locus-tag	class	description
HUT13_RS00010	COG0477	Major facilitator Superfamily
HUT13_RS00060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HUT13_RS00080	COG2267	carboxylic ester hydrolase activity
HUT13_RS00085	COG3953	SLT domain
HUT13_RS00085	COG5412	phage tail tape measure protein
HUT13_RS00095	COG3442	glutamine amidotransferase
HUT13_RS00110	COG1940	carbohydrate kinase activity
HUT13_RS00140	COG1660	Displays ATPase and GTPase activities
HUT13_RS00145	COG1940	carbohydrate kinase activity
HUT13_RS00155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HUT13_RS00170	COG0204	Acyl-transferase
HUT13_RS00190	COG0584	glycerophosphoryl diester phosphodiesterase
HUT13_RS00215	COG1309	transcriptional regulator
HUT13_RS00235	COG1902	pentaerythritol trinitrate reductase activity
HUT13_RS00240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT13_RS00255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT13_RS00265	COG3903	Transcriptional regulator
HUT13_RS00265	COG3629	intracellular signal transduction
HUT13_RS00315	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS00320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS00365	COG0318	PFAM AMP-dependent synthetase and ligase
HUT13_RS00370	COG1414	Transcriptional regulator
HUT13_RS00380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT13_RS00385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT13_RS00405	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
HUT13_RS00465	COG1175	transmembrane transport
HUT13_RS00470	COG0395	ABC-type sugar transport system, permease component
HUT13_RS00475	COG2409	Drug exporters of the RND superfamily
HUT13_RS00480	COG3629	intracellular signal transduction
HUT13_RS00480	COG3903	Transcriptional regulator
HUT13_RS00520	COG1175	transmembrane transport
HUT13_RS00525	COG0395	ABC-type sugar transport system, permease component
HUT13_RS00530	COG3250	beta-galactosidase activity
HUT13_RS00550	COG1309	transcriptional regulator
HUT13_RS00560	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUT13_RS00560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HUT13_RS00575	COG0432	Pfam Uncharacterised protein family UPF0047
HUT13_RS00585	COG3254	rhamnose metabolic process
HUT13_RS00590	COG4952	isomerase
HUT13_RS00595	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS00595	COG3347	Dehydrogenase
HUT13_RS00600	COG1070	Carbohydrate kinase
HUT13_RS00605	COG0247	lactate metabolic process
HUT13_RS00610	COG1139	Iron-sulfur cluster binding protein
HUT13_RS00615	COG1556	Lactate utilization protein
HUT13_RS00625	COG0667	Aldo Keto reductase
HUT13_RS00650	COG0494	nUDIX hydrolase
HUT13_RS00660	COG2267	carboxylic ester hydrolase activity
HUT13_RS00665	COG1132	(ABC) transporter
HUT13_RS00690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HUT13_RS00700	COG3397	chitin binding
HUT13_RS00715	COG0640	Transcriptional regulator
HUT13_RS00720	COG1132	(ABC) transporter
HUT13_RS00725	COG1132	(ABC) transporter
HUT13_RS00745	COG2018	Roadblock/LC7 domain
HUT13_RS00760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HUT13_RS00815	COG1940	carbohydrate kinase activity
HUT13_RS00820	COG0697	spore germination
HUT13_RS00830	COG3940	Belongs to the glycosyl hydrolase 43 family
HUT13_RS00855	COG1940	carbohydrate kinase activity
HUT13_RS00875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS00880	COG2197	response regulator
HUT13_RS00885	COG4585	Histidine kinase
HUT13_RS00895	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS00905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT13_RS00910	COG0601	transmembrane transport
HUT13_RS00920	COG3458	cephalosporin-C deacetylase activity
HUT13_RS00935	COG2124	cytochrome p450
HUT13_RS00945	COG2345	Transcriptional regulator
HUT13_RS01010	COG3537	Alpha-1,2-mannosidase
HUT13_RS01030	COG0656	L-ascorbic acid biosynthetic process
HUT13_RS01090	COG1215	transferase activity, transferring glycosyl groups
HUT13_RS01110	COG0673	inositol 2-dehydrogenase activity
HUT13_RS01145	COG1045	serine acetyltransferase
HUT13_RS01150	COG0697	spore germination
HUT13_RS01155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT13_RS01175	COG1120	ATPase activity
HUT13_RS01190	COG0673	inositol 2-dehydrogenase activity
HUT13_RS01200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT13_RS01205	COG1414	Transcriptional regulator
HUT13_RS01235	COG3415	Transposase
HUT13_RS01235	COG2801	Transposase and inactivated derivatives
HUT13_RS01250	COG0488	(ABC) transporter
HUT13_RS01285	COG2186	Transcriptional regulator
HUT13_RS01310	COG3842	ATPase activity
HUT13_RS01330	COG0586	Pfam SNARE associated Golgi protein
HUT13_RS01335	COG0488	(ABC) transporter
HUT13_RS01340	COG0488	(ABC) transporter
HUT13_RS01345	COG0038	chloride channel
HUT13_RS01355	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS01395	COG1846	Transcriptional regulator
HUT13_RS01400	COG2409	Drug exporters of the RND superfamily
HUT13_RS01425	COG1132	(ABC) transporter
HUT13_RS01470	COG0702	epimerase
HUT13_RS01475	COG2111	Na H antiporter
HUT13_RS01475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT13_RS01500	COG1320	monovalent cation:proton antiporter activity
HUT13_RS01515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT13_RS01550	COG3340	Belongs to the peptidase S51 family
HUT13_RS01555	COG0137	argininosuccinate synthase activity
HUT13_RS01560	COG4585	Histidine kinase
HUT13_RS01565	COG2197	response regulator
HUT13_RS01570	COG2197	response regulator
HUT13_RS01575	COG2197	response regulator
HUT13_RS01585	COG4585	Histidine kinase
HUT13_RS01590	COG2197	response regulator
HUT13_RS01610	COG1914	H( )-stimulated, divalent metal cation uptake system
HUT13_RS01620	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT13_RS01635	COG0318	PFAM AMP-dependent synthetase and ligase
HUT13_RS01645	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT13_RS01665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT13_RS01735	COG1879	ABC-type sugar transport system periplasmic component
HUT13_RS01745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT13_RS01750	COG1129	ABC transporter
HUT13_RS01765	COG1834	amidinotransferase
HUT13_RS01770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT13_RS01790	COG0477	Major facilitator Superfamily
HUT13_RS01830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUT13_RS01835	COG1940	carbohydrate kinase activity
HUT13_RS01840	COG2188	Transcriptional regulator
HUT13_RS01845	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS01850	COG1595	DNA-templated transcription, initiation
HUT13_RS01865	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS01870	COG0419	ATPase involved in DNA repair
HUT13_RS01870	COG0419	ATPase involved in DNA repair
HUT13_RS01875	COG0420	3'-5' exonuclease activity
HUT13_RS01885	COG4677	pectinesterase activity
HUT13_RS01895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS01900	COG1739	Uncharacterized protein family UPF0029
HUT13_RS01905	COG1832	CoA-binding protein
HUT13_RS01930	COG1802	Transcriptional regulator
HUT13_RS01960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT13_RS01965	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HUT13_RS01990	COG3415	Transposase
HUT13_RS01990	COG2801	Transposase and inactivated derivatives
HUT13_RS02005	COG3209	COG3209 Rhs family protein
HUT13_RS02040	COG2072	flavoprotein involved in K transport
HUT13_RS02070	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS02075	COG0395	ABC-type sugar transport system, permease component
HUT13_RS02090	COG2186	Transcriptional regulator
HUT13_RS02095	COG2610	gluconate transmembrane transporter activity
HUT13_RS02130	COG0384	phenazine biosynthesis protein PhzF
HUT13_RS02150	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT13_RS02150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HUT13_RS02160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUT13_RS02190	COG3879	Bacterial protein of unknown function (DUF881)
HUT13_RS02195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT13_RS02210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT13_RS02220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT13_RS02230	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS02260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HUT13_RS02265	COG0140	phosphoribosyl-ATP diphosphatase activity
HUT13_RS02270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HUT13_RS02275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT13_RS02275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUT13_RS02280	COG3201	nicotinamide mononucleotide transporter
HUT13_RS02305	COG2390	Transcriptional regulator
HUT13_RS02310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUT13_RS02320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HUT13_RS02340	COG0789	Transcriptional regulator
HUT13_RS02350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HUT13_RS02360	COG1758	RNA polymerase activity
HUT13_RS02365	COG0194	GDP metabolic process
HUT13_RS02375	COG0284	orotidine-5'-phosphate decarboxylase activity
HUT13_RS02380	COG0167	dihydroorotate dehydrogenase activity
HUT13_RS02385	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HUT13_RS02390	COG0505	Belongs to the CarA family
HUT13_RS02400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT13_RS02405	COG0540	Belongs to the ATCase OTCase family
HUT13_RS02410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HUT13_RS02420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HUT13_RS02425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HUT13_RS02430	COG0006	proline dipeptidase activity
HUT13_RS02440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HUT13_RS02445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HUT13_RS02450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HUT13_RS02455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUT13_RS02465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HUT13_RS02470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT13_RS02490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT13_RS02510	COG0124	histidyl-tRNA synthetase
HUT13_RS02520	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HUT13_RS02525	COG1196	nuclear chromosome segregation
HUT13_RS02530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT13_RS02535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUT13_RS02540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT13_RS02545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT13_RS02555	COG2255	four-way junction helicase activity
HUT13_RS02560	COG0632	four-way junction helicase activity
HUT13_RS02565	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HUT13_RS02570	COG0217	transcriptional regulatory protein
HUT13_RS02575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HUT13_RS02580	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HUT13_RS02590	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS02595	COG1560	Kdo2-lipid A biosynthetic process
HUT13_RS02600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUT13_RS02615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT13_RS02660	COG0512	Glutamine amidotransferase of anthranilate synthase
HUT13_RS02660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT13_RS02705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT13_RS02705	COG1648	precorrin-2 dehydrogenase activity
HUT13_RS02710	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT13_RS02725	COG1464	Belongs to the NlpA lipoprotein family
HUT13_RS02735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT13_RS02755	COG0584	glycerophosphoryl diester phosphodiesterase
HUT13_RS02760	COG0204	Acyl-transferase
HUT13_RS02760	COG0318	PFAM AMP-dependent synthetase and ligase
HUT13_RS02780	COG0714	Associated with various cellular activities
HUT13_RS02800	COG0165	Argininosuccinate lyase
HUT13_RS02810	COG1438	arginine binding
HUT13_RS02815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT13_RS02820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HUT13_RS02825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HUT13_RS02830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HUT13_RS02840	COG4221	oxidoreductase activity
HUT13_RS02860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT13_RS02865	COG0697	spore germination
HUT13_RS02890	COG0028	Belongs to the TPP enzyme family
HUT13_RS02915	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS02925	COG1649	PFAM Uncharacterised BCR, COG1649
HUT13_RS02940	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HUT13_RS02950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT13_RS02950	COG0072	phenylalanine-tRNA ligase activity
HUT13_RS02955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HUT13_RS02960	COG5002	protein histidine kinase activity
HUT13_RS02965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT13_RS02970	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HUT13_RS02975	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HUT13_RS02980	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUT13_RS02990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT13_RS03025	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS03035	COG2186	Transcriptional regulator
HUT13_RS03040	COG1113	amino acid transport
HUT13_RS03045	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUT13_RS03050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT13_RS03060	COG0805	protein transport
HUT13_RS03065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT13_RS03080	COG2378	regulation of single-species biofilm formation
HUT13_RS03095	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT13_RS03110	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT13_RS03115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HUT13_RS03125	COG4122	O-methyltransferase activity
