locus-tag	class	description
DWB77_RS00070	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS00110	COG3631	Ketosteroid isomerase-related protein
DWB77_RS00120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS00135	COG1309	transcriptional regulator
DWB77_RS00145	COG1073	alpha beta
DWB77_RS00185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB77_RS00235	COG2226	methyltransferase
DWB77_RS00265	COG0113	porphobilinogen synthase activity
DWB77_RS00360	COG0791	NLP P60 protein
DWB77_RS00360	COG3883	PFAM NLP P60 protein
DWB77_RS00460	COG3335	DDE superfamily endonuclease
DWB77_RS00475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS00495	COG3321	synthase
DWB77_RS00495	COG0604	alcohol dehydrogenase
DWB77_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS00515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB77_RS00560	COG2124	cytochrome p450
DWB77_RS00580	COG2409	Drug exporters of the RND superfamily
DWB77_RS00590	COG1309	transcriptional regulator
DWB77_RS00615	COG0515	serine threonine protein kinase
DWB77_RS00615	COG2815	serine threonine protein kinase
DWB77_RS00640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB77_RS00660	COG3335	DDE superfamily endonuclease
DWB77_RS00665	COG2124	cytochrome p450
DWB77_RS00690	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS00695	COG1309	transcriptional regulator
DWB77_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS00720	COG0667	Aldo Keto reductase
DWB77_RS00725	COG3321	synthase
DWB77_RS00725	COG0604	alcohol dehydrogenase
DWB77_RS00730	COG2267	carboxylic ester hydrolase activity
DWB77_RS00750	COG0500	methyltransferase
DWB77_RS00755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB77_RS00785	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS00800	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS00815	COG3483	tryptophan 2,3-dioxygenase activity
DWB77_RS00870	COG2814	Major facilitator Superfamily
DWB77_RS00885	COG1247	-acetyltransferase
DWB77_RS00890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB77_RS00895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB77_RS00900	COG0640	Transcriptional regulator
DWB77_RS00945	COG0604	alcohol dehydrogenase
DWB77_RS00945	COG3321	synthase
DWB77_RS00950	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB77_RS00955	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DWB77_RS00955	COG2070	2-Nitropropane dioxygenase
DWB77_RS00995	COG1846	Transcriptional regulator
DWB77_RS01060	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS01060	COG0569	domain protein
DWB77_RS01130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB77_RS01135	COG1063	alcohol dehydrogenase
DWB77_RS01185	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS01205	COG1335	isochorismatase
DWB77_RS01330	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DWB77_RS01365	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWB77_RS01395	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB77_RS01460	COG0745	RESPONSE REGULATOR receiver
DWB77_RS01480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB77_RS01530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS01575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS01580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS01590	COG3335	DDE superfamily endonuclease
DWB77_RS01675	COG1191	sigma factor activity
DWB77_RS01705	COG2208	phosphoserine phosphatase activity
DWB77_RS01705	COG2770	Histidine kinase
DWB77_RS01715	COG2172	sigma factor antagonist activity
DWB77_RS01720	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS01725	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS01795	COG0222	ribosome binding
DWB77_RS01865	COG0640	Transcriptional regulator
DWB77_RS01910	COG2409	Drug exporters of the RND superfamily
DWB77_RS01915	COG1846	Transcriptional regulator
DWB77_RS01935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS02045	COG3335	DDE superfamily endonuclease
DWB77_RS02120	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS02140	COG2124	cytochrome p450
DWB77_RS02235	COG2175	clavaminate synthase activity
DWB77_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS02275	COG2124	cytochrome p450
DWB77_RS02280	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS02295	COG1846	Transcriptional regulator
DWB77_RS02310	COG1476	TRANSCRIPTIONal
DWB77_RS02320	COG1609	Transcriptional regulator
DWB77_RS02325	COG1609	Transcriptional regulator
DWB77_RS02330	COG3250	beta-galactosidase activity
DWB77_RS02340	COG1175	transmembrane transport
DWB77_RS02350	COG2909	trisaccharide binding
DWB77_RS02355	COG3866	Pectate lyase
DWB77_RS02370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS02385	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DWB77_RS02390	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DWB77_RS02395	COG0531	amino acid
DWB77_RS02435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS02445	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS02470	COG0509	glycine decarboxylation via glycine cleavage system
DWB77_RS02535	COG3335	DDE superfamily endonuclease
DWB77_RS02575	COG2226	methyltransferase
DWB77_RS02620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB77_RS02630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS02665	COG2267	carboxylic ester hydrolase activity
DWB77_RS02750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS02755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS02775	COG0583	DNA-binding transcription factor activity
DWB77_RS02780	COG0604	alcohol dehydrogenase
DWB77_RS02820	COG2208	phosphoserine phosphatase activity
DWB77_RS02830	COG0513	Belongs to the DEAD box helicase family
DWB77_RS02835	COG1278	Cold shock
DWB77_RS02955	COG1733	regulation of RNA biosynthetic process
DWB77_RS02970	COG1595	DNA-templated transcription, initiation
DWB77_RS02985	COG1846	Transcriptional regulator
DWB77_RS03060	COG2267	carboxylic ester hydrolase activity
DWB77_RS03070	COG4977	sequence-specific DNA binding
DWB77_RS03095	COG1309	transcriptional regulator
DWB77_RS03105	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DWB77_RS03115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWB77_RS03140	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
DWB77_RS03145	COG0477	Major facilitator Superfamily
DWB77_RS03150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB77_RS03155	COG1090	epimerase
DWB77_RS03160	COG2197	response regulator
DWB77_RS03170	COG0583	DNA-binding transcription factor activity
DWB77_RS03225	COG2186	Transcriptional regulator
DWB77_RS03230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB77_RS03235	COG2223	nitrite transmembrane transporter activity
DWB77_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS03275	COG2223	nitrite transmembrane transporter activity
DWB77_RS03280	COG0243	molybdopterin cofactor binding
DWB77_RS03290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB77_RS03290	COG2146	nitrite reductase [NAD(P)H] activity
DWB77_RS03320	COG1404	Belongs to the peptidase S8 family
DWB77_RS03385	COG2226	methyltransferase
DWB77_RS03390	COG0640	Transcriptional regulator
DWB77_RS03395	COG0798	PFAM Bile acid sodium symporter
DWB77_RS03440	COG1695	Transcriptional regulator
DWB77_RS03450	COG1733	regulation of RNA biosynthetic process
DWB77_RS03475	COG3629	intracellular signal transduction
DWB77_RS03475	COG3903	Transcriptional regulator
DWB77_RS03485	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB77_RS03505	COG0483	inositol monophosphate 1-phosphatase activity
DWB77_RS03510	COG0583	DNA-binding transcription factor activity
DWB77_RS03580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DWB77_RS03595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DWB77_RS03665	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWB77_RS03675	COG1605	Chorismate mutase
DWB77_RS03680	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB77_RS03680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB77_RS03700	COG1228	amidohydrolase
DWB77_RS03755	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DWB77_RS03775	COG0367	asparagine synthase
DWB77_RS03800	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS03810	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWB77_RS03825	COG4310	Domain of unknown function (DUF2172)
DWB77_RS03835	COG1215	transferase activity, transferring glycosyl groups
DWB77_RS03845	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DWB77_RS03850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB77_RS03875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS03895	COG4585	Histidine kinase
DWB77_RS03900	COG2197	response regulator
DWB77_RS03920	COG1022	Amp-dependent synthetase and ligase
DWB77_RS03925	COG0367	asparagine synthase
DWB77_RS03930	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWB77_RS03945	COG2072	flavoprotein involved in K transport
DWB77_RS03965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DWB77_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS03975	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB77_RS03980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB77_RS03990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS04015	COG2409	Drug exporters of the RND superfamily
DWB77_RS04045	COG1755	Isoprenylcysteine carboxyl methyltransferase
DWB77_RS04070	COG0189	ligase activity
DWB77_RS04095	COG2205	protein histidine kinase activity
DWB77_RS04100	COG0745	RESPONSE REGULATOR receiver
DWB77_RS04105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB77_RS04105	COG1017	nitric oxide dioxygenase activity
DWB77_RS04135	COG2208	phosphoserine phosphatase activity
DWB77_RS04150	COG1733	regulation of RNA biosynthetic process
DWB77_RS04155	COG0702	epimerase
DWB77_RS04165	COG1309	transcriptional regulator
DWB77_RS04195	COG2197	response regulator
DWB77_RS04200	COG4585	Histidine kinase
DWB77_RS04240	COG0300	oxidoreductase activity
DWB77_RS04275	COG1295	ribonuclease BN
DWB77_RS04275	COG1959	2 iron, 2 sulfur cluster binding
DWB77_RS04285	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS04310	COG3135	benzoate transporter
DWB77_RS04315	COG0442	prolyl-tRNA aminoacylation
DWB77_RS04330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWB77_RS04335	COG3835	regulator
DWB77_RS04365	COG0596	Alpha beta hydrolase
DWB77_RS04395	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS04400	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS04405	COG2172	sigma factor antagonist activity
DWB77_RS04430	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS04485	COG4221	oxidoreductase activity
DWB77_RS04490	COG2226	methyltransferase
DWB77_RS04530	COG1280	lysine exporter protein (LysE YggA)
DWB77_RS04580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB77_RS04585	COG2233	PERMEase
DWB77_RS04590	COG0402	S-adenosylhomocysteine deaminase activity
DWB77_RS04625	COG3903	Transcriptional regulator
DWB77_RS04625	COG3629	intracellular signal transduction
DWB77_RS04675	COG2208	phosphoserine phosphatase activity
DWB77_RS04675	COG2770	Histidine kinase
DWB77_RS04680	COG2378	regulation of single-species biofilm formation
DWB77_RS04715	COG1073	alpha beta
DWB77_RS04725	COG0135	phosphoribosylanthranilate isomerase activity
DWB77_RS04735	COG1309	transcriptional regulator
DWB77_RS04795	COG1335	isochorismatase
DWB77_RS04805	COG2814	Major facilitator Superfamily
DWB77_RS04810	COG2267	carboxylic ester hydrolase activity
DWB77_RS04830	COG0596	Alpha beta hydrolase
DWB77_RS04835	COG0288	reversible hydration of carbon dioxide
DWB77_RS04850	COG1191	sigma factor activity
DWB77_RS04905	COG0483	inositol monophosphate 1-phosphatase activity
DWB77_RS04915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB77_RS04925	COG0477	Major facilitator Superfamily
DWB77_RS04940	COG1280	lysine exporter protein (LysE YggA)
DWB77_RS04955	COG0574	Belongs to the PEP-utilizing enzyme family
DWB77_RS04955	COG3848	Pyruvate phosphate dikinase
DWB77_RS04965	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DWB77_RS04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB77_RS05005	COG0242	peptide deformylase activity
DWB77_RS05010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DWB77_RS05075	COG2198	Histidine kinase
DWB77_RS05075	COG2205	protein histidine kinase activity
DWB77_RS05075	COG0784	Response regulator, receiver
DWB77_RS05125	COG4221	oxidoreductase activity
DWB77_RS05150	COG0477	Major facilitator Superfamily
