locus-tag class description CEB94_RS00005 ENOG4108FPN Integrase CEB94_RS00090 ENOG4105C57 major facilitator superfamily CEB94_RS00180 ENOG4105C57 major facilitator superfamily CEB94_RS00215 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CEB94_RS00245 ENOG41067SE Tetr family transcriptional regulator CEB94_RS00250 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CEB94_RS00255 ENOG4105D1H recombination factor protein RarA CEB94_RS00260 ENOG4105MSB protein, conserved in bacteria CEB94_RS00275 ENOG4108FN7 Aldo keto reductase CEB94_RS00290 ENOG4105EBR Carboxylesterase CEB94_RS00330 ENOG4105FDF Could be involved in DNA repair (By similarity) CEB94_RS00495 ENOG4105JZI cytochrome P450 CEB94_RS00510 ENOG4105EPC oxidoreductase CEB94_RS00515 ENOG4108TKH Nitroreductase CEB94_RS00520 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CEB94_RS00535 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CEB94_RS00540 ENOG4107QJT sodium dicarboxylate symporter CEB94_RS00545 ENOG4105CMJ mandelate racemase muconate lactonizing CEB94_RS00580 ENOG4105EUB pirin domain protein CEB94_RS00585 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS00595 ENOG4105F6U Short-chain dehydrogenase reductase Sdr CEB94_RS00620 ENOG4105EUB pirin domain protein CEB94_RS00660 ENOG4107ZQV short-chain dehydrogenase reductase CEB94_RS00685 ENOG4105CPC Aldo Keto reductase CEB94_RS00700 ENOG4105E1F short-chain dehydrogenase reductase CEB94_RS00720 ENOG4105E1F short-chain dehydrogenase reductase CEB94_RS00755 ENOG4105J7D transcriptional regulator CEB94_RS00845 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEB94_RS00860 ENOG4108KPJ rna polymerase sigma factor CEB94_RS00915 ENOG4105CG3 alpha amylase, catalytic region CEB94_RS00920 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CEB94_RS01020 ENOG41082YX Transcriptional regulator, arsr family CEB94_RS01045 ENOG4105HS2 Arsenate reductase CEB94_RS01050 ENOG410832A alpha/beta hydrolase fold CEB94_RS01110 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) CEB94_RS01125 ENOG4108Z5V transcriptional regulator, merr family CEB94_RS01155 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CEB94_RS01175 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEB94_RS01180 ENOG4105KVH Transcriptional regulator CEB94_RS01195 ENOG4105D4M Lactamase_B CEB94_RS01205 ENOG4105MSB protein, conserved in bacteria CEB94_RS01210 ENOG4105MSB protein, conserved in bacteria CEB94_RS01290 ENOG4105CHH sulfate transporter CEB94_RS01310 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CEB94_RS01330 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CEB94_RS01370 ENOG4105BZ1 (ABC) transporter CEB94_RS01390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CEB94_RS01425 ENOG4105FS7 Transcriptional regulator CEB94_RS01505 ENOG4108JGH Tetr family transcriptional regulator CEB94_RS01525 ENOG4108HKT sucrose-6-phosphate hydrolase CEB94_RS01535 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator CEB94_RS01540 ENOG4105CNN ABC, transporter CEB94_RS01545 ENOG4105C2J ABC transporter CEB94_RS01550 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS01555 ENOG4105KME endoribonuclease L-psp CEB94_RS01565 ENOG4105CHR reductase CEB94_RS01575 ENOG4105CJP fad dependent oxidoreductase CEB94_RS01590 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS01610 ENOG4105DSE periplasmic solute binding protein CEB94_RS01620 ENOG4105CC5 ABC transporter CEB94_RS01625 ENOG4105E0A ABC, transporter CEB94_RS01630 ENOG4105CKI cobalamin synthesis protein CEB94_RS01640 ENOG4105BZ1 (ABC) transporter CEB94_RS01670 ENOG4105E0A ABC, transporter CEB94_RS01675 ENOG4105DQ5 transport system permease protein CEB94_RS01710 ENOG4105C7W Xanthine dehydrogenase CEB94_RS01715 ENOG4105CI2 imidazolone-5-propionate hydrolase CEB94_RS01725 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS01730 ENOG4105IIU Aminopeptidase CEB94_RS01780 ENOG4105VEQ Cold shock protein CEB94_RS01805 ENOG4105WN5 stage II sporulation protein CEB94_RS01840 ENOG4105E39 Enoyl-CoA hydratase CEB94_RS01845 ENOG4108N5B 2-phosphosulfolactate phosphatase CEB94_RS01895 ENOG4105C32 Amino acid ABC transporter (Permease) CEB94_RS01900 ENOG4105C0Z ABC transporter CEB94_RS01905 ENOG4108IV0 ABC, transporter CEB94_RS01910 ENOG4105G9B Transcriptional regulator CEB94_RS01915 ENOG4108Q9V regulatoR CEB94_RS01930 ENOG4105S7M extracellular small neutral protease CEB94_RS01935 ENOG4105N14 lysine exporter protein LysE YggA CEB94_RS01945 ENOG4105CD8 aminopeptidase N CEB94_RS01955 ENOG4105NAE bifunctional deaminase-reductase domain protein CEB94_RS02075 ENOG4105EYF MMPL domain protein CEB94_RS02115 ENOG4108M1A Chitin-binding protein CEB94_RS02120 ENOG4108ZBR Gcn5-related n-acetyltransferase CEB94_RS02125 ENOG4107U9T Pfam:Ribonuclease_BN CEB94_RS02185 ENOG4105DGI Alkaline phosphatase CEB94_RS02190 ENOG4106T9R serine protease CEB94_RS02220 ENOG4105CXN decarboxylase CEB94_RS02225 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B CEB94_RS02245 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CEB94_RS02250 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CEB94_RS02255 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS02270 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CEB94_RS02285 ENOG4108IAJ Nad-dependent epimerase dehydratase CEB94_RS02315 ENOG4105CH6 catalase CEB94_RS02355 ENOG4106A3M Cytochrome p-450 CEB94_RS02365 ENOG4107RTD sua5 ycio yrdc ywlc family protein CEB94_RS02375 ENOG4105BZU Histidine kinase CEB94_RS02395 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS02400 ENOG4105DRS transport system, permease CEB94_RS02420 ENOG4105DQE DNA ligase CEB94_RS02440 ENOG4105R1U AraC Family Transcriptional Regulator CEB94_RS02445 ENOG4105EU0 Major facilitator Superfamily CEB94_RS02455 ENOG4105DQE DNA ligase CEB94_RS02470 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CEB94_RS02525 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) CEB94_RS02540 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CEB94_RS02545 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) CEB94_RS02575 ENOG4107MMM Anti-sigma-factor antagonist CEB94_RS02580 ENOG4105FUA antagonist CEB94_RS02585 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CEB94_RS02600 ENOG4105CEP NADH dehydrogenase CEB94_RS02615 ENOG4108TM9 integral membrane protein CEB94_RS02640 ENOG4105CXN decarboxylase CEB94_RS02650 ENOG4105E8G Major facilitator Superfamily CEB94_RS02705 ENOG4105C5X domain protein CEB94_RS02735 ENOG4107SM8 Adenylate Guanylate cyclase CEB94_RS02745 ENOG4105K4I Scp-like extracellular CEB94_RS02765 ENOG4105C7B Threonine dehydratase CEB94_RS02770 ENOG4107TPY serine threonine protein kinase CEB94_RS02780 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CEB94_RS02810 ENOG4107SET aldo keto reductase CEB94_RS02835 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CEB94_RS02860 ENOG4105CIR epoxide hydrolase CEB94_RS02865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEB94_RS02870 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEB94_RS02875 ENOG4105WBV Transcriptional regulator CEB94_RS02880 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS02915 ENOG4105D9P serine threonine protein kinase CEB94_RS02925 ENOG4105IDI abc transporter atp-binding protein CEB94_RS02945 ENOG4105CPC Aldo Keto reductase CEB94_RS02950 ENOG4108M0I Transcriptional regulator CEB94_RS02965 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CEB94_RS02970 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase CEB94_RS02985 ENOG4107S5I aldo keto reductase CEB94_RS03020 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CEB94_RS03105 ENOG4108YV4 Universal stress protein CEB94_RS03145 ENOG4107S9D Alpha beta hydrolase CEB94_RS03155 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS03175 ENOG4107S1E Beta-lactamase CEB94_RS03200 ENOG4108EU3 peptide transport system, permease CEB94_RS03205 ENOG4105C5I Dehydrogenase CEB94_RS03215 ENOG4105CJP fad dependent oxidoreductase CEB94_RS03220 ENOG4105D38 putrescine abc transporter CEB94_RS03230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS03245 ENOG4105F76 Sarcosine oxidase CEB94_RS03260 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS03275 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS03290 ENOG4105X7H acyl-CoA dehydrogenase CEB94_RS03370 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) CEB94_RS03380 ENOG4105BZ9 Cytochrome C oxidase, subunit I CEB94_RS03405 ENOG4105CMT Dihydroxyacetone kinase CEB94_RS03410 ENOG4108UTZ Dihydroxyacetone kinase CEB94_RS03415 ENOG4105VDH Dihydroxyacetone kinase CEB94_RS03440 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS03455 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CEB94_RS03480 ENOG4105I82 acetyl xylan esterase CEB94_RS03490 ENOG4105FDP GntR family transcriptional regulator CEB94_RS03530 ENOG4107JC6 Membrane CEB94_RS03540 ENOG4108IJ0 Aspartate ammonia-lyase CEB94_RS03555 ENOG41073TP transcriptional regulator CEB94_RS03560 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CEB94_RS03565 ENOG41083TI Protein CrcB homolog CEB94_RS03570 ENOG4105KJJ Uncharacterized ACR, COG1993 CEB94_RS03605 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS03615 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS03645 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS03665 ENOG4107SET aldo keto reductase CEB94_RS03680 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CEB94_RS03695 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS03720 ENOG4108FUF Transcriptional regulator, IclR family CEB94_RS03735 ENOG4105CQB FAD linked oxidase domain protein CEB94_RS03740 ENOG4108JPW Aminotransferase CEB94_RS03770 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CEB94_RS03775 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CEB94_RS03780 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CEB94_RS03785 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CEB94_RS03805 ENOG4105F71 Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CEB94_RS03810 ENOG4108USZ hydrogenase CEB94_RS03830 ENOG4105CQS hydrogenase expression formation protein HypD CEB94_RS03835 ENOG4105C45 hydrogenase expression formation protein (HypE) CEB94_RS03840 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CEB94_RS03865 ENOG4105DPX Hydrogenase, large subunit CEB94_RS03885 ENOG4107R1I NAD-dependent malic enzyme CEB94_RS03910 ENOG4105BZU Histidine kinase CEB94_RS03925 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS03945 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEB94_RS03965 ENOG4105G2Y Transcriptional regulator CEB94_RS03970 ENOG4105ECY inositol monophosphatase CEB94_RS04010 ENOG4105NPE arsR family transcriptional regulator CEB94_RS04040 ENOG4108BUD transposase CEB94_RS04105 ENOG4105CPN adenine deaminase CEB94_RS04125 ENOG4105BZU Histidine kinase CEB94_RS04155 ENOG4105ERH Fumarylacetoacetate hydrolase CEB94_RS04165 ENOG41061H0 Monooxygenase CEB94_RS04180 ENOG4105ERH Fumarylacetoacetate hydrolase CEB94_RS04205 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS04210 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS04240 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS04245 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS04255 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CEB94_RS04295 ENOG4107TDE lipolytic protein G-D-S-L family CEB94_RS04310 ENOG4105DRS transport system, permease CEB94_RS04355 ENOG4105BZU Histidine kinase CEB94_RS04360 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS04380 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS04385 ENOG4107TTA Xylose isomerase domain protein TIM barrel CEB94_RS04395 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CEB94_RS04400 ENOG4107QP6 Xylose isomerase domain protein TIM barrel CEB94_RS04420 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CEB94_RS04425 ENOG41060BG Tetr family transcriptional regulator CEB94_RS04435 ENOG4105C26 Dehydrogenase CEB94_RS04470 ENOG4105CPQ Dehydrogenase CEB94_RS04475 ENOG4105CPQ Dehydrogenase CEB94_RS04480 ENOG4107FB0 transcriptional regulator DeoR family CEB94_RS04485 ENOG4107URF beta-phospho-glucomutase CEB94_RS04495 ENOG4105EQ2 LysR family Transcriptional regulator CEB94_RS04520 ENOG4108Q50 Histidine kinase CEB94_RS04545 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS04555 ENOG4105F76 Sarcosine oxidase CEB94_RS04560 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CEB94_RS04590 ENOG4105EW9 transcriptional regulator AsnC family CEB94_RS04640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CEB94_RS04645 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS04660 ENOG4105DSG hydrolase family 43 CEB94_RS04665 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CEB94_RS04690 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEB94_RS04760 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS04775 ENOG4105KME endoribonuclease L-psp CEB94_RS04785 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS04790 ENOG4105EMU Dehydrogenase CEB94_RS04825 ENOG4105D9P serine threonine protein kinase CEB94_RS04905 ENOG4107RRZ synthase CEB94_RS04940 ENOG4105MVE transcriptional regulator CEB94_RS04995 ENOG4105DKQ ROK family CEB94_RS05005 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) CEB94_RS05010 ENOG4105D2N Aldolase CEB94_RS05015 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CEB94_RS05020 ENOG4107FB0 transcriptional regulator DeoR family CEB94_RS05025 ENOG4105BZP glycoside hydrolase 15-related CEB94_RS05045 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CEB94_RS05060 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS05065 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS05135 ENOG41060NJ transcriptional regulator CEB94_RS05145 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CEB94_RS05155 ENOG4105DBE peroxidase CEB94_RS05175 ENOG4108TGC Acyltransferase CEB94_RS05185 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS05210 ENOG4108N23 SpoOM-related protein CEB94_RS05240 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CEB94_RS05270 ENOG4107S91 Sodium hydrogen exchanger CEB94_RS05280 ENOG4108SC4 )-transporter CEB94_RS05290 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS05310 ENOG41082K6 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CEB94_RS05320 ENOG4105CK5 oxidoreductase CEB94_RS05335 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CEB94_RS05355 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS05360 ENOG4105BZU Histidine kinase CEB94_RS05375 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CEB94_RS05380 ENOG4107PP3 Acetylornithine deacetylase CEB94_RS05390 ENOG4108JQ7 (ABC) transporter CEB94_RS05395 ENOG4105C3U ABC transporter CEB94_RS05400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEB94_RS05410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS05415 ENOG4105I1F Resistance protein CEB94_RS05435 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEB94_RS05455 ENOG41060NJ transcriptional regulator CEB94_RS05465 ENOG4107TPY serine threonine protein kinase CEB94_RS05480 ENOG4105C10 Electron transfer flavoprotein CEB94_RS05505 ENOG4105PSQ Acyl-transferase CEB94_RS05535 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CEB94_RS05560 ENOG4105CPC Aldo Keto reductase CEB94_RS05585 ENOG410841Q phosphoesterase PA-phosphatase related protein CEB94_RS05635 ENOG4105YVS arsR family transcriptional regulator CEB94_RS05640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS05645 ENOG4107S46 esterase, PHB depolymerase CEB94_RS05660 ENOG4105CSU acyl-Coa dehydrogenase CEB94_RS05680 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CEB94_RS05695 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CEB94_RS05710 ENOG4107VXZ Hydrolase CEB94_RS05735 ENOG4105E0S extracellular solute-binding protein family 1 CEB94_RS05740 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component CEB94_RS05745 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CEB94_RS05755 ENOG4105EQX glucarate dehydratase CEB94_RS05850 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS05865 ENOG4105F7P transcriptional regulator AsnC family CEB94_RS05920 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CEB94_RS05950 ENOG4105JZI cytochrome P450 CEB94_RS05985 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase CEB94_RS05995 ENOG4105CNN ABC, transporter CEB94_RS06000 ENOG4105C2J ABC transporter CEB94_RS06015 ENOG4107ZED Uncharacterised protein family UPF0047 CEB94_RS06020 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CEB94_RS06025 ENOG4105E2Y ABC, transporter CEB94_RS06050 ENOG4105BZ1 (ABC) transporter CEB94_RS06060 ENOG4105CK2 sodium dicarboxylate symporter CEB94_RS06070 ENOG4105BZ1 (ABC) transporter CEB94_RS06075 ENOG4105BZ1 (ABC) transporter CEB94_RS06100 ENOG4105C29 acyl-CoA thioesterase CEB94_RS06115 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CEB94_RS06130 ENOG4105GWZ Roadblock lc7 family protein CEB94_RS06160 ENOG4105BZU Histidine kinase CEB94_RS06190 ENOG4105C0D helicase CEB94_RS06205 ENOG4105C93 Xylose Isomerase CEB94_RS06215 ENOG4105E2R ROK family CEB94_RS06230 ENOG4108Z4K mutator MutT protein CEB94_RS06250 ENOG4105D2B acyl-CoA dehydrogenase CEB94_RS06255 ENOG4105D2B acyl-CoA dehydrogenase CEB94_RS06260 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CEB94_RS06265 ENOG4105CFF transcriptional regulator CEB94_RS06270 ENOG4105C3M thioredoxin reductase CEB94_RS06275 ENOG4107RYT DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity) CEB94_RS06285 ENOG4105C26 Dehydrogenase CEB94_RS06300 ENOG41065KQ synthase CEB94_RS06305 ENOG4106A3M Cytochrome p-450 CEB94_RS06315 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS06325 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CEB94_RS06335 ENOG4105F1K Glutamine amidotransferase CEB94_RS06340 ENOG4105CTQ phosphohexokinase CEB94_RS06355 ENOG4108HRK Histidine kinase CEB94_RS06370 ENOG4108NEV two component