HUT13_RS03130	COG1222	aaa ATPase
HUT13_RS03150	COG1994	Peptidase M50
HUT13_RS03150	COG0517	IMP dehydrogenase activity
HUT13_RS03160	COG2197	response regulator
HUT13_RS03165	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT13_RS03170	COG1410	methionine synthase
HUT13_RS03170	COG0646	methionine synthase
HUT13_RS03175	COG1414	Transcriptional regulator
HUT13_RS03180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUT13_RS03185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HUT13_RS03190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT13_RS03200	COG0215	cysteine-tRNA ligase activity
HUT13_RS03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS03225	COG0667	Aldo Keto reductase
HUT13_RS03260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT13_RS03275	COG5520	Belongs to the glycosyl hydrolase 30 family
HUT13_RS03290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HUT13_RS03300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS03305	COG1942	4-Oxalocrotonate Tautomerase
HUT13_RS03310	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS03315	COG0596	Alpha beta hydrolase
HUT13_RS03330	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT13_RS03345	COG1802	Transcriptional regulator
HUT13_RS03390	COG0515	serine threonine protein kinase
HUT13_RS03390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT13_RS03405	COG1733	regulation of RNA biosynthetic process
HUT13_RS03420	COG0110	maltose O-acetyltransferase activity
HUT13_RS03425	COG3226	Transcriptional regulator
HUT13_RS03435	COG1309	transcriptional regulator
HUT13_RS03485	COG1113	amino acid transport
HUT13_RS03495	COG0477	Major facilitator Superfamily
HUT13_RS03500	COG2197	response regulator
HUT13_RS03510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT13_RS03515	COG1295	ribonuclease BN
HUT13_RS03515	COG1959	2 iron, 2 sulfur cluster binding
HUT13_RS03525	COG1302	Protein conserved in bacteria
HUT13_RS03530	COG1595	DNA-templated transcription, initiation
HUT13_RS03545	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS03565	COG3842	ATPase activity
HUT13_RS03575	COG0583	DNA-binding transcription factor activity
HUT13_RS03580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT13_RS03585	COG0586	Pfam SNARE associated Golgi protein
HUT13_RS03590	COG0475	glutathione-regulated potassium exporter activity
HUT13_RS03595	COG4326	sporulation control protein
HUT13_RS03615	COG1131	(ABC) transporter
HUT13_RS03625	COG0475	glutathione-regulated potassium exporter activity
HUT13_RS03630	COG1846	Transcriptional regulator
HUT13_RS03640	COG1757	Na H antiporter
HUT13_RS03645	COG0583	DNA-binding transcription factor activity
HUT13_RS03650	COG2072	flavoprotein involved in K transport
HUT13_RS03655	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS03680	COG0410	ABC transporter
HUT13_RS03740	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HUT13_RS03745	COG2188	Transcriptional regulator
HUT13_RS03765	COG0738	Major facilitator superfamily
HUT13_RS03805	COG2226	methyltransferase
HUT13_RS03845	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS03850	COG0800	Aldolase
HUT13_RS03855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS03875	COG0494	nUDIX hydrolase
HUT13_RS03895	COG1609	Transcriptional regulator
HUT13_RS03900	COG0366	Alpha amylase catalytic
HUT13_RS03905	COG1725	Transcriptional regulator
HUT13_RS03915	COG2259	Doxx family
HUT13_RS03920	COG3384	dioxygenase
HUT13_RS03980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HUT13_RS03995	COG2018	Roadblock/LC7 domain
HUT13_RS04075	COG2815	serine threonine protein kinase
HUT13_RS04075	COG0515	serine threonine protein kinase
HUT13_RS04080	COG0431	NADPH-dependent FMN reductase
HUT13_RS04090	COG0800	Aldolase
HUT13_RS04100	COG3619	membrane
HUT13_RS04105	COG2376	Dihydroxyacetone kinase
HUT13_RS04110	COG1461	Dihydroxyacetone kinase
HUT13_RS04140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS04145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS04145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS04150	COG0464	growth
HUT13_RS04160	COG1349	DNA-binding transcription factor activity
HUT13_RS04170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT13_RS04170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HUT13_RS04180	COG2186	Transcriptional regulator
HUT13_RS04200	COG1216	Glycosyl transferase, family 2
HUT13_RS04215	COG1522	sequence-specific DNA binding
HUT13_RS04220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT13_RS04225	COG1131	(ABC) transporter
HUT13_RS04235	COG4585	Histidine kinase
HUT13_RS04240	COG2197	response regulator
HUT13_RS04250	COG0829	nickel cation binding
HUT13_RS04255	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUT13_RS04265	COG0804	urea catabolic process
HUT13_RS04270	COG0832	Belongs to the urease beta subunit family
HUT13_RS04275	COG0831	urea catabolic process
HUT13_RS04300	COG1799	cell septum assembly
HUT13_RS04305	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS04310	COG0477	Major facilitator Superfamily
HUT13_RS04315	COG0671	phosphoesterase, PA-phosphatase related
HUT13_RS04335	COG1160	GTP binding
HUT13_RS04345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT13_RS04355	COG1187	pseudouridine synthase activity
HUT13_RS04360	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUT13_RS04365	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUT13_RS04380	COG0686	Belongs to the AlaDH PNT family
HUT13_RS04390	COG0494	nUDIX hydrolase
HUT13_RS04395	COG0504	CTP synthase activity
HUT13_RS04400	COG3387	PFAM Glycoside hydrolase 15-related
HUT13_RS04425	COG0497	DNA recombination
HUT13_RS04430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HUT13_RS04455	COG0647	UMP catabolic process
HUT13_RS04495	COG2094	Belongs to the DNA glycosylase MPG family
HUT13_RS04505	COG1881	PFAM PEBP family protein
HUT13_RS04525	COG1119	ATPase activity
HUT13_RS04545	COG2197	response regulator
HUT13_RS04550	COG3850	Histidine kinase
HUT13_RS04555	COG1716	ATPase activity
HUT13_RS04555	COG1131	(ABC) transporter
HUT13_RS04555	COG0842	Transport permease protein
HUT13_RS04560	COG0560	Phosphoserine phosphatase
HUT13_RS04560	COG3830	Belongs to the UPF0237 family
HUT13_RS04575	COG2807	transmembrane transport
HUT13_RS04580	COG2186	Transcriptional regulator
HUT13_RS04585	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HUT13_RS04590	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS04615	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HUT13_RS04630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HUT13_RS04685	COG0488	(ABC) transporter
HUT13_RS04720	COG1595	DNA-templated transcription, initiation
HUT13_RS04730	COG0456	acetyltransferase
HUT13_RS04740	COG1917	Cupin 2, conserved barrel domain protein
HUT13_RS04745	COG5285	phytanoyl-CoA dioxygenase
HUT13_RS04765	COG1175	transmembrane transport
HUT13_RS04770	COG0395	ABC-type sugar transport system, permease component
HUT13_RS04795	COG1414	Transcriptional regulator
HUT13_RS04800	COG1309	transcriptional regulator
HUT13_RS04805	COG2814	Major facilitator Superfamily
HUT13_RS04810	COG2252	PERMEase
HUT13_RS04820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT13_RS04825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT13_RS04835	COG3866	Pectate lyase
HUT13_RS04850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT13_RS04855	COG1802	Transcriptional regulator
HUT13_RS04865	COG1309	transcriptional regulator
HUT13_RS04870	COG0477	Major facilitator Superfamily
HUT13_RS04885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT13_RS04895	COG2171	N-acyltransferase activity
HUT13_RS04900	COG2076	Multidrug Resistance protein
HUT13_RS04910	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT13_RS04915	COG0822	iron-sulfur transferase activity
HUT13_RS04920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT13_RS04925	COG0396	ATPase activity
HUT13_RS04935	COG0719	Fe-S assembly protein
HUT13_RS04950	COG1609	Transcriptional regulator
HUT13_RS04955	COG1175	transmembrane transport
HUT13_RS04960	COG0395	ABC-type sugar transport system, permease component
HUT13_RS04970	COG0673	inositol 2-dehydrogenase activity
HUT13_RS04990	COG0483	inositol monophosphate 1-phosphatase activity
HUT13_RS05010	COG0494	nUDIX hydrolase
HUT13_RS05015	COG2234	aminopeptidase activity
HUT13_RS05020	COG1131	(ABC) transporter
HUT13_RS05030	COG1612	heme a metabolic process
HUT13_RS05045	COG0109	protoheme IX farnesyltransferase activity
HUT13_RS05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUT13_RS05070	COG0363	glucosamine-6-phosphate deaminase activity
HUT13_RS05075	COG0166	Belongs to the GPI family
HUT13_RS05085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUT13_RS05090	COG0149	triose-phosphate isomerase activity
HUT13_RS05095	COG0126	phosphoglycerate kinase activity
HUT13_RS05100	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HUT13_RS05105	COG1481	regulation of sporulation
HUT13_RS05110	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT13_RS05115	COG1660	Displays ATPase and GTPase activities
HUT13_RS05120	COG0322	excinuclease ABC activity
HUT13_RS05135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT13_RS05150	COG0556	nucleotide-excision repair
HUT13_RS05155	COG0584	glycerophosphoryl diester phosphodiesterase
HUT13_RS05160	COG0739	heme binding
HUT13_RS05245	COG0237	dephospho-CoA kinase activity
HUT13_RS05255	COG0539	negative regulation of cytoplasmic translation
HUT13_RS05275	COG2050	protein possibly involved in aromatic compounds catabolism
HUT13_RS05360	COG0287	Prephenate dehydrogenase
HUT13_RS05360	COG1605	Chorismate mutase
HUT13_RS05370	COG0515	serine threonine protein kinase
HUT13_RS05370	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT13_RS05380	COG0395	ABC-type sugar transport system, permease component
HUT13_RS05385	COG1175	transmembrane transport
HUT13_RS05390	COG1653	transport
HUT13_RS05405	COG0067	glutamate synthase
HUT13_RS05405	COG0070	glutamate synthase
HUT13_RS05405	COG0069	glutamate synthase activity
HUT13_RS05415	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HUT13_RS05435	COG0159	tryptophan synthase activity
HUT13_RS05440	COG0133	tryptophan synthase activity
HUT13_RS05450	COG0134	indole-3-glycerol-phosphate synthase activity
HUT13_RS05470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HUT13_RS05475	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HUT13_RS05490	COG2755	lipolytic protein G-D-S-L family
HUT13_RS05495	COG3401	FG-GAP repeat protein
HUT13_RS05505	COG1175	transmembrane transport
HUT13_RS05510	COG0395	ABC-type sugar transport system, permease component
HUT13_RS05520	COG0583	DNA-binding transcription factor activity
HUT13_RS05530	COG1053	succinate dehydrogenase
HUT13_RS05535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT13_RS05545	COG1509	lysine 2,3-aminomutase activity
HUT13_RS05580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT13_RS05590	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HUT13_RS05600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT13_RS05635	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT13_RS05660	COG0107	imidazoleglycerol-phosphate synthase activity
HUT13_RS05665	COG0251	oxidation-reduction process
HUT13_RS05670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HUT13_RS05675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HUT13_RS05685	COG0131	Imidazoleglycerol-phosphate dehydratase
HUT13_RS05690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT13_RS05695	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HUT13_RS05705	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUT13_RS05750	COG1404	Belongs to the peptidase S8 family
HUT13_RS05770	COG0587	DNA-directed DNA polymerase activity
HUT13_RS05805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HUT13_RS05815	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HUT13_RS05820	COG3599	regulation of cell shape
HUT13_RS05830	COG1799	cell septum assembly
HUT13_RS05850	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HUT13_RS05855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HUT13_RS05865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HUT13_RS05870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUT13_RS05875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUT13_RS05880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HUT13_RS05885	COG0768	penicillin binding
HUT13_RS05895	COG0275	rRNA processing
HUT13_RS05905	COG0714	Associated with various cellular activities
HUT13_RS05925	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HUT13_RS05955	COG0352	thiamine-phosphate diphosphorylase activity
HUT13_RS05970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HUT13_RS05970	COG2022	thiamine diphosphate biosynthetic process
HUT13_RS05980	COG2022	thiamine diphosphate biosynthetic process
HUT13_RS05990	COG2815	serine threonine protein kinase
HUT13_RS05990	COG0515	serine threonine protein kinase
HUT13_RS06000	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HUT13_RS06015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HUT13_RS06020	COG2193	ferroxidase activity
HUT13_RS06030	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HUT13_RS06085	COG3903	Transcriptional regulator
HUT13_RS06085	COG3629	intracellular signal transduction
HUT13_RS06095	COG1940	carbohydrate kinase activity
HUT13_RS06105	COG0003	Pfam Anion-transporting ATPase
HUT13_RS06115	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS06140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUT13_RS06145	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HUT13_RS06150	COG0723	plastoquinol--plastocyanin reductase activity