DWB77_RS05165	COG0477	Major facilitator Superfamily
DWB77_RS05175	COG1295	ribonuclease BN
DWB77_RS05215	COG2208	phosphoserine phosphatase activity
DWB77_RS05215	COG2770	Histidine kinase
DWB77_RS05220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWB77_RS05225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DWB77_RS05230	COG2080	2 iron, 2 sulfur cluster binding
DWB77_RS05235	COG0783	Belongs to the Dps family
DWB77_RS05255	COG1191	sigma factor activity
DWB77_RS05265	COG0702	epimerase
DWB77_RS05270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DWB77_RS05285	COG2205	protein histidine kinase activity
DWB77_RS05285	COG5002	protein histidine kinase activity
DWB77_RS05285	COG0784	Response regulator, receiver
DWB77_RS05300	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB77_RS05320	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB77_RS05325	COG1595	DNA-templated transcription, initiation
DWB77_RS05340	COG0187	DNA topoisomerase II activity
DWB77_RS05355	COG1070	Carbohydrate kinase
DWB77_RS05415	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWB77_RS05420	COG0693	protein deglycase activity
DWB77_RS05425	COG0300	oxidoreductase activity
DWB77_RS05430	COG4948	Mandelate Racemase Muconate Lactonizing
DWB77_RS05435	COG0028	Belongs to the TPP enzyme family
DWB77_RS05440	COG0277	FAD linked oxidase domain protein
DWB77_RS05440	COG0247	lactate metabolic process
DWB77_RS05445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS05455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB77_RS05530	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS05535	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS05545	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS05550	COG1024	Enoyl-CoA hydratase
DWB77_RS05570	COG4591	ABC-type transport system involved in lipoprotein release permease component
DWB77_RS05570	COG1136	(ABC) transporter
DWB77_RS05575	COG1136	(ABC) transporter
DWB77_RS05575	COG0577	efflux transmembrane transporter activity
DWB77_RS05585	COG0745	RESPONSE REGULATOR receiver
DWB77_RS05590	COG2205	protein histidine kinase activity
DWB77_RS05595	COG1125	glycine betaine transport
DWB77_RS05595	COG0517	IMP dehydrogenase activity
DWB77_RS05610	COG1174	glycine betaine transport
DWB77_RS05615	COG1174	glycine betaine transport
DWB77_RS05625	COG1228	amidohydrolase
DWB77_RS05635	COG4948	Mandelate Racemase Muconate Lactonizing
DWB77_RS05660	COG4214	carbohydrate transport
DWB77_RS05670	COG3386	PFAM SMP-30 Gluconolaconase
DWB77_RS05675	COG1414	Transcriptional regulator
DWB77_RS05750	COG4044	May play a role in the intracellular transport of hydrophobic ligands
DWB77_RS05785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB77_RS05825	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS05835	COG1819	glycosyl
DWB77_RS05850	COG1595	DNA-templated transcription, initiation
DWB77_RS05890	COG1131	(ABC) transporter
DWB77_RS05890	COG0842	Transport permease protein
DWB77_RS05890	COG1716	ATPase activity
DWB77_RS05900	COG0495	leucyl-tRNA aminoacylation
DWB77_RS05925	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS05930	COG0697	spore germination
DWB77_RS05950	COG3977	Valine--pyruvate aminotransferase
DWB77_RS05955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS05955	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DWB77_RS05965	COG0662	Cupin 2, conserved barrel domain protein
DWB77_RS05975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB77_RS05985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB77_RS06025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS06045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS06055	COG2226	methyltransferase
DWB77_RS06120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
DWB77_RS06150	COG0330	HflC and HflK could
DWB77_RS06185	COG1309	transcriptional regulator
DWB77_RS06225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB77_RS06240	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS06250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB77_RS06255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWB77_RS06285	COG0183	Belongs to the thiolase family
DWB77_RS06295	COG1609	Transcriptional regulator
DWB77_RS06305	COG0596	Alpha beta hydrolase
DWB77_RS06320	COG0531	amino acid
DWB77_RS06325	COG1940	carbohydrate kinase activity
DWB77_RS06330	COG3250	beta-galactosidase activity
DWB77_RS06340	COG3858	chitin binding
DWB77_RS06355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DWB77_RS06360	COG0121	glutamine amidotransferase
DWB77_RS06365	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DWB77_RS06390	COG2182	Extracellular solute-binding protein
DWB77_RS06410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS06440	COG3979	chitinase
DWB77_RS06445	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB77_RS06450	COG1053	succinate dehydrogenase
DWB77_RS06460	COG0583	DNA-binding transcription factor activity
DWB77_RS06505	COG0726	polysaccharide deacetylase
DWB77_RS06510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWB77_RS06510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB77_RS06540	COG3275	phosphorelay sensor kinase activity
DWB77_RS06545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB77_RS06565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB77_RS06585	COG0823	Involved in the tonB-independent uptake of proteins
DWB77_RS06585	COG1506	peptidase
DWB77_RS06595	COG0542	response to heat
DWB77_RS06620	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWB77_RS06635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DWB77_RS06650	COG0501	Belongs to the peptidase M48B family
DWB77_RS06660	COG0586	Pfam SNARE associated Golgi protein
DWB77_RS06665	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS06730	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS06735	COG1285	pathogenesis
DWB77_RS06750	COG1556	Lactate utilization protein
DWB77_RS06755	COG1139	Iron-sulfur cluster binding protein
DWB77_RS06760	COG0247	lactate metabolic process
DWB77_RS06775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB77_RS06780	COG1349	DNA-binding transcription factor activity
DWB77_RS06800	COG0604	alcohol dehydrogenase
DWB77_RS06850	COG0673	inositol 2-dehydrogenase activity
DWB77_RS06855	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS06960	COG2365	Tyrosine phosphatase family
DWB77_RS06975	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWB77_RS06990	COG1657	PFAM Prenyltransferase squalene oxidase
DWB77_RS07000	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB77_RS07015	COG1134	teichoic acid transport
DWB77_RS07035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB77_RS07055	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DWB77_RS07070	COG1024	Enoyl-CoA hydratase
DWB77_RS07080	COG4977	sequence-specific DNA binding
DWB77_RS07090	COG2183	response to ionizing radiation
DWB77_RS07095	COG0488	(ABC) transporter
DWB77_RS07110	COG2936	dipeptidyl-peptidase activity
DWB77_RS07130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB77_RS07145	COG1024	Enoyl-CoA hydratase
DWB77_RS07145	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB77_RS07150	COG0183	Belongs to the thiolase family
DWB77_RS07155	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS07160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWB77_RS07165	COG3268	Saccharopine dehydrogenase
DWB77_RS07170	COG1515	deoxyribonuclease V activity
DWB77_RS07190	COG0488	(ABC) transporter
DWB77_RS07210	COG2188	Transcriptional regulator
DWB77_RS07215	COG1263	PTS System
DWB77_RS07230	COG1793	dna ligase
DWB77_RS07275	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DWB77_RS07290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DWB77_RS07335	COG4413	Urea transporter
DWB77_RS07345	COG3012	SEC-C Motif Domain Protein
DWB77_RS07360	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
DWB77_RS07390	COG0583	DNA-binding transcription factor activity
DWB77_RS07395	COG0156	8-amino-7-oxononanoate synthase activity
DWB77_RS07400	COG1063	alcohol dehydrogenase
DWB77_RS07420	COG3629	intracellular signal transduction
DWB77_RS07420	COG3903	Transcriptional regulator
DWB77_RS07460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB77_RS07465	COG3511	phospholipase C
DWB77_RS07485	COG0137	argininosuccinate synthase activity
DWB77_RS07530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB77_RS07535	COG3291	Pkd domain containing protein
DWB77_RS07555	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS07575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS07590	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWB77_RS07615	COG3321	synthase
DWB77_RS07615	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS07615	COG0604	alcohol dehydrogenase
DWB77_RS07645	COG3469	chitinase activity
DWB77_RS07660	COG0656	L-ascorbic acid biosynthetic process
DWB77_RS07690	COG2154	pterin-4-alpha-carbinolamine dehydratase
DWB77_RS07700	COG5002	protein histidine kinase activity
DWB77_RS07705	COG0745	RESPONSE REGULATOR receiver
DWB77_RS07795	COG0531	amino acid
DWB77_RS07905	COG0457	Tetratricopeptide repeat
DWB77_RS07930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWB77_RS07940	COG1619	proteins homologs of microcin C7 resistance protein MccF
DWB77_RS07950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB77_RS07955	COG2362	D-Aminopeptidase
DWB77_RS07980	COG2226	methyltransferase
DWB77_RS07985	COG2208	phosphoserine phosphatase activity
DWB77_RS07985	COG2172	sigma factor antagonist activity
DWB77_RS07985	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS08030	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB77_RS08040	COG0604	alcohol dehydrogenase
DWB77_RS08045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS08045	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS08060	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS08065	COG0688	phosphatidylethanolamine metabolic process
DWB77_RS08080	COG1929	Belongs to the glycerate kinase type-1 family
DWB77_RS08085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB77_RS08095	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS08100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DWB77_RS08105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB77_RS08130	COG0483	inositol monophosphate 1-phosphatase activity
DWB77_RS08135	COG0095	Lipoate-protein ligase
DWB77_RS08145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB77_RS08150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWB77_RS08170	COG1051	belongs to the nudix hydrolase family
DWB77_RS08190	COG0405	Gamma-glutamyltransferase
DWB77_RS08220	COG2205	protein histidine kinase activity
DWB77_RS08225	COG0745	RESPONSE REGULATOR receiver
DWB77_RS08240	COG1376	ErfK ybiS ycfS ynhG family protein
DWB77_RS08250	COG0765	amino acid transport
DWB77_RS08255	COG0765	amino acid transport
DWB77_RS08260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB77_RS08265	COG1126	abc transporter atp-binding protein
DWB77_RS08285	COG2267	carboxylic ester hydrolase activity
DWB77_RS08305	COG1940	carbohydrate kinase activity
DWB77_RS08330	COG2188	Transcriptional regulator
DWB77_RS08335	COG0673	inositol 2-dehydrogenase activity
DWB77_RS08355	COG2197	response regulator
DWB77_RS08380	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS08385	COG4266	Belongs to the allantoicase family
DWB77_RS08390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB77_RS08395	COG1414	Transcriptional regulator
DWB77_RS08410	COG4585	Histidine kinase
DWB77_RS08415	COG2197	response regulator
DWB77_RS08420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS08435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DWB77_RS08440	COG1288	antiporter activity
DWB77_RS08460	COG1357	PFAM Pentapeptide repeats (8 copies)
DWB77_RS08465	COG3548	integral membrane protein
DWB77_RS08485	COG2233	PERMEase
DWB77_RS08495	COG2233	PERMEase
DWB77_RS08505	COG2351	hydroxyisourate hydrolase activity
DWB77_RS08525	COG3622	Belongs to the hyi family
DWB77_RS08530	COG2084	Dehydrogenase
DWB77_RS08535	COG0753	catalase activity
DWB77_RS08555	COG0640	Transcriptional regulator
DWB77_RS08560	COG3960	tartronate-semialdehyde synthase activity
DWB77_RS08570	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS08575	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS08595	COG0583	DNA-binding transcription factor activity