transcriptional regulator, LytTR family CEB94_RS06380 ENOG4105CIK Amidinotransferase CEB94_RS06385 ENOG4105C8Y Acetylornithine aminotransferase CEB94_RS06400 ENOG4108YZG isomerase CEB94_RS06425 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CEB94_RS06435 ENOG4105CQM Urea amidohydrolase subunit alpha CEB94_RS06440 ENOG4105KI2 Urea amidohydrolase subunit beta CEB94_RS06445 ENOG4108YZ9 Urea amidohydrolase subunit gamma CEB94_RS06505 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CEB94_RS06510 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CEB94_RS06515 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CEB94_RS06535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS06540 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS06565 ENOG4105C83 adenylosuccinate lyase CEB94_RS06570 ENOG4108VCA G U mismatch-specific DNA glycosylase CEB94_RS06590 ENOG4105BZU Histidine kinase CEB94_RS06595 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS06605 ENOG4105FDP GntR family transcriptional regulator CEB94_RS06610 ENOG4108KPJ rna polymerase sigma factor CEB94_RS06620 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 CEB94_RS06625 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS06660 ENOG4105EYH Exonuclease CEB94_RS06665 ENOG4107RH8 nuclease SbcCD subunit D CEB94_RS06670 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CEB94_RS06680 ENOG4105C8N cysteinyl-tRNA synthetase CEB94_RS06690 ENOG4105EHG Permease protein CEB94_RS06700 ENOG4105K4P CoA-binding domain protein CEB94_RS06705 ENOG4107QTZ amino acid CEB94_RS06715 ENOG41082SX arsR family transcriptional regulator CEB94_RS06745 ENOG4108Z0R Transferase CEB94_RS06755 ENOG4107QRI Phosphoketolase CEB94_RS06760 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CEB94_RS06770 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CEB94_RS06795 ENOG4108ARV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CEB94_RS06815 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CEB94_RS06830 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CEB94_RS06835 ENOG4105EP9 oxidoreductase CEB94_RS06865 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CEB94_RS06870 ENOG4105DEF Extracellular solute-binding protein, family 5 CEB94_RS06875 ENOG4105CHR reductase CEB94_RS06915 ENOG4105JQN Transcriptional regulator CEB94_RS06920 ENOG4108Q5Y Membrane CEB94_RS06925 ENOG4105CSW GntR family transcriptional regulator CEB94_RS06965 ENOG4107TIF Phenazine biosynthesis protein, PhzF family CEB94_RS06990 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS07035 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CEB94_RS07045 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CEB94_RS07065 ENOG4108UW8 fha domain-containing protein CEB94_RS07115 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CEB94_RS07125 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CEB94_RS07140 ENOG4108UQS dipeptidase CEB94_RS07150 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CEB94_RS07155 ENOG4105BZU Histidine kinase CEB94_RS07160 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEB94_RS07165 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CEB94_RS07185 ENOG4105GWZ Roadblock lc7 family protein CEB94_RS07200 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase CEB94_RS07210 ENOG4105VQD rieske 2fe-2S domain-containing protein CEB94_RS07215 ENOG41069M3 Transcriptional regulator CEB94_RS07230 ENOG4105DVW rieske (2Fe-2S) CEB94_RS07240 ENOG4105CUB amino acid CEB94_RS07270 ENOG4105CFM UPF0317 protein CEB94_RS07275 ENOG4105E7W lamb ycsf family protein CEB94_RS07280 ENOG4105P4J Allophanate hydrolase, subunit 1 CEB94_RS07295 ENOG4108MJN Glycosyl Transferase CEB94_RS07310 ENOG4105JXB ankyrin repeat-containing protein CEB94_RS07325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS07340 ENOG4105DEU major facilitator superfamily CEB94_RS07345 ENOG4105Q70 CEB94_RS07355 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CEB94_RS07365 ENOG4105EW9 transcriptional regulator AsnC family CEB94_RS07375 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS07425 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CEB94_RS07430 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase CEB94_RS07435 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CEB94_RS07440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CEB94_RS07455 ENOG4105E2R ROK family CEB94_RS07460 ENOG4106UW1 Major Facilitator superfamily CEB94_RS07465 ENOG4105C2W permease CEB94_RS07470 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) CEB94_RS07505 ENOG4105CUB amino acid CEB94_RS07510 ENOG4105ERX Dehydrogenase CEB94_RS07520 ENOG4105DKT Transcriptional regulator CEB94_RS07525 ENOG4105DJV ribulose-phosphate 3-epimerase CEB94_RS07530 ENOG4105EYF MMPL domain protein CEB94_RS07540 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CEB94_RS07555 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CEB94_RS07565 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CEB94_RS07570 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CEB94_RS07580 ENOG4105SKN orotidine 5''-phosphate decarboxylase CEB94_RS07585 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CEB94_RS07590 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CEB94_RS07595 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CEB94_RS07605 ENOG4105CD3 dihydroorotase CEB94_RS07610 ENOG4105CXT aspartate transcarbamylase CEB94_RS07615 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CEB94_RS07625 ENOG410803B Involved in the transcription termination process (By similarity) CEB94_RS07630 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CEB94_RS07635 ENOG4105DC7 peptidase M24 CEB94_RS07645 ENOG4105D49 3-dehydroquinate synthase CEB94_RS07650 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CEB94_RS07655 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CEB94_RS07665 ENOG4105E2X shikimate dehydrogenase CEB94_RS07675 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CEB94_RS07680 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CEB94_RS07695 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CEB94_RS07720 ENOG4105BZU Histidine kinase CEB94_RS07725 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS07730 ENOG4105CUT histidyl-tRNA synthetase CEB94_RS07740 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) CEB94_RS07745 ENOG4105C99 atpase involved in dna repair CEB94_RS07750 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CEB94_RS07755 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CEB94_RS07760 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CEB94_RS07765 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CEB94_RS07775 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CEB94_RS07780 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CEB94_RS07785 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CEB94_RS07790 ENOG4105CDY transcriptional regulatory protein CEB94_RS07795 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CEB94_RS07800 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CEB94_RS07810 ENOG4105E2K Glycosyl transferase (Group 1 CEB94_RS07815 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase CEB94_RS07840 ENOG4105C22 threonyL-tRNA synthetase CEB94_RS07855 ENOG4108IRC dna polymerase iii CEB94_RS07880 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CEB94_RS07890 ENOG4105EKC CEB94_RS07900 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS07905 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS07925 ENOG4105KF0 sporulation and cell division protein, SsgA CEB94_RS07955 ENOG4105F0I Aminotransferase CEB94_RS07960 ENOG4105CRQ synthase (Component I) CEB94_RS08015 ENOG4105E09 nadh pyrophosphatase CEB94_RS08025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEB94_RS08030 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CEB94_RS08045 ENOG4105D01 (LipO)protein CEB94_RS08050 ENOG4108UMI ABC transporter, permease CEB94_RS08055 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS08085 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CEB94_RS08090 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS08095 ENOG4105C57 major facilitator superfamily CEB94_RS08100 ENOG4105RJZ Transcriptional regulator CEB94_RS08110 ENOG4105CH7 arginosuccinase CEB94_RS08130 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CEB94_RS08145 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CEB94_RS08150 ENOG4105C8Y Acetylornithine aminotransferase CEB94_RS08155 ENOG4105CAS nag kinase CEB94_RS08160 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CEB94_RS08165 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CEB94_RS08200 ENOG4105T38 integral membrane protein CEB94_RS08210 ENOG4105F32 YngK protein CEB94_RS08240 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CEB94_RS08245 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CEB94_RS08250 ENOG4105BZU Histidine kinase CEB94_RS08255 ENOG4108RWN rrna methyltransferase CEB94_RS08260 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CEB94_RS08265 ENOG41084BS 50S ribosomal protein L35 CEB94_RS08270 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CEB94_RS08305 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CEB94_RS08310 ENOG4105C26 Dehydrogenase CEB94_RS08315 ENOG4105C5F glutamine synthetase CEB94_RS08325 ENOG4105CUB amino acid CEB94_RS08330 ENOG4108Z86 Glutamine amidotransferase CEB94_RS08355 ENOG4108HQS Glycine betaine CEB94_RS08360 ENOG4108IJ7 Glycine betaine CEB94_RS08365 ENOG4105HFS 5'-3' exonuclease CEB94_RS08380 ENOG4105D3G Pseudouridine synthase CEB94_RS08420 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CEB94_RS08425 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CEB94_RS08445 ENOG4108FFZ Transcriptional regulator CEB94_RS08460 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) CEB94_RS08470 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS08475 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CEB94_RS08480 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CEB94_RS08490 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) CEB94_RS08495 ENOG4105E5F proteasome CEB94_RS08500 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) CEB94_RS08530 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS08535 ENOG4105DEF Extracellular solute-binding protein, family 5 CEB94_RS08540 ENOG4108J59 Extracellular solute-binding protein, family 5 CEB94_RS08550 ENOG4105C3R Methionine synthase CEB94_RS08555 ENOG4108K8U Glycerol operon regulatory protein CEB94_RS08560 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEB94_RS08565 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CEB94_RS08575 ENOG4105JXH GntR family transcriptional regulator CEB94_RS08585 ENOG4105C8N cysteinyl-tRNA synthetase CEB94_RS08600 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEB94_RS08605 ENOG4105D7N magnesium and cobalt transport protein CorA CEB94_RS08615 ENOG4105DYW oxidoreductase CEB94_RS08625 ENOG4105CPC Aldo Keto reductase CEB94_RS08645 ENOG4105S2J secreted protein CEB94_RS08655 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CEB94_RS08665 ENOG4105K5B UPF0225 protein CEB94_RS08670 ENOG4105C6F GntR Family Transcriptional Regulator CEB94_RS08675 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CEB94_RS08680 ENOG4105C6Z Gluconate CEB94_RS08685 ENOG4105CHR reductase CEB94_RS08690 ENOG4105CPQ Dehydrogenase CEB94_RS08720 ENOG4105PTV Nudix Hydrolase CEB94_RS08725 ENOG4105VG5 Membrane CEB94_RS08735 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CEB94_RS08745 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS08750 ENOG4108IG5 Transcriptional regulator CEB94_RS08755 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS08765 ENOG4105EHZ conserved protein UCP016719 CEB94_RS08790 ENOG4108Z4X TRANSCRIPTIONal CEB94_RS08810 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS08820 ENOG4108ZHR arsR family transcriptional regulator CEB94_RS08865 ENOG4105D4T Citrate transporter CEB94_RS08870 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEB94_RS08875 ENOG4108SGK Tetr family transcriptional regulator CEB94_RS08885 ENOG4105F1J Homogentisate 1,2-dioxygenase CEB94_RS08920 ENOG4105RNG membrane CEB94_RS08925 ENOG4105K6V RNA polymerase CEB94_RS08940 ENOG41061MD high-affinity nickel-transporter CEB94_RS08950 ENOG4108TCJ secreted hydrolase CEB94_RS08965 ENOG4105K64 Glycosyl transferase, family 2 CEB94_RS08970 ENOG4107BJW polysaccharide deacetylase CEB94_RS08990 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS09005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEB94_RS09030 ENOG4108Z2K Cupin 2, conserved barrel domain protein CEB94_RS09040 ENOG4105C0B DNA polymerase III (alpha subunit) CEB94_RS09055 ENOG4106NMR serine protease CEB94_RS09070 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CEB94_RS09075 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS09080 ENOG4105C57 major facilitator superfamily CEB94_RS09090 ENOG410841Q phosphoesterase PA-phosphatase related protein CEB94_RS09125 ENOG4105C0Z ABC transporter CEB94_RS09130 ENOG4108IV0 ABC, transporter CEB94_RS09135 ENOG4105MS9 Resuscitation-promoting factor CEB94_RS09150 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CEB94_RS09160 ENOG4105CAT Cytidine monophosphate kinase CEB94_RS09190 ENOG4105FE9 pseudouridine synthase CEB94_RS09195 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CEB94_RS09200 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CEB94_RS09215 ENOG4105DCF alanine dehydrogenase CEB94_RS09225 ENOG4108YZ4 nudix hydrolase CEB94_RS09230 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CEB94_RS09235 ENOG4105BZP glycoside hydrolase 15-related CEB94_RS09255 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CEB94_RS09260 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CEB94_RS09280 ENOG4105E0A ABC, transporter CEB94_RS09285 ENOG4105TVJ transport system, permease CEB94_RS09290 ENOG4105DQ5 transport system permease protein CEB94_RS09295 ENOG4105DSU hydrolase CEB94_RS09325 ENOG4108VX5 3-methyladenine DNA glycosylase CEB94_RS09335 ENOG4108V1U phospholipid-binding protein CEB94_RS09355 ENOG4105DKW ABC transporter CEB94_RS09360 ENOG4108UF8 CEB94_RS09370 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS09375 ENOG4108XG2 Histidine kinase CEB94_RS09380 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CEB94_RS09385 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CEB94_RS09395 ENOG4105IDI abc transporter atp-binding protein CEB94_RS09405 ENOG4105EAC phosphoserine phosphatase CEB94_RS09420 ENOG4105DJ2 Major Facilitator Superfamily CEB94_RS09425 ENOG4107YCY Transcriptional regulator CEB94_RS09455 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CEB94_RS09460 ENOG4105Y3U Transglycosylase-associated protein CEB94_RS09475 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CEB94_RS09480 ENOG4107QN1 sodium solute CEB94_RS09515 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CEB94_RS09530 ENOG4105BZP glycoside hydrolase 15-related CEB94_RS09535 ENOG4105CHR reductase CEB94_RS09560 ENOG4105VBF alkaline shock protein CEB94_RS09580 ENOG4105C5H ABC transporter CEB94_RS09595 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CEB94_RS09600 ENOG4107W7X Aldolase CEB94_RS09620 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CEB94_RS09625 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CEB94_RS09630 ENOG4105CTK cobaltochelatase, cobn subunit CEB94_RS09640 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CEB94_RS09645 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CEB94_RS09655 ENOG4105CIA precorrin-4 C(11)-methyltransferase CEB94_RS09665 ENOG4105E4R Precorrin-3B C17-methyltransferase CEB94_RS09670 ENOG41081F0 Precorrin-8x methylmutase CEB94_RS09700 ENOG4105C5R Aminotransferase CEB94_RS09710 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase CEB94_RS09715 ENOG4108JPW Aminotransferase CEB94_RS09720 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) CEB94_RS09725 ENOG4105EV8 ectoine hydroxylase CEB94_RS09735 ENOG4107ZXU DSBA oxidoreductase CEB94_RS09755 ENOG4107HP6 Transcriptional regulator CEB94_RS09770 ENOG4105BZU Histidine kinase CEB94_RS09775 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS09780 ENOG4105CJN penicillin-binding protein CEB94_RS09785 ENOG4105C7N Xanthine uracil vitamin C permease CEB94_RS09790 ENOG4105NAF rna polymerase sigma factor CEB94_RS09805 ENOG4108J21 pectate lyase CEB94_RS09820 ENOG4105NBR Pectinesterase CEB94_RS09830 ENOG4107TDE lipolytic protein G-D-S-L family CEB94_RS09860 ENOG4108J20 pectate lyase CEB94_RS09870 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS09885 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS09935 ENOG4105E9Z Nad-dependent epimerase dehydratase CEB94_RS09955 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CEB94_RS09960 ENOG4105CPQ Dehydrogenase CEB94_RS09975 ENOG4105XEA Tetr family transcriptional regulator CEB94_RS09980 ENOG4105DRS transport system, permease CEB94_RS09995 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS10010 ENOG4107XBN GntR Family Transcriptional Regulator CEB94_RS10045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CEB94_RS10055 ENOG4105NAF rna polymerase sigma factor CEB94_RS10065 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) CEB94_RS10070 ENOG4108RFG Tetr family transcriptional regulator CEB94_RS10075 ENOG410814C multidrug resistance protein CEB94_RS10085 ENOG4105VG1 fes assembly suf system protein CEB94_RS10090 ENOG4108UNV SUF system FeS assembly protein, NifU family CEB94_RS10095 ENOG4105C9B Cysteine desulfurase CEB94_RS10100 ENOG4105C3K feS assembly ATPase SufC CEB94_RS10110 ENOG4105JRK feS assembly protein SufD CEB94_RS10125 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CEB94_RS10130 ENOG4105CJ1 ABC, transporter CEB94_RS10155 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CEB94_RS10165 