HUT13_RS06155	COG2010	Cytochrome c
HUT13_RS06160	COG1845	cytochrome c oxidase, subunit III
HUT13_RS06170	COG1376	ErfK ybiS ycfS ynhG family protein
HUT13_RS06180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HUT13_RS06185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HUT13_RS06195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS06210	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUT13_RS06215	COG2197	response regulator
HUT13_RS06220	COG4585	Histidine kinase
HUT13_RS06240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT13_RS06265	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HUT13_RS06275	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HUT13_RS06280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HUT13_RS06285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUT13_RS06300	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT13_RS06330	COG1522	sequence-specific DNA binding
HUT13_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS06390	COG0321	lipoyl(octanoyl) transferase activity
HUT13_RS06395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HUT13_RS06435	COG3415	Transposase
HUT13_RS06435	COG2801	Transposase and inactivated derivatives
HUT13_RS06445	COG0673	inositol 2-dehydrogenase activity
HUT13_RS06465	COG2197	response regulator
HUT13_RS06485	COG0366	Alpha amylase catalytic
HUT13_RS06490	COG3833	ABC-type maltose transport systems, permease component
HUT13_RS06500	COG2182	Extracellular solute-binding protein
HUT13_RS06515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HUT13_RS06520	COG0174	glutamine synthetase
HUT13_RS06550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS06560	COG0501	Belongs to the peptidase M48B family
HUT13_RS06570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HUT13_RS06620	COG0366	Alpha amylase catalytic
HUT13_RS06625	COG0667	Aldo Keto reductase
HUT13_RS06640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HUT13_RS06645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS06650	COG1120	ATPase activity
HUT13_RS06655	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT13_RS06660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT13_RS06665	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HUT13_RS06695	COG4122	O-methyltransferase activity
HUT13_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS06715	COG1846	Transcriptional regulator
HUT13_RS06720	COG0745	RESPONSE REGULATOR receiver
HUT13_RS06740	COG2072	flavoprotein involved in K transport
HUT13_RS06765	COG2234	aminopeptidase activity
HUT13_RS06765	COG4935	Belongs to the peptidase S8 family
HUT13_RS06780	COG3206	protein involved in exopolysaccharide biosynthesis
HUT13_RS06780	COG0489	protein tyrosine kinase activity
HUT13_RS06785	COG0297	glycogen (starch) synthase activity
HUT13_RS06795	COG0583	DNA-binding transcription factor activity
HUT13_RS06800	COG5006	permease, DMT superfamily
HUT13_RS06815	COG0702	epimerase
HUT13_RS06870	COG1902	pentaerythritol trinitrate reductase activity
HUT13_RS06875	COG2814	Major facilitator Superfamily
HUT13_RS06880	COG3540	Alkaline phosphatase
HUT13_RS06890	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT13_RS06900	COG3903	Transcriptional regulator
HUT13_RS06900	COG3629	intracellular signal transduction
HUT13_RS06910	COG1309	transcriptional regulator
HUT13_RS06920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT13_RS06920	COG0574	Belongs to the PEP-utilizing enzyme family
HUT13_RS06945	COG4221	oxidoreductase activity
HUT13_RS06955	COG3022	response to hydroperoxide
HUT13_RS06970	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUT13_RS06995	COG2226	methyltransferase
HUT13_RS07000	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS07025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT13_RS07110	COG1358	cellular component organization or biogenesis
HUT13_RS07165	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HUT13_RS07180	COG4585	Histidine kinase
HUT13_RS07210	COG0667	Aldo Keto reductase
HUT13_RS07215	COG0789	Transcriptional regulator
HUT13_RS07225	COG2233	PERMEase
HUT13_RS07245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT13_RS07250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT13_RS07255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT13_RS07290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT13_RS07295	COG1595	DNA-templated transcription, initiation
HUT13_RS07310	COG1846	Transcriptional regulator
HUT13_RS07310	COG0456	acetyltransferase
HUT13_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS07325	COG1309	transcriptional regulator
HUT13_RS07365	COG2205	protein histidine kinase activity
HUT13_RS07370	COG0745	RESPONSE REGULATOR receiver
HUT13_RS07375	COG0577	efflux transmembrane transporter activity
HUT13_RS07385	COG1136	(ABC) transporter
HUT13_RS07415	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS07440	COG4214	carbohydrate transport
HUT13_RS07450	COG0542	response to heat
HUT13_RS07470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS07480	COG2130	NADP-dependent
HUT13_RS07485	COG3386	PFAM SMP-30 Gluconolaconase
HUT13_RS07490	COG1414	Transcriptional regulator
HUT13_RS07515	COG0745	RESPONSE REGULATOR receiver
HUT13_RS07520	COG2205	protein histidine kinase activity
HUT13_RS07525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT13_RS07540	COG0655	NAD(P)H dehydrogenase (quinone) activity
HUT13_RS07560	COG2072	flavoprotein involved in K transport
HUT13_RS07580	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS07585	COG0318	PFAM AMP-dependent synthetase and ligase
HUT13_RS07595	COG3903	Transcriptional regulator
HUT13_RS07595	COG3629	intracellular signal transduction
HUT13_RS07610	COG1695	Transcriptional regulator
HUT13_RS07635	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT13_RS07650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUT13_RS07665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HUT13_RS07675	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HUT13_RS07715	COG0235	Class ii aldolase
HUT13_RS07720	COG3395	kinase activity
HUT13_RS07735	COG1349	DNA-binding transcription factor activity
HUT13_RS07740	COG1070	Carbohydrate kinase
HUT13_RS07755	COG0358	DNA primase activity
HUT13_RS07765	COG0028	Belongs to the TPP enzyme family
HUT13_RS07785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HUT13_RS07800	COG0243	molybdopterin cofactor binding
HUT13_RS07810	COG1324	tolerance protein
HUT13_RS07830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT13_RS07830	COG2146	nitrite reductase [NAD(P)H] activity
HUT13_RS07835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT13_RS07835	COG2146	nitrite reductase [NAD(P)H] activity
HUT13_RS07840	COG2146	nitrite reductase [NAD(P)H] activity
HUT13_RS07840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT13_RS07870	COG1609	Transcriptional regulator
HUT13_RS07885	COG1175	transmembrane transport
HUT13_RS07895	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT13_RS07910	COG3290	protein histidine kinase activity
HUT13_RS07915	COG4565	transcriptional regulatory protein
HUT13_RS07925	COG0574	Belongs to the PEP-utilizing enzyme family
HUT13_RS07925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUT13_RS07935	COG2813	Specifically methylates the guanine in position
HUT13_RS07940	COG2318	DinB family
HUT13_RS07950	COG1846	Transcriptional regulator
HUT13_RS07950	COG1940	carbohydrate kinase activity
HUT13_RS07980	COG0667	Aldo Keto reductase
HUT13_RS08000	COG0423	glycine-tRNA ligase activity
HUT13_RS08010	COG1121	(ABC) transporter
HUT13_RS08015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT13_RS08030	COG2815	serine threonine protein kinase
HUT13_RS08030	COG0515	serine threonine protein kinase
HUT13_RS08035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT13_RS08040	COG1381	Involved in DNA repair and RecF pathway recombination
HUT13_RS08050	COG1733	regulation of RNA biosynthetic process
HUT13_RS08055	COG2318	DinB family
HUT13_RS08075	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS08090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT13_RS08095	COG0456	acetyltransferase
HUT13_RS08100	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HUT13_RS08120	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HUT13_RS08130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS08135	COG1486	melibiose metabolic process
HUT13_RS08140	COG3507	Belongs to the glycosyl hydrolase 43 family
HUT13_RS08145	COG1234	tRNA 3'-trailer cleavage
HUT13_RS08150	COG0537	adenosine 5'-monophosphoramidase activity
HUT13_RS08160	COG0733	neurotransmitter:sodium symporter activity
HUT13_RS08175	COG0484	heat shock protein binding
HUT13_RS08180	COG1420	regulation of RNA biosynthetic process
HUT13_RS08205	COG0481	GTPase activity
HUT13_RS08210	COG0268	Binds directly to 16S ribosomal RNA
HUT13_RS08245	COG1307	EDD domain protein, DegV family
HUT13_RS08255	COG0495	leucyl-tRNA aminoacylation
HUT13_RS08270	COG0588	phosphoglycerate mutase activity
HUT13_RS08285	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUT13_RS08295	COG0501	Belongs to the peptidase M48B family
HUT13_RS08310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HUT13_RS08320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HUT13_RS08340	COG1215	transferase activity, transferring glycosyl groups
HUT13_RS08355	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT13_RS08360	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HUT13_RS08365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HUT13_RS08370	COG1530	ribonuclease E activity
HUT13_RS08380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUT13_RS08385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HUT13_RS08390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HUT13_RS08395	COG0193	aminoacyl-tRNA hydrolase activity
HUT13_RS08420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUT13_RS08430	COG1309	transcriptional regulator
HUT13_RS08440	COG3401	FG-GAP repeat protein
HUT13_RS08445	COG4106	trans-aconitate 2-methyltransferase activity
HUT13_RS08475	COG2197	response regulator
HUT13_RS08490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUT13_RS08515	COG0488	(ABC) transporter
HUT13_RS08520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HUT13_RS08525	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT13_RS08530	COG0084	hydrolase, TatD family'
HUT13_RS08560	COG2409	Drug exporters of the RND superfamily
HUT13_RS08565	COG4946	Tricorn protease homolog
HUT13_RS08565	COG0793	Belongs to the peptidase S41A family
HUT13_RS08580	COG1316	TRANSCRIPTIONal
HUT13_RS08585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT13_RS08590	COG0640	Transcriptional regulator
HUT13_RS08595	COG1309	transcriptional regulator
HUT13_RS08610	COG0708	Exodeoxyribonuclease III
HUT13_RS08615	COG4209	transmembrane transport
HUT13_RS08620	COG0395	ABC-type sugar transport system, permease component
HUT13_RS08625	COG1653	transport
HUT13_RS08635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS08650	COG0254	rRNA binding
HUT13_RS08660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS08665	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS08670	COG1120	ATPase activity
HUT13_RS08675	COG4607	ABC-type enterochelin transport system periplasmic component
HUT13_RS08695	COG2188	Transcriptional regulator
HUT13_RS08700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUT13_RS08705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUT13_RS08710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HUT13_RS08710	COG0825	malonyl-CoA metabolic process
HUT13_RS08715	COG2124	cytochrome p450
HUT13_RS08725	COG0596	Alpha beta hydrolase
HUT13_RS08730	COG1216	Glycosyl transferase, family 2
HUT13_RS08755	COG2188	Transcriptional regulator
HUT13_RS08775	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT13_RS08775	COG0521	Mo-molybdopterin cofactor biosynthetic process
HUT13_RS08780	COG0315	cyclic pyranopterin monophosphate synthase activity
HUT13_RS08790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HUT13_RS08795	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HUT13_RS08810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HUT13_RS08820	COG1970	mechanosensitive ion channel activity
HUT13_RS08825	COG1764	response to oxidative stress
HUT13_RS08830	COG1846	Transcriptional regulator
HUT13_RS08845	COG3191	aminopeptidase activity
HUT13_RS08855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT13_RS08870	COG1349	DNA-binding transcription factor activity
HUT13_RS08890	COG1473	amidohydrolase
HUT13_RS08915	COG2186	Transcriptional regulator
HUT13_RS08920	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS08940	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS08950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT13_RS08955	COG0456	acetyltransferase
HUT13_RS08970	COG0802	atpase or kinase
HUT13_RS08975	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUT13_RS08980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HUT13_RS08980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HUT13_RS08985	COG0736	holo-[acyl-carrier-protein] synthase activity
HUT13_RS08990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT13_RS08995	COG1072	(Pantothenic acid kinase))
HUT13_RS09000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT13_RS09005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HUT13_RS09010	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HUT13_RS09015	COG0488	(ABC) transporter
HUT13_RS09055	COG0101	tRNA pseudouridine synthase activity
HUT13_RS09060	COG0203	ribosomal protein L17
HUT13_RS09065	COG0202	RNA polymerase activity