DWB77_RS08615	COG0598	Magnesium transport protein CorA
DWB77_RS08630	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DWB77_RS08635	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DWB77_RS08640	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DWB77_RS08650	COG0513	Belongs to the DEAD box helicase family
DWB77_RS08655	COG1278	Cold shock
DWB77_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS08665	COG4585	Histidine kinase
DWB77_RS08670	COG2197	response regulator
DWB77_RS08680	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB77_RS08690	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS08695	COG4552	Acetyltransferase involved in intracellular survival and related
DWB77_RS08700	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DWB77_RS08700	COG3608	succinylglutamate desuccinylase aspartoacylase
DWB77_RS08710	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWB77_RS08725	COG3835	regulator
DWB77_RS08735	COG1802	Transcriptional regulator
DWB77_RS08760	COG0028	Belongs to the TPP enzyme family
DWB77_RS08770	COG1404	Belongs to the peptidase S8 family
DWB77_RS08795	COG0367	asparagine synthase
DWB77_RS08800	COG0387	Pfam Sodium calcium exchanger
DWB77_RS08810	COG1162	GTPase activity
DWB77_RS08815	COG2124	cytochrome p450
DWB77_RS08825	COG1132	(ABC) transporter
DWB77_RS08870	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS08885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB77_RS08895	COG0175	sulfate reduction
DWB77_RS08900	COG0529	Catalyzes the synthesis of activated sulfate
DWB77_RS08920	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
DWB77_RS08925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWB77_RS08945	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB77_RS09010	COG2124	cytochrome p450
DWB77_RS09010	COG2124	cytochrome p450
DWB77_RS09015	COG0583	DNA-binding transcription factor activity
DWB77_RS09020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB77_RS09050	COG0464	growth
DWB77_RS09055	COG0346	lactoylglutathione lyase activity
DWB77_RS09085	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB77_RS09090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB77_RS09115	COG2326	polyphosphate kinase activity
DWB77_RS09150	COG3220	belongs to the UPF0276 family
DWB77_RS09170	COG3253	May function as heme-dependent peroxidase
DWB77_RS09175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB77_RS09180	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB77_RS09185	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DWB77_RS09200	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DWB77_RS09205	COG0183	Belongs to the thiolase family
DWB77_RS09210	COG1024	Enoyl-CoA hydratase
DWB77_RS09210	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB77_RS09225	COG0531	amino acid
DWB77_RS09230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DWB77_RS09235	COG4214	carbohydrate transport
DWB77_RS09245	COG4213	ABC transporter substrate-binding protein
DWB77_RS09250	COG1940	carbohydrate kinase activity
DWB77_RS09255	COG0395	ABC-type sugar transport system, permease component
DWB77_RS09260	COG1175	transmembrane transport
DWB77_RS09265	COG1653	transport
DWB77_RS09280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWB77_RS09285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB77_RS09295	COG3938	Belongs to the proline racemase family
DWB77_RS09305	COG0006	proline dipeptidase activity
DWB77_RS09315	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS09335	COG1024	Enoyl-CoA hydratase
DWB77_RS09345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DWB77_RS09355	COG2040	homocysteine
DWB77_RS09395	COG1799	cell septum assembly
DWB77_RS09405	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DWB77_RS09445	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DWB77_RS09460	COG2814	Major facilitator Superfamily
DWB77_RS09485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DWB77_RS09505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB77_RS09510	COG1309	transcriptional regulator
DWB77_RS09515	COG0667	Aldo Keto reductase
DWB77_RS09520	COG2814	Major facilitator Superfamily
DWB77_RS09565	COG0367	asparagine synthase
DWB77_RS09635	COG1414	Transcriptional regulator
DWB77_RS09655	COG0657	acetylesterase activity
DWB77_RS09675	COG2159	amidohydrolase
DWB77_RS09700	COG0667	Aldo Keto reductase
DWB77_RS09725	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS09740	COG0747	negative chemotaxis
DWB77_RS09745	COG0154	amidase activity
DWB77_RS09755	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB77_RS09760	COG2755	lipolytic protein G-D-S-L family
DWB77_RS09775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS09795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB77_RS09800	COG0531	amino acid
DWB77_RS09805	COG0569	domain protein
DWB77_RS09835	COG1136	(ABC) transporter
DWB77_RS09845	COG0756	dUTP diphosphatase activity
DWB77_RS09870	COG2205	protein histidine kinase activity
DWB77_RS09875	COG0745	RESPONSE REGULATOR receiver
DWB77_RS09885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB77_RS09920	COG1435	thymidine kinase activity
DWB77_RS09935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB77_RS09935	COG1042	CoA-binding domain protein
DWB77_RS09935	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB77_RS09940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB77_RS09945	COG1802	Transcriptional regulator
DWB77_RS09950	COG0739	heme binding
DWB77_RS09960	COG0612	Peptidase, M16
DWB77_RS09965	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB77_RS09975	COG0372	Belongs to the citrate synthase family
DWB77_RS09990	COG0366	Alpha amylase catalytic
DWB77_RS09995	COG0395	ABC-type sugar transport system, permease component
DWB77_RS10000	COG1175	transmembrane transport
DWB77_RS10020	COG3290	protein histidine kinase activity
DWB77_RS10025	COG4565	transcriptional regulatory protein
DWB77_RS10030	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB77_RS10040	COG2197	response regulator
DWB77_RS10045	COG4585	Histidine kinase
DWB77_RS10055	COG0187	DNA topoisomerase II activity
DWB77_RS10070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB77_RS10075	COG1802	Transcriptional regulator
DWB77_RS10080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB77_RS10115	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB77_RS10150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB77_RS10155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB77_RS10160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DWB77_RS10200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB77_RS10210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB77_RS10215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DWB77_RS10225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWB77_RS10240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB77_RS10245	COG2358	TRAP transporter, solute receptor (TAXI family
DWB77_RS10250	COG2205	protein histidine kinase activity
DWB77_RS10255	COG0745	RESPONSE REGULATOR receiver
DWB77_RS10260	COG1126	abc transporter atp-binding protein
DWB77_RS10270	COG0765	amino acid transport
DWB77_RS10275	COG0765	amino acid transport
DWB77_RS10280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS10300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB77_RS10370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB77_RS10370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB77_RS10380	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
DWB77_RS10390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB77_RS10530	COG5280	Phage tail tape measure protein TP901
DWB77_RS10530	COG3953	SLT domain
DWB77_RS10575	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB77_RS10575	COG1388	LysM domain
DWB77_RS10675	COG1201	RNA secondary structure unwinding
DWB77_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS10695	COG0783	Belongs to the Dps family
DWB77_RS10700	COG1396	sequence-specific DNA binding
DWB77_RS10705	COG1546	Belongs to the CinA family
DWB77_RS10705	COG1058	Belongs to the CinA family
DWB77_RS10715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB77_RS10725	COG1674	ftsk spoiiie
DWB77_RS10735	COG2205	protein histidine kinase activity
DWB77_RS10735	COG3437	response regulator, receiver
DWB77_RS10735	COG4999	Histidine kinase
DWB77_RS10735	COG3850	Histidine kinase
DWB77_RS10740	COG2770	Histidine kinase
DWB77_RS10740	COG2208	phosphoserine phosphatase activity
DWB77_RS10775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB77_RS10780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB77_RS10800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB77_RS10805	COG0612	Peptidase, M16
DWB77_RS10810	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB77_RS10815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWB77_RS10850	COG1404	Belongs to the peptidase S8 family
DWB77_RS10855	COG3266	domain, Protein
DWB77_RS10870	COG0455	bacterial-type flagellum organization
DWB77_RS10875	COG0747	negative chemotaxis
DWB77_RS10880	COG0601	transmembrane transport
DWB77_RS10885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS10895	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS10910	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWB77_RS10915	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB77_RS10925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DWB77_RS10940	COG0779	Required for maturation of 30S ribosomal subunits
DWB77_RS10960	COG0442	prolyl-tRNA aminoacylation
DWB77_RS10975	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DWB77_RS10980	COG0750	zinc metalloprotease
DWB77_RS10985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DWB77_RS11000	COG2508	Transcriptional regulator
DWB77_RS11030	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS11035	COG1177	transmembrane transport
DWB77_RS11040	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWB77_RS11045	COG3842	ATPase activity
DWB77_RS11070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWB77_RS11090	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS11100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWB77_RS11105	COG1136	(ABC) transporter
DWB77_RS11125	COG3842	ATPase activity
DWB77_RS11130	COG1177	transmembrane transport
DWB77_RS11140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB77_RS11145	COG2188	Transcriptional regulator
DWB77_RS11235	COG0575	Belongs to the CDS family
DWB77_RS11240	COG0233	cytoplasmic translational termination
DWB77_RS11245	COG0528	UMP kinase activity
DWB77_RS11250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB77_RS11255	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB77_RS11270	COG1191	sigma factor activity
DWB77_RS11285	COG0792	nuclease activity
DWB77_RS11305	COG0681	Belongs to the peptidase S26 family
DWB77_RS11320	COG0335	large ribosomal subunit rRNA binding
DWB77_RS11325	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB77_RS11330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWB77_RS11335	COG1837	Belongs to the UPF0109 family
DWB77_RS11340	COG0228	four-way junction DNA binding
DWB77_RS11350	COG0442	prolyl-tRNA aminoacylation
DWB77_RS11360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB77_RS11375	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
DWB77_RS11415	COG0477	Major facilitator Superfamily
DWB77_RS11420	COG1196	nuclear chromosome segregation
DWB77_RS11435	COG1254	Belongs to the acylphosphatase family
DWB77_RS11440	COG2340	Cysteine-rich secretory protein family
DWB77_RS11450	COG1733	regulation of RNA biosynthetic process
DWB77_RS11455	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB77_RS11460	COG0571	ribonuclease III activity
DWB77_RS11465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB77_RS11480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB77_RS11485	COG0742	ribosomal rna small subunit methyltransferase
DWB77_RS11490	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB77_RS11495	COG1461	Dihydroxyacetone kinase
DWB77_RS11500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWB77_RS11505	COG0351	phosphomethylpyrimidine kinase
DWB77_RS11525	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB77_RS11530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWB77_RS11540	COG1920	GTP binding
DWB77_RS11550	COG0776	regulation of translation