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CEB94_RS10180 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) CEB94_RS10185 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CEB94_RS10190 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component CEB94_RS10200 ENOG4105CG3 alpha amylase, catalytic region CEB94_RS10205 ENOG4105WEM extracellular solute-binding protein CEB94_RS10210 ENOG4105U3E Transcriptional regulator CEB94_RS10215 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS10230 ENOG4107QP8 phosphohexose isomerase CEB94_RS10250 ENOG4105CP7 Triose-phosphate isomerase CEB94_RS10255 ENOG4105BZA Phosphoglycerate kinase CEB94_RS10260 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CEB94_RS10270 ENOG4105CIE May be required for sporulation (By similarity) CEB94_RS10275 ENOG4105CHW UPF0052 protein CEB94_RS10280 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CEB94_RS10285 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CEB94_RS10320 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEB94_RS10335 ENOG4107R0W ABC transporter CEB94_RS10340 ENOG4105E5Q amino acid AbC transporter CEB94_RS10350 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CEB94_RS10355 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CEB94_RS10360 ENOG4105CSH Transporter CEB94_RS10390 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CEB94_RS10395 ENOG4105BZU Histidine kinase CEB94_RS10400 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CEB94_RS10405 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CEB94_RS10415 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) CEB94_RS10420 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CEB94_RS10430 ENOG4105D7N magnesium and cobalt transport protein CorA CEB94_RS10460 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS10465 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS10505 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CEB94_RS10545 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CEB94_RS10550 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS10585 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEB94_RS10605 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CEB94_RS10620 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CEB94_RS10625 ENOG4105CQ7 ATP-dependent helicase CEB94_RS10665 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) CEB94_RS10680 ENOG4105C32 Amino acid ABC transporter (Permease) CEB94_RS10685 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CEB94_RS10690 ENOG4105C0Z ABC transporter CEB94_RS10695 ENOG4108IV0 ABC, transporter CEB94_RS10720 ENOG4105MPN Membrane CEB94_RS10725 ENOG4105CGH 5'-nucleotidase CEB94_RS10745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS10750 ENOG4105EHE chorismate mutase- prephenate dehydrogenase CEB94_RS10760 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr CEB94_RS10770 ENOG4105E39 Enoyl-CoA hydratase CEB94_RS10785 ENOG4105EA8 2-Nitropropane dioxygenase CEB94_RS10790 ENOG4105F2C Acetyl-CoA acetyltransferase CEB94_RS10795 ENOG4108RZE Tetr family transcriptional regulator CEB94_RS10800 ENOG4105CHR reductase CEB94_RS10805 ENOG4105CC9 acyl-Coa dehydrogenase CEB94_RS10815 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CEB94_RS10820 ENOG4105MUA Resistance protein CEB94_RS10825 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CEB94_RS10840 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS10850 ENOG4105CBC glutamate synthase CEB94_RS10860 ENOG41065RQ ADP-ribosylation crystallin J1 CEB94_RS10880 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CEB94_RS10885 ENOG4105CI0 Citrate lyase CEB94_RS10890 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CEB94_RS10900 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CEB94_RS10905 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CEB94_RS10915 ENOG4105DK0 Indole-3-glycerol phosphate synthase CEB94_RS10940 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CEB94_RS10960 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CEB94_RS10965 ENOG4108176 endoribonuclease L-psp CEB94_RS10970 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CEB94_RS10975 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CEB94_RS10985 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CEB94_RS10990 ENOG4105CIH Imidazole acetol-phosphate transaminase CEB94_RS10995 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CEB94_RS11020 ENOG4108Z66 YbaK ebsC protein CEB94_RS11050 ENOG4105C0B DNA polymerase III (alpha subunit) CEB94_RS11105 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CEB94_RS11115 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CEB94_RS11120 ENOG4107VQS DivIVA family CEB94_RS11130 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CEB94_RS11135 ENOG4105DFA alanine racemase domain protein CEB94_RS11140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CEB94_RS11145 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CEB94_RS11150 ENOG4105ME9 cell division protein FtsQ CEB94_RS11155 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CEB94_RS11165 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CEB94_RS11170 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CEB94_RS11175 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CEB94_RS11180 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CEB94_RS11185 ENOG4105CJN penicillin-binding protein CEB94_RS11195 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CEB94_RS11205 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CEB94_RS11225 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEB94_RS11235 ENOG4105C2J ABC transporter CEB94_RS11245 ENOG4107Z3H Transcriptional regulator, TetR family CEB94_RS11250 ENOG4105EWK phytoene CEB94_RS11265 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CEB94_RS11275 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase CEB94_RS11295 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CEB94_RS11305 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CEB94_RS11315 ENOG4108UQY Iron-storage protein CEB94_RS11325 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CEB94_RS11340 ENOG4105CTQ phosphohexokinase CEB94_RS11350 ENOG4105ENE Histidine kinase CEB94_RS11375 ENOG4105DKQ ROK family CEB94_RS11385 ENOG4105D0U Arsenite-activated ATPase (ArsA) CEB94_RS11400 ENOG4108IQE Amp-dependent synthetase and ligase CEB94_RS11425 ENOG4105ZXU NLP P60 protein CEB94_RS11460 ENOG4106F60 Histidine kinase CEB94_RS11465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS11475 ENOG4105BZW Glycerate kinase CEB94_RS11480 ENOG4105C9B Cysteine desulfurase CEB94_RS11485 ENOG4108I0Q anthranilate phosphoribosyltransferase CEB94_RS11490 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CEB94_RS11495 ENOG4107EUI c reductase, iron-sulfur CEB94_RS11500 ENOG4107UDY cytochrome C CEB94_RS11505 ENOG4105CCU oxidase (Subunit III) CEB94_RS11515 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CEB94_RS11520 ENOG4105MCD Part of cytochrome c oxidase, its function is CEB94_RS11525 ENOG4105BZ9 Cytochrome C oxidase, subunit I CEB94_RS11530 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CEB94_RS11540 ENOG4107T4Z adenosine kinase CEB94_RS11560 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CEB94_RS11570 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS11575 ENOG4105BZU Histidine kinase CEB94_RS11595 ENOG4105DXX methyltransferase CEB94_RS11605 ENOG4108YZT Adenosylcobinamide kinase CEB94_RS11615 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CEB94_RS11630 ENOG410813T Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CEB94_RS11655 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS11665 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CEB94_RS11685 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CEB94_RS11720 ENOG4105ECP epimerase CEB94_RS11735 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CEB94_RS11740 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CEB94_RS11760 ENOG4105C5F glutamine synthetase CEB94_RS11790 ENOG4105D0M Protease HtpX homolog CEB94_RS11815 ENOG4105CPC Aldo Keto reductase CEB94_RS11825 ENOG4108222 arsenate reductase CEB94_RS11830 ENOG4106SPC secreted protein CEB94_RS11835 ENOG4107R5B glutamine synthetase CEB94_RS11840 ENOG4107NHD transcriptional regulator CEB94_RS11855 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS11880 ENOG41060BG Tetr family transcriptional regulator CEB94_RS11905 ENOG4105CG3 alpha amylase, catalytic region CEB94_RS11910 ENOG4105EG2 ABC transporter, permease CEB94_RS11915 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component CEB94_RS11925 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS11935 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CEB94_RS11955 ENOG4105C5F glutamine synthetase CEB94_RS11960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CEB94_RS11965 ENOG41081JD Transcriptional regulator CEB94_RS11985 ENOG4105C4K Nad synthetase CEB94_RS11990 ENOG4105NPE arsR family transcriptional regulator CEB94_RS11995 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CEB94_RS12000 ENOG4105F27 Major Facilitator CEB94_RS12020 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CEB94_RS12045 ENOG4107XZ0 Peptidase M50 CEB94_RS12090 ENOG410650H (LipO)protein CEB94_RS12095 ENOG4105DBE peroxidase CEB94_RS12105 ENOG4106A0S CEB94_RS12115 ENOG4107T6V glycerophosphoryl diester phosphodiesterase CEB94_RS12140 ENOG4107S1E Beta-lactamase CEB94_RS12145 ENOG4105C2C drug resistance transporter, Bcr CflA CEB94_RS12160 ENOG4105DZ1 carboxypeptidase CEB94_RS12165 ENOG4107SET aldo keto reductase CEB94_RS12175 ENOG4108VGI doxx family CEB94_RS12230 ENOG4105E7U AraC family transcriptional regulator CEB94_RS12250 ENOG4107XFJ UPF0246 protein CEB94_RS12255 ENOG4108UHU Aldolase CEB94_RS12270 ENOG4105EGD dinuclear metal center protein, YbgI family CEB94_RS12285 ENOG4105CHR reductase CEB94_RS12305 ENOG41088CC tellurite resistance protein tehB CEB94_RS12325 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CEB94_RS12340 ENOG4105DYW oxidoreductase CEB94_RS12355 ENOG4107QVI Methyltransferase, type 11 CEB94_RS12360 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS12365 ENOG4108SGK Tetr family transcriptional regulator CEB94_RS12420 ENOG4108JJB ABC transporter CEB94_RS12430 ENOG4106A3M Cytochrome p-450 CEB94_RS12435 ENOG4105F2C Acetyl-CoA acetyltransferase CEB94_RS12450 ENOG4105CSH Transporter CEB94_RS12530 ENOG4105NQG DoxX CEB94_RS12550 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CEB94_RS12585 ENOG4107T5V SNARE associated Golgi CEB94_RS12595 ENOG4105DAX Pfam:DUF2983 CEB94_RS12640 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CEB94_RS12645 ENOG4105EYW Ion transport protein CEB94_RS12675 ENOG4105CPC Aldo Keto reductase CEB94_RS12680 ENOG4105VUF Transcriptional regulator CEB94_RS12710 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CEB94_RS12730 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CEB94_RS12735 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CEB94_RS12745 ENOG4105NGS secreted protein CEB94_RS12765 ENOG4108ZHJ Organic hydroperoxide resistance protein CEB94_RS12770 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CEB94_RS12800 ENOG4105CXK mandelate racemase muconate lactonizing CEB94_RS12820 ENOG4105C2J ABC transporter CEB94_RS12825 ENOG4108HWW ABC transporter CEB94_RS12830 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) CEB94_RS12835 ENOG4105CIH Imidazole acetol-phosphate transaminase CEB94_RS12840 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CEB94_RS12845 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase CEB94_RS12855 ENOG410905P Pyridoxamine 5-phosphate CEB94_RS12880 ENOG4105J7D transcriptional regulator CEB94_RS12885 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CEB94_RS12910 ENOG4105DRS transport system, permease CEB94_RS12915 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component CEB94_RS12940 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CEB94_RS12945 ENOG4105J4Q Transcriptional regulator CEB94_RS12980 ENOG41073B4 coagulation factor 5 8 type domain-containing protein CEB94_RS13015 ENOG4105C57 major facilitator superfamily CEB94_RS13035 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS13040 ENOG4105D8K carboxyl transferase CEB94_RS13055 ENOG4105DFF Rod shape-determining protein mreb CEB94_RS13140 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS13155 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CEB94_RS13165 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CEB94_RS13175 ENOG4107GZ4 SanA protein CEB94_RS13195 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEB94_RS13225 ENOG4105KVH Transcriptional regulator CEB94_RS13230 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CEB94_RS13245 ENOG4107QZF nitrite reductase NADPH large subunit CEB94_RS13270 ENOG4105CHH sulfate transporter CEB94_RS13275 ENOG4107B2H carbonic anhydrase CEB94_RS13280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS13285 ENOG4105DHQ Histidine kinase CEB94_RS13305 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CEB94_RS13310 ENOG4105E2R ROK family CEB94_RS13360 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CEB94_RS13365 ENOG4105DSE periplasmic solute binding protein CEB94_RS13370 ENOG4105FDK ABC transporter CEB94_RS13375 ENOG4105FAV ABC, transporter CEB94_RS13390 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CEB94_RS13395 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CEB94_RS13430 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CEB94_RS13435 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS13440 ENOG4105BZU Histidine kinase CEB94_RS13445 ENOG4105EYF MMPL domain protein CEB94_RS13455 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CEB94_RS13460 ENOG4105D4Y metalloprotease CEB94_RS13495 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CEB94_RS13520 ENOG4105MSB protein, conserved in bacteria CEB94_RS13530 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CEB94_RS13545 ENOG4105EQX glucarate dehydratase CEB94_RS13550 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CEB94_RS13570 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CEB94_RS13575 ENOG4107YU2 histidine triad (hIT) protein CEB94_RS13580 ENOG4107RE3 peptidase, S41 CEB94_RS13600 ENOG4105EA8 2-Nitropropane dioxygenase CEB94_RS13605 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CEB94_RS13610 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CEB94_RS13650 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CEB94_RS13655 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CEB94_RS13675 ENOG4108YYC ycei family CEB94_RS13680 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CEB94_RS13685 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CEB94_RS13695 ENOG4105EPR degv family CEB94_RS13705 ENOG4105C8T Leucyl-tRNA synthetase CEB94_RS13715 ENOG4107QIZ NADH dehydrogenase CEB94_RS13740 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEB94_RS13745 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CEB94_RS13755 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CEB94_RS13770 ENOG4105D0M Protease HtpX homolog CEB94_RS13785 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CEB94_RS13795 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CEB94_RS13805 ENOG4108SHN Glycosyl transferase, family 2 CEB94_RS13820 ENOG4105DGI Alkaline phosphatase CEB94_RS13825 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CEB94_RS13830 ENOG4105K46 50S ribosomal protein l27 CEB94_RS13835 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CEB94_RS13840 ENOG4105C03 ribonuclease CEB94_RS13860 ENOG4105VMP Transcriptional regulator CEB94_RS13885 ENOG4105CNI cell division protein FtsW CEB94_RS13905 ENOG4105DFF Rod shape-determining protein mreb CEB94_RS13910 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CEB94_RS13920 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CEB94_RS13925 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CEB94_RS13935 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CEB94_RS13940 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEB94_RS13945 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEB94_RS13950 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CEB94_RS13970 ENOG4108762 serine threonine protein kinase CEB94_RS13980 ENOG4108TGC Acyltransferase CEB94_RS14010 ENOG4105C85 amino acid CEB94_RS14015 ENOG4108UGD Serine Threonine protein kinase CEB94_RS14030 ENOG4105C85 amino acid CEB94_RS14035 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CEB94_RS14045 ENOG4108ZM9 phosphoglycerate mutase CEB94_RS14050 ENOG4105CMG Carbohydrate kinase CEB94_RS14055 ENOG4107VUR extracellular solute-binding protein CEB94_RS14070 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS14075 ENOG4107FB0 transcriptional regulator DeoR family CEB94_RS14095 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase CEB94_RS14105 ENOG4105MC2 DSBA oxidoreductase CEB94_RS14125 ENOG4105RNG membrane CEB94_RS14210 ENOG4108ZT1 Transcriptional regulator CEB94_RS14240 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CEB94_RS14255 ENOG4105D8X mechanosensitive ion channel CEB94_RS14260 ENOG4105E2R ROK family CEB94_RS14275 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS14280 ENOG4105F8D glycoside hydrolase family 4 CEB94_RS14295 ENOG4107UBR Extracellular solute-binding protein family 3 CEB94_RS14325 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CEB94_RS14330 ENOG4108Z18 K06886 hemoglobin CEB94_RS14365 ENOG4105CNA YD repeat protein CEB94_RS14445 ENOG4105VHU single-stranded DNA-binding protein CEB94_RS14520 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CEB94_RS14590 ENOG4105JNK Glycosyl transferase (Group 1 CEB94_RS14600 ENOG4105BZU Histidine kinase CEB94_RS14605 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS14620 