HUT13_RS09070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HUT13_RS09075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HUT13_RS09080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HUT13_RS09085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUT13_RS09090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HUT13_RS09100	COG0563	adenylate kinase activity
HUT13_RS09110	COG0200	Binds to the 23S rRNA
HUT13_RS09115	COG1841	ribosomal large subunit assembly
HUT13_RS09120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HUT13_RS09125	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HUT13_RS09130	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HUT13_RS09135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HUT13_RS09140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT13_RS09145	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HUT13_RS09150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HUT13_RS09155	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HUT13_RS09160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HUT13_RS09165	COG0255	Belongs to the universal ribosomal protein uL29 family
HUT13_RS09170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HUT13_RS09175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HUT13_RS09180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HUT13_RS09185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HUT13_RS09190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HUT13_RS09195	COG0089	rRNA binding
HUT13_RS09200	COG0088	Forms part of the polypeptide exit tunnel
HUT13_RS09205	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HUT13_RS09210	COG0051	transcription antitermination factor activity, RNA binding
HUT13_RS09215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT13_RS09225	COG3279	Response regulator of the LytR AlgR family
HUT13_RS09230	COG3275	phosphorelay sensor kinase activity
HUT13_RS09240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT13_RS09250	COG1653	transport
HUT13_RS09260	COG1175	transmembrane transport
HUT13_RS09265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUT13_RS09275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HUT13_RS09280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUT13_RS09285	COG0049	tRNA binding
HUT13_RS09290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HUT13_RS09295	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HUT13_RS09300	COG0085	RNA polymerase activity
HUT13_RS09305	COG0222	ribosome binding
HUT13_RS09310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HUT13_RS09320	COG0081	regulation of translation
HUT13_RS09325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HUT13_RS09340	COG2205	protein histidine kinase activity
HUT13_RS09345	COG0745	RESPONSE REGULATOR receiver
HUT13_RS09360	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HUT13_RS09370	COG0250	Participates in transcription elongation, termination and antitermination
HUT13_RS09385	COG0436	Aminotransferase
HUT13_RS09390	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT13_RS09400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUT13_RS09420	COG2030	dehydratase
HUT13_RS09425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUT13_RS09445	COG0596	Alpha beta hydrolase
HUT13_RS09450	COG0702	epimerase
HUT13_RS09460	COG2197	response regulator
HUT13_RS09470	COG0464	growth
HUT13_RS09555	COG3959	Transketolase, thiamine diphosphate binding domain
HUT13_RS09560	COG3958	Transketolase
HUT13_RS09565	COG2814	Major facilitator Superfamily
HUT13_RS09585	COG0477	Major facilitator Superfamily
HUT13_RS09590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT13_RS09595	COG1535	isochorismatase
HUT13_RS09595	COG3433	isochorismatase activity
HUT13_RS09615	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT13_RS09620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT13_RS09635	COG1120	ATPase activity
HUT13_RS09675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HUT13_RS09680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HUT13_RS09695	COG1666	GTP binding
HUT13_RS09700	COG3304	Inner membrane component domain
HUT13_RS09705	COG0501	Belongs to the peptidase M48B family
HUT13_RS09710	COG1007	ATP synthesis coupled electron transport
HUT13_RS09725	COG0713	ATP synthesis coupled electron transport
HUT13_RS09735	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09740	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT13_RS09745	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09750	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09755	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09760	COG4585	Histidine kinase
HUT13_RS09765	COG4585	Histidine kinase
HUT13_RS09775	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HUT13_RS09775	COG0674	pyruvate-flavodoxin oxidoreductase activity
HUT13_RS09780	COG1013	pyruvate-flavodoxin oxidoreductase activity
HUT13_RS09835	COG1007	ATP synthesis coupled electron transport
HUT13_RS09845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HUT13_RS09850	COG0713	ATP synthesis coupled electron transport
HUT13_RS09860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HUT13_RS09870	COG1034	ATP synthesis coupled electron transport
HUT13_RS09875	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HUT13_RS09885	COG0649	NAD binding
HUT13_RS09890	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09895	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HUT13_RS09930	COG2226	methyltransferase
HUT13_RS09945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT13_RS09955	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT13_RS09985	COG1301	dicarboxylic acid transport
HUT13_RS10000	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT13_RS10010	COG0163	prenyltransferase activity
HUT13_RS10020	COG0705	Rhomboid family
HUT13_RS10030	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT13_RS10035	COG2815	serine threonine protein kinase
HUT13_RS10035	COG0515	serine threonine protein kinase
HUT13_RS10040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HUT13_RS10075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT13_RS10075	COG0515	serine threonine protein kinase
HUT13_RS10155	COG0640	Transcriptional regulator
HUT13_RS10175	COG4555	ABC transporter
HUT13_RS10200	COG0129	dihydroxy-acid dehydratase activity
HUT13_RS10210	COG0248	Ppx GppA phosphatase
HUT13_RS10220	COG1129	ABC transporter
HUT13_RS10220	COG0842	Transport permease protein
HUT13_RS10225	COG1082	Xylose isomerase domain protein TIM barrel
HUT13_RS10230	COG1309	transcriptional regulator
HUT13_RS10255	COG0772	Belongs to the SEDS family
HUT13_RS10260	COG0768	penicillin binding
HUT13_RS10275	COG1077	Cell shape determining protein MreB Mrl
HUT13_RS10280	COG0105	UTP biosynthetic process
HUT13_RS10290	COG0285	dihydrofolate synthase activity
HUT13_RS10295	COG1136	(ABC) transporter
HUT13_RS10335	COG0525	valine-tRNA ligase activity
HUT13_RS10350	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HUT13_RS10355	COG0740	serine-type endopeptidase activity
HUT13_RS10360	COG0740	serine-type endopeptidase activity
HUT13_RS10365	COG0544	peptidyl-prolyl cis-trans isomerase activity
HUT13_RS10385	COG3594	Acyltransferase
HUT13_RS10390	COG0739	heme binding
HUT13_RS10400	COG4552	Acetyltransferase involved in intracellular survival and related
HUT13_RS10420	COG0747	negative chemotaxis
HUT13_RS10435	COG0698	ribose 5-phosphate isomerase
HUT13_RS10470	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HUT13_RS10475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HUT13_RS10520	COG0668	transmembrane transport
HUT13_RS10550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT13_RS10585	COG1131	(ABC) transporter
HUT13_RS10635	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HUT13_RS10675	COG1733	regulation of RNA biosynthetic process
HUT13_RS10735	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT13_RS10765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT13_RS10770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HUT13_RS10775	COG0028	Belongs to the TPP enzyme family
HUT13_RS10785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT13_RS10805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HUT13_RS10810	COG1301	dicarboxylic acid transport
HUT13_RS10825	COG2409	Drug exporters of the RND superfamily
HUT13_RS10830	COG1063	alcohol dehydrogenase
HUT13_RS10840	COG1132	(ABC) transporter
HUT13_RS10845	COG0789	Transcriptional regulator
HUT13_RS10980	COG2255	four-way junction helicase activity
HUT13_RS10995	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT13_RS11005	COG3842	ATPase activity
HUT13_RS11010	COG0395	ABC-type sugar transport system, permease component
HUT13_RS11015	COG1175	transmembrane transport
HUT13_RS11025	COG2188	Transcriptional regulator
HUT13_RS11030	COG0673	inositol 2-dehydrogenase activity
HUT13_RS11040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS11050	COG3718	enzyme involved in inositol metabolism
HUT13_RS11055	COG3962	Belongs to the TPP enzyme family
HUT13_RS11080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUT13_RS11115	COG0702	epimerase
HUT13_RS11120	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUT13_RS11125	COG0583	DNA-binding transcription factor activity
HUT13_RS11135	COG0768	penicillin binding
HUT13_RS11145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HUT13_RS11150	COG0793	Belongs to the peptidase S41A family
HUT13_RS11150	COG3409	Peptidoglycan-binding domain 1 protein
HUT13_RS11155	COG2177	Part of the ABC transporter FtsEX involved in
HUT13_RS11160	COG2884	Cell division ATP-binding protein ftsE
HUT13_RS11175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUT13_RS11180	COG0515	serine threonine protein kinase
HUT13_RS11185	COG0515	serine threonine protein kinase
HUT13_RS11200	COG1175	transmembrane transport
HUT13_RS11205	COG0395	ABC-type sugar transport system, permease component
HUT13_RS11245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS11250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT13_RS11255	COG1216	Glycosyl transferase, family 2
HUT13_RS11280	COG1396	sequence-specific DNA binding
HUT13_RS11280	COG3800	Transcriptional regulator
HUT13_RS11290	COG0463	Glycosyl transferase, family 2
HUT13_RS11300	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HUT13_RS11305	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS11325	COG2902	Dehydrogenase
HUT13_RS11345	COG0653	protein targeting
HUT13_RS11350	COG3214	Protein conserved in bacteria
HUT13_RS11355	COG2197	response regulator
HUT13_RS11360	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUT13_RS11370	COG0823	Involved in the tonB-independent uptake of proteins
HUT13_RS11375	COG5002	protein histidine kinase activity
HUT13_RS11380	COG0745	RESPONSE REGULATOR receiver
HUT13_RS11400	COG0714	Associated with various cellular activities
HUT13_RS11440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUT13_RS11445	COG1482	cell wall glycoprotein biosynthetic process
HUT13_RS11455	COG2835	tetraacyldisaccharide 4'-kinase activity
HUT13_RS11495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HUT13_RS11500	COG0778	Nitroreductase
HUT13_RS11500	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HUT13_RS11520	COG1316	TRANSCRIPTIONal
HUT13_RS11535	COG1316	TRANSCRIPTIONal
HUT13_RS11560	COG1607	acyl-coa hydrolase
HUT13_RS11565	COG1316	TRANSCRIPTIONal
HUT13_RS11570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HUT13_RS11580	COG1309	transcriptional regulator
HUT13_RS11595	COG0739	heme binding
HUT13_RS11620	COG5002	protein histidine kinase activity
HUT13_RS11625	COG0745	RESPONSE REGULATOR receiver
HUT13_RS11640	COG1191	sigma factor activity
HUT13_RS11655	COG1228	amidohydrolase
HUT13_RS11665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT13_RS11670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HUT13_RS11675	COG0019	diaminopimelate decarboxylase activity
HUT13_RS11695	COG2755	lipolytic protein G-D-S-L family
HUT13_RS11700	COG0183	Belongs to the thiolase family
HUT13_RS11715	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT13_RS11795	COG1136	(ABC) transporter
HUT13_RS11795	COG0577	efflux transmembrane transporter activity
HUT13_RS11800	COG0577	efflux transmembrane transporter activity
HUT13_RS11805	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT13_RS11850	COG0148	phosphopyruvate hydratase activity
HUT13_RS11855	COG1652	LysM domain
HUT13_RS11870	COG4585	Histidine kinase
HUT13_RS11880	COG0515	serine threonine protein kinase
HUT13_RS11880	COG2815	serine threonine protein kinase
HUT13_RS11985	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HUT13_RS11995	COG1194	a g-specific adenine glycosylase
HUT13_RS12005	COG1733	regulation of RNA biosynthetic process
HUT13_RS12015	COG1595	DNA-templated transcription, initiation
HUT13_RS12020	COG3226	Transcriptional regulator
HUT13_RS12025	COG0154	amidase activity
HUT13_RS12035	COG0519	Catalyzes the synthesis of GMP from XMP
HUT13_RS12060	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HUT13_RS12080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HUT13_RS12090	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUT13_RS12095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HUT13_RS12105	COG2197	response regulator
HUT13_RS12120	COG0649	NAD binding
HUT13_RS12145	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUT13_RS12150	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HUT13_RS12160	COG1125	glycine betaine transport
HUT13_RS12160	COG0517	IMP dehydrogenase activity
HUT13_RS12165	COG1174	glycine betaine transport
HUT13_RS12170	COG1174	glycine betaine transport
HUT13_RS12190	COG0302	gtp cyclohydrolase