DWB77_RS11560	COG0066	3-isopropylmalate dehydratase activity
DWB77_RS11565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWB77_RS11570	COG1414	Transcriptional regulator
DWB77_RS11610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DWB77_RS11615	COG0179	Fumarylacetoacetate (FAA) hydrolase
DWB77_RS11625	COG5002	protein histidine kinase activity
DWB77_RS11630	COG2018	Roadblock/LC7 domain
DWB77_RS11650	COG2018	Roadblock/LC7 domain
DWB77_RS11665	COG0596	Alpha beta hydrolase
DWB77_RS11680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS11685	COG5492	domain, Protein
DWB77_RS11690	COG1349	DNA-binding transcription factor activity
DWB77_RS11720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB77_RS11725	COG0477	Major facilitator Superfamily
DWB77_RS11745	COG2957	Belongs to the agmatine deiminase family
DWB77_RS11750	COG0804	urea catabolic process
DWB77_RS11755	COG0831	urea catabolic process
DWB77_RS11755	COG0832	Belongs to the urease beta subunit family
DWB77_RS11765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB77_RS11770	COG0473	3-isopropylmalate dehydrogenase activity
DWB77_RS11780	COG0477	Major facilitator Superfamily
DWB77_RS11790	COG3511	phospholipase C
DWB77_RS11800	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS11805	COG0506	proline dehydrogenase activity
DWB77_RS11820	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB77_RS11825	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DWB77_RS11830	COG0440	acetolactate synthase activity
DWB77_RS11850	COG0656	L-ascorbic acid biosynthetic process
DWB77_RS11855	COG2133	pyrroloquinoline quinone binding
DWB77_RS11860	COG2197	response regulator
DWB77_RS11875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB77_RS11880	COG2409	Drug exporters of the RND superfamily
DWB77_RS11900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB77_RS11910	COG0154	amidase activity
DWB77_RS11915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DWB77_RS11925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB77_RS11935	COG4221	oxidoreductase activity
DWB77_RS11960	COG0482	sulfurtransferase activity
DWB77_RS11990	COG2860	membrane
DWB77_RS12000	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS12005	COG0444	Belongs to the ABC transporter superfamily
DWB77_RS12015	COG4166	transmembrane transport
DWB77_RS12020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS12040	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB77_RS12045	COG0509	glycine decarboxylation via glycine cleavage system
DWB77_RS12050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB77_RS12055	COG1760	l-serine dehydratase
DWB77_RS12060	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB77_RS12090	COG0726	polysaccharide deacetylase
DWB77_RS12100	COG1024	Enoyl-CoA hydratase
DWB77_RS12105	COG1376	ErfK ybiS ycfS ynhG family protein
DWB77_RS12110	COG1376	ErfK ybiS ycfS ynhG family protein
DWB77_RS12120	COG2197	response regulator
DWB77_RS12125	COG4585	Histidine kinase
DWB77_RS12135	COG1131	(ABC) transporter
DWB77_RS12140	COG1132	(ABC) transporter
DWB77_RS12145	COG1132	(ABC) transporter
DWB77_RS12155	COG0745	RESPONSE REGULATOR receiver
DWB77_RS12160	COG2205	protein histidine kinase activity
DWB77_RS12165	COG2318	DinB family
DWB77_RS12180	COG0058	SHG alpha-glucan phosphorylase activity
DWB77_RS12185	COG0366	Alpha amylase catalytic
DWB77_RS12190	COG0366	Alpha amylase catalytic
DWB77_RS12195	COG3281	Trehalose synthase
DWB77_RS12200	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DWB77_RS12230	COG0395	ABC-type sugar transport system, permease component
DWB77_RS12235	COG1175	transmembrane transport
DWB77_RS12240	COG1653	transport
DWB77_RS12275	COG3118	belongs to the thioredoxin family
DWB77_RS12285	COG1522	sequence-specific DNA binding
DWB77_RS12295	COG0667	Aldo Keto reductase
DWB77_RS12300	COG0477	Major facilitator Superfamily
DWB77_RS12315	COG1301	dicarboxylic acid transport
DWB77_RS12320	COG3290	protein histidine kinase activity
DWB77_RS12325	COG4565	transcriptional regulatory protein
DWB77_RS12335	COG1175	transmembrane transport
DWB77_RS12340	COG3833	ABC-type maltose transport systems, permease component
DWB77_RS12345	COG0454	-acetyltransferase
DWB77_RS12345	COG0456	acetyltransferase
DWB77_RS12365	COG0205	6-phosphofructokinase activity
DWB77_RS12370	COG0280	phosphate acetyltransferase
DWB77_RS12370	COG0857	belongs to the CobB CobQ family
DWB77_RS12375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB77_RS12385	COG1686	Belongs to the peptidase S11 family
DWB77_RS12425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB77_RS12430	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB77_RS12445	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS12445	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS12510	COG0183	Belongs to the thiolase family
DWB77_RS12565	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
DWB77_RS12580	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB77_RS12610	COG2205	protein histidine kinase activity
DWB77_RS12625	COG4585	Histidine kinase
DWB77_RS12630	COG2197	response regulator
DWB77_RS12645	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWB77_RS12650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWB77_RS12655	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB77_RS12660	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DWB77_RS12665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB77_RS12670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DWB77_RS12675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB77_RS12695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB77_RS12700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB77_RS12710	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB77_RS12715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DWB77_RS12720	COG0254	rRNA binding
DWB77_RS12725	COG1316	TRANSCRIPTIONal
DWB77_RS12735	COG0083	homoserine kinase activity
DWB77_RS12740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB77_RS12745	COG0460	homoserine dehydrogenase
DWB77_RS12750	COG0019	diaminopimelate decarboxylase activity
DWB77_RS12755	COG0018	arginyl-trna synthetase
DWB77_RS12760	COG0745	RESPONSE REGULATOR receiver
DWB77_RS12800	COG2208	phosphoserine phosphatase activity
DWB77_RS12800	COG2770	Histidine kinase
DWB77_RS12805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DWB77_RS12810	COG3285	dna ligase
DWB77_RS12810	COG1793	dna ligase
DWB77_RS12815	COG1793	dna ligase
DWB77_RS12835	COG2205	protein histidine kinase activity
DWB77_RS12850	COG0768	penicillin binding
DWB77_RS12875	COG3883	PFAM NLP P60 protein
DWB77_RS12875	COG0791	NLP P60 protein
DWB77_RS12925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DWB77_RS12945	COG0745	RESPONSE REGULATOR receiver
DWB77_RS12950	COG2205	protein histidine kinase activity
DWB77_RS12955	COG0567	Dehydrogenase, E1 component
DWB77_RS12955	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB77_RS12995	COG0604	alcohol dehydrogenase
DWB77_RS13000	COG0281	malic enzyme
DWB77_RS13005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB77_RS13010	COG0765	amino acid transport
DWB77_RS13015	COG1126	abc transporter atp-binding protein
DWB77_RS13020	COG4106	trans-aconitate 2-methyltransferase activity
DWB77_RS13040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS13070	COG0142	geranyltranstransferase activity
DWB77_RS13075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB77_RS13080	COG1959	2 iron, 2 sulfur cluster binding
DWB77_RS13085	COG1017	nitric oxide dioxygenase activity
DWB77_RS13085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB77_RS13095	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DWB77_RS13110	COG2172	sigma factor antagonist activity
DWB77_RS13125	COG1597	lipid kinase activity
DWB77_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS13150	COG0363	glucosamine-6-phosphate deaminase activity
DWB77_RS13155	COG0738	Major facilitator superfamily
DWB77_RS13165	COG0019	diaminopimelate decarboxylase activity
DWB77_RS13180	COG1472	Belongs to the glycosyl hydrolase 3 family
DWB77_RS13185	COG0395	ABC-type sugar transport system, permease component
DWB77_RS13190	COG1175	transmembrane transport
DWB77_RS13195	COG2182	Extracellular solute-binding protein
DWB77_RS13200	COG2188	Transcriptional regulator
DWB77_RS13215	COG1215	transferase activity, transferring glycosyl groups
DWB77_RS13220	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DWB77_RS13230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWB77_RS13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB77_RS13240	COG1215	transferase activity, transferring glycosyl groups
DWB77_RS13255	COG0667	Aldo Keto reductase
DWB77_RS13295	COG0242	peptide deformylase activity
DWB77_RS13310	COG2199	diguanylate cyclase activity
DWB77_RS13310	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
DWB77_RS13315	COG5662	AntiSigma factor
DWB77_RS13320	COG1595	DNA-templated transcription, initiation
DWB77_RS13330	COG2135	peptidase activity
DWB77_RS13340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DWB77_RS13350	COG2076	Multidrug Resistance protein
DWB77_RS13360	COG0483	inositol monophosphate 1-phosphatase activity
DWB77_RS13370	COG0753	catalase activity
DWB77_RS13400	COG1615	UPF0182 protein
DWB77_RS13410	COG3480	Lon protease (S16) C-terminal proteolytic domain
DWB77_RS13460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
DWB77_RS13500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB77_RS13505	COG0210	DNA helicase
DWB77_RS13535	COG1140	nitrate reductase beta subunit
DWB77_RS13550	COG0535	radical SAM domain protein
DWB77_RS13555	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB77_RS13590	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS13600	COG0601	transmembrane transport
DWB77_RS13605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS13610	COG0747	negative chemotaxis
DWB77_RS13650	COG0513	Belongs to the DEAD box helicase family
DWB77_RS13655	COG0596	Alpha beta hydrolase
DWB77_RS13660	COG1432	Conserved Protein
DWB77_RS13665	COG2095	MarC family integral membrane protein
DWB77_RS13680	COG2814	Major facilitator Superfamily
DWB77_RS13690	COG0598	Magnesium transport protein CorA
DWB77_RS13730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB77_RS13735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB77_RS13745	COG1595	DNA-templated transcription, initiation
DWB77_RS13760	COG1024	Enoyl-CoA hydratase
DWB77_RS13765	COG0519	Catalyzes the synthesis of GMP from XMP
DWB77_RS13775	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DWB77_RS13780	COG1611	Belongs to the LOG family
DWB77_RS13785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB77_RS13825	COG2197	response regulator
DWB77_RS13830	COG4585	Histidine kinase
DWB77_RS13840	COG1131	(ABC) transporter
DWB77_RS13855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB77_RS13870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS13875	COG0747	negative chemotaxis
DWB77_RS13880	COG0601	transmembrane transport
DWB77_RS13885	COG0444	Belongs to the ABC transporter superfamily
DWB77_RS13890	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS13895	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS13905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS13910	COG0601	transmembrane transport
DWB77_RS13915	COG4166	transmembrane transport
DWB77_RS13920	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS13925	COG0444	Belongs to the ABC transporter superfamily
DWB77_RS13930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS13940	COG4166	transmembrane transport
DWB77_RS13945	COG1217	gtp-binding protein TYPA
DWB77_RS13965	COG1053	succinate dehydrogenase
DWB77_RS14035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWB77_RS14050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS14055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB77_RS14065	COG3251	PFAM MbtH domain protein
DWB77_RS14115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS14130	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS14140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB77_RS14160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS14165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB77_RS14170	COG0577	efflux transmembrane transporter activity
DWB77_RS14170	COG1136	(ABC) transporter