ENOG4108JQ1 Dehydrogenase CEB94_RS14675 ENOG4105BZF Glycosyl transferase (Group 1 CEB94_RS14680 ENOG4105D3Q Sugar transferase CEB94_RS14690 ENOG4105CJR Integral membrane protein (MviN CEB94_RS14700 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS14720 ENOG4105C3M thioredoxin reductase CEB94_RS14725 ENOG4105S2J secreted protein CEB94_RS14750 ENOG4105C26 Dehydrogenase CEB94_RS14755 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CEB94_RS14770 ENOG4105EDK PfkB domain protein CEB94_RS14805 ENOG4105C7H Helicase, RecD TraA family CEB94_RS14825 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CEB94_RS14830 ENOG4108RVA ribokinase CEB94_RS14835 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CEB94_RS14840 ENOG4105C2J ABC transporter CEB94_RS14845 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS14880 ENOG410645S MarR family Transcriptional regulator CEB94_RS14890 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS14915 ENOG4108594 Permease of the drug metabolite transporter CEB94_RS14925 ENOG4105D17 glycoside hydrolase, family 3 domain protein CEB94_RS14965 ENOG4105EDW glycosyl transferase, family 39 CEB94_RS14980 ENOG4105C7K acetolactate synthase CEB94_RS14995 ENOG4108XFF CEB94_RS15000 ENOG4105C29 acyl-CoA thioesterase CEB94_RS15015 ENOG4107QX3 carboxylase CEB94_RS15025 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CEB94_RS15030 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS15050 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) CEB94_RS15065 ENOG4105E2D ec 3.2.1.52 CEB94_RS15085 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CEB94_RS15105 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS15110 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CEB94_RS15125 ENOG4105PTV Nudix Hydrolase CEB94_RS15135 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS15150 ENOG4105DRS transport system, permease CEB94_RS15170 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS15185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS15210 ENOG4105CVJ phosphoglycerate mutase CEB94_RS15255 ENOG4105BZU Histidine kinase CEB94_RS15260 ENOG4105DEN Luciferase family CEB94_RS15290 ENOG4105C5I Dehydrogenase CEB94_RS15295 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS15340 ENOG4105J5T Amp-dependent synthetase and ligase CEB94_RS15345 ENOG4108M1A Chitin-binding protein CEB94_RS15365 ENOG4105JXH GntR family transcriptional regulator CEB94_RS15380 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) CEB94_RS15410 ENOG4105D9R oxidoreductase CEB94_RS15415 ENOG41090KN UPF0303 protein CEB94_RS15430 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CEB94_RS15455 ENOG4108F3G Type I restriction-modification system, R subunit CEB94_RS15485 ENOG4105EV9 Alpha Beta Hydrolase CEB94_RS15510 ENOG4105C54 Major Facilitator superfamily CEB94_RS15515 ENOG4106BRA Membrane CEB94_RS15530 ENOG4108IUW ABC transporter CEB94_RS15545 ENOG4105BZ4 penicillin-binding protein CEB94_RS15550 ENOG4105KPY Small multidrug resistance protein CEB94_RS15585 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CEB94_RS15595 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CEB94_RS15615 ENOG4108RQ5 Beta-lactamase domain-containing protein CEB94_RS15640 ENOG4105C85 amino acid CEB94_RS15650 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CEB94_RS15660 ENOG4108RWI nicotinamidase CEB94_RS15690 ENOG4105KF0 sporulation and cell division protein, SsgA CEB94_RS15695 ENOG4105CQB FAD linked oxidase domain protein CEB94_RS15710 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase CEB94_RS15720 ENOG4105E90 ABC transporter CEB94_RS15725 ENOG4108IJ8 ABC transporter CEB94_RS15735 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CEB94_RS15825 ENOG4105E2D ec 3.2.1.52 CEB94_RS15850 ENOG4108UJU UPF0301 protein CEB94_RS15855 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CEB94_RS15860 ENOG4108426 dNA-binding protein CEB94_RS15870 ENOG4105EEM helicase CEB94_RS15895 ENOG4107QND Nitrite extrusion protein CEB94_RS15940 ENOG4105CJQ hydrolase, family 31 CEB94_RS15945 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS15955 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CEB94_RS15960 ENOG4105CN1 protease CEB94_RS15970 ENOG4105CAK Cell division ATP-binding protein ftsE CEB94_RS15985 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CEB94_RS15990 ENOG4108QVN serine threonine protein kinase CEB94_RS15995 ENOG4108UGD Serine Threonine protein kinase CEB94_RS16015 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CEB94_RS16020 ENOG4107SJB teichoic acid biosynthesis CEB94_RS16025 ENOG4107SJB teichoic acid biosynthesis CEB94_RS16030 ENOG4105K64 Glycosyl transferase, family 2 CEB94_RS16035 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids CEB94_RS16045 ENOG4108ZHJ Organic hydroperoxide resistance protein CEB94_RS16050 ENOG4105K56 Transcriptional regulator CEB94_RS16080 ENOG4105EY8 ABC transporter CEB94_RS16085 ENOG4107SJB teichoic acid biosynthesis CEB94_RS16090 ENOG4107QRS glycosyltransferase group 2 family protein CEB94_RS16105 ENOG4105C7I Dehydrogenase CEB94_RS16125 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CEB94_RS16135 ENOG4105T0Z Conserved Protein CEB94_RS16140 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS16145 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CEB94_RS16155 ENOG4105G3P Lipoprotein lpqB CEB94_RS16160 ENOG4105BZU Histidine kinase CEB94_RS16165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS16170 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CEB94_RS16185 ENOG4108WQ6 secreted protein CEB94_RS16190 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CEB94_RS16230 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CEB94_RS16240 ENOG4105EIP mannose-6-phosphate isomerase CEB94_RS16250 ENOG4105W49 UPF0434 protein CEB94_RS16255 ENOG4107QKV phosphomannomutase CEB94_RS16280 ENOG4107RGC Glycosyl transferase, family 2 CEB94_RS16285 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS16300 ENOG41088YA Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) CEB94_RS16310 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CEB94_RS16325 ENOG4108KGH TRANSCRIPTIONal CEB94_RS16330 ENOG4108KGH TRANSCRIPTIONal CEB94_RS16335 ENOG4108KGH TRANSCRIPTIONal CEB94_RS16340 ENOG4108KGH TRANSCRIPTIONal CEB94_RS16350 ENOG4107TB5 TRANSCRIPTIONal CEB94_RS16360 ENOG4108KGH TRANSCRIPTIONal CEB94_RS16370 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CEB94_RS16430 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS16440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CEB94_RS16455 ENOG41065SU Two-component system sensor kinase CEB94_RS16460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS16465 ENOG4105DUX Transporter CEB94_RS16485 ENOG41082AN stage II sporulation protein CEB94_RS16490 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS16500 ENOG4105CI2 imidazolone-5-propionate hydrolase CEB94_RS16515 ENOG4105CGP Urocanate hydratase CEB94_RS16550 ENOG4105CHU acetyl-coa acetyltransferase CEB94_RS16585 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS16590 ENOG4107RBB ABC transporter, permease CEB94_RS16595 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase CEB94_RS16600 ENOG4105CEP NADH dehydrogenase CEB94_RS16630 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CEB94_RS16680 ENOG4105F27 Major Facilitator CEB94_RS16710 ENOG4108Z6Z Transcriptional regulator CEB94_RS16725 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS16730 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS16735 ENOG4105C0R drug resistance transporter emrb qaca subfamily CEB94_RS16755 ENOG4107QN1 sodium solute CEB94_RS16790 ENOG4105BZU Histidine kinase CEB94_RS16805 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CEB94_RS16810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CEB94_RS16815 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CEB94_RS16820 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CEB94_RS16835 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CEB94_RS16845 ENOG41067SE Tetr family transcriptional regulator CEB94_RS16850 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CEB94_RS16855 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CEB94_RS16860 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS16870 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CEB94_RS16910 ENOG4105C5H ABC transporter CEB94_RS16920 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CEB94_RS16925 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CEB94_RS16930 ENOG41069ER domain protein CEB94_RS16935 ENOG4105F8V Hydrolase, tatD family CEB94_RS16965 ENOG4105KF0 sporulation and cell division protein, SsgA CEB94_RS16970 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CEB94_RS16980 ENOG4108JJB ABC transporter CEB94_RS16985 ENOG4105K56 Transcriptional regulator CEB94_RS16990 ENOG4108ZHJ Organic hydroperoxide resistance protein CEB94_RS17010 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CEB94_RS17020 ENOG4105E2A Dehydrogenase CEB94_RS17025 ENOG4105EYF MMPL domain protein CEB94_RS17045 ENOG4105CHR reductase CEB94_RS17050 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CEB94_RS17055 ENOG4105F95 Monooxygenase CEB94_RS17065 ENOG4105CGK Exodeoxyribonuclease III CEB94_RS17070 ENOG4105VEV -acetyltransferase CEB94_RS17090 ENOG4105D9U N-acetyltransferase CEB94_RS17095 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CEB94_RS17100 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CEB94_RS17110 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CEB94_RS17115 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase CEB94_RS17140 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) CEB94_RS17150 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CEB94_RS17165 ENOG4105KXX peptidase s58 dmpa CEB94_RS17170 ENOG4105FF0 ErfK YbiS YcfS YnhG CEB94_RS17185 ENOG4105DM4 PTS System CEB94_RS17190 ENOG4105DE4 1-phosphofructokinase CEB94_RS17195 ENOG410804X Transcriptional regulator CEB94_RS17220 ENOG4108Z7F N-acetyltransferase CEB94_RS17225 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b CEB94_RS17250 ENOG4107HP6 Transcriptional regulator CEB94_RS17265 ENOG4106NZI LysR family Transcriptional regulator CEB94_RS17315 ENOG4105CPC Aldo Keto reductase CEB94_RS17325 ENOG4105F04 LysR family Transcriptional regulator CEB94_RS17340 ENOG4108Z6Z Transcriptional regulator CEB94_RS17345 ENOG4105EMU Dehydrogenase CEB94_RS17375 ENOG4107T94 Endo-14-beta-xylanase CEB94_RS17395 ENOG4108V8F Transcriptional regulator, MarR family CEB94_RS17410 ENOG4108V06 Glutathione peroxidase CEB94_RS17455 ENOG4107ZQV short-chain dehydrogenase reductase CEB94_RS17490 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 CEB94_RS17505 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CEB94_RS17580 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS17600 ENOG4105D74 hydrolase CEB94_RS17610 ENOG4108762 serine threonine protein kinase CEB94_RS17620 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CEB94_RS17630 ENOG4105D2B acyl-CoA dehydrogenase CEB94_RS17645 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CEB94_RS17680 ENOG4105H3G oxidoreductase CEB94_RS17690 ENOG4105CGU Enoyl-CoA hydratase CEB94_RS17705 ENOG4105D2S major facilitator superfamily CEB94_RS17715 ENOG4107QPD alcohol dehydrogenase CEB94_RS17720 ENOG4105CC9 acyl-Coa dehydrogenase CEB94_RS17740 ENOG4105D2B acyl-CoA dehydrogenase CEB94_RS17750 ENOG4105CC9 acyl-Coa dehydrogenase CEB94_RS17770 ENOG4105WN5 stage II sporulation protein CEB94_RS17775 ENOG4105K6V RNA polymerase CEB94_RS17830 ENOG4108XEP Alpha Beta Hydrolase Fold protein CEB94_RS17840 ENOG4108SU4 UPF0309 protein CEB94_RS17865 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CEB94_RS17880 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS17895 ENOG4107QX3 carboxylase CEB94_RS17930 ENOG4105CQB FAD linked oxidase domain protein CEB94_RS17935 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CEB94_RS17945 ENOG4106R7G Glycoside hydrolase family 5 CEB94_RS17985 ENOG4105CPC Aldo Keto reductase CEB94_RS18020 ENOG4105C7N Xanthine uracil vitamin C permease CEB94_RS18035 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic CEB94_RS18060 ENOG4108N0W Major Facilitator superfamily CEB94_RS18070 ENOG4108UIH futalosine nucleosidase CEB94_RS18075 ENOG4105E63 Pfam:DUF178 CEB94_RS18080 ENOG4105VEQ Cold shock protein CEB94_RS18110 ENOG4108TEB UPF0114 protein CEB94_RS18115 ENOG4105CFI type iii restriction protein res subunit CEB94_RS18125 ENOG4105EEM helicase CEB94_RS18130 ENOG4105CHR reductase CEB94_RS18170 ENOG4105QEK Transcriptional regulator CEB94_RS18175 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CEB94_RS18215 ENOG4105EBR Carboxylesterase CEB94_RS18225 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CEB94_RS18230 ENOG4105VEQ Cold shock protein CEB94_RS18245 ENOG4105C3Q Glycosyl transferase, family 2 CEB94_RS18275 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) CEB94_RS18280 ENOG4105CE4 GlcNAc 6-P deacetylase CEB94_RS18295 ENOG4105BZU Histidine kinase CEB94_RS18380 ENOG4105C2N RNA methyltransferase TrmH family group 3 CEB94_RS18385 ENOG4105C8N cysteinyl-tRNA synthetase CEB94_RS18390 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CEB94_RS18395 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CEB94_RS18400 ENOG4108VJ1 Transcriptional regulator (CarD family CEB94_RS18415 ENOG4105BZU Histidine kinase CEB94_RS18435 ENOG4105CHP RNA polymerase CEB94_RS18440 ENOG4105GRZ Ycii-related protein CEB94_RS18525 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEB94_RS18560 ENOG41075H3 AraC family transcriptional regulator CEB94_RS18570 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS18640 ENOG4105CAQ asparagine synthetase CEB94_RS18655 ENOG4105M0C cytoplasmic protein CEB94_RS18670 ENOG4105HDK L-asparaginase CEB94_RS18675 ENOG4105JAB phenazine biosynthesis protein, phzf family CEB94_RS18685 ENOG4105KME endoribonuclease L-psp CEB94_RS18705 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEB94_RS18730 ENOG4105EEM helicase CEB94_RS18735 ENOG4108XFH Transcriptional regulator CEB94_RS18745 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CEB94_RS18760 ENOG4107YCY Transcriptional regulator CEB94_RS18765 ENOG4105HHS UPF0256 protein CEB94_RS18775 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CEB94_RS18780 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CEB94_RS18785 ENOG41090R7 Ferric uptake CEB94_RS18805 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands CEB94_RS18830 ENOG4105PKJ carbohydrate binding CEB94_RS18835 ENOG4105KHC sulfurtransferase CEB94_RS18860 ENOG4107NHD transcriptional regulator CEB94_RS18865 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS18870 ENOG4105C0H protease CEB94_RS18940 ENOG4105CGH 5'-nucleotidase CEB94_RS18945 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CEB94_RS18970 ENOG4105CJ1 ABC, transporter CEB94_RS18985 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS18990 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS19005 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CEB94_RS19035 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS19040 ENOG4105CJ3 phosphate transporter CEB94_RS19050 ENOG4105VPX protein, conserved in bacteria CEB94_RS19070 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CEB94_RS19075 ENOG4105E4C Lytic transglycosylase catalytic CEB94_RS19130 ENOG4105CJ1 ABC, transporter CEB94_RS19140 ENOG4105BZU Histidine kinase CEB94_RS19145 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS19205 ENOG4105D5U fad dependent oxidoreductase CEB94_RS19210 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CEB94_RS19220 ENOG4105CPC Aldo Keto reductase CEB94_RS19250 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CEB94_RS19265 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CEB94_RS19270 ENOG4105FUA antagonist CEB94_RS19275 ENOG4107MMM Anti-sigma-factor antagonist CEB94_RS19290 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS19300 ENOG4105C1J atp-dependent rna helicase CEB94_RS19335 ENOG4105CQ7 ATP-dependent helicase CEB94_RS19355 ENOG4108TAC CEB94_RS19370 ENOG4105CXB phosphoribosylaminoimidazole synthetase CEB94_RS19400 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CEB94_RS19405 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CEB94_RS19410 ENOG410839H phosphoribosylformylglycinamidine synthase CEB94_RS19455 ENOG4105C8V SAICAR synthetase CEB94_RS19470 ENOG4105C12 Phosphoribosylglycinamide synthetase CEB94_RS19520 ENOG4105I3N Conserved Protein CEB94_RS19565 ENOG4105D7A ATP-binding protein CEB94_RS19580 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CEB94_RS19595 ENOG4108Z6B deaminase CEB94_RS19610 ENOG4106C0N stress responsive alpha-beta barrel domain-containing protein CEB94_RS19615 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS19620 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS19630 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CEB94_RS19640 ENOG4108YYC ycei family CEB94_RS19660 ENOG410905P Pyridoxamine 5-phosphate CEB94_RS19670 ENOG4105C57 major facilitator superfamily CEB94_RS19675 ENOG4105EDW glycosyl transferase, family 39 CEB94_RS19685 ENOG4105BZU Histidine kinase CEB94_RS19690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS19730 ENOG4108UXN response regulator CEB94_RS19735 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS19740 ENOG4105NAF rna polymerase sigma factor CEB94_RS19745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CEB94_RS19790 ENOG4108HMN Caspase domain CEB94_RS19805 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) CEB94_RS19840 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CEB94_RS19860 ENOG4107T6F Xaa-Pro aminopeptidase CEB94_RS19865 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase CEB94_RS19870 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CEB94_RS19905 