 ENOG4108Z6Z Transcriptional regulator HUT13_RS26085 ENOG4108IG5 Transcriptional regulator HUT13_RS26090 ENOG4105EYF MMPL domain protein HUT13_RS26100 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HUT13_RS26140 ENOG4105CHR reductase HUT13_RS26145 ENOG4105DJ2 Major Facilitator Superfamily HUT13_RS26150 ENOG4105C6F GntR Family Transcriptional Regulator HUT13_RS26170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HUT13_RS26175 ENOG4108W6C Dehydrogenase HUT13_RS26180 ENOG4105RV9 Transcriptional regulator