DWB77_RS14185	COG3629	intracellular signal transduction
DWB77_RS14190	COG3251	PFAM MbtH domain protein
DWB77_RS14205	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS14220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB77_RS14225	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS14355	COG0012	GTP binding
DWB77_RS14365	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS14375	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DWB77_RS14385	COG1570	exodeoxyribonuclease VII activity
DWB77_RS14390	COG1722	exodeoxyribonuclease VII activity
DWB77_RS14395	COG0778	Nitroreductase
DWB77_RS14420	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
DWB77_RS14420	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
DWB77_RS14435	COG0114	fumarate hydratase activity
DWB77_RS14450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB77_RS14465	COG1136	(ABC) transporter
DWB77_RS14480	COG0450	alkyl hydroperoxide reductase
DWB77_RS14485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB77_RS14500	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DWB77_RS14505	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB77_RS14510	COG0667	Aldo Keto reductase
DWB77_RS14520	COG2226	methyltransferase
DWB77_RS14545	COG2885	chlorophyll binding
DWB77_RS14625	COG2610	gluconate transmembrane transporter activity
DWB77_RS14630	COG0251	oxidation-reduction process
DWB77_RS14635	COG1414	Transcriptional regulator
DWB77_RS14650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DWB77_RS14680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
DWB77_RS14690	COG1331	Highly conserved protein containing a thioredoxin domain
DWB77_RS14695	COG2255	four-way junction helicase activity
DWB77_RS14705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB77_RS14715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB77_RS14730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DWB77_RS14760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB77_RS14790	COG1064	alcohol dehydrogenase
DWB77_RS14800	COG1376	ErfK ybiS ycfS ynhG family protein
DWB77_RS14825	COG1024	Enoyl-CoA hydratase
DWB77_RS14830	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWB77_RS14840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS14850	COG0424	maF-like protein
DWB77_RS14860	COG4770	biotin carboxylase activity
DWB77_RS14890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB77_RS14915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWB77_RS14920	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS14925	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS14940	COG1595	DNA-templated transcription, initiation
DWB77_RS14945	COG0745	RESPONSE REGULATOR receiver
DWB77_RS14950	COG2205	protein histidine kinase activity
DWB77_RS14980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWB77_RS14990	COG0583	DNA-binding transcription factor activity
DWB77_RS14995	COG2814	Major facilitator Superfamily
DWB77_RS15010	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS15040	COG1079	Belongs to the binding-protein-dependent transport system permease family
DWB77_RS15045	COG4603	Belongs to the binding-protein-dependent transport system permease family
DWB77_RS15050	COG3845	ABC transporter
DWB77_RS15055	COG1744	ABC transporter substrate-binding protein PnrA-like
DWB77_RS15070	COG2089	acid synthase
DWB77_RS15085	COG1216	Glycosyl transferase, family 2
DWB77_RS15105	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DWB77_RS15115	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS15115	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS15130	COG1595	DNA-templated transcription, initiation
DWB77_RS15135	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWB77_RS15145	COG2009	succinate dehydrogenase
DWB77_RS15155	COG1053	succinate dehydrogenase
DWB77_RS15160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB77_RS15180	COG0747	negative chemotaxis
DWB77_RS15190	COG1686	Belongs to the peptidase S11 family
DWB77_RS15205	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DWB77_RS15210	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS15230	COG0180	Tryptophanyl-tRNA synthetase
DWB77_RS15235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DWB77_RS15240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWB77_RS15260	COG0754	glutathionylspermidine amidase activity
DWB77_RS15320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS15325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS15330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB77_RS15345	COG1476	TRANSCRIPTIONal
DWB77_RS15355	COG0039	L-malate dehydrogenase activity
DWB77_RS15365	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB77_RS15375	COG0138	bifunctional purine biosynthesis protein purh
DWB77_RS15405	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB77_RS15410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
DWB77_RS15420	COG0714	Associated with various cellular activities
DWB77_RS15435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DWB77_RS15475	COG2197	response regulator
DWB77_RS15510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB77_RS15510	COG0519	Catalyzes the synthesis of GMP from XMP
DWB77_RS15535	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS15545	COG0515	serine threonine protein kinase
DWB77_RS15570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB77_RS15585	COG0516	GMP reductase activity
DWB77_RS15595	COG1595	DNA-templated transcription, initiation
DWB77_RS15610	COG0583	DNA-binding transcription factor activity
DWB77_RS15620	COG4221	oxidoreductase activity
DWB77_RS15630	COG1609	Transcriptional regulator
DWB77_RS15645	COG0395	ABC-type sugar transport system, permease component
DWB77_RS15650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB77_RS15660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB77_RS15665	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS15670	COG0726	polysaccharide deacetylase
DWB77_RS15675	COG0726	polysaccharide deacetylase
DWB77_RS15695	COG3973	AAA domain
DWB77_RS15700	COG0726	polysaccharide deacetylase
DWB77_RS15710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB77_RS15730	COG0802	atpase or kinase
DWB77_RS15740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWB77_RS15755	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB77_RS15760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB77_RS15765	COG1072	(Pantothenic acid kinase))
DWB77_RS15775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB77_RS15780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DWB77_RS15785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWB77_RS15790	COG0488	(ABC) transporter
DWB77_RS15800	COG0101	tRNA pseudouridine synthase activity
DWB77_RS15805	COG0203	ribosomal protein L17
DWB77_RS15810	COG0202	RNA polymerase activity
DWB77_RS15815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB77_RS15820	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWB77_RS15825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DWB77_RS15830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWB77_RS15840	COG0563	adenylate kinase activity
DWB77_RS15845	COG0201	protein transport
DWB77_RS15850	COG0200	Binds to the 23S rRNA
DWB77_RS15860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB77_RS15865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWB77_RS15870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWB77_RS15875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB77_RS15885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB77_RS15890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DWB77_RS15895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB77_RS15900	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB77_RS15905	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWB77_RS15910	COG0255	Belongs to the universal ribosomal protein uL29 family
DWB77_RS15915	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWB77_RS15920	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWB77_RS15925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWB77_RS15930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB77_RS15935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DWB77_RS15940	COG0089	rRNA binding
DWB77_RS15945	COG0088	Forms part of the polypeptide exit tunnel
DWB77_RS15950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB77_RS15955	COG0051	transcription antitermination factor activity, RNA binding
DWB77_RS15970	COG3209	COG3209 Rhs family protein
DWB77_RS15970	COG4104	PAAR repeat-containing protein
DWB77_RS15990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB77_RS15995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB77_RS16000	COG0049	tRNA binding
DWB77_RS16005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB77_RS16010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB77_RS16015	COG0085	RNA polymerase activity
DWB77_RS16025	COG0222	ribosome binding
DWB77_RS16030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB77_RS16040	COG0081	regulation of translation
DWB77_RS16045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB77_RS16065	COG0436	Aminotransferase
DWB77_RS16070	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWB77_RS16075	COG1309	transcriptional regulator
DWB77_RS16085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB77_RS16105	COG2030	dehydratase
DWB77_RS16110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB77_RS16125	COG0402	S-adenosylhomocysteine deaminase activity
DWB77_RS16140	COG1666	GTP binding
DWB77_RS16155	COG2261	transglycosylase associated protein
DWB77_RS16160	COG3304	Inner membrane component domain
DWB77_RS16165	COG0501	Belongs to the peptidase M48B family
DWB77_RS16170	COG1970	mechanosensitive ion channel activity
DWB77_RS16175	COG1007	ATP synthesis coupled electron transport
DWB77_RS16185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB77_RS16190	COG0713	ATP synthesis coupled electron transport
DWB77_RS16195	COG0839	Belongs to the complex I subunit 6 family
DWB77_RS16200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DWB77_RS16210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16240	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB77_RS16240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB77_RS16245	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB77_RS16250	COG1733	regulation of RNA biosynthetic process
DWB77_RS16255	COG0702	epimerase
DWB77_RS16265	COG0488	(ABC) transporter
DWB77_RS16305	COG0142	geranyltranstransferase activity
DWB77_RS16310	COG3104	oligopeptide transport
DWB77_RS16310	COG3104	oligopeptide transport
DWB77_RS16325	COG0514	ATP-dependent DNA helicase (RecQ)
DWB77_RS16330	COG1007	ATP synthesis coupled electron transport
DWB77_RS16340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB77_RS16345	COG0713	ATP synthesis coupled electron transport
DWB77_RS16350	COG0839	Belongs to the complex I subunit 6 family
DWB77_RS16355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DWB77_RS16365	COG1034	ATP synthesis coupled electron transport
DWB77_RS16370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DWB77_RS16380	COG0649	NAD binding
DWB77_RS16385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DWB77_RS16420	COG2226	methyltransferase
DWB77_RS16435	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWB77_RS16440	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DWB77_RS16545	COG1674	ftsk spoiiie
DWB77_RS16575	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DWB77_RS16580	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DWB77_RS16585	COG1278	Cold shock
DWB77_RS16595	COG2207	Transcriptional regulator
DWB77_RS16620	COG1309	transcriptional regulator
DWB77_RS16630	COG1301	dicarboxylic acid transport
DWB77_RS16645	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWB77_RS16655	COG0163	prenyltransferase activity
DWB77_RS16665	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DWB77_RS16675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB77_RS16680	COG1333	cytochrome c biogenesis protein
DWB77_RS16685	COG0785	Cytochrome C biogenesis protein
DWB77_RS16690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB77_RS16700	COG0406	alpha-ribazole phosphatase activity
DWB77_RS16705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB77_RS16715	COG3585	molybdate ion transport