ENOG4105DBE peroxidase CEB94_RS19910 ENOG4105CQC Prephenate dehydratase CEB94_RS19915 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CEB94_RS19920 ENOG410667J hydrolase CEB94_RS19960 ENOG4108UMS Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) CEB94_RS19970 ENOG4108KP7 hydrolase CEB94_RS19975 ENOG4105E4C Lytic transglycosylase catalytic CEB94_RS19980 ENOG4108JJ9 ABC, transporter CEB94_RS19985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CEB94_RS19990 ENOG4105C4M (Ubiquinol oxidase) subunit I CEB94_RS20000 ENOG4105CIH Imidazole acetol-phosphate transaminase CEB94_RS20005 ENOG4107P2S Transcriptional regulator CEB94_RS20020 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CEB94_RS20045 ENOG4106048 Cupin 2, conserved barrel domain protein CEB94_RS20050 ENOG41082T9 Membrane CEB94_RS20055 ENOG4105KJF protein tyrosine phosphatase CEB94_RS20060 ENOG4105C28 cystathionine CEB94_RS20090 ENOG4105F27 Major Facilitator CEB94_RS20095 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CEB94_RS20110 ENOG4105CDU Replicative dna helicase CEB94_RS20120 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CEB94_RS20125 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CEB94_RS20130 ENOG4107YH6 single-stranded DNA-binding protein CEB94_RS20135 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) CEB94_RS20160 ENOG4108JQC penicillin-binding protein 1A CEB94_RS20170 ENOG4105CZA synthase CEB94_RS20185 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CEB94_RS20200 ENOG4105D9P serine threonine protein kinase CEB94_RS20225 ENOG4105C3M thioredoxin reductase CEB94_RS20230 ENOG4105K63 Thioredoxin CEB94_RS20245 ENOG4107QJE Chromosome Partitioning Protein CEB94_RS20250 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CEB94_RS20260 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CEB94_RS20265 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CEB94_RS20270 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CEB94_RS20280 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CEB94_RS20285 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CEB94_RS20290 ENOG4108J5G 6-phosphogluconate dehydrogenase CEB94_RS20295 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CEB94_RS20300 ENOG4105K7N UPF0232 protein CEB94_RS20305 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEB94_RS20310 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEB94_RS20340 ENOG4108UGD Serine Threonine protein kinase CEB94_RS20390 ENOG4105ZJT Cell division protein CrgA CEB94_RS20400 ENOG4108U4N (sortase) family CEB94_RS20415 ENOG4108U4N (sortase) family CEB94_RS20420 ENOG4108RN7 integral membrane protein CEB94_RS20435 ENOG4105CJN penicillin-binding protein CEB94_RS20450 ENOG4105HZM Fha domain containing protein CEB94_RS20455 ENOG4105TV9 FHA Domain-Containing protein CEB94_RS20490 ENOG41064MX Tetr family transcriptional regulator CEB94_RS20535 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS20540 ENOG4108IG5 Transcriptional regulator CEB94_RS20565 ENOG4107QSN dihydrolipoamide acetyltransferase CEB94_RS20615 ENOG4107QPV Serine Threonine protein kinase CEB94_RS20630 ENOG4105CPP Dehydrogenase, E1 component CEB94_RS20635 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CEB94_RS20665 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CEB94_RS20685 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS20700 ENOG4105DFM M18 family aminopeptidase CEB94_RS20705 ENOG4105CSU acyl-Coa dehydrogenase CEB94_RS20725 ENOG4105C57 major facilitator superfamily CEB94_RS20730 ENOG4105EUB pirin domain protein CEB94_RS20745 ENOG4105C9M aspartyl-trna synthetase CEB94_RS20775 ENOG4105KWG Pfam:DUF1696 CEB94_RS20780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CEB94_RS20800 ENOG4105F2Z 3-oxoadipate enol-lactonase CEB94_RS20805 ENOG4107U9B transcriptional regulator CEB94_RS20840 ENOG4108PJD permease CEB94_RS20865 ENOG4108YYC ycei family CEB94_RS20880 ENOG4105CG3 alpha amylase, catalytic region CEB94_RS20930 ENOG4106NZI LysR family Transcriptional regulator CEB94_RS20990 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CEB94_RS21030 ENOG4105KVH Transcriptional regulator CEB94_RS21040 ENOG4106NZI LysR family Transcriptional regulator CEB94_RS21055 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS21065 ENOG4108IG5 Transcriptional regulator CEB94_RS21070 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CEB94_RS21085 ENOG4105C1J atp-dependent rna helicase CEB94_RS21090 ENOG4105VEQ Cold shock protein CEB94_RS21095 ENOG4105EYF MMPL domain protein CEB94_RS21100 ENOG4105BZU Histidine kinase CEB94_RS21105 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS21120 ENOG4105BZU Histidine kinase CEB94_RS21140 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS21155 ENOG4108HMN Caspase domain CEB94_RS21170 ENOG4107RA9 decarboxylase CEB94_RS21180 ENOG4106NZI LysR family Transcriptional regulator CEB94_RS21185 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CEB94_RS21190 ENOG4106YT9 Enoyl-CoA hydratase CEB94_RS21200 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) CEB94_RS21205 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS21225 ENOG4105T16 Transcriptional regulator (AraC family) CEB94_RS21230 ENOG4107S91 Sodium hydrogen exchanger CEB94_RS21260 ENOG4105C1J atp-dependent rna helicase CEB94_RS21265 ENOG4105VEQ Cold shock protein CEB94_RS21275 ENOG4105DTD Dehydrogenase CEB94_RS21280 ENOG4107RSM transcriptional regulator CEB94_RS21325 ENOG4108J2P Alpha beta hydrolase fold CEB94_RS21350 ENOG41090G8 Toxic component of a toxin-antitoxin (TA) module. A CEB94_RS21495 ENOG4105DHP deoxycytidine triphosphate deaminase CEB94_RS21500 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CEB94_RS21550 ENOG4108NV9 Glycosyl Transferase CEB94_RS21560 ENOG4107QQG Dehydrogenase CEB94_RS21585 ENOG4105DF6 Fe-S oxidoreductase CEB94_RS21595 ENOG4105CFG Acts as a chaperone (By similarity) CEB94_RS21600 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CEB94_RS21605 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CEB94_RS21610 ENOG4105KNI merR family transcriptional Regulator CEB94_RS21615 ENOG4105DFW ABC transporter CEB94_RS21645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEB94_RS21685 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CEB94_RS21700 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CEB94_RS21725 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) CEB94_RS21745 ENOG4105BZU Histidine kinase CEB94_RS21750 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS21755 ENOG4105BZU Histidine kinase CEB94_RS21760 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS21765 ENOG4106A3M Cytochrome p-450 CEB94_RS21775 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CEB94_RS21790 ENOG4108WYP Transcriptional regulator CEB94_RS21795 ENOG4108JPW Aminotransferase CEB94_RS21800 ENOG4108V4B ThiJ pfpI CEB94_RS21820 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CEB94_RS21825 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CEB94_RS21845 ENOG4105BZU Histidine kinase CEB94_RS21850 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS21855 ENOG4105CFH Aspartokinase CEB94_RS21865 ENOG4105NAF rna polymerase sigma factor CEB94_RS21895 ENOG4108PJD permease CEB94_RS21915 ENOG4105F0K SARP family transcriptional regulator CEB94_RS21975 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CEB94_RS21980 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS21990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEB94_RS22005 ENOG410900P UPF0336 protein CEB94_RS22020 ENOG4105M6F mutator MutT protein CEB94_RS22110 ENOG4108JQC penicillin-binding protein 1A CEB94_RS22145 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CEB94_RS22160 ENOG4105P8F nudix hydrolase CEB94_RS22170 ENOG4105D74 hydrolase CEB94_RS22180 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CEB94_RS22185 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CEB94_RS22190 ENOG4107B2H carbonic anhydrase CEB94_RS22245 ENOG4108I5C dEAD DEAH box helicase CEB94_RS22250 ENOG4105WN5 stage II sporulation protein CEB94_RS22260 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for CEB94_RS22270 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CEB94_RS22280 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CEB94_RS22285 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CEB94_RS22320 ENOG4105F27 Major Facilitator CEB94_RS22325 ENOG4106A3M Cytochrome p-450 CEB94_RS22330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CEB94_RS22350 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CEB94_RS22365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEB94_RS22370 ENOG41086VD Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CEB94_RS22380 ENOG4106IPI cyclase, family CEB94_RS22385 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CEB94_RS22395 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEB94_RS22420 ENOG4105C19 ABC transporter CEB94_RS22435 ENOG4107VQW regulatoR CEB94_RS22445 ENOG41086D8 Transcriptional regulator CEB94_RS22460 ENOG4105C2M dna polymerase I CEB94_RS22485 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CEB94_RS22490 ENOG4105KDC 50s ribosomal protein l28 CEB94_RS22495 ENOG4105W0E 50S ribosomal protein L33 CEB94_RS22500 ENOG4105NRA 50s ribosomal protein l31 type b CEB94_RS22510 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CEB94_RS22535 ENOG4105C26 Dehydrogenase CEB94_RS22560 ENOG4105CVK Glutamate decarboxylase CEB94_RS22570 ENOG4107TXC Transcriptional regulator CEB94_RS22575 ENOG41082VC UPF0145 protein CEB94_RS22580 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CEB94_RS22590 ENOG4105F0N pyrophosphate phospho-hydrolase CEB94_RS22605 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CEB94_RS22610 ENOG4108UGV hypoxanthine phosphoribosyltransferase CEB94_RS22620 ENOG4105EUJ GTP cyclohydrolase i CEB94_RS22650 ENOG4105CRK lysyL-tRNA synthetase CEB94_RS22675 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS22690 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS22695 ENOG41082SX arsR family transcriptional regulator CEB94_RS22715 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CEB94_RS22720 ENOG4108IYU L-aspartate oxidase CEB94_RS22730 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CEB94_RS22775 ENOG4105DR5 peptidase CEB94_RS22780 ENOG4108IG5 Transcriptional regulator CEB94_RS22795 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CEB94_RS22800 ENOG4108FKE two-component system sensor kinase CEB94_RS22805 ENOG4108PYU two-component system response regulator CEB94_RS22810 ENOG41075QH Lipoprotein CseA CEB94_RS22815 ENOG4105NAF rna polymerase sigma factor CEB94_RS22825 ENOG4105BZU Histidine kinase CEB94_RS22835 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CEB94_RS22845 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CEB94_RS22860 ENOG4108JWX CEB94_RS22865 ENOG4107R33 ppx gppa phosphatase CEB94_RS22870 ENOG4105EY0 Xylose isomerase domain protein TIM barrel CEB94_RS22875 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) CEB94_RS22880 ENOG4105C01 Dihydroxy-acid dehydratase CEB94_RS22885 ENOG4108762 serine threonine protein kinase CEB94_RS22890 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CEB94_RS22915 ENOG4105CJ1 ABC, transporter CEB94_RS22925 ENOG4105II7 pyrroline-5-carboxylate reductase CEB94_RS22930 ENOG4105C31 Tryptophanyl-tRNA synthetase CEB94_RS22960 ENOG4105DGU Histone deacetylase CEB94_RS22965 ENOG4108XFF CEB94_RS23010 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CEB94_RS23015 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CEB94_RS23020 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CEB94_RS23025 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CEB94_RS23035 ENOG4105D52 delta-aminolevulinic acid dehydratase CEB94_RS23055 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CEB94_RS23085 ENOG4105C75 arginyL-tRNA synthetase CEB94_RS23090 ENOG4105DK7 lysyl-tRNA synthetase CEB94_RS23110 ENOG4105E0Y RtcB Protein CEB94_RS23125 ENOG4105KK4 UPF0060 membrane protein CEB94_RS23135 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CEB94_RS23200 ENOG4105C57 major facilitator superfamily CEB94_RS23215 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CEB94_RS23220 ENOG4108YYH Nadph-dependent fmn reductase CEB94_RS23245 ENOG4106ARF phosphopantetheine-binding protein CEB94_RS23265 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CEB94_RS23270 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CEB94_RS23290 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CEB94_RS23295 ENOG4108RH7 phosphoglycerate mutase CEB94_RS23305 ENOG4107ZT5 Thiol disulfide interchange protein CEB94_RS23310 ENOG4107QIV Cytochrome c biogenesis protein CEB94_RS23315 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) CEB94_RS23320 ENOG4105CRE cytochrome C CEB94_RS23360 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CEB94_RS23365 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) CEB94_RS23375 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CEB94_RS23385 ENOG4105DVY radical SAM domain protein CEB94_RS23405 ENOG4105CK2 sodium dicarboxylate symporter CEB94_RS23410 ENOG4108R86 Transcriptional regulator CEB94_RS23420 ENOG4105CHR reductase CEB94_RS23425 ENOG4105CHU acetyl-coa acetyltransferase CEB94_RS23435 ENOG4105DFW ABC transporter CEB94_RS23440 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein CEB94_RS23445 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CEB94_RS23455 ENOG4105VEQ Cold shock protein CEB94_RS23460 ENOG4105EV6 Pfam:DUF178 CEB94_RS23475 ENOG4105EC2 ftsk spoIIIe CEB94_RS23550 ENOG4108ZJ4 polysaccharide deacetylase CEB94_RS23555 ENOG4108KGH TRANSCRIPTIONal CEB94_RS23580 ENOG4108EHY type IV secretion system CEB94_RS23645 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) CEB94_RS23660 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEB94_RS23670 ENOG4105KNA -acetyltransferase CEB94_RS23680 ENOG41068JE domain protein CEB94_RS23690 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23695 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CEB94_RS23700 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23710 ENOG4107QIZ NADH dehydrogenase CEB94_RS23715 ENOG4108IEH NADH dehydrogenase subunit g CEB94_RS23720 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CEB94_RS23725 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23730 ENOG41087XN oxidoreductase CEB94_RS23735 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23740 ENOG4105D65 subunit l CEB94_RS23750 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23760 ENOG4105C9U ATP-dependent DNA helicase RecQ CEB94_RS23765 ENOG4108IYU L-aspartate oxidase CEB94_RS23770 ENOG4108IY8 ABC, transporter CEB94_RS23775 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CEB94_RS23790 ENOG41073TP transcriptional regulator CEB94_RS23805 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CEB94_RS23835 ENOG4107QRS glycosyltransferase group 2 family protein CEB94_RS23845 ENOG410667J hydrolase CEB94_RS23865 ENOG4105CJ1 ABC, transporter CEB94_RS23880 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS23895 ENOG4105IIU Aminopeptidase CEB94_RS23920 ENOG4105ECR NmrA family CEB94_RS23925 ENOG4105KVH Transcriptional regulator CEB94_RS23930 ENOG4105DQU oxidoreductase, subunit beta CEB94_RS23935 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CEB94_RS23955 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CEB94_RS23960 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23965 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain CEB94_RS23970 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) CEB94_RS23975 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23980 ENOG4107YX3 NADH dehydrogenase subunit j CEB94_RS23985 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS23990 ENOG4105D65 subunit l CEB94_RS23995 ENOG4105C8S subunit m CEB94_RS24000 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) CEB94_RS24005 ENOG4105D0M Protease HtpX homolog CEB94_RS24010 ENOG410901E Membrane CEB94_RS24020 ENOG4105Y3U Transglycosylase-associated protein CEB94_RS24025 ENOG4108VPT UPF0234 protein CEB94_RS24100 ENOG41062IR nudix hydrolase CEB94_RS24160 ENOG4105WDJ 50S ribosomal protein L33 CEB94_RS24165 ENOG410900P UPF0336 protein CEB94_RS24190 ENOG4107R4N Cell wall formation (By similarity) CEB94_RS24195 ENOG4108RYK Nad-dependent epimerase dehydratase CEB94_RS24205 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CEB94_RS24220 ENOG410683Z Preprotein translocase SecE subunit CEB94_RS24225 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CEB94_RS24230 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CEB94_RS24235 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CEB94_RS24245 ENOG4105QCJ Lipoprotein CEB94_RS24250 ENOG4108VZM 50s ribosomal protein L10 CEB94_RS24255 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CEB94_RS24260 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEB94_RS24265 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEB94_RS24275 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CEB94_RS24280 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CEB94_RS24285 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CEB94_RS24290 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CEB94_RS24315 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CEB94_RS24320 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CEB94_RS24325 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CEB94_RS24330 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CEB94_RS24335 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CEB94_RS24340 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CEB94_RS24345 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CEB94_RS24350 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CEB94_RS24355 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CEB94_RS24360 