HUT13_RS12205	COG0037	tRNA processing
HUT13_RS12215	COG2027	D-alanyl-D-alanine carboxypeptidase
HUT13_RS12220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUT13_RS12235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT13_RS12240	COG1595	DNA-templated transcription, initiation
HUT13_RS12295	COG0739	heme binding
HUT13_RS12300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT13_RS12305	COG1993	acr, cog1993
HUT13_RS12310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HUT13_RS12315	COG1077	Cell shape determining protein MreB Mrl
HUT13_RS12350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUT13_RS12355	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT13_RS12365	COG0254	rRNA binding
HUT13_RS12375	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT13_RS12435	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT13_RS12440	COG0667	Aldo Keto reductase
HUT13_RS12460	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS12490	COG1132	(ABC) transporter
HUT13_RS12505	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT13_RS12505	COG3443	Belongs to the bacterial solute-binding protein 9 family
HUT13_RS12515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT13_RS12520	COG1121	(ABC) transporter
HUT13_RS12580	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS12585	COG1063	alcohol dehydrogenase
HUT13_RS12590	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS12620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HUT13_RS12630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HUT13_RS12635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUT13_RS12635	COG1754	DNA topoisomerase type I activity
HUT13_RS12655	COG2264	protein methyltransferase activity
HUT13_RS12670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUT13_RS12680	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HUT13_RS12690	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT13_RS12695	COG1205	dead DEAH box helicase
HUT13_RS12695	COG1111	helicase
HUT13_RS12755	COG0659	secondary active sulfate transmembrane transporter activity
HUT13_RS12760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HUT13_RS12770	COG2267	carboxylic ester hydrolase activity
HUT13_RS12785	COG0688	phosphatidylethanolamine metabolic process
HUT13_RS12820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HUT13_RS12855	COG1609	Transcriptional regulator
HUT13_RS12855	COG2207	Transcriptional regulator
HUT13_RS12885	COG1408	metallophosphoesterase
HUT13_RS12895	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUT13_RS12895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT13_RS12930	COG1595	DNA-templated transcription, initiation
HUT13_RS12940	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT13_RS12955	COG0667	Aldo Keto reductase
HUT13_RS13015	COG1309	transcriptional regulator
HUT13_RS13020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HUT13_RS13030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HUT13_RS13040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HUT13_RS13045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HUT13_RS13085	COG4133	protoheme IX ABC transporter activity
HUT13_RS13125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT13_RS13210	COG0673	inositol 2-dehydrogenase activity
HUT13_RS13220	COG1172	Belongs to the binding-protein-dependent transport system permease family
HUT13_RS13225	COG1129	ABC transporter
HUT13_RS13230	COG1940	carbohydrate kinase activity
HUT13_RS13235	COG1278	Cold shock
HUT13_RS13250	COG1595	DNA-templated transcription, initiation
HUT13_RS13265	COG0667	Aldo Keto reductase
HUT13_RS13275	COG2409	Drug exporters of the RND superfamily
HUT13_RS13295	COG2197	response regulator
HUT13_RS13300	COG3401	FG-GAP repeat protein
HUT13_RS13325	COG0433	COG0433 Predicted ATPase
HUT13_RS13325	COG1674	ftsk spoiiie
HUT13_RS13370	COG2234	aminopeptidase activity
HUT13_RS13385	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HUT13_RS13395	COG0590	tRNA wobble adenosine to inosine editing
HUT13_RS13405	COG1191	sigma factor activity
HUT13_RS13410	COG1191	sigma factor activity
HUT13_RS13435	COG2226	methyltransferase
HUT13_RS13460	COG0318	PFAM AMP-dependent synthetase and ligase
HUT13_RS13465	COG1595	DNA-templated transcription, initiation
HUT13_RS13515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT13_RS13530	COG0653	protein targeting
HUT13_RS13545	COG0006	proline dipeptidase activity
HUT13_RS13570	COG1595	DNA-templated transcription, initiation
HUT13_RS13595	COG1999	signal sequence binding
HUT13_RS13600	COG2847	Copper chaperone PCu(A)C
HUT13_RS13605	COG2372	response to copper ion
HUT13_RS13610	COG2837	iron assimilation
HUT13_RS13620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HUT13_RS13625	COG0561	phosphatase activity
HUT13_RS13655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS13660	COG0561	phosphatase activity
HUT13_RS13675	COG1609	Transcriptional regulator
HUT13_RS13680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HUT13_RS13685	COG1271	oxidase subunit
HUT13_RS13690	COG1294	oxidase, subunit
HUT13_RS13695	COG4988	ABC transporter
HUT13_RS13725	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HUT13_RS13740	COG0662	Cupin 2, conserved barrel domain protein
HUT13_RS13745	COG1950	PFAM Membrane protein of
HUT13_RS13750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT13_RS13755	COG0626	cystathionine gamma-synthase activity
HUT13_RS13790	COG2814	Major facilitator Superfamily
HUT13_RS13815	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS13825	COG0492	ferredoxin-NADP+ reductase activity
HUT13_RS13825	COG3118	belongs to the thioredoxin family
HUT13_RS13830	COG0305	Participates in initiation and elongation during chromosome replication
HUT13_RS13840	COG0359	binds to the 23S rRNA
HUT13_RS13845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HUT13_RS13850	COG0629	single-stranded DNA binding
HUT13_RS13855	COG0360	Binds together with S18 to 16S ribosomal RNA
HUT13_RS13875	COG1260	myo-inositol-1-phosphate synthase
HUT13_RS13885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUT13_RS13900	COG0617	tRNA 3'-terminal CCA addition
HUT13_RS13920	COG1595	DNA-templated transcription, initiation
HUT13_RS13930	COG0492	ferredoxin-NADP+ reductase activity
HUT13_RS13935	COG3118	belongs to the thioredoxin family
HUT13_RS13945	COG1192	Involved in chromosome partitioning
HUT13_RS13950	COG0357	Ribosomal RNA small subunit methyltransferase G
HUT13_RS13960	COG0706	membrane insertase activity
HUT13_RS13965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HUT13_RS13975	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HUT13_RS13985	COG0592	DNA-directed DNA polymerase activity
HUT13_RS13990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HUT13_RS13995	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUT13_RS14000	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HUT13_RS14005	COG0187	DNA topoisomerase II activity
HUT13_RS14010	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT13_RS14045	COG3764	Sortase (surface protein transpeptidase)
HUT13_RS14050	COG3764	Sortase (surface protein transpeptidase)
HUT13_RS14075	COG0705	Rhomboid family
HUT13_RS14090	COG0515	serine threonine protein kinase
HUT13_RS14095	COG0768	penicillin binding
HUT13_RS14110	COG1716	ATPase activity
HUT13_RS14115	COG1716	ATPase activity
HUT13_RS14140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HUT13_RS14160	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS14195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT13_RS14200	COG1733	regulation of RNA biosynthetic process
HUT13_RS14210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT13_RS14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT13_RS14260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HUT13_RS14265	COG1741	Belongs to the pirin family
HUT13_RS14275	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS14320	COG1674	ftsk spoiiie
HUT13_RS14330	COG1362	aminopeptidase activity
HUT13_RS14340	COG0515	serine threonine protein kinase
HUT13_RS14345	COG0515	serine threonine protein kinase
HUT13_RS14360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HUT13_RS14365	COG1414	Transcriptional regulator
HUT13_RS14385	COG0022	dehydrogenase e1 component
HUT13_RS14405	COG1136	(ABC) transporter
HUT13_RS14405	COG0577	efflux transmembrane transporter activity
HUT13_RS14425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HUT13_RS14440	COG0778	Nitroreductase
HUT13_RS14450	COG2080	2 iron, 2 sulfur cluster binding
HUT13_RS14455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HUT13_RS14460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT13_RS14490	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HUT13_RS14495	COG1309	transcriptional regulator
HUT13_RS14565	COG3396	Phenylacetate-CoA oxygenase
HUT13_RS14570	COG3460	Phenylacetate-CoA oxygenase
HUT13_RS14575	COG3396	Phenylacetate-CoA oxygenase
HUT13_RS14580	COG2151	metal-sulfur cluster biosynthetic enzyme
HUT13_RS14585	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HUT13_RS14610	COG1672	PFAM Archaeal ATPase
HUT13_RS14610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT13_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS14630	COG2197	response regulator
HUT13_RS14665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HUT13_RS14670	COG0076	glutamate decarboxylase activity
HUT13_RS14710	COG1120	ATPase activity
HUT13_RS14715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS14740	COG0640	Transcriptional regulator
HUT13_RS14745	COG0798	PFAM Bile acid sodium symporter
HUT13_RS14750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUT13_RS14770	COG3693	PFAM glycoside hydrolase, family 10
HUT13_RS14860	COG0717	Belongs to the dCTP deaminase family
HUT13_RS14870	COG0247	lactate metabolic process
HUT13_RS14870	COG2181	nitrate reductase activity
HUT13_RS14875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT13_RS14885	COG0443	Heat shock 70 kDa protein
HUT13_RS14890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HUT13_RS14895	COG0484	heat shock protein binding
HUT13_RS14900	COG0789	Transcriptional regulator
HUT13_RS14905	COG0596	Alpha beta hydrolase
HUT13_RS14910	COG3842	ATPase activity
HUT13_RS14920	COG0671	phosphoesterase, PA-phosphatase related
HUT13_RS14940	COG0542	response to heat
HUT13_RS14955	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS15000	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HUT13_RS15005	COG0191	fructose-bisphosphate aldolase activity
HUT13_RS15015	COG3483	tryptophan 2,3-dioxygenase activity
HUT13_RS15050	COG0393	Putative heavy-metal-binding
HUT13_RS15070	COG3559	Exporter of polyketide antibiotics
HUT13_RS15075	COG1131	(ABC) transporter
HUT13_RS15090	COG2272	Belongs to the type-B carboxylesterase lipase family
HUT13_RS15100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HUT13_RS15125	COG0693	protein deglycase activity
HUT13_RS15130	COG1802	Transcriptional regulator
HUT13_RS15145	COG0151	Belongs to the GarS family
HUT13_RS15165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HUT13_RS15185	COG2197	response regulator
HUT13_RS15225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT13_RS15230	COG0047	phosphoribosylformylglycinamidine synthase activity
HUT13_RS15235	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUT13_RS15245	COG0640	Transcriptional regulator
HUT13_RS15265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT13_RS15305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HUT13_RS15335	COG1643	Atp-dependent helicase
HUT13_RS15365	COG1695	Transcriptional regulator
HUT13_RS15385	COG2188	Transcriptional regulator
HUT13_RS15475	COG0582	viral genome integration into host DNA
HUT13_RS15490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUT13_RS15510	COG0513	Belongs to the DEAD box helicase family
HUT13_RS15530	COG1196	nuclear chromosome segregation
HUT13_RS15530	COG0739	heme binding
HUT13_RS15530	COG0741	lytic transglycosylase activity
HUT13_RS15540	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HUT13_RS15595	COG0123	including yeast histone deacetylase and acetoin utilization protein
HUT13_RS15630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HUT13_RS15635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HUT13_RS15640	COG0181	hydroxymethylbilane synthase activity
HUT13_RS15645	COG1648	precorrin-2 dehydrogenase activity
HUT13_RS15645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HUT13_RS15650	COG0113	porphobilinogen synthase activity
HUT13_RS15665	COG0738	Major facilitator superfamily
HUT13_RS15675	COG0596	Alpha beta hydrolase
HUT13_RS15685	COG0018	arginyl-trna synthetase
HUT13_RS15690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HUT13_RS15700	COG0659	secondary active sulfate transmembrane transporter activity
HUT13_RS15735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HUT13_RS15740	COG0406	alpha-ribazole phosphatase activity
HUT13_RS15745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HUT13_RS15750	COG0785	Cytochrome C biogenesis protein
HUT13_RS15755	COG1333	cytochrome c biogenesis protein
HUT13_RS15760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HUT13_RS15770	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HUT13_RS15775	COG0109	protoheme IX farnesyltransferase activity
HUT13_RS15800	COG1196	nuclear chromosome segregation
HUT13_RS15800	COG0741	lytic transglycosylase activity
HUT13_RS15800	COG0739	heme binding
HUT13_RS15805	COG0671	phosphoesterase, PA-phosphatase related
HUT13_RS15820	COG1937	Protein conserved in bacteria
HUT13_RS15835	COG0581	inorganic phosphate transmembrane transporter activity