DWB77_RS16730	COG0640	Transcriptional regulator
DWB77_RS16735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWB77_RS16765	COG1846	Transcriptional regulator
DWB77_RS16775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS16785	COG1742	UPF0060 membrane protein
DWB77_RS16805	COG1690	Belongs to the RtcB family
DWB77_RS16825	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
DWB77_RS16830	COG0018	arginyl-trna synthetase
DWB77_RS16860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS16890	COG0113	porphobilinogen synthase activity
DWB77_RS16895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB77_RS16900	COG1648	precorrin-2 dehydrogenase activity
DWB77_RS16900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWB77_RS16905	COG0181	hydroxymethylbilane synthase activity
DWB77_RS16910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB77_RS16915	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DWB77_RS16965	COG0123	including yeast histone deacetylase and acetoin utilization protein
DWB77_RS16975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB77_RS17005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB77_RS17015	COG1131	(ABC) transporter
DWB77_RS17030	COG4991	sh3 domain protein
DWB77_RS17040	COG0129	dihydroxy-acid dehydratase activity
DWB77_RS17050	COG1082	Xylose isomerase domain protein TIM barrel
DWB77_RS17055	COG0248	Ppx GppA phosphatase
DWB77_RS17075	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DWB77_RS17095	COG1194	a g-specific adenine glycosylase
DWB77_RS17100	COG1595	DNA-templated transcription, initiation
DWB77_RS17110	COG0745	RESPONSE REGULATOR receiver
DWB77_RS17115	COG2205	protein histidine kinase activity
DWB77_RS17130	COG0739	heme binding
DWB77_RS17165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DWB77_RS17180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DWB77_RS17190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DWB77_RS17195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB77_RS17215	COG0640	Transcriptional regulator
DWB77_RS17225	COG2197	response regulator
DWB77_RS17240	COG0649	NAD binding
DWB77_RS17265	COG1174	glycine betaine transport
DWB77_RS17270	COG1174	glycine betaine transport
DWB77_RS17290	COG0477	Major facilitator Superfamily
DWB77_RS17310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWB77_RS17325	COG0302	gtp cyclohydrolase
DWB77_RS17340	COG0037	tRNA processing
DWB77_RS17350	COG2027	D-alanyl-D-alanine carboxypeptidase
DWB77_RS17355	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DWB77_RS17370	COG0393	Putative heavy-metal-binding
DWB77_RS17375	COG0076	glutamate decarboxylase activity
DWB77_RS17385	COG2318	DinB family
DWB77_RS17390	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS17430	COG0667	Aldo Keto reductase
DWB77_RS17435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB77_RS17440	COG2814	Major facilitator Superfamily
DWB77_RS17445	COG1846	Transcriptional regulator
DWB77_RS17455	COG2252	PERMEase
DWB77_RS17465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DWB77_RS17480	COG2814	Major facilitator Superfamily
DWB77_RS17490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB77_RS17495	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DWB77_RS17500	COG1278	Cold shock
DWB77_RS17535	COG1061	Type III restriction enzyme res subunit
DWB77_RS17555	COG3973	AAA domain
DWB77_RS17590	COG1595	DNA-templated transcription, initiation
DWB77_RS17610	COG1278	Cold shock
DWB77_RS17625	COG1737	Transcriptional regulator
DWB77_RS17630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB77_RS17730	COG0463	Glycosyl transferase, family 2
DWB77_RS17755	COG1653	transport
DWB77_RS17790	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DWB77_RS17830	COG0456	acetyltransferase
DWB77_RS17845	COG0723	plastoquinol--plastocyanin reductase activity
DWB77_RS17845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS17865	COG3842	ATPase activity
DWB77_RS17875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DWB77_RS17885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB77_RS17890	COG0215	cysteine-tRNA ligase activity
DWB77_RS17895	COG3467	pyridoxamine 5'-phosphate
DWB77_RS17900	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DWB77_RS17905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DWB77_RS17910	COG1329	Transcriptional regulator
DWB77_RS17930	COG5002	protein histidine kinase activity
DWB77_RS17950	COG2188	Transcriptional regulator
DWB77_RS18015	COG0588	phosphoglycerate mutase activity
DWB77_RS18030	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS18070	COG0604	alcohol dehydrogenase
DWB77_RS18075	COG4552	Acetyltransferase involved in intracellular survival and related
DWB77_RS18105	COG3485	protocatechuate 3,4-dioxygenase
DWB77_RS18150	COG2897	thiosulfate sulfurtransferase activity
DWB77_RS18175	COG0745	RESPONSE REGULATOR receiver
DWB77_RS18180	COG1609	Transcriptional regulator
DWB77_RS18185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB77_RS18190	COG0745	RESPONSE REGULATOR receiver
DWB77_RS18200	COG0737	Belongs to the 5'-nucleotidase family
DWB77_RS18205	COG0456	acetyltransferase
DWB77_RS18210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DWB77_RS18220	COG0406	alpha-ribazole phosphatase activity
DWB77_RS18220	COG0494	nUDIX hydrolase
DWB77_RS18240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB77_RS18255	COG1937	Protein conserved in bacteria
DWB77_RS18285	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS18290	COG0791	NLP P60 protein
DWB77_RS18335	COG2197	response regulator
DWB77_RS18365	COG1846	Transcriptional regulator
DWB77_RS18380	COG1252	NADH dehydrogenase
DWB77_RS18410	COG0579	oxidoreductase
DWB77_RS18415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB77_RS18440	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB77_RS18455	COG0513	Belongs to the DEAD box helicase family
DWB77_RS18480	COG0785	Cytochrome C biogenesis protein
DWB77_RS18485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DWB77_RS18485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DWB77_RS18495	COG1643	Atp-dependent helicase
DWB77_RS18525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB77_RS18545	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB77_RS18550	COG0047	phosphoribosylformylglycinamidine synthase activity
DWB77_RS18555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB77_RS18585	COG3850	Histidine kinase
DWB77_RS18590	COG2197	response regulator
DWB77_RS18600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB77_RS18615	COG0151	Belongs to the GarS family
DWB77_RS18645	COG0745	RESPONSE REGULATOR receiver
DWB77_RS18665	COG0433	COG0433 Predicted ATPase
DWB77_RS18680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB77_RS18695	COG0590	tRNA wobble adenosine to inosine editing
DWB77_RS18710	COG1191	sigma factor activity
DWB77_RS18715	COG1191	sigma factor activity
DWB77_RS18730	COG1846	Transcriptional regulator
DWB77_RS18740	COG2353	YceI-like domain
DWB77_RS18750	COG0477	Major facilitator Superfamily
DWB77_RS18755	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DWB77_RS18765	COG2205	protein histidine kinase activity
DWB77_RS18770	COG0745	RESPONSE REGULATOR receiver
DWB77_RS18815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB77_RS18850	COG0784	Response regulator, receiver
DWB77_RS18855	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS18860	COG1595	DNA-templated transcription, initiation
DWB77_RS18880	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS18890	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS18910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB77_RS18925	COG0653	protein targeting
DWB77_RS18945	COG0006	proline dipeptidase activity
DWB77_RS18965	COG1999	signal sequence binding
DWB77_RS18975	COG2372	response to copper ion
DWB77_RS18980	COG2837	iron assimilation
DWB77_RS18990	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWB77_RS18995	COG0561	phosphatase activity
DWB77_RS19005	COG2186	Transcriptional regulator
DWB77_RS19010	COG2807	transmembrane transport
DWB77_RS19035	COG1131	(ABC) transporter
DWB77_RS19055	COG0789	Transcriptional regulator
DWB77_RS19060	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DWB77_RS19075	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
DWB77_RS19085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS19095	COG0561	phosphatase activity
DWB77_RS19105	COG4988	ABC transporter
DWB77_RS19110	COG1294	oxidase, subunit
DWB77_RS19115	COG1271	oxidase subunit
DWB77_RS19125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB77_RS19130	COG1609	Transcriptional regulator
DWB77_RS19135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DWB77_RS19145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DWB77_RS19170	COG0662	Cupin 2, conserved barrel domain protein
DWB77_RS19175	COG1950	PFAM Membrane protein of
DWB77_RS19180	COG0626	cystathionine gamma-synthase activity
DWB77_RS19215	COG2814	Major facilitator Superfamily
DWB77_RS19235	COG0305	Participates in initiation and elongation during chromosome replication
DWB77_RS19240	COG0534	Mate efflux family protein
DWB77_RS19245	COG0359	binds to the 23S rRNA
DWB77_RS19250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB77_RS19255	COG0629	single-stranded DNA binding
DWB77_RS19260	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB77_RS19285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB77_RS19310	COG0617	tRNA 3'-terminal CCA addition
DWB77_RS19330	COG1595	DNA-templated transcription, initiation
DWB77_RS19340	COG0492	ferredoxin-NADP+ reductase activity
DWB77_RS19345	COG3118	belongs to the thioredoxin family
DWB77_RS19360	COG1192	Involved in chromosome partitioning
DWB77_RS19365	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB77_RS19375	COG0706	membrane insertase activity
DWB77_RS19380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DWB77_RS19385	COG0594	ribonuclease P activity
DWB77_RS19390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DWB77_RS19405	COG0592	DNA-directed DNA polymerase activity
DWB77_RS19410	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DWB77_RS19415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB77_RS19420	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
DWB77_RS19430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB77_RS19460	COG0515	serine threonine protein kinase
DWB77_RS19485	COG0705	Rhomboid family
DWB77_RS19485	COG0457	Tetratricopeptide repeat
DWB77_RS19500	COG3764	Sortase (surface protein transpeptidase)
DWB77_RS19515	COG3764	Sortase (surface protein transpeptidase)
DWB77_RS19520	COG3764	Sortase (surface protein transpeptidase)
DWB77_RS19525	COG0515	serine threonine protein kinase
DWB77_RS19530	COG0768	penicillin binding
DWB77_RS19545	COG1716	ATPase activity
DWB77_RS19550	COG1716	ATPase activity
DWB77_RS19565	COG2197	response regulator
DWB77_RS19590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB77_RS19595	COG2151	metal-sulfur cluster biosynthetic enzyme
DWB77_RS19600	COG3396	Phenylacetate-CoA oxygenase
DWB77_RS19605	COG3460	Phenylacetate-CoA oxygenase
DWB77_RS19610	COG3396	Phenylacetate-CoA oxygenase
DWB77_RS19640	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB77_RS19645	COG1309	transcriptional regulator
DWB77_RS19680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DWB77_RS19695	COG0515	serine threonine protein kinase
DWB77_RS19700	COG0515	serine threonine protein kinase
DWB77_RS19725	COG0022	dehydrogenase e1 component
DWB77_RS19730	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB77_RS19745	COG2271	Major facilitator Superfamily
DWB77_RS19770	COG3629	intracellular signal transduction
DWB77_RS19770	COG3903	Transcriptional regulator
DWB77_RS19780	COG1362	aminopeptidase activity
DWB77_RS19785	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS19810	COG1741	Belongs to the pirin family
DWB77_RS19830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB77_RS19920	COG3629	intracellular signal transduction
DWB77_RS19920	COG3903	Transcriptional regulator
DWB77_RS19940	COG1222	aaa ATPase
DWB77_RS19950	COG2197	response regulator
DWB77_RS19955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB77_RS19960	COG2304	oxidoreductase activity
DWB77_RS19975	COG0583	DNA-binding transcription factor activity
DWB77_RS19980	COG5640	endopeptidase activity