ENOG41082SA 50s ribosomal protein l29 CEB94_RS24365 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CEB94_RS24370 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CEB94_RS24375 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CEB94_RS24380 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CEB94_RS24385 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CEB94_RS24390 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CEB94_RS24395 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CEB94_RS24400 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CEB94_RS24405 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CEB94_RS24410 ENOG410849U 50S ribosomal protein L30 CEB94_RS24415 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CEB94_RS24425 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CEB94_RS24435 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CEB94_RS24440 ENOG41067V7 50S ribosomal protein L36 CEB94_RS24445 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CEB94_RS24450 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CEB94_RS24455 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CEB94_RS24460 ENOG4108ZT0 50S ribosomal protein l17 CEB94_RS24465 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CEB94_RS24480 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CEB94_RS24485 ENOG4108UJD 30S ribosomal protein S9 CEB94_RS24490 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CEB94_RS24500 ENOG4105CS9 pantothenic acid kinase CEB94_RS24505 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CEB94_RS24515 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CEB94_RS24535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CEB94_RS24540 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 CEB94_RS24545 ENOG4108097 ATP-binding protein CEB94_RS24570 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CEB94_RS24585 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CEB94_RS24590 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS24600 ENOG4107TB5 TRANSCRIPTIONal CEB94_RS24610 ENOG4105CHP RNA polymerase CEB94_RS24630 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CEB94_RS24635 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CEB94_RS24645 ENOG4105EMU Dehydrogenase CEB94_RS24655 ENOG4105DND Transcriptional regulator CEB94_RS24660 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS24670 ENOG4108MMM RNA Polymerase CEB94_RS24680 ENOG4107QVP Dehydrogenase CEB94_RS24685 ENOG4107QQG Dehydrogenase CEB94_RS24690 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CEB94_RS24705 ENOG4105D9P serine threonine protein kinase CEB94_RS24710 ENOG4107TPY serine threonine protein kinase CEB94_RS24715 ENOG4108DT4 serine threonine protein kinase CEB94_RS24730 ENOG4105C26 Dehydrogenase CEB94_RS24755 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CEB94_RS24795 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS24825 ENOG4105DR5 peptidase CEB94_RS24830 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CEB94_RS24850 ENOG4105KKX ATPase associated with various cellular activities aaa_5 CEB94_RS24855 ENOG4105RD5 CEB94_RS24860 ENOG4105DEG Vwa containing coxe family protein CEB94_RS24865 ENOG4105CMV Succinyl-CoA synthetase subunit beta CEB94_RS24895 ENOG4105DC1 bifunctional purine biosynthesis protein purh CEB94_RS24900 ENOG4108762 serine threonine protein kinase CEB94_RS24945 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CEB94_RS24960 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CEB94_RS24975 ENOG4108IJ7 Glycine betaine CEB94_RS24995 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS25000 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS25010 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS25060 ENOG4106032 Glutathionylspermidine synthase CEB94_RS25065 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CEB94_RS25075 ENOG4105C31 Tryptophanyl-tRNA synthetase CEB94_RS25110 ENOG4107H3J ribonuclease CEB94_RS25125 ENOG4107RN3 metallophosphoesterase CEB94_RS25135 ENOG41067SE Tetr family transcriptional regulator CEB94_RS25165 ENOG4108J01 L-aspartate oxidase CEB94_RS25185 ENOG4105E2D ec 3.2.1.52 CEB94_RS25235 ENOG4105D5P Methylmalonyl-coA mutase CEB94_RS25240 ENOG4108NIW Leucine export protein LeuE CEB94_RS25270 ENOG4105K64 Glycosyl transferase, family 2 CEB94_RS25280 ENOG4105F0R Cytidylyltransferase CEB94_RS25285 ENOG4105D2T synthase CEB94_RS25300 ENOG4107RM1 amidohydrolase CEB94_RS25305 ENOG4105DIH basic membrane CEB94_RS25310 ENOG4105DIH basic membrane CEB94_RS25315 ENOG4108JQ9 ABC transporter CEB94_RS25355 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CEB94_RS25360 ENOG4105D94 Major Facilitator Superfamily CEB94_RS25365 ENOG4107RSM transcriptional regulator CEB94_RS25375 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CEB94_RS25400 ENOG41065SU Two-component system sensor kinase CEB94_RS25405 ENOG4108KXV response regulator CEB94_RS25410 ENOG4105NAF rna polymerase sigma factor CEB94_RS25415 ENOG4108KQ5 Integrase catalytic subunit CEB94_RS25430 ENOG4105C26 Dehydrogenase CEB94_RS25435 ENOG4105C26 Dehydrogenase CEB94_RS25455 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CEB94_RS25480 ENOG4108JIK carboxylase CEB94_RS25490 ENOG4107WR6 Maf-like protein CEB94_RS25500 ENOG4105D8K carboxyl transferase CEB94_RS25510 ENOG4108QER Adenylate cyclase CEB94_RS25520 ENOG4105E39 Enoyl-CoA hydratase CEB94_RS25525 ENOG4105KDM Diguanylate cyclase with gaf sensor CEB94_RS25530 ENOG4105C84 Histidine ammonia-lyase CEB94_RS25555 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS25570 ENOG4105DQ4 alcohol dehydrogenase CEB94_RS25580 ENOG4105ECP epimerase CEB94_RS25625 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CEB94_RS25630 ENOG4105C7B Threonine dehydratase CEB94_RS25645 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CEB94_RS25655 ENOG4105T1M mycothiol conjugate amidase mca CEB94_RS25670 ENOG4105C7Z Conserved Protein CEB94_RS25705 ENOG4105C57 major facilitator superfamily CEB94_RS25715 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) CEB94_RS25720 ENOG4105ESF Peptidoglycan binding domain protein CEB94_RS25750 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS25755 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS25765 ENOG4105CHM Aminotransferase CEB94_RS25795 ENOG4108FUF Transcriptional regulator, IclR family CEB94_RS25800 ENOG4105KME endoribonuclease L-psp CEB94_RS25805 ENOG4105C6Z Gluconate CEB94_RS25885 ENOG4105RAK Histidine kinase CEB94_RS25890 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS25935 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS25975 ENOG4105F2W methyltransferase CEB94_RS25980 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CEB94_RS25985 ENOG4108IAB Phoh family CEB94_RS26000 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS26005 ENOG4105D3R alkyl hydroperoxide reductase CEB94_RS26020 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CEB94_RS26040 ENOG4105BZ4 penicillin-binding protein CEB94_RS26055 ENOG4105C9Q fumarate hydratase class II CEB94_RS26060 ENOG4107GFK fumarate CEB94_RS26070 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS26085 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CEB94_RS26095 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CEB94_RS26100 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CEB94_RS26105 ENOG4105DFK Polyphosphate glucokinase CEB94_RS26115 ENOG4105C3G gtp-binding protein CEB94_RS26170 ENOG4105DZR Type I site-specific deoxyribonuclease CEB94_RS26180 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CEB94_RS26250 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CEB94_RS26255 ENOG4105CVN desaturase CEB94_RS26280 ENOG4105CVP deoxyribo-dipyrimidine photolyase CEB94_RS26285 ENOG4105CGD Nad-dependent epimerase dehydratase CEB94_RS26290 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin CEB94_RS26345 ENOG4105E33 succinate dehydrogenase CEB94_RS26350 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CEB94_RS26375 ENOG4105CI3 gtp-binding protein typa CEB94_RS26385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEB94_RS26390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS26400 ENOG4108JQ7 (ABC) transporter CEB94_RS26455 ENOG4108M15 ABC transporter CEB94_RS26465 ENOG4108ZGX Histidine kinase CEB94_RS26470 ENOG4108S01 response regulator CEB94_RS26485 ENOG4108Z4U Ferredoxin CEB94_RS26505 ENOG4107R4C succinyl-diaminopimelate desuccinylase CEB94_RS26510 ENOG4108URH decarboxylase CEB94_RS26515 ENOG4105EEI dihydropteroate synthase CEB94_RS26525 ENOG4108R3E Dna-3-methyladenine glycosylase i CEB94_RS26530 ENOG4105CGU Enoyl-CoA hydratase CEB94_RS26550 ENOG4105DU6 RNA polymerase CEB94_RS26565 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CEB94_RS26600 ENOG4105D7N magnesium and cobalt transport protein CorA CEB94_RS26610 ENOG4105DXB Major Facilitator superfamily CEB94_RS26625 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CEB94_RS26720 ENOG4106JDR secreted CEB94_RS26745 ENOG4105C4R Atp-dependent dna helicase CEB94_RS26750 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CEB94_RS26775 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS26790 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) CEB94_RS26845 ENOG41063PX domain protein CEB94_RS26855 ENOG4105DJZ UPF0182 protein CEB94_RS26970 ENOG4107TK4 histidinol-phosphate phosphatase CEB94_RS27000 ENOG4105KPY Small multidrug resistance protein CEB94_RS27005 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CEB94_RS27010 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CEB94_RS27020 ENOG4108RAV Conserved protein CEB94_RS27030 ENOG4105EMN RNA polymerase sigma factor CEB94_RS27035 ENOG4105WMN AntiSigma factor CEB94_RS27040 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CEB94_RS27055 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CEB94_RS27065 ENOG41068W2 Cytochrome p-450 CEB94_RS27080 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEB94_RS27085 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEB94_RS27100 ENOG4105FDP GntR family transcriptional regulator CEB94_RS27120 ENOG4105D17 glycoside hydrolase, family 3 domain protein CEB94_RS27130 ENOG4105VZ8 Transcriptional regulator CEB94_RS27140 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CEB94_RS27145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CEB94_RS27150 ENOG4105CHR reductase CEB94_RS27155 ENOG4108IND Tetr family transcriptional regulator CEB94_RS27170 ENOG4105CBD Diacylglycerol kinase CEB94_RS27200 ENOG4105K6H D-cysteine desulfhydrase CEB94_RS27205 ENOG4105ESN nucleotide-binding protein CEB94_RS27215 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CEB94_RS27230 ENOG4105CHP RNA polymerase CEB94_RS27255 ENOG4108VEQ Superoxide dismutase CEB94_RS27275 ENOG4105CDA abc transporter atp-binding protein CEB94_RS27290 ENOG4105C6K Malic enzyme CEB94_RS27295 ENOG4105CB2 alcohol dehydrogenase CEB94_RS27330 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CEB94_RS27335 ENOG4105EB3 Histidine kinase CEB94_RS27340 ENOG4108PYU two-component system response regulator CEB94_RS27360 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CEB94_RS27400 ENOG4105ZXU NLP P60 protein CEB94_RS27410 ENOG41060BG Tetr family transcriptional regulator CEB94_RS27450 ENOG4108FKE two-component system sensor kinase CEB94_RS27470 ENOG4105DQE DNA ligase CEB94_RS27475 ENOG4105FDF Could be involved in DNA repair (By similarity) CEB94_RS27485 ENOG4105VBF alkaline shock protein CEB94_RS27565 ENOG4105C75 arginyL-tRNA synthetase CEB94_RS27570 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CEB94_RS27575 ENOG4105D6E homoserine dehydrogenase CEB94_RS27580 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CEB94_RS27585 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CEB94_RS27595 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CEB94_RS27600 ENOG4108RCF TRANSCRIPTIONal CEB94_RS27605 ENOG4105VFB Binds the 23S rRNA (By similarity) CEB94_RS27610 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CEB94_RS27615 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CEB94_RS27625 ENOG4107ZF2 Phosphatase CEB94_RS27630 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CEB94_RS27635 ENOG4105ESV Glycosyl transferase, family 4 CEB94_RS27640 ENOG4105Z3P ATP synthase CEB94_RS27650 ENOG4105ZA1 atp synthase CEB94_RS27655 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CEB94_RS27660 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CEB94_RS27665 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CEB94_RS27670 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CEB94_RS27675 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CEB94_RS27680 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CEB94_RS27695 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS27700 ENOG4105BZU Histidine kinase CEB94_RS27705 ENOG4105IIP Membrane CEB94_RS27725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS27740 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) CEB94_RS27775 ENOG4105CJ1 ABC, transporter CEB94_RS27795 ENOG4105CHU acetyl-coa acetyltransferase CEB94_RS27810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS27815 ENOG41062D9 Histidine kinase CEB94_RS27860 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) CEB94_RS27870 ENOG4105WX6 Membrane CEB94_RS27910 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CEB94_RS27915 ENOG4105C6K Malic enzyme CEB94_RS27920 ENOG4105CTQ phosphohexokinase CEB94_RS27935 ENOG4108KQ5 Integrase catalytic subunit CEB94_RS27940 ENOG4107HP6 Transcriptional regulator CEB94_RS27945 ENOG4105C6Z Gluconate CEB94_RS27950 ENOG4105EQX glucarate dehydratase CEB94_RS27955 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CEB94_RS27960 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS27970 ENOG4108MRH transcriptional regulatory protein CEB94_RS27980 ENOG4107QJT sodium dicarboxylate symporter CEB94_RS27995 ENOG4105C57 major facilitator superfamily CEB94_RS28000 ENOG4108FN7 Aldo keto reductase CEB94_RS28020 ENOG4105C3M thioredoxin reductase CEB94_RS28040 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CEB94_RS28045 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) CEB94_RS28055 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) CEB94_RS28060 ENOG4107QR7 peptidase S8 and S53, subtilisin, kexin, sedolisin CEB94_RS28065 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) CEB94_RS28085 ENOG4105BZ1 (ABC) transporter CEB94_RS28090 ENOG4105BZ1 (ABC) transporter CEB94_RS28095 ENOG4105BZ1 (ABC) transporter CEB94_RS28100 ENOG4105BZ1 (ABC) transporter CEB94_RS28105 ENOG4105CJ1 ABC, transporter CEB94_RS28115 ENOG4105BZU Histidine kinase CEB94_RS28120 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS28135 ENOG41069FZ L,D-transpeptidase catalytic domain CEB94_RS28170 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) CEB94_RS28180 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CEB94_RS28185 ENOG4105EJQ L-serine dehydratase CEB94_RS28190 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CEB94_RS28195 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CEB94_RS28200 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CEB94_RS28220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS28235 ENOG4105C3U ABC transporter CEB94_RS28240 ENOG4108JQ7 (ABC) transporter CEB94_RS28245 ENOG4105EN6 Membrane CEB94_RS28265 ENOG4105YIP Tetr family transcriptional regulator CEB94_RS28290 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CEB94_RS28310 ENOG4108URH decarboxylase CEB94_RS28315 ENOG4105EMU Dehydrogenase CEB94_RS28325 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CEB94_RS28330 ENOG4105BZU Histidine kinase CEB94_RS28345 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS28350 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS28360 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS28370 ENOG4105EYF MMPL domain protein CEB94_RS28375 ENOG4105D9U N-acetyltransferase CEB94_RS28390 ENOG4107SM8 Adenylate Guanylate cyclase CEB94_RS28405 ENOG4105CPC Aldo Keto reductase CEB94_RS28425 ENOG4108ZP8 Acetolactate synthase small subunit CEB94_RS28430 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CEB94_RS28435 ENOG4108JQ1 Dehydrogenase CEB94_RS28440 ENOG4105C57 major facilitator superfamily CEB94_RS28450 ENOG4108JQ7 (ABC) transporter CEB94_RS28460 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS28485 ENOG4105C26 Dehydrogenase CEB94_RS28500 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CEB94_RS28505 ENOG4105CM2 brancheD-chain amino acid aminotransferase CEB94_RS28515 ENOG4105CQM Urea amidohydrolase subunit alpha CEB94_RS28520 ENOG4105DWY Agmatine deiminase CEB94_RS28535 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CEB94_RS28570 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CEB94_RS28575 ENOG4108YYC ycei family CEB94_RS28580 ENOG4108W6C Dehydrogenase CEB94_RS28590 ENOG4105D8K carboxyl transferase CEB94_RS28615 ENOG4105GWZ Roadblock lc7 family protein CEB94_RS28635 ENOG4105GWZ Roadblock lc7 family protein CEB94_RS28650 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase CEB94_RS28655 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CEB94_RS28690 ENOG41069M3 Transcriptional regulator CEB94_RS28695 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CEB94_RS28700 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CEB94_RS28710 ENOG4105K70 DNA-binding protein CEB94_RS28730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CEB94_RS28735 ENOG4105CPF Cell wall formation (By similarity) CEB94_RS28755 ENOG4105DWF phosphomethylpyrimidine kinase CEB94_RS28760 ENOG4105VB9 50S ribosomal protein l28 CEB94_RS28765 ENOG4105DP4 dak2 domain fusion protein ylov CEB94_RS28785 ENOG4106H78 methyltransferase CEB94_RS28790 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CEB94_RS28805 ENOG41084BZ 50S ribosomal