HUT13_RS15840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT13_RS15845	COG1404	Belongs to the peptidase S8 family
HUT13_RS15850	COG1404	Belongs to the peptidase S8 family
HUT13_RS15890	COG4585	Histidine kinase
HUT13_RS15895	COG2197	response regulator
HUT13_RS15900	COG1271	oxidase subunit
HUT13_RS15910	COG2409	Drug exporters of the RND superfamily
HUT13_RS15915	COG0546	phosphoglycolate phosphatase activity
HUT13_RS15920	COG2186	Transcriptional regulator
HUT13_RS15930	COG4552	Acetyltransferase involved in intracellular survival and related
HUT13_RS15940	COG1490	D-aminoacyl-tRNA deacylase activity
HUT13_RS15960	COG0354	folic acid binding
HUT13_RS15970	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS15980	COG3485	protocatechuate 3,4-dioxygenase
HUT13_RS16010	COG0745	RESPONSE REGULATOR receiver
HUT13_RS16015	COG1609	Transcriptional regulator
HUT13_RS16030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT13_RS16060	COG0737	Belongs to the 5'-nucleotidase family
HUT13_RS16065	COG0456	acetyltransferase
HUT13_RS16070	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUT13_RS16085	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS16105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS16125	COG0588	phosphoglycerate mutase activity
HUT13_RS16130	COG4585	Histidine kinase
HUT13_RS16140	COG5002	protein histidine kinase activity
HUT13_RS16155	COG1329	Transcriptional regulator
HUT13_RS16160	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HUT13_RS16165	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HUT13_RS16175	COG0215	cysteine-tRNA ligase activity
HUT13_RS16180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUT13_RS16190	COG0596	Alpha beta hydrolase
HUT13_RS16195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HUT13_RS16205	COG3842	ATPase activity
HUT13_RS16255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HUT13_RS16320	COG5001	Diguanylate cyclase
HUT13_RS16320	COG3300	MHYT domain
HUT13_RS16330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HUT13_RS16335	COG1940	carbohydrate kinase activity
HUT13_RS16370	COG0463	Glycosyl transferase, family 2
HUT13_RS16385	COG1278	Cold shock
HUT13_RS16395	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HUT13_RS16400	COG1737	Transcriptional regulator
HUT13_RS16420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT13_RS16425	COG0745	RESPONSE REGULATOR receiver
HUT13_RS16430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HUT13_RS16440	COG0581	inorganic phosphate transmembrane transporter activity
HUT13_RS16445	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HUT13_RS16470	COG1196	nuclear chromosome segregation
HUT13_RS16470	COG0741	lytic transglycosylase activity
HUT13_RS16470	COG0739	heme binding
HUT13_RS16475	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HUT13_RS16490	COG1061	Type III restriction enzyme res subunit
HUT13_RS16495	COG3973	AAA domain
HUT13_RS16515	COG1396	sequence-specific DNA binding
HUT13_RS16560	COG1278	Cold shock
HUT13_RS16565	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HUT13_RS16570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUT13_RS16580	COG2814	Major facilitator Superfamily
HUT13_RS16615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUT13_RS16625	COG1846	Transcriptional regulator
HUT13_RS16630	COG2814	Major facilitator Superfamily
HUT13_RS16645	COG0667	Aldo Keto reductase
HUT13_RS16655	COG0667	Aldo Keto reductase
HUT13_RS16685	COG1609	Transcriptional regulator
HUT13_RS16695	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUT13_RS16735	COG0277	FAD linked oxidase domain protein
HUT13_RS16735	COG0247	lactate metabolic process
HUT13_RS16825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS16830	COG0259	pyridoxamine-phosphate oxidase activity
HUT13_RS16835	COG4821	SIS domain
HUT13_RS16885	COG0477	Major facilitator Superfamily
HUT13_RS16920	COG1366	Belongs to the anti-sigma-factor antagonist family
HUT13_RS16930	COG2072	flavoprotein involved in K transport
HUT13_RS16940	COG0515	serine threonine protein kinase
HUT13_RS16940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HUT13_RS16975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HUT13_RS17000	COG1686	Belongs to the peptidase S11 family
HUT13_RS17030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT13_RS17045	COG4221	oxidoreductase activity
HUT13_RS17055	COG2197	response regulator
HUT13_RS17060	COG1595	DNA-templated transcription, initiation
HUT13_RS17070	COG0516	GMP reductase activity
HUT13_RS17085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HUT13_RS17090	COG2815	serine threonine protein kinase
HUT13_RS17090	COG0515	serine threonine protein kinase
HUT13_RS17100	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS17115	COG0519	Catalyzes the synthesis of GMP from XMP
HUT13_RS17115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HUT13_RS17130	COG2197	response regulator
HUT13_RS17165	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HUT13_RS17165	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HUT13_RS17175	COG0456	acetyltransferase
HUT13_RS17175	COG0454	-acetyltransferase
HUT13_RS17190	COG1902	pentaerythritol trinitrate reductase activity
HUT13_RS17225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT13_RS17230	COG0045	succinate-CoA ligase (ADP-forming) activity
HUT13_RS17265	COG0138	bifunctional purine biosynthesis protein purh
HUT13_RS17285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HUT13_RS17300	COG1846	Transcriptional regulator
HUT13_RS17315	COG0039	L-malate dehydrogenase activity
HUT13_RS17320	COG0538	isocitrate dehydrogenase activity
HUT13_RS17330	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT13_RS17335	COG0180	Tryptophanyl-tRNA synthetase
HUT13_RS17350	COG1686	Belongs to the peptidase S11 family
HUT13_RS17355	COG1408	metallophosphoesterase
HUT13_RS17375	COG0477	Major facilitator Superfamily
HUT13_RS17380	COG0277	FAD linked oxidase domain protein
HUT13_RS17385	COG2264	protein methyltransferase activity
HUT13_RS17400	COG4941	Belongs to the sigma-70 factor family
HUT13_RS17415	COG2362	D-Aminopeptidase
HUT13_RS17425	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS17435	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HUT13_RS17485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HUT13_RS17500	COG2009	succinate dehydrogenase
HUT13_RS17515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT13_RS17515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT13_RS17545	COG1083	cytidylyl-transferase
HUT13_RS17550	COG2089	acid synthase
HUT13_RS17560	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HUT13_RS17560	COG1473	amidohydrolase
HUT13_RS17595	COG2239	Acts as a magnesium transporter
HUT13_RS17605	COG2186	Transcriptional regulator
HUT13_RS17610	COG3265	gluconokinase activity
HUT13_RS17615	COG2610	gluconate transmembrane transporter activity
HUT13_RS17655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HUT13_RS17675	COG2814	Major facilitator Superfamily
HUT13_RS17680	COG0583	DNA-binding transcription factor activity
HUT13_RS17685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT13_RS17710	COG2205	protein histidine kinase activity
HUT13_RS17715	COG0745	RESPONSE REGULATOR receiver
HUT13_RS17720	COG1595	DNA-templated transcription, initiation
HUT13_RS17730	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS17735	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS17750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HUT13_RS17775	COG4770	biotin carboxylase activity
HUT13_RS17780	COG0424	maF-like protein
HUT13_RS17810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT13_RS17820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT13_RS17825	COG1024	Enoyl-CoA hydratase
HUT13_RS17855	COG1376	ErfK ybiS ycfS ynhG family protein
HUT13_RS17860	COG1396	sequence-specific DNA binding
HUT13_RS17865	COG0740	serine-type endopeptidase activity
HUT13_RS17870	COG0740	serine-type endopeptidase activity
HUT13_RS17880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT13_RS17900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUT13_RS17925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT13_RS17935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUT13_RS17940	COG1331	Highly conserved protein containing a thioredoxin domain
HUT13_RS17950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HUT13_RS17990	COG2894	cell division
HUT13_RS18035	COG2885	chlorophyll binding
HUT13_RS18045	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HUT13_RS18050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HUT13_RS18055	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HUT13_RS18080	COG1136	(ABC) transporter
HUT13_RS18100	COG0515	serine threonine protein kinase
HUT13_RS18105	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT13_RS18105	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HUT13_RS18110	COG0114	fumarate hydratase activity
HUT13_RS18125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HUT13_RS18130	COG0450	alkyl hydroperoxide reductase
HUT13_RS18170	COG0778	Nitroreductase
HUT13_RS18175	COG1722	exodeoxyribonuclease VII activity
HUT13_RS18180	COG1570	exodeoxyribonuclease VII activity
HUT13_RS18185	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HUT13_RS18195	COG0012	GTP binding
HUT13_RS18240	COG4166	transmembrane transport
HUT13_RS18245	COG0601	transmembrane transport
HUT13_RS18260	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS18265	COG4166	transmembrane transport
HUT13_RS18270	COG0601	transmembrane transport
HUT13_RS18275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUT13_RS18280	COG0444	Belongs to the ABC transporter superfamily
HUT13_RS18285	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS18320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS18325	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HUT13_RS18340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HUT13_RS18350	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS18355	COG0444	Belongs to the ABC transporter superfamily
HUT13_RS18360	COG0601	transmembrane transport
HUT13_RS18365	COG0747	negative chemotaxis
HUT13_RS18415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT13_RS18425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUT13_RS18435	COG1024	Enoyl-CoA hydratase
HUT13_RS18450	COG1595	DNA-templated transcription, initiation
HUT13_RS18460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HUT13_RS18465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT13_RS18500	COG0737	Belongs to the 5'-nucleotidase family
HUT13_RS18510	COG0613	PHP domain protein
HUT13_RS18630	COG0210	DNA helicase
HUT13_RS18750	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT13_RS18760	COG1615	UPF0182 protein
HUT13_RS18800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT13_RS18815	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS18835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS18840	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS18845	COG1120	ATPase activity
HUT13_RS18855	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT13_RS18860	COG0589	response to stress
HUT13_RS18895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HUT13_RS18900	COG1162	GTPase activity
HUT13_RS18915	COG0577	efflux transmembrane transporter activity
HUT13_RS18915	COG1136	(ABC) transporter
HUT13_RS18925	COG2197	response regulator
HUT13_RS18940	COG0483	inositol monophosphate 1-phosphatase activity
HUT13_RS18945	COG0753	catalase activity
HUT13_RS18960	COG1946	Acyl-CoA thioesterase
HUT13_RS18995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HUT13_RS19005	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HUT13_RS19010	COG1396	sequence-specific DNA binding
HUT13_RS19015	COG1051	belongs to the nudix hydrolase family
HUT13_RS19025	COG0583	DNA-binding transcription factor activity
HUT13_RS19035	COG1609	Transcriptional regulator
HUT13_RS19040	COG0673	inositol 2-dehydrogenase activity
HUT13_RS19060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT13_RS19095	COG3963	phosphatidate phosphatase activity
HUT13_RS19100	COG2197	response regulator
HUT13_RS19105	COG1733	regulation of RNA biosynthetic process
HUT13_RS19150	COG0300	oxidoreductase activity
HUT13_RS19155	COG0300	oxidoreductase activity
HUT13_RS19170	COG0789	Transcriptional regulator
HUT13_RS19180	COG0515	serine threonine protein kinase
HUT13_RS19185	COG2226	methyltransferase
HUT13_RS19215	COG2223	nitrite transmembrane transporter activity
HUT13_RS19255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HUT13_RS19265	COG0583	DNA-binding transcription factor activity
HUT13_RS19270	COG0367	asparagine synthase
HUT13_RS19335	COG0776	regulation of translation
HUT13_RS19340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUT13_RS19345	COG1678	Uncharacterized ACR, COG1678
HUT13_RS19355	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HUT13_RS19370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT13_RS19380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUT13_RS19405	COG2814	Major facilitator Superfamily
HUT13_RS19410	COG1061	Type III restriction enzyme res subunit
HUT13_RS19420	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUT13_RS19425	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT13_RS19465	COG1335	isochorismatase
HUT13_RS19475	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HUT13_RS19485	COG1115	amino acid carrier protein
HUT13_RS19505	COG0772	Belongs to the SEDS family
HUT13_RS19515	COG1234	tRNA 3'-trailer cleavage
HUT13_RS19520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HUT13_RS19530	COG1653	transport
HUT13_RS19535	COG1175	transmembrane transport