DWB77_RS20005	COG0180	Tryptophanyl-tRNA synthetase
DWB77_RS20035	COG0531	amino acid
DWB77_RS20065	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DWB77_RS20100	COG2226	methyltransferase
DWB77_RS20105	COG2188	Transcriptional regulator
DWB77_RS20110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS20120	COG2837	iron assimilation
DWB77_RS20125	COG4608	Belongs to the ABC transporter superfamily
DWB77_RS20135	COG0601	transmembrane transport
DWB77_RS20140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB77_RS20145	COG0747	negative chemotaxis
DWB77_RS20150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS20160	COG1802	Transcriptional regulator
DWB77_RS20165	COG3708	Transcriptional regulator
DWB77_RS20165	COG2207	Transcriptional regulator
DWB77_RS20185	COG0513	Belongs to the DEAD box helicase family
DWB77_RS20190	COG1278	Cold shock
DWB77_RS20245	COG2837	iron assimilation
DWB77_RS20265	COG0501	Belongs to the peptidase M48B family
DWB77_RS20270	COG0745	RESPONSE REGULATOR receiver
DWB77_RS20285	COG1136	(ABC) transporter
DWB77_RS20295	COG5002	protein histidine kinase activity
DWB77_RS20305	COG2205	protein histidine kinase activity
DWB77_RS20310	COG0745	RESPONSE REGULATOR receiver
DWB77_RS20365	COG0717	Belongs to the dCTP deaminase family
DWB77_RS20380	COG2181	nitrate reductase activity
DWB77_RS20380	COG0247	lactate metabolic process
DWB77_RS20385	COG1088	dTDP-glucose 4,6-dehydratase activity
DWB77_RS20390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB77_RS20400	COG0443	Heat shock 70 kDa protein
DWB77_RS20405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB77_RS20410	COG0484	heat shock protein binding
DWB77_RS20415	COG0789	Transcriptional regulator
DWB77_RS20445	COG0542	response to heat
DWB77_RS20475	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DWB77_RS20490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB77_RS20495	COG0191	fructose-bisphosphate aldolase activity
DWB77_RS20500	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DWB77_RS20505	COG0477	Major facilitator Superfamily
DWB77_RS20525	COG3844	kynureninase activity
DWB77_RS20545	COG4585	Histidine kinase
DWB77_RS20550	COG2197	response regulator
DWB77_RS20565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DWB77_RS20610	COG0346	lactoylglutathione lyase activity
DWB77_RS20635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DWB77_RS20640	COG1802	Transcriptional regulator
DWB77_RS20645	COG0463	Glycosyl transferase, family 2
DWB77_RS20660	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB77_RS20665	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB77_RS20685	COG1595	DNA-templated transcription, initiation
DWB77_RS20715	COG1316	TRANSCRIPTIONal
DWB77_RS20775	COG1408	metallophosphoesterase
DWB77_RS20780	COG1610	YqeY-like protein
DWB77_RS20785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB77_RS20800	COG0003	Pfam Anion-transporting ATPase
DWB77_RS20825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB77_RS20850	COG1486	melibiose metabolic process
DWB77_RS20860	COG2267	carboxylic ester hydrolase activity
DWB77_RS20870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DWB77_RS20875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB77_RS20945	COG1111	helicase
DWB77_RS20945	COG1205	dead DEAH box helicase
DWB77_RS20950	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS20955	COG2172	sigma factor antagonist activity
DWB77_RS20960	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DWB77_RS20970	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB77_RS20980	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB77_RS20980	COG1754	DNA topoisomerase type I activity
DWB77_RS20985	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DWB77_RS20990	COG0470	DNA polymerase III
DWB77_RS21080	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DWB77_RS21085	COG0406	alpha-ribazole phosphatase activity
DWB77_RS21095	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
DWB77_RS21190	COG0667	Aldo Keto reductase
DWB77_RS21200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS21280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB77_RS21280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB77_RS21285	COG2197	response regulator
DWB77_RS21290	COG1063	alcohol dehydrogenase
DWB77_RS21300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
DWB77_RS21320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DWB77_RS21355	COG0277	FAD linked oxidase domain protein
DWB77_RS21355	COG0247	lactate metabolic process
DWB77_RS21360	COG5006	permease, DMT superfamily
DWB77_RS21375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS21390	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS21450	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS21460	COG0728	peptidoglycan biosynthetic process
DWB77_RS21475	COG0297	glycogen (starch) synthase activity
DWB77_RS21570	COG0259	pyridoxamine-phosphate oxidase activity
DWB77_RS21585	COG4821	SIS domain
DWB77_RS21605	COG1131	(ABC) transporter
DWB77_RS21650	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS21660	COG0823	Involved in the tonB-independent uptake of proteins
DWB77_RS21665	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS21675	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS21680	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS21700	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS21730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB77_RS21735	COG1024	Enoyl-CoA hydratase
DWB77_RS21745	COG2072	flavoprotein involved in K transport
DWB77_RS21770	COG0183	Belongs to the thiolase family
DWB77_RS21775	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS21795	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DWB77_RS21795	COG0515	serine threonine protein kinase
DWB77_RS21800	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB77_RS21815	COG1024	Enoyl-CoA hydratase
DWB77_RS21830	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS21915	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS21935	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DWB77_RS21940	COG0662	Cupin 2, conserved barrel domain protein
DWB77_RS21955	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DWB77_RS21980	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS22005	COG1686	Belongs to the peptidase S11 family
DWB77_RS22055	COG3384	dioxygenase
DWB77_RS22060	COG1247	-acetyltransferase
DWB77_RS22075	COG0477	Major facilitator Superfamily
DWB77_RS22080	COG1349	DNA-binding transcription factor activity
DWB77_RS22085	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB77_RS22125	COG2223	nitrite transmembrane transporter activity
DWB77_RS22135	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWB77_RS22145	COG0243	molybdopterin cofactor binding
DWB77_RS22150	COG0437	4 iron, 4 sulfur cluster binding
DWB77_RS22170	COG1970	mechanosensitive ion channel activity
DWB77_RS22180	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DWB77_RS22195	COG3263	regulation of cellular component size
DWB77_RS22205	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DWB77_RS22210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB77_RS22220	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB77_RS22250	COG0708	Exodeoxyribonuclease III
DWB77_RS22255	COG0789	Transcriptional regulator
DWB77_RS22260	COG2072	flavoprotein involved in K transport
DWB77_RS22265	COG2267	carboxylic ester hydrolase activity
DWB77_RS22270	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS22275	COG0793	Belongs to the peptidase S41A family
DWB77_RS22275	COG4946	Tricorn protease homolog
DWB77_RS22285	COG2409	Drug exporters of the RND superfamily
DWB77_RS22295	COG0310	cobalt ion transport
DWB77_RS22305	COG1122	ATPase activity
DWB77_RS22315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB77_RS22325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS22340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DWB77_RS22395	COG0084	hydrolase, TatD family'
DWB77_RS22405	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB77_RS22415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS22445	COG0488	(ABC) transporter
DWB77_RS22485	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWB77_RS22495	COG2197	response regulator
DWB77_RS22500	COG1846	Transcriptional regulator
DWB77_RS22505	COG4106	trans-aconitate 2-methyltransferase activity
DWB77_RS22515	COG1309	transcriptional regulator
DWB77_RS22525	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DWB77_RS22535	COG0193	aminoacyl-tRNA hydrolase activity
DWB77_RS22540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWB77_RS22545	COG0583	DNA-binding transcription factor activity
DWB77_RS22555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB77_RS22560	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB77_RS22575	COG4585	Histidine kinase
DWB77_RS22605	COG0477	Major facilitator Superfamily
DWB77_RS22610	COG1136	(ABC) transporter
DWB77_RS22615	COG0577	efflux transmembrane transporter activity
DWB77_RS22630	COG1595	DNA-templated transcription, initiation
DWB77_RS22660	COG2815	serine threonine protein kinase
DWB77_RS22660	COG0515	serine threonine protein kinase
DWB77_RS22680	COG2124	cytochrome p450
DWB77_RS22695	COG0148	phosphopyruvate hydratase activity
DWB77_RS22720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB77_RS22725	COG0577	efflux transmembrane transporter activity
DWB77_RS22725	COG1136	(ABC) transporter
DWB77_RS22730	COG1136	(ABC) transporter
DWB77_RS22770	COG0183	Belongs to the thiolase family
DWB77_RS22775	COG2755	lipolytic protein G-D-S-L family
DWB77_RS22820	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DWB77_RS22835	COG1228	amidohydrolase
DWB77_RS22845	COG1191	sigma factor activity
DWB77_RS22850	COG1366	Belongs to the anti-sigma-factor antagonist family
DWB77_RS22880	COG3104	oligopeptide transport
DWB77_RS22885	COG0745	RESPONSE REGULATOR receiver
DWB77_RS22890	COG2205	protein histidine kinase activity
DWB77_RS22905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB77_RS22920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DWB77_RS22930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS22975	COG1316	TRANSCRIPTIONal
DWB77_RS22985	COG1316	TRANSCRIPTIONal
DWB77_RS22995	COG1316	TRANSCRIPTIONal
DWB77_RS23030	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
DWB77_RS23030	COG0778	Nitroreductase
DWB77_RS23035	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB77_RS23075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB77_RS23080	COG2835	tetraacyldisaccharide 4'-kinase activity
DWB77_RS23100	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
DWB77_RS23140	COG0714	Associated with various cellular activities
DWB77_RS23160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DWB77_RS23165	COG0745	RESPONSE REGULATOR receiver
DWB77_RS23170	COG5002	protein histidine kinase activity
DWB77_RS23170	COG5000	phosphorelay sensor kinase activity
DWB77_RS23175	COG0823	Involved in the tonB-independent uptake of proteins
DWB77_RS23185	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB77_RS23190	COG2197	response regulator
DWB77_RS23195	COG3214	Protein conserved in bacteria
DWB77_RS23200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB77_RS23205	COG0653	protein targeting
DWB77_RS23230	COG2902	Dehydrogenase
DWB77_RS23250	COG1309	transcriptional regulator
DWB77_RS23255	COG1473	amidohydrolase
DWB77_RS23260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS23270	COG2130	NADP-dependent
DWB77_RS23275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS23275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DWB77_RS23285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS23295	COG0156	8-amino-7-oxononanoate synthase activity
DWB77_RS23340	COG0560	Phosphoserine phosphatase
DWB77_RS23390	COG0395	ABC-type sugar transport system, permease component
DWB77_RS23395	COG1175	transmembrane transport
DWB77_RS23400	COG1653	transport
DWB77_RS23405	COG1674	ftsk spoiiie
DWB77_RS23410	COG0515	serine threonine protein kinase
DWB77_RS23415	COG0515	serine threonine protein kinase
DWB77_RS23420	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DWB77_RS23435	COG2884	Cell division ATP-binding protein ftsE
DWB77_RS23445	COG0793	Belongs to the peptidase S41A family
DWB77_RS23450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DWB77_RS23465	COG0583	DNA-binding transcription factor activity