protein L32 CEB94_RS28810 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CEB94_RS28815 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CEB94_RS28820 ENOG4105KVH Transcriptional regulator CEB94_RS28830 ENOG4105K4I Scp-like extracellular CEB94_RS28835 ENOG4108375 Acylphosphatase (EC 3.6.1.7) CEB94_RS28845 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CEB94_RS28890 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CEB94_RS28910 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) CEB94_RS28920 ENOG4105K5M 30s ribosomal protein S16 CEB94_RS28925 ENOG41082KU UPF0109 protein CEB94_RS28930 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CEB94_RS28935 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CEB94_RS28940 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CEB94_RS28945 ENOG4107QYR Signal peptidase i CEB94_RS28955 ENOG4107QYR Signal peptidase i CEB94_RS28960 ENOG4107QYR Signal peptidase i CEB94_RS28975 ENOG41080R2 UPF0102 protein CEB94_RS29025 ENOG4105GC4 N-4 methylation of cytosine CEB94_RS29100 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CEB94_RS29115 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS29125 ENOG41063SB peptidase CEB94_RS29130 ENOG4105CE9 30S ribosomal protein S2 CEB94_RS29135 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CEB94_RS29140 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CEB94_RS29145 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CEB94_RS29150 ENOG4105KNE Phosphatidate cytidylyltransferase CEB94_RS29170 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CEB94_RS29180 ENOG4108I5D sulfate abc transporter CEB94_RS29185 ENOG4108UCS ABC, transporter CEB94_RS29215 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CEB94_RS29220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CEB94_RS29230 ENOG4105C26 Dehydrogenase CEB94_RS29250 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CEB94_RS29280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS29290 ENOG4105D38 putrescine abc transporter CEB94_RS29295 ENOG4105CJP fad dependent oxidoreductase CEB94_RS29315 ENOG4105KVH Transcriptional regulator CEB94_RS29320 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CEB94_RS29335 ENOG4105G9B Transcriptional regulator CEB94_RS29335 ENOG4105G9B Transcriptional regulator CEB94_RS29345 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CEB94_RS29350 ENOG4105E0S extracellular solute-binding protein family 1 CEB94_RS29360 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CEB94_RS29405 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CEB94_RS29410 ENOG4105DZP Membrane-associated zinc metalloprotease CEB94_RS29415 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CEB94_RS29430 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CEB94_RS29435 ENOG4105NFX aminoglycoside hydroxyurea antibiotic resistance kinase CEB94_RS29450 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) CEB94_RS29465 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CEB94_RS29475 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CEB94_RS29480 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CEB94_RS29510 ENOG4105C3U ABC transporter CEB94_RS29515 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS29520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CEB94_RS29525 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CEB94_RS29615 ENOG4105EC2 ftsk spoIIIe CEB94_RS29630 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CEB94_RS29635 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CEB94_RS29640 ENOG4105C1V Peptidase, M16 CEB94_RS29645 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CEB94_RS29670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CEB94_RS29675 ENOG4105CN5 Metallo-Beta-Lactamase CEB94_RS29710 ENOG4105BZU Histidine kinase CEB94_RS29715 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase CEB94_RS29730 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) CEB94_RS29740 ENOG4105CEV competence damage-inducible protein CEB94_RS29745 ENOG4105WBV Transcriptional regulator CEB94_RS29750 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CEB94_RS29760 ENOG4105CHR reductase CEB94_RS29765 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CEB94_RS29770 ENOG4107QRT dEAD DEAH box helicase CEB94_RS29800 ENOG4105DSF transport protein CEB94_RS29810 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CEB94_RS29820 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) CEB94_RS29835 ENOG4105DRP amino acid AbC transporter CEB94_RS29840 ENOG4108Q1T ABC transporter CEB94_RS29845 ENOG4107UBR Extracellular solute-binding protein family 3 CEB94_RS29850 ENOG4105CDA abc transporter atp-binding protein CEB94_RS29855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS29860 ENOG4105EB3 Histidine kinase CEB94_RS29885 ENOG4105BZU Histidine kinase CEB94_RS29890 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS29895 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CEB94_RS29915 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CEB94_RS29925 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CEB94_RS29930 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CEB94_RS29940 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CEB94_RS29975 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CEB94_RS29980 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CEB94_RS29985 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CEB94_RS30000 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEB94_RS30010 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CEB94_RS30025 ENOG4105C9U ATP-dependent DNA helicase RecQ CEB94_RS30040 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CEB94_RS30045 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS30050 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS30055 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CEB94_RS30060 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CEB94_RS30070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEB94_RS30080 ENOG4105BZU Histidine kinase CEB94_RS30090 ENOG4107QN1 sodium solute CEB94_RS30095 ENOG4108MRH transcriptional regulatory protein CEB94_RS30100 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CEB94_RS30110 ENOG4105BZN citrate synthase CEB94_RS30115 ENOG4105BZN citrate synthase CEB94_RS30135 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CEB94_RS30155 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS30160 ENOG410849S phosphocarrier protein (HPr) CEB94_RS30180 ENOG4107W53 thymidine kinase CEB94_RS30215 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CEB94_RS30230 ENOG4105F44 Two component transcriptional regulator, winged helix family CEB94_RS30235 ENOG4106F60 Histidine kinase CEB94_RS30260 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CEB94_RS30300 ENOG4107VEG TrkA-N domain protein CEB94_RS30315 ENOG4108U3T pfkb domain protein CEB94_RS30320 ENOG4105C0X amino acid CEB94_RS30325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CEB94_RS30400 ENOG4105EMU Dehydrogenase CEB94_RS30405 ENOG4105EMU Dehydrogenase CEB94_RS30440 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CEB94_RS30475 ENOG4106048 Cupin 2, conserved barrel domain protein CEB94_RS30485 ENOG4106A3M Cytochrome p-450 CEB94_RS30515 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS30520 ENOG4105DVH amino acid CEB94_RS30540 ENOG4108J2P Alpha beta hydrolase fold CEB94_RS30585 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS30590 ENOG4105BZU Histidine kinase CEB94_RS30605 ENOG4106KE4 Dehydrogenase CEB94_RS30630 ENOG4108TGC Acyltransferase CEB94_RS30660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEB94_RS30700 ENOG4107S1Q Phosphatase CEB94_RS30710 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CEB94_RS30740 ENOG4105CEU Arginine dihydrolase CEB94_RS30745 ENOG4105DBV ornithine carbamoyltransferase CEB94_RS30755 ENOG4108UKI Enoyl-CoA hydratase CEB94_RS30760 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CEB94_RS30765 ENOG4108KPJ rna polymerase sigma factor CEB94_RS30785 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CEB94_RS30835 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS30840 ENOG4105C3U ABC transporter CEB94_RS30865 ENOG4105C9B Cysteine desulfurase CEB94_RS30870 ENOG4105C6T cysteine synthase CEB94_RS30895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CEB94_RS30905 ENOG4107QM5 aconitate hydratase CEB94_RS30915 ENOG4108HWW ABC transporter CEB94_RS30920 ENOG4105C2J ABC transporter CEB94_RS30925 ENOG4105DFW ABC transporter CEB94_RS30950 ENOG4105I82 acetyl xylan esterase CEB94_RS30960 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CEB94_RS30965 ENOG4105E0S extracellular solute-binding protein family 1 CEB94_RS31005 ENOG4105E2R ROK family CEB94_RS31010 ENOG4105DFW ABC transporter CEB94_RS31015 ENOG4105C2J ABC transporter CEB94_RS31020 ENOG4108HWW ABC transporter CEB94_RS31025 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CEB94_RS31030 ENOG4105CUB amino acid CEB94_RS31045 ENOG4107QQG Dehydrogenase CEB94_RS31065 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS31070 ENOG4105CHU acetyl-coa acetyltransferase CEB94_RS31075 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS31090 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS31095 ENOG4105EG2 ABC transporter, permease CEB94_RS31100 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) CEB94_RS31115 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CEB94_RS31130 ENOG4105TRI Hydrolase CEB94_RS31155 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CEB94_RS31165 ENOG4105C1Q protoporphyrinogen oxidase CEB94_RS31170 ENOG4107JTW chlorite dismutase CEB94_RS31200 ENOG4105E18 UPF0276 protein CEB94_RS31205 ENOG4107SVH Potassium channel protein CEB94_RS31240 ENOG4105CSR polyphosphate kinase 2 CEB94_RS31255 ENOG4105CHH sulfate transporter CEB94_RS31260 ENOG4107B2H carbonic anhydrase CEB94_RS31285 ENOG4105DFU Cell wall formation (By similarity) CEB94_RS31290 ENOG4105E0X reductase CEB94_RS31300 ENOG41060NJ transcriptional regulator CEB94_RS31310 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS31315 ENOG4105DRS transport system, permease CEB94_RS31320 ENOG4105C4C beta-galactosidase CEB94_RS31330 ENOG41081YB ApbE family CEB94_RS31345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS31350 ENOG4105BZU Histidine kinase CEB94_RS31355 ENOG4108IJ8 ABC transporter CEB94_RS31360 ENOG4105E90 ABC transporter CEB94_RS31365 ENOG4105E90 ABC transporter CEB94_RS31400 ENOG41082SX arsR family transcriptional regulator CEB94_RS31415 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CEB94_RS31440 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CEB94_RS31445 ENOG4105YA8 Transcriptional regulator CEB94_RS31455 ENOG4105IK6 Terpene synthase metal-binding domain-containing protein CEB94_RS31465 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) CEB94_RS31590 ENOG4107R13 MMPL domain protein CEB94_RS31630 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CEB94_RS31665 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CEB94_RS31675 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CEB94_RS31690 ENOG4107RR1 TRANSCRIPTIONal CEB94_RS31695 ENOG4105CSU acyl-Coa dehydrogenase CEB94_RS31710 ENOG4105E7U AraC family transcriptional regulator CEB94_RS31755 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS31770 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS31775 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS31795 ENOG4105EBR Carboxylesterase CEB94_RS31805 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS31810 ENOG4108J5H Homocysteine s-methyltransferase CEB94_RS31815 ENOG4105D5Q Arginine ornithine antiporter CEB94_RS31910 ENOG4105CJ1 ABC, transporter CEB94_RS31920 ENOG4105DRS transport system, permease CEB94_RS31950 ENOG4105QE3 oxidoreductase CEB94_RS31965 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) CEB94_RS31970 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CEB94_RS31995 ENOG4105C7K acetolactate synthase CEB94_RS32025 ENOG4105DRR Transcriptional regulator, GntR family CEB94_RS32050 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CEB94_RS32055 ENOG4105C7N Xanthine uracil vitamin C permease CEB94_RS32060 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family CEB94_RS32070 ENOG4108ZJ4 polysaccharide deacetylase CEB94_RS32080 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CEB94_RS32100 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) CEB94_RS32105 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS32110 ENOG4107T3P ABC, transporter CEB94_RS32125 ENOG4105CG3 alpha amylase, catalytic region CEB94_RS32145 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CEB94_RS32150 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CEB94_RS32155 ENOG4105CDH Citrulline--aspartate ligase CEB94_RS32180 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CEB94_RS32185 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CEB94_RS32190 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CEB94_RS32225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CEB94_RS32230 ENOG4105BZU Histidine kinase CEB94_RS32245 ENOG410645S MarR family Transcriptional regulator CEB94_RS32250 ENOG4105GTG Isochorismatase CEB94_RS32285 ENOG4105NDH peptidase s1 and s6 chymotrypsin hap CEB94_RS32300 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CEB94_RS32305 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS32315 ENOG4105XYF acetyltransferase CEB94_RS32325 ENOG41060W2 glyoxylate carboligase CEB94_RS32340 ENOG4105CH6 catalase CEB94_RS32345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CEB94_RS32350 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CEB94_RS32370 ENOG4105VT2 5-hydroxyisourate hydrolase CEB94_RS32380 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CEB94_RS32495 ENOG4105CHM Aminotransferase CEB94_RS32515 ENOG4105DUU IucA IucC family protein CEB94_RS32540 ENOG4105S6R Iron-hydroxamate transporter permease subunit CEB94_RS32545 ENOG4105J76 Periplasmic binding protein CEB94_RS32550 ENOG4105E0A ABC, transporter CEB94_RS32575 ENOG4107R9S Malate synthase CEB94_RS32590 ENOG4107HP6 Transcriptional regulator CEB94_RS32600 ENOG4105DHG Allantoate amidinohydrolase CEB94_RS32605 ENOG4105F6U Short-chain dehydrogenase reductase Sdr CEB94_RS32630 ENOG4108ZGX Histidine kinase CEB94_RS32635 ENOG4105WH1 Two component transcriptional regulator luxr family CEB94_RS32640 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CEB94_RS32650 ENOG4105DKQ ROK family CEB94_RS32660 ENOG4105C0D helicase CEB94_RS32700 ENOG41073TP transcriptional regulator CEB94_RS32715 ENOG4107EJG GntR family transcriptional regulator CEB94_RS32720 ENOG4105CXK mandelate racemase muconate lactonizing CEB94_RS32730 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS32740 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CEB94_RS32820 ENOG4106JUT Streptomycin 3''-adenylyltransferase CEB94_RS32920 ENOG4105CPQ Dehydrogenase CEB94_RS32940 ENOG4105CHR reductase CEB94_RS32950 ENOG4105CEY Amp-dependent synthetase and ligase CEB94_RS32955 ENOG4105WQT MbtH domain protein CEB94_RS32975 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CEB94_RS33050 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CEB94_RS33100 ENOG4105D0M Protease HtpX homolog CEB94_RS33215 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS33245 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CEB94_RS33290 ENOG4105CXK mandelate racemase muconate lactonizing CEB94_RS33300 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CEB94_RS33325 ENOG4105BZ1 (ABC) transporter CEB94_RS33335 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) CEB94_RS33405 ENOG4105BZP glycoside hydrolase 15-related CEB94_RS33440 ENOG4105VF7 tolerance protein CEB94_RS33450 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CEB94_RS33455 ENOG4105E8R UPF0173 metal-dependent hydrolase CEB94_RS33475 ENOG4105CDA abc transporter atp-binding protein CEB94_RS33480 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) CEB94_RS33490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CEB94_RS33495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEB94_RS33520 ENOG4105C8Y Acetylornithine aminotransferase CEB94_RS33535 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) CEB94_RS33545 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CEB94_RS33580 ENOG4105ECY inositol monophosphatase CEB94_RS33590 ENOG4108UVJ appr-1-p processing domain protein CEB94_RS33635 ENOG41066UM arsR family transcriptional regulator CEB94_RS33645 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CEB94_RS33655 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CEB94_RS33670 ENOG4105BZW Glycerate kinase CEB94_RS33680 ENOG41071I4 Phosphatidylserine decarboxylase proenzyme CEB94_RS33685 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS33695 ENOG4105CI0 Citrate lyase CEB94_RS33715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS33730 ENOG4106JDR secreted CEB94_RS33750 ENOG4108Q50 Histidine kinase CEB94_RS33805 ENOG4108PC0 lipolytic protein G-D-S-L family CEB94_RS33810 ENOG4108ME1 Peptidase M55 D-aminopeptidase CEB94_RS33815 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CEB94_RS33825 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CEB94_RS33860 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CEB94_RS33870 ENOG4105CV1 Transketolase (EC 2.2.1.1) CEB94_RS33875 ENOG4105DQE DNA ligase CEB94_RS33885 ENOG4105MRC Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth CEB94_RS33910 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) CEB94_RS33920 ENOG4105W2E Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity) CEB94_RS33965 ENOG4105CH6 catalase CEB94_RS33975 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CEB94_RS34010 ENOG4105C9U ATP-dependent DNA helicase RecQ CEB94_RS34095 ENOG4105DQR SNARE