HUT13_RS19540	COG0395	ABC-type sugar transport system, permease component
HUT13_RS19550	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HUT13_RS19580	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HUT13_RS19585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HUT13_RS19595	COG2733	membrane
HUT13_RS19630	COG1126	abc transporter atp-binding protein
HUT13_RS19635	COG0765	amino acid transport
HUT13_RS19640	COG0765	amino acid transport
HUT13_RS19650	COG1404	Belongs to the peptidase S8 family
HUT13_RS19665	COG0154	amidase activity
HUT13_RS19670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUT13_RS19720	COG0406	alpha-ribazole phosphatase activity
HUT13_RS19750	COG2205	protein histidine kinase activity
HUT13_RS19750	COG5002	protein histidine kinase activity
HUT13_RS19750	COG0784	Response regulator, receiver
HUT13_RS19780	COG0492	ferredoxin-NADP+ reductase activity
HUT13_RS19795	COG5297	Belongs to the glycosyl hydrolase family 6
HUT13_RS19800	COG4733	cellulase activity
HUT13_RS19800	COG5297	Belongs to the glycosyl hydrolase family 6
HUT13_RS19810	COG5297	Belongs to the glycosyl hydrolase family 6
HUT13_RS19815	COG2135	peptidase activity
HUT13_RS19820	COG1595	DNA-templated transcription, initiation
HUT13_RS19825	COG5662	AntiSigma factor
HUT13_RS19845	COG0242	peptide deformylase activity
HUT13_RS19855	COG1404	Belongs to the peptidase S8 family
HUT13_RS19865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUT13_RS19880	COG1966	Carbon starvation protein
HUT13_RS19885	COG2188	Transcriptional regulator
HUT13_RS19890	COG2182	Extracellular solute-binding protein
HUT13_RS19895	COG1175	transmembrane transport
HUT13_RS19900	COG0395	ABC-type sugar transport system, permease component
HUT13_RS19905	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT13_RS19910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUT13_RS19925	COG1597	lipid kinase activity
HUT13_RS19940	COG2172	sigma factor antagonist activity
HUT13_RS19945	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HUT13_RS19985	COG4106	trans-aconitate 2-methyltransferase activity
HUT13_RS19990	COG0281	malic enzyme
HUT13_RS20000	COG0765	amino acid transport
HUT13_RS20010	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS20035	COG0604	alcohol dehydrogenase
HUT13_RS20040	COG2186	Transcriptional regulator
HUT13_RS20050	COG2376	Dihydroxyacetone kinase
HUT13_RS20055	COG0698	ribose 5-phosphate isomerase
HUT13_RS20060	COG0149	triose-phosphate isomerase activity
HUT13_RS20065	COG1082	Xylose isomerase domain protein TIM barrel
HUT13_RS20070	COG2084	Dehydrogenase
HUT13_RS20075	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HUT13_RS20085	COG1309	transcriptional regulator
HUT13_RS20090	COG0300	oxidoreductase activity
HUT13_RS20160	COG2255	four-way junction helicase activity
HUT13_RS20200	COG0567	Dehydrogenase, E1 component
HUT13_RS20200	COG0508	dehydrogenase complex catalyzes the overall conversion of
HUT13_RS20205	COG2205	protein histidine kinase activity
HUT13_RS20210	COG0745	RESPONSE REGULATOR receiver
HUT13_RS20255	COG1309	transcriptional regulator
HUT13_RS20265	COG1796	DNA polymerase
HUT13_RS20265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HUT13_RS20285	COG3572	ergothioneine biosynthetic process
HUT13_RS20290	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HUT13_RS20340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HUT13_RS20345	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT13_RS20355	COG2130	NADP-dependent
HUT13_RS20360	COG1233	COG1233 Phytoene dehydrogenase and related
HUT13_RS20380	COG0726	polysaccharide deacetylase
HUT13_RS20390	COG3800	Transcriptional regulator
HUT13_RS20390	COG1396	sequence-specific DNA binding
HUT13_RS20395	COG2079	MmgE PrpD family protein
HUT13_RS20400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HUT13_RS20445	COG0346	lactoylglutathione lyase activity
HUT13_RS20475	COG0019	diaminopimelate decarboxylase activity
HUT13_RS20485	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HUT13_RS20490	COG0083	homoserine kinase activity
HUT13_RS20500	COG1316	TRANSCRIPTIONal
HUT13_RS20505	COG0254	rRNA binding
HUT13_RS20510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HUT13_RS20515	COG2890	protein-(glutamine-N5) methyltransferase activity
HUT13_RS20545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT13_RS20550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HUT13_RS20555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HUT13_RS20560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HUT13_RS20565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HUT13_RS20570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HUT13_RS20575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUT13_RS20595	COG2197	response regulator
HUT13_RS20600	COG3850	Histidine kinase
HUT13_RS20635	COG1250	3-hydroxyacyl-CoA dehydrogenase
HUT13_RS20650	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HUT13_RS20675	COG0431	NADPH-dependent FMN reductase
HUT13_RS20705	COG1131	(ABC) transporter
HUT13_RS20725	COG0183	Belongs to the thiolase family
HUT13_RS20755	COG4977	sequence-specific DNA binding
HUT13_RS20760	COG1357	PFAM Pentapeptide repeats (8 copies)
HUT13_RS20770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT13_RS20775	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HUT13_RS20785	COG4221	oxidoreductase activity
HUT13_RS20805	COG0789	Transcriptional regulator
HUT13_RS20915	COG1595	DNA-templated transcription, initiation
HUT13_RS20935	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT13_RS20935	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HUT13_RS20940	COG2124	cytochrome p450
HUT13_RS20950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUT13_RS20980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUT13_RS20985	COG0280	phosphate acetyltransferase
HUT13_RS20985	COG0857	belongs to the CobB CobQ family
HUT13_RS20990	COG0205	6-phosphofructokinase activity
HUT13_RS21035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS21040	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HUT13_RS21085	COG4565	transcriptional regulatory protein
HUT13_RS21090	COG3290	protein histidine kinase activity
HUT13_RS21095	COG0471	metal ion transport
HUT13_RS21100	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HUT13_RS21110	COG0366	Alpha amylase catalytic
HUT13_RS21115	COG0366	Alpha amylase catalytic
HUT13_RS21135	COG0444	Belongs to the ABC transporter superfamily
HUT13_RS21140	COG4608	Belongs to the ABC transporter superfamily
HUT13_RS21145	COG0058	SHG alpha-glucan phosphorylase activity
HUT13_RS21150	COG1132	(ABC) transporter
HUT13_RS21155	COG1132	(ABC) transporter
HUT13_RS21175	COG1376	ErfK ybiS ycfS ynhG family protein
HUT13_RS21190	COG3629	intracellular signal transduction
HUT13_RS21190	COG3903	Transcriptional regulator
HUT13_RS21220	COG2226	methyltransferase
HUT13_RS21225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HUT13_RS21245	COG1794	racemase activity, acting on amino acids and derivatives
HUT13_RS21250	COG3321	synthase
HUT13_RS21250	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS21250	COG0604	alcohol dehydrogenase
HUT13_RS21290	COG1131	(ABC) transporter
HUT13_RS21315	COG1473	amidohydrolase
HUT13_RS21370	COG1131	(ABC) transporter
HUT13_RS21405	COG3629	intracellular signal transduction
HUT13_RS21405	COG3903	Transcriptional regulator
HUT13_RS21410	COG1760	l-serine dehydratase
HUT13_RS21415	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT13_RS21420	COG0509	glycine decarboxylation via glycine cleavage system
HUT13_RS21425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HUT13_RS21445	COG0783	Belongs to the Dps family
HUT13_RS21475	COG0482	sulfurtransferase activity
HUT13_RS21480	COG3655	Transcriptional regulator
HUT13_RS21505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HUT13_RS21515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT13_RS21520	COG0154	amidase activity
HUT13_RS21530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HUT13_RS21540	COG1672	PFAM Archaeal ATPase
HUT13_RS21540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT13_RS21555	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HUT13_RS21555	COG1672	PFAM Archaeal ATPase
HUT13_RS21560	COG0667	Aldo Keto reductase
HUT13_RS21570	COG5001	Diguanylate cyclase
HUT13_RS21580	COG0440	acetolactate synthase activity
HUT13_RS21585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HUT13_RS21620	COG0506	proline dehydrogenase activity
HUT13_RS21625	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS21635	COG0473	3-isopropylmalate dehydrogenase activity
HUT13_RS21640	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUT13_RS21645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HUT13_RS21650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUT13_RS21670	COG2018	Roadblock/LC7 domain
HUT13_RS21690	COG2018	Roadblock/LC7 domain
HUT13_RS21705	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUT13_RS21710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HUT13_RS21760	COG1414	Transcriptional regulator
HUT13_RS21765	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HUT13_RS21770	COG0066	3-isopropylmalate dehydratase activity
HUT13_RS21780	COG0776	regulation of translation
HUT13_RS21790	COG1920	GTP binding
HUT13_RS21800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HUT13_RS21805	COG1181	Belongs to the D-alanine--D-alanine ligase family
HUT13_RS21830	COG0351	phosphomethylpyrimidine kinase
HUT13_RS21835	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUT13_RS21840	COG1461	Dihydroxyacetone kinase
HUT13_RS21865	COG0742	ribosomal rna small subunit methyltransferase
HUT13_RS21870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HUT13_RS21885	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HUT13_RS21890	COG0571	ribonuclease III activity
HUT13_RS21895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HUT13_RS21900	COG2340	Cysteine-rich secretory protein family
HUT13_RS21905	COG1254	Belongs to the acylphosphatase family
HUT13_RS21920	COG0477	Major facilitator Superfamily
HUT13_RS21950	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUT13_RS21960	COG0442	prolyl-tRNA aminoacylation
HUT13_RS21970	COG0228	four-way junction DNA binding
HUT13_RS21975	COG1837	Belongs to the UPF0109 family
HUT13_RS21980	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HUT13_RS21985	COG0336	Belongs to the RNA methyltransferase TrmD family
HUT13_RS21990	COG0335	large ribosomal subunit rRNA binding
HUT13_RS22005	COG0681	Belongs to the peptidase S26 family
HUT13_RS22010	COG0681	Belongs to the peptidase S26 family
HUT13_RS22025	COG1191	sigma factor activity
HUT13_RS22040	COG0792	nuclease activity
HUT13_RS22045	COG0052	Belongs to the universal ribosomal protein uS2 family
HUT13_RS22050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HUT13_RS22055	COG0528	UMP kinase activity
HUT13_RS22060	COG0233	cytoplasmic translational termination
HUT13_RS22065	COG0575	Belongs to the CDS family
HUT13_RS22155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HUT13_RS22170	COG3842	ATPase activity
HUT13_RS22185	COG1136	(ABC) transporter
HUT13_RS22190	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS22205	COG0584	glycerophosphoryl diester phosphodiesterase
HUT13_RS22210	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT13_RS22225	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HUT13_RS22245	COG2508	Transcriptional regulator
HUT13_RS22255	COG1012	belongs to the aldehyde dehydrogenase family
HUT13_RS22265	COG1472	Belongs to the glycosyl hydrolase 3 family
HUT13_RS22275	COG4209	transmembrane transport
HUT13_RS22280	COG0395	ABC-type sugar transport system, permease component
HUT13_RS22315	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HUT13_RS22320	COG0750	zinc metalloprotease
HUT13_RS22325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HUT13_RS22330	COG0454	-acetyltransferase
HUT13_RS22330	COG0456	acetyltransferase
HUT13_RS22335	COG0456	acetyltransferase
HUT13_RS22340	COG0442	prolyl-tRNA aminoacylation
HUT13_RS22360	COG0779	Required for maturation of 30S ribosomal subunits
HUT13_RS22375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HUT13_RS22385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HUT13_RS22390	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HUT13_RS22400	COG0455	bacterial-type flagellum organization
HUT13_RS22420	COG3266	domain, Protein
HUT13_RS22425	COG1404	Belongs to the peptidase S8 family
HUT13_RS22475	COG1674	ftsk spoiiie
HUT13_RS22485	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HUT13_RS22490	COG1185	polyribonucleotide nucleotidyltransferase activity
HUT13_RS22495	COG0612	Peptidase, M16
HUT13_RS22500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HUT13_RS22520	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HUT13_RS22525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUT13_RS22530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUT13_RS22555	COG2770	Histidine kinase
HUT13_RS22555	COG2208	phosphoserine phosphatase activity
HUT13_RS22570	COG1674	ftsk spoiiie
HUT13_RS22580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT13_RS22590	COG1058	Belongs to the CinA family
HUT13_RS22590	COG1546	Belongs to the CinA family
HUT13_RS22595	COG1396	sequence-specific DNA binding
HUT13_RS22600	COG1201	RNA secondary structure unwinding
HUT13_RS22610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HUT13_RS22620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT13_RS22625	COG0765	amino acid transport
HUT13_RS22630	COG0765	amino acid transport
HUT13_RS22635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUT13_RS22640	COG1126	abc transporter atp-binding protein
HUT13_RS22645	COG0745	RESPONSE REGULATOR receiver
HUT13_RS22665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HUT13_RS22690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HUT13_RS22700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUT13_RS22705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUT13_RS22710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUT13_RS22725	COG1609	Transcriptional regulator
HUT13_RS22730	COG3976	FMN-binding domain protein
HUT13_RS22730	COG1053	succinate dehydrogenase
HUT13_RS22745	COG0395	ABC-type sugar transport system, permease component
HUT13_RS22750	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HUT13_RS22785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUT13_RS22795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT13_RS22805	COG0588	phosphoglycerate mutase activity
HUT13_RS22810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUT13_RS22830	COG1802	Transcriptional regulator
HUT13_RS22835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUT13_RS22850	COG0187	DNA topoisomerase II activity
HUT13_RS22860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUT13_RS22865	COG0612	Peptidase, M16
HUT13_RS22875	COG1802	Transcriptional regulator
HUT13_RS22880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HUT13_RS22900	COG1435	thymidine kinase activity
HUT13_RS22935	COG0745	RESPONSE REGULATOR receiver
HUT13_RS22940	COG2205	protein histidine kinase activity
HUT13_RS22955	COG0756	dUTP diphosphatase activity
HUT13_RS22995	COG0569	domain protein
HUT13_RS23000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUT13_RS23010	COG1278	Cold shock
HUT13_RS23015	COG0513	Belongs to the DEAD box helicase family
HUT13_RS23060	COG1674	ftsk spoiiie
HUT13_RS23100	COG2040	homocysteine
HUT13_RS23105	COG2267	carboxylic ester hydrolase activity
HUT13_RS23125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HUT13_RS23165	COG1309	transcriptional regulator
HUT13_RS23170	COG2409	Drug exporters of the RND superfamily
HUT13_RS23225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUT13_RS23235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HUT13_RS23240	COG1653	transport
HUT13_RS23245	COG1175	transmembrane transport
HUT13_RS23250	COG0395	ABC-type sugar transport system, permease component
HUT13_RS23255	COG1940	carbohydrate kinase activity
HUT13_RS23270	COG4214	carbohydrate transport
HUT13_RS23275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUT13_RS23285	COG1316	TRANSCRIPTIONal
HUT13_RS23295	COG0183	Belongs to the thiolase family
HUT13_RS23315	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HUT13_RS23330	COG2326	polyphosphate kinase activity
HUT13_RS23350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HUT13_RS23355	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUT13_RS23360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS23365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT13_RS23385	COG1716	ATPase activity
HUT13_RS23420	COG0477	Major facilitator Superfamily
HUT13_RS23430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUT13_RS23440	COG0431	NADPH-dependent FMN reductase
HUT13_RS23445	COG0745	RESPONSE REGULATOR receiver
HUT13_RS23455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUT13_RS23460	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HUT13_RS23480	COG0529	Catalyzes the synthesis of activated sulfate
HUT13_RS23485	COG0175	sulfate reduction
HUT13_RS23495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HUT13_RS23505	COG1960	acyl-CoA dehydrogenase activity
HUT13_RS23520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HUT13_RS23525	COG3467	pyridoxamine 5'-phosphate
HUT13_RS23555	COG1802	Transcriptional regulator
HUT13_RS23570	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HUT13_RS23570	COG2508	Transcriptional regulator
HUT13_RS23585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HUT13_RS23655	COG1414	Transcriptional regulator
HUT13_RS23660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT13_RS23665	COG4266	Belongs to the allantoicase family
HUT13_RS23700	COG1129	ABC transporter
HUT13_RS23705	COG1940	carbohydrate kinase activity
HUT13_RS23715	COG3842	ATPase activity
HUT13_RS23730	COG1929	Belongs to the glycerate kinase type-1 family
HUT13_RS23735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HUT13_RS23745	COG0483	inositol monophosphate 1-phosphatase activity
HUT13_RS23775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUT13_RS23785	COG2192	nodulation
HUT13_RS23790	COG0492	ferredoxin-NADP+ reductase activity
HUT13_RS23825	COG2226	methyltransferase
HUT13_RS23855	COG1120	ATPase activity
HUT13_RS23860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS23875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HUT13_RS23880	COG1121	(ABC) transporter
HUT13_RS23890	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUT13_RS23905	COG0523	cobalamin synthesis protein
HUT13_RS23925	COG0673	inositol 2-dehydrogenase activity
HUT13_RS23935	COG3433	isochorismatase activity
HUT13_RS23935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT13_RS23935	COG2226	methyltransferase
HUT13_RS23940	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HUT13_RS23940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUT13_RS23945	COG1021	2,3-dihydroxybenzoate-AMP ligase
HUT13_RS23955	COG0747	negative chemotaxis
HUT13_RS23960	COG0601	transmembrane transport
HUT13_RS23970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUT13_RS23995	COG3693	PFAM glycoside hydrolase, family 10
HUT13_RS24000	COG1609	Transcriptional regulator
HUT13_RS24100	COG2197	response regulator
HUT13_RS24120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HUT13_RS24145	COG0708	Exodeoxyribonuclease III
HUT13_RS24160	COG0688	phosphatidylethanolamine metabolic process
HUT13_RS24165	COG2301	Belongs to the HpcH HpaI aldolase family
HUT13_RS24185	COG1011	Hydrolase
HUT13_RS24195	COG0583	DNA-binding transcription factor activity
HUT13_RS24245	COG2362	D-Aminopeptidase
HUT13_RS24250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUT13_RS24275	COG1619	proteins homologs of microcin C7 resistance protein MccF
HUT13_RS24285	COG2318	DinB family
HUT13_RS24320	COG0395	ABC-type sugar transport system, permease component
HUT13_RS24325	COG1063	alcohol dehydrogenase
HUT13_RS24335	COG0596	Alpha beta hydrolase
HUT13_RS24340	COG3629	intracellular signal transduction
HUT13_RS24340	COG3903	Transcriptional regulator
HUT13_RS24345	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HUT13_RS24350	COG2226	methyltransferase
HUT13_RS24395	COG1335	isochorismatase
HUT13_RS24405	COG2154	pterin-4-alpha-carbinolamine dehydratase
HUT13_RS24430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUT13_RS24455	COG0656	L-ascorbic acid biosynthetic process
HUT13_RS24465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HUT13_RS24505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS24510	COG0435	Glutathione S-transferase
HUT13_RS24535	COG2318	DinB family
HUT13_RS24550	COG0587	DNA-directed DNA polymerase activity
HUT13_RS24560	COG0277	FAD linked oxidase domain protein
HUT13_RS24580	COG2226	methyltransferase
HUT13_RS24585	COG1162	GTPase activity
HUT13_RS24590	COG1609	Transcriptional regulator
HUT13_RS24595	COG4209	transmembrane transport
HUT13_RS24600	COG0395	ABC-type sugar transport system, permease component
HUT13_RS24620	COG1280	lysine exporter protein (LysE YggA)
HUT13_RS24635	COG1215	transferase activity, transferring glycosyl groups
HUT13_RS24655	COG3845	ABC transporter
HUT13_RS24680	COG2271	Major facilitator Superfamily
HUT13_RS24685	COG2409	Drug exporters of the RND superfamily
HUT13_RS24690	COG3629	intracellular signal transduction
HUT13_RS24690	COG3903	Transcriptional regulator
HUT13_RS24700	COG2356	endonuclease I
HUT13_RS24705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HUT13_RS24720	COG1132	(ABC) transporter
HUT13_RS24730	COG1595	DNA-templated transcription, initiation
HUT13_RS24740	COG4214	carbohydrate transport
HUT13_RS24750	COG4213	ABC transporter substrate-binding protein
HUT13_RS24755	COG0406	alpha-ribazole phosphatase activity
HUT13_RS24765	COG1070	Carbohydrate kinase
HUT13_RS24770	COG1070	Carbohydrate kinase
HUT13_RS24780	COG3509	depolymerase
HUT13_RS24785	COG2207	Transcriptional regulator
HUT13_RS24785	COG3708	Transcriptional regulator
HUT13_RS24800	COG2197	response regulator
HUT13_RS24805	COG0604	alcohol dehydrogenase
HUT13_RS24835	COG1131	(ABC) transporter
HUT13_RS24865	COG0431	NADPH-dependent FMN reductase
HUT13_RS24895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HUT13_RS24990	COG0745	RESPONSE REGULATOR receiver
HUT13_RS25050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS25075	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS25080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HUT13_RS25085	COG2192	nodulation
HUT13_RS25095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HUT13_RS25100	COG0859	PFAM glycosyl transferase family 9
HUT13_RS25110	COG0438	transferase activity, transferring glycosyl groups
HUT13_RS25115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HUT13_RS25120	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUT13_RS25120	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUT13_RS25140	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS25150	COG4948	Mandelate Racemase Muconate Lactonizing
HUT13_RS25160	COG0277	FAD linked oxidase domain protein
HUT13_RS25160	COG0247	lactate metabolic process
HUT13_RS25175	COG3046	protein related to deoxyribodipyrimidine photolyase
HUT13_RS25195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS25200	COG1404	Belongs to the peptidase S8 family
HUT13_RS25205	COG1609	Transcriptional regulator
HUT13_RS25210	COG1176	ABC-type spermidine putrescine transport system, permease component I
HUT13_RS25215	COG1177	transmembrane transport
HUT13_RS25220	COG3842	ATPase activity
HUT13_RS25230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HUT13_RS25250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUT13_RS25275	COG2755	lipolytic protein G-D-S-L family
HUT13_RS25350	COG2124	cytochrome p450
HUT13_RS25360	COG3360	Dodecin
HUT13_RS25365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HUT13_RS25370	COG1515	deoxyribonuclease V activity
HUT13_RS25375	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUT13_RS25395	COG0702	epimerase
HUT13_RS25400	COG1733	regulation of RNA biosynthetic process
HUT13_RS25405	COG1309	transcriptional regulator
HUT13_RS25415	COG2409	Drug exporters of the RND superfamily
HUT13_RS25420	COG2183	response to ionizing radiation
HUT13_RS25430	COG1132	(ABC) transporter
HUT13_RS25440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HUT13_RS25465	COG0371	Dehydrogenase
HUT13_RS25485	COG1134	teichoic acid transport
HUT13_RS25485	COG1388	LysM domain
HUT13_RS25490	COG1562	ergosterol biosynthetic process
HUT13_RS25500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HUT13_RS25535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HUT13_RS25540	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HUT13_RS25545	COG5001	Diguanylate cyclase
HUT13_RS25560	COG1690	Belongs to the RtcB family
HUT13_RS25570	COG1940	carbohydrate kinase activity
HUT13_RS25595	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS25620	COG1501	Belongs to the glycosyl hydrolase 31 family
HUT13_RS25630	COG0395	ABC-type sugar transport system, permease component
HUT13_RS25635	COG1175	transmembrane transport
HUT13_RS25645	COG1609	Transcriptional regulator
HUT13_RS25650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HUT13_RS25655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HUT13_RS25660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HUT13_RS25675	COG1793	dna ligase
HUT13_RS25680	COG0537	adenosine 5'-monophosphoramidase activity
HUT13_RS25685	COG2072	flavoprotein involved in K transport
HUT13_RS25720	COG0747	negative chemotaxis
HUT13_RS25725	COG0601	transmembrane transport
HUT13_RS25730	COG0444	Belongs to the ABC transporter superfamily
HUT13_RS25760	COG0477	Major facilitator Superfamily
HUT13_RS25770	COG0431	NADPH-dependent FMN reductase
HUT13_RS25775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HUT13_RS25780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HUT13_RS25830	COG1609	Transcriptional regulator
HUT13_RS25840	COG1175	transmembrane transport
HUT13_RS25845	COG0395	ABC-type sugar transport system, permease component
HUT13_RS25850	COG3285	dna ligase
HUT13_RS25850	COG1793	dna ligase
HUT13_RS25860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUT13_RS25875	COG1733	regulation of RNA biosynthetic process
HUT13_RS25900	COG1120	ATPase activity
HUT13_RS25905	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS25910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HUT13_RS25920	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HUT13_RS26025	COG1309	transcriptional regulator
HUT13_RS26030	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HUT13_RS26085	COG1309	transcriptional regulator
HUT13_RS26090	COG2409	Drug exporters of the RND superfamily
HUT13_RS26100	COG0243	molybdopterin cofactor binding
HUT13_RS26120	COG2217	Heavy metal translocating P-type atpase
HUT13_RS26140	COG1028	Short-chain dehydrogenase reductase Sdr
HUT13_RS26145	COG2807	transmembrane transport
HUT13_RS26150	COG2186	Transcriptional regulator
HUT13_RS26165	COG0148	phosphopyruvate hydratase activity
HUT13_RS26170	COG1902	pentaerythritol trinitrate reductase activity
HUT13_RS26170	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUT13_RS26175	COG0300	oxidoreductase activity
HUT13_RS26180	COG1846	Transcriptional regulator
HUT13_RS26210	COG0604	alcohol dehydrogenase