associated Golgi CEB94_RS34140 ENOG4105CFG Acts as a chaperone (By similarity) CEB94_RS34170 ENOG4106GCT Dehydratase CEB94_RS34175 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CEB94_RS34185 ENOG4105CYP glycoside hydrolase, family CEB94_RS34190 ENOG41065HY 1,4-beta-cellobiosidase CEB94_RS34200 ENOG4105CV8 reductase CEB94_RS34210 ENOG4105DUM transcriptional regulator, lysR family CEB94_RS34215 ENOG4105DHU Bile acid CEB94_RS34225 ENOG4108478 ec 3.2.1.18 CEB94_RS34240 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CEB94_RS34250 ENOG4107QIZ NADH dehydrogenase CEB94_RS34255 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CEB94_RS34260 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CEB94_RS34275 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CEB94_RS34285 ENOG4105DKQ ROK family CEB94_RS34290 ENOG4105C2J ABC transporter CEB94_RS34295 ENOG4105CNN ABC, transporter CEB94_RS34300 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CEB94_RS34325 ENOG4105DB3 bacteriochlorophyll chlorophyll a synthase CEB94_RS34370 ENOG4105FCD Major Facilitator CEB94_RS34390 ENOG4105CMV Succinyl-CoA synthetase subunit beta CEB94_RS34400 ENOG4105C26 Dehydrogenase CEB94_RS34435 ENOG4108YYC ycei family CEB94_RS34440 ENOG4108NVJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CEB94_RS34460 ENOG4107RRN ABC transporter substrate-binding protein CEB94_RS34465 ENOG4108UQ8 endoribonuclease L-psp CEB94_RS34470 ENOG4105KVH Transcriptional regulator CEB94_RS34475 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CEB94_RS34490 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS34505 ENOG4107QJN gtp cyclohydrolase ii CEB94_RS34525 ENOG4105CSH Transporter CEB94_RS34535 ENOG4107S9B Shikimate dehydrogenase CEB94_RS34550 ENOG4107TB6 phosphoglycerate mutase CEB94_RS34555 ENOG4108J5G 6-phosphogluconate dehydrogenase CEB94_RS34560 ENOG4107QP8 phosphohexose isomerase CEB94_RS34575 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CEB94_RS34605 ENOG4108KEZ Dehydrogenase CEB94_RS34625 ENOG4105CSH Transporter CEB94_RS34635 ENOG4105CHR reductase CEB94_RS34665 ENOG41088CQ domain protein CEB94_RS34670 ENOG4105CNT hydrolase family 2 CEB94_RS34675 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CEB94_RS34695 ENOG4108MGF sugar kinase CEB94_RS34705 ENOG4105F8D glycoside hydrolase family 4 CEB94_RS34755 ENOG4105MWK D-amino acid dehydrogenase, small subunit CEB94_RS34765 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein CEB94_RS34775 ENOG4105CTU Proline racemase CEB94_RS34810 ENOG4105CSH Transporter CEB94_RS34845 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) CEB94_RS34850 ENOG4105CSH Transporter CEB94_RS34865 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CEB94_RS34870 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CEB94_RS34875 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha CEB94_RS34900 ENOG41067TZ transcriptional regulator, MarR family CEB94_RS34920 ENOG4105DQE DNA ligase CEB94_RS34940 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS34950 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CEB94_RS34960 ENOG4106V2I dimethylaminohydrolase CEB94_RS34965 ENOG4105CXN decarboxylase CEB94_RS34970 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CEB94_RS34975 ENOG4105C5H ABC transporter CEB94_RS35005 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CEB94_RS35015 ENOG4105EG6 Saccharopine dehydrogenase CEB94_RS35025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CEB94_RS35030 ENOG4105CHU acetyl-coa acetyltransferase CEB94_RS35035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS35070 ENOG4105C94 Transporter CEB94_RS35085 ENOG4105C5H ABC transporter CEB94_RS35090 ENOG4105BZM domain protein CEB94_RS35110 ENOG4105E39 Enoyl-CoA hydratase CEB94_RS35120 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CEB94_RS35145 ENOG4108MDK Dehydrogenase CEB94_RS35165 ENOG4105EY8 ABC transporter CEB94_RS35170 ENOG4105FBD synthase CEB94_RS35180 ENOG4107S11 squalene-associated FAD-dependent desaturase CEB94_RS35205 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CEB94_RS35250 ENOG41090WU lipolytic protein G-D-S-L family CEB94_RS35315 ENOG4105CPQ Dehydrogenase CEB94_RS35320 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CEB94_RS35325 ENOG4106NZI LysR family Transcriptional regulator CEB94_RS35395 ENOG4108IMY Transcriptional regulator CEB94_RS35400 ENOG4105H1N peptidase, M24 CEB94_RS35405 ENOG4107RUY (E1 component), alpha subunit CEB94_RS35415 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CEB94_RS35525 ENOG4105FDP GntR family transcriptional regulator CEB94_RS35530 ENOG4105C26 Dehydrogenase CEB94_RS35535 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CEB94_RS35540 ENOG4105DH8 myo-inositol catabolism CEB94_RS35550 ENOG4105EDK PfkB domain protein CEB94_RS35560 ENOG4105CNN ABC, transporter CEB94_RS35565 ENOG4105C2J ABC transporter CEB94_RS35570 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CEB94_RS35575 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CEB94_RS35590 ENOG4105CHR reductase CEB94_RS35600 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS35615 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS35645 ENOG4107Q25 Serine Threonine protein kinase CEB94_RS35655 ENOG4105EPJ extracellular solute-binding protein family 1 CEB94_RS35665 ENOG4106S2D Transcriptional regulator CEB94_RS35690 ENOG4106A3M Cytochrome p-450 CEB94_RS35705 ENOG4105E9K Isocitrate dehydrogenase CEB94_RS35715 ENOG4105D64 Mechanosensitive ion channel CEB94_RS35725 ENOG4105BZ1 (ABC) transporter CEB94_RS35735 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CEB94_RS35740 ENOG4108V9W transcriptional regulatory protein CEB94_RS35760 ENOG4105DQ5 transport system permease protein CEB94_RS35765 ENOG4105TVJ transport system, permease CEB94_RS35770 ENOG4105E0A ABC, transporter CEB94_RS35775 ENOG4108HUF Transporter CEB94_RS35780 ENOG4105BZ1 (ABC) transporter CEB94_RS35790 ENOG4105BZ1 (ABC) transporter CEB94_RS35795 ENOG4105E93 esterase CEB94_RS35815 ENOG4105CAS nag kinase CEB94_RS35885 ENOG4107TPY serine threonine protein kinase CEB94_RS35890 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) CEB94_RS35925 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CEB94_RS35970 ENOG4105C4R Atp-dependent dna helicase CEB94_RS36010 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CEB94_RS36020 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CEB94_RS36040 ENOG4107QPH glycogen) synthase CEB94_RS36045 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CEB94_RS36090 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CEB94_RS36095 ENOG41073TP transcriptional regulator CEB94_RS36105 ENOG4105C2J ABC transporter CEB94_RS36115 ENOG4105DIA mandelate racemase muconate lactonizing CEB94_RS36120 ENOG4105CHR reductase CEB94_RS36160 ENOG4107SGM protein serine threonine phosphatase CEB94_RS36195 ENOG4105CRK lysyL-tRNA synthetase CEB94_RS36200 ENOG4108ZJ4 polysaccharide deacetylase CEB94_RS36240 ENOG4105BZU Histidine kinase CEB94_RS36245 ENOG4105C5Q Transcriptional regulator CEB94_RS36260 ENOG4105E33 succinate dehydrogenase CEB94_RS36275 ENOG4108Z20 Acyl-transferase CEB94_RS36290 ENOG4105DEN Luciferase family CEB94_RS36300 ENOG41068HZ 50S ribosomal protein L32 CEB94_RS36305 ENOG4107QN1 sodium solute CEB94_RS36320 ENOG4105WKW Pfam:DUF1458 CEB94_RS36325 ENOG41067HS methyltransferase CEB94_RS36330 ENOG4108V75 Glutamine amidotransferase CEB94_RS36335 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process CEB94_RS36340 ENOG4105D1K glutamate--cysteine ligase CEB94_RS36355 ENOG4105DZ6 Band 7 protein CEB94_RS36395 ENOG4108DT4 serine threonine protein kinase CEB94_RS36420 ENOG4108V1U phospholipid-binding protein CEB94_RS36455 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CEB94_RS36475 ENOG4107RSM transcriptional regulator CEB94_RS36485 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit CEB94_RS36490 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding CEB94_RS36495 ENOG4105C7W Xanthine dehydrogenase CEB94_RS36515 ENOG41060NJ transcriptional regulator CEB94_RS36525 ENOG41080RH Thioredoxin CEB94_RS36540 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CEB94_RS36560 ENOG4105EUB pirin domain protein CEB94_RS36595 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CEB94_RS36605 ENOG4105HX0 Transcriptional regulator CEB94_RS36615 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) CEB94_RS36620 ENOG4105E98 transcriptional regulator DeoR family CEB94_RS36640 ENOG4105E6M Sulphatase-modifying factor protein CEB94_RS36645 ENOG4105CBG Sulfatase CEB94_RS36655 ENOG4105CQF Transcriptional regulator CEB94_RS36715 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CEB94_RS36725 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CEB94_RS36730 ENOG4106A3M Cytochrome p-450 CEB94_RS36775 ENOG4108IG5 Transcriptional regulator CEB94_RS36800 ENOG4105DYW oxidoreductase CEB94_RS36840 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CEB94_RS36865 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CEB94_RS36885 ENOG4105CSH Transporter CEB94_RS36915 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase CEB94_RS36920 ENOG410680H amp-dependent synthetase and ligase CEB94_RS36925 ENOG4108J2P Alpha beta hydrolase fold CEB94_RS36930 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CEB94_RS36940 ENOG4105BZ1 (ABC) transporter CEB94_RS36945 ENOG4107S5I aldo keto reductase CEB94_RS36965 ENOG4107R6F Alpha Beta Hydrolase Fold protein CEB94_RS36975 ENOG4108JJB ABC transporter CEB94_RS36990 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) CEB94_RS37005 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CEB94_RS37030 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CEB94_RS37060 ENOG4107S9D Alpha beta hydrolase CEB94_RS37065 ENOG4105CC5 ABC transporter CEB94_RS37070 ENOG4105DIK (ABC) transporter CEB94_RS37075 ENOG4105DSE periplasmic solute binding protein CEB94_RS37100 ENOG4105CHR reductase CEB94_RS37110 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CEB94_RS37125 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CEB94_RS37135 ENOG41080R8 Conserved Protein CEB94_RS37145 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CEB94_RS37150 ENOG4105DET Rhamnulokinase CEB94_RS37165 ENOG4105C2J ABC transporter CEB94_RS37170 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane CEB94_RS37195 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS37210 ENOG4108KPJ rna polymerase sigma factor CEB94_RS37215 ENOG4105DDN Pentapeptide repeat-containing protein CEB94_RS37220 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CEB94_RS37225 ENOG4108R86 Transcriptional regulator CEB94_RS37235 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CEB94_RS37260 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CEB94_RS37285 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 CEB94_RS37290 ENOG4105DCG PHP domain protein CEB94_RS37295 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CEB94_RS37320 ENOG4105RV9 Transcriptional regulator CEB94_RS37325 ENOG4105C26 Dehydrogenase CEB94_RS37385 ENOG4105CHF Glutathione S-transferase CEB94_RS37405 ENOG4106YKD Cytochrome p-450 CEB94_RS37455 ENOG4105CNT hydrolase family 2 CEB94_RS37470 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CEB94_RS37495 ENOG4105DMF Dehydrogenase CEB94_RS37520 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) CEB94_RS37545 ENOG4108JJA ABC, transporter CEB94_RS37590 ENOG4105CJA serine threonine protein kinase CEB94_RS37600 ENOG4107R7Y intracellular protease Pfpi family CEB94_RS37610 ENOG41080XP Cbs domain CEB94_RS37620 ENOG4107V9E glucose-1-phosphate thymidylyltransferase CEB94_RS37640 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CEB94_RS37675 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CEB94_RS37685 ENOG4105XRQ Xanthine dehydrogenase accessory factor CEB94_RS37715 ENOG4105BZ9 Cytochrome C oxidase, subunit I CEB94_RS37755 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CEB94_RS37760 ENOG4105CHR reductase CEB94_RS37785 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CEB94_RS37790 ENOG4105E2R ROK family CEB94_RS37815 ENOG4105C87 Aminotransferase class I and II CEB94_RS37825 ENOG4105DDC Oxidoreductase domain protein CEB94_RS37895 ENOG41066F8 ROK family CEB94_RS37905 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component CEB94_RS37910 ENOG4105DRS transport system, permease CEB94_RS37950 ENOG4105D9G High-affinity CEB94_RS37990 ENOG4105D9R oxidoreductase CEB94_RS37995 ENOG4105EEM helicase CEB94_RS38000 ENOG4105F0H myo-inositol catabolism protein CEB94_RS38010 ENOG4107QNK )-transporter CEB94_RS38020 ENOG41060NJ transcriptional regulator CEB94_RS38030 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase CEB94_RS38035 ENOG4107S5I aldo keto reductase CEB94_RS38070 ENOG4107RCI amp-dependent synthetase and ligase CEB94_RS38075 ENOG4105D8K carboxyl transferase CEB94_RS38080 ENOG4108FN7 Aldo keto reductase CEB94_RS38095 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS38130 ENOG4105C7W Xanthine dehydrogenase CEB94_RS38135 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding CEB94_RS38140 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit CEB94_RS38170 ENOG4105CSR polyphosphate kinase 2 CEB94_RS38175 ENOG4105DSG hydrolase family 43 CEB94_RS38180 ENOG4108KEZ Dehydrogenase CEB94_RS38195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CEB94_RS38200 ENOG4105EUJ GTP cyclohydrolase i CEB94_RS38215 ENOG4105CX8 fg-gap repeat protein CEB94_RS38230 ENOG4107TDE lipolytic protein G-D-S-L family CEB94_RS38240 ENOG4105DND Transcriptional regulator CEB94_RS38245 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CEB94_RS38250 ENOG4105F76 Sarcosine oxidase CEB94_RS38265 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CEB94_RS38275 ENOG4105D2N Aldolase CEB94_RS38290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CEB94_RS38320 ENOG4105D38 putrescine abc transporter CEB94_RS38330 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CEB94_RS38360 ENOG4105CJP fad dependent oxidoreductase CEB94_RS38380 ENOG4105ECQ AraC Family Transcriptional Regulator CEB94_RS38410 ENOG4105D22 carbon starvation protein CEB94_RS38430 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator CEB94_RS38435 ENOG4105C2J ABC transporter CEB94_RS38440 ENOG4107R9N ABC transporter CEB94_RS38445 ENOG41062B0 ABC transporter, permease CEB94_RS38495 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CEB94_RS38555 ENOG4108JQ7 (ABC) transporter CEB94_RS38620 ENOG4108KQ5 Integrase catalytic subunit CEB94_RS38625 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) CEB94_RS38635 ENOG4108YYC ycei family CEB94_RS38655 ENOG4105NX3 Membrane CEB94_RS38705 ENOG4105CQB FAD linked oxidase domain protein CEB94_RS38710 ENOG4107MVR Transcriptional regulator CEB94_RS38740 ENOG4108JGH Tetr family transcriptional regulator CEB94_RS38850 ENOG4108IAJ Nad-dependent epimerase dehydratase CEB94_RS38860 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CEB94_RS38875 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CEB94_RS38885 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CEB94_RS38890 ENOG4105EBM Alpha Beta Hydrolase Fold protein CEB94_RS38930 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS38935 ENOG4108JE9 extracellular solute-binding protein family 1 CEB94_RS38945 ENOG4105EG2 ABC transporter, permease CEB94_RS39010 ENOG4105ESN nucleotide-binding protein CEB94_RS39035 ENOG4105KBH arsR family transcriptional regulator CEB94_RS39055 ENOG4105D9P serine threonine protein kinase CEB94_RS39070 ENOG4105D9P serine threonine protein kinase CEB94_RS39080 ENOG4105EMU Dehydrogenase CEB94_RS39085 ENOG4107E6A Cytochrome p-450 CEB94_RS39140 ENOG41061ZR Transcriptional regulator CEB94_RS39165 ENOG4105C1G acyl-Coa dehydrogenase CEB94_RS39170 ENOG4105BZJ Electron transfer flavoprotein CEB94_RS39175 ENOG4105C10 Electron transfer flavoprotein CEB94_RS39200 ENOG4107RSM transcriptional regulator CEB94_RS39205 ENOG4105CPQ Dehydrogenase CEB94_RS39220 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CEB94_RS39230 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS39235 ENOG4105ERH Fumarylacetoacetate hydrolase CEB94_RS39240 ENOG4108SC4 )-transporter CEB94_RS39285 ENOG4105VEQ Cold shock protein CEB94_RS39290 ENOG4105C1J atp-dependent rna helicase CEB94_RS39320 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CEB94_RS39325 ENOG4105C32 Amino acid ABC transporter (Permease) CEB94_RS39335 ENOG4105C0Z ABC transporter CEB94_RS39340 ENOG4108IV0 ABC, transporter CEB94_RS39350 ENOG4105VEQ Cold shock protein CEB94_RS39365 ENOG4105CN5 Metallo-Beta-Lactamase CEB94_RS39370 ENOG4107ZTW SNARE associated Golgi CEB94_RS39470 ENOG4105ESF Peptidoglycan binding domain protein CEB94_RS39500 ENOG4105C26 Dehydrogenase CEB94_RS39510 ENOG4105ETE Transcriptional regulator (LacI family CEB94_RS39515 ENOG4105EPJ extracellular solute-binding protein family 1 CEB94_RS39520 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CEB94_RS39540 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CEB94_RS39570 ENOG4106UW1 Major Facilitator superfamily CEB94_RS39670 ENOG4105DUM transcriptional regulator, lysR family CEB94_RS39715 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CEB94_RS39720 ENOG4105DQU oxidoreductase, subunit beta CEB94_RS39815 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CEB94_RS39850 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 CEB94_RS39865 ENOG4105PAD Hydrolase CEB94_RS39985 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CEB94_RS39990 ENOG4105CPC Aldo Keto reductase CEB94_RS40000 ENOG4108SGK Tetr family transcriptional regulator CEB94_RS40150 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CEB94_RS40185 ENOG4105I6B RNA polymerase CEB94_RS40280 ENOG4105KVH Transcriptional regulator CEB94_RS40290 ENOG4105C57 major facilitator superfamily