DWB77_RS23515	COG3973	AAA domain
DWB77_RS23525	COG0776	regulation of translation
DWB77_RS23530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB77_RS23535	COG1678	Uncharacterized ACR, COG1678
DWB77_RS23550	COG1175	transmembrane transport
DWB77_RS23555	COG0395	ABC-type sugar transport system, permease component
DWB77_RS23560	COG3525	Glycosyl hydrolase, family 20, catalytic domain
DWB77_RS23575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DWB77_RS23635	COG1174	glycine betaine transport
DWB77_RS23640	COG0517	IMP dehydrogenase activity
DWB77_RS23640	COG1125	glycine betaine transport
DWB77_RS23645	COG1174	glycine betaine transport
DWB77_RS23655	COG3185	4-Hydroxyphenylpyruvate dioxygenase
DWB77_RS23665	COG0277	FAD linked oxidase domain protein
DWB77_RS23705	COG1335	isochorismatase
DWB77_RS23715	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
DWB77_RS23725	COG1113	amino acid transport
DWB77_RS23740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB77_RS23745	COG1120	ATPase activity
DWB77_RS23765	COG1234	tRNA 3'-trailer cleavage
DWB77_RS23775	COG1263	PTS System
DWB77_RS23780	COG1263	PTS System
DWB77_RS23785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB77_RS23790	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DWB77_RS23800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWB77_RS23840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB77_RS23855	COG4555	ABC transporter
DWB77_RS23865	COG2733	membrane
DWB77_RS23920	COG3764	Sortase (surface protein transpeptidase)
DWB77_RS23930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB77_RS23935	COG0477	Major facilitator Superfamily
DWB77_RS23950	COG0706	membrane insertase activity
DWB77_RS23965	COG4702	Belongs to the UPF0303 family
DWB77_RS23970	COG0673	inositol 2-dehydrogenase activity
DWB77_RS23990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS24055	COG3397	chitin binding
DWB77_RS24070	COG0477	Major facilitator Superfamily
DWB77_RS24090	COG1126	abc transporter atp-binding protein
DWB77_RS24095	COG0765	amino acid transport
DWB77_RS24100	COG0765	amino acid transport
DWB77_RS24105	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
DWB77_RS24110	COG0154	amidase activity
DWB77_RS24115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS24170	COG0588	phosphoglycerate mutase activity
DWB77_RS24185	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DWB77_RS24195	COG0745	RESPONSE REGULATOR receiver
DWB77_RS24200	COG5002	protein histidine kinase activity
DWB77_RS24265	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
DWB77_RS24270	COG4977	sequence-specific DNA binding
DWB77_RS24280	COG0589	response to stress
DWB77_RS24290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DWB77_RS24315	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DWB77_RS24320	COG0076	glutamate decarboxylase activity
DWB77_RS24340	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS24345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB77_RS24355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS24360	COG1309	transcriptional regulator
DWB77_RS24375	COG1946	Acyl-CoA thioesterase
DWB77_RS24395	COG0028	Belongs to the TPP enzyme family
DWB77_RS24400	COG1132	(ABC) transporter
DWB77_RS24415	COG1472	Belongs to the glycosyl hydrolase 3 family
DWB77_RS24420	COG0702	epimerase
DWB77_RS24445	COG0583	DNA-binding transcription factor activity
DWB77_RS24460	COG2378	regulation of single-species biofilm formation
DWB77_RS24490	COG0673	inositol 2-dehydrogenase activity
DWB77_RS24495	COG1609	Transcriptional regulator
DWB77_RS24515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB77_RS24535	COG0673	inositol 2-dehydrogenase activity
DWB77_RS24560	COG3718	enzyme involved in inositol metabolism
DWB77_RS24565	COG3962	Belongs to the TPP enzyme family
DWB77_RS24615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS24620	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB77_RS24625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWB77_RS24660	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DWB77_RS24665	COG2197	response regulator
DWB77_RS24680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB77_RS24735	COG2816	NAD+ diphosphatase activity
DWB77_RS24780	COG0531	amino acid
DWB77_RS24780	COG1674	ftsk spoiiie
DWB77_RS24800	COG0270	DNA (cytosine-5-)-methyltransferase activity
DWB77_RS24845	COG0629	single-stranded DNA binding
DWB77_RS24870	COG0577	efflux transmembrane transporter activity
DWB77_RS24870	COG1136	(ABC) transporter
DWB77_RS24890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS24920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB77_RS24935	COG1486	melibiose metabolic process
DWB77_RS24940	COG0395	ABC-type sugar transport system, permease component
DWB77_RS24945	COG1175	transmembrane transport
DWB77_RS24960	COG0668	transmembrane transport
DWB77_RS24980	COG1846	Transcriptional regulator
DWB77_RS24990	COG0697	spore germination
DWB77_RS25005	COG0667	Aldo Keto reductase
DWB77_RS25010	COG4266	Belongs to the allantoicase family
DWB77_RS25065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB77_RS25070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DWB77_RS25075	COG1113	amino acid transport
DWB77_RS25080	COG1113	amino acid transport
DWB77_RS25085	COG1268	BioY protein
DWB77_RS25100	COG0515	serine threonine protein kinase
DWB77_RS25105	COG1113	amino acid transport
DWB77_RS25120	COG4552	Acetyltransferase involved in intracellular survival and related
DWB77_RS25130	COG1136	(ABC) transporter
DWB77_RS25130	COG0577	efflux transmembrane transporter activity
DWB77_RS25155	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB77_RS25160	COG0740	serine-type endopeptidase activity
DWB77_RS25165	COG0740	serine-type endopeptidase activity
DWB77_RS25170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWB77_RS25180	COG0525	valine-tRNA ligase activity
DWB77_RS25185	COG4585	Histidine kinase
DWB77_RS25190	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS25195	COG1077	Cell shape determining protein MreB Mrl
DWB77_RS25200	COG0285	dihydrofolate synthase activity
DWB77_RS25210	COG0105	UTP biosynthetic process
DWB77_RS25215	COG1077	Cell shape determining protein MreB Mrl
DWB77_RS25230	COG0768	penicillin binding
DWB77_RS25235	COG0772	Belongs to the SEDS family
DWB77_RS25260	COG1530	ribonuclease E activity
DWB77_RS25265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB77_RS25270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB77_RS25275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWB77_RS25290	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS25295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB77_RS25305	COG0463	Glycosyl transferase, family 2
DWB77_RS25320	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DWB77_RS25330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DWB77_RS25345	COG0501	Belongs to the peptidase M48B family
DWB77_RS25355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWB77_RS25365	COG0799	negative regulation of ribosome biogenesis
DWB77_RS25410	COG0495	leucyl-tRNA aminoacylation
DWB77_RS25420	COG1307	EDD domain protein, DegV family
DWB77_RS25425	COG1596	polysaccharide export
DWB77_RS25425	COG1555	photosystem II stabilization
DWB77_RS25455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DWB77_RS25480	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DWB77_RS25500	COG0431	NADPH-dependent FMN reductase
DWB77_RS25515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB77_RS25530	COG1819	glycosyl
DWB77_RS25550	COG1131	(ABC) transporter
DWB77_RS25590	COG0667	Aldo Keto reductase
DWB77_RS25600	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS25625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS25630	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS25635	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DWB77_RS25640	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DWB77_RS25660	COG3851	Histidine kinase
DWB77_RS25665	COG4585	Histidine kinase
DWB77_RS25670	COG2197	response regulator
DWB77_RS25695	COG0268	Binds directly to 16S ribosomal RNA
DWB77_RS25700	COG0481	GTPase activity
DWB77_RS25715	COG2208	phosphoserine phosphatase activity
DWB77_RS25715	COG2770	Histidine kinase
DWB77_RS25735	COG1420	regulation of RNA biosynthetic process
DWB77_RS25740	COG0484	heat shock protein binding
DWB77_RS25760	COG0537	adenosine 5'-monophosphoramidase activity
DWB77_RS25765	COG1234	tRNA 3'-trailer cleavage
DWB77_RS25770	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DWB77_RS25780	COG4948	Mandelate Racemase Muconate Lactonizing
DWB77_RS25785	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DWB77_RS25785	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWB77_RS25795	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DWB77_RS25805	COG2315	Protein conserved in bacteria
DWB77_RS25845	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB77_RS25865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DWB77_RS25875	COG2409	Drug exporters of the RND superfamily
DWB77_RS25880	COG4585	Histidine kinase
DWB77_RS25885	COG2197	response regulator
DWB77_RS25895	COG1381	Involved in DNA repair and RecF pathway recombination
DWB77_RS25900	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DWB77_RS25910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB77_RS25915	COG1121	(ABC) transporter
DWB77_RS25920	COG3443	Belongs to the bacterial solute-binding protein 9 family
DWB77_RS25920	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB77_RS25925	COG0423	glycine-tRNA ligase activity
DWB77_RS25940	COG2197	response regulator
DWB77_RS25955	COG0667	Aldo Keto reductase
DWB77_RS25965	COG0477	Major facilitator Superfamily
DWB77_RS25985	COG0574	Belongs to the PEP-utilizing enzyme family
DWB77_RS25985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB77_RS25995	COG0395	ABC-type sugar transport system, permease component
DWB77_RS26005	COG2182	Extracellular solute-binding protein
DWB77_RS26020	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS26025	COG1309	transcriptional regulator
DWB77_RS26040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB77_RS26050	COG3850	Histidine kinase
DWB77_RS26060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB77_RS26060	COG1017	nitric oxide dioxygenase activity
DWB77_RS26100	COG0243	molybdopterin cofactor binding
DWB77_RS26105	COG2949	membrane
DWB77_RS26115	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DWB77_RS26125	COG0358	DNA primase activity
DWB77_RS26130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB77_RS26145	COG1070	Carbohydrate kinase
DWB77_RS26180	COG0825	malonyl-CoA metabolic process
DWB77_RS26180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB77_RS26185	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS26220	COG2130	NADP-dependent
DWB77_RS26225	COG1764	response to oxidative stress
DWB77_RS26230	COG2267	carboxylic ester hydrolase activity
DWB77_RS26245	COG2084	Dehydrogenase
DWB77_RS26255	COG1309	transcriptional regulator
DWB77_RS26285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS26290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB77_RS26295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS26310	COG1741	Belongs to the pirin family
DWB77_RS26320	COG0789	Transcriptional regulator
DWB77_RS26325	COG0667	Aldo Keto reductase
DWB77_RS26340	COG2197	response regulator
DWB77_RS26345	COG4585	Histidine kinase
DWB77_RS26360	COG1309	transcriptional regulator
DWB77_RS26365	COG0477	Major facilitator Superfamily
DWB77_RS26385	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DWB77_RS26430	COG1358	cellular component organization or biogenesis
DWB77_RS26535	COG4762	Protein conserved in bacteria
DWB77_RS26540	COG0598	Magnesium transport protein CorA
DWB77_RS26590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB77_RS26625	COG2124	cytochrome p450
DWB77_RS26630	COG0183	Belongs to the thiolase family
DWB77_RS26645	COG3845	ABC transporter
DWB77_RS26680	COG1309	transcriptional regulator
DWB77_RS26685	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS26705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS26725	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS26730	COG0183	Belongs to the thiolase family
DWB77_RS26740	COG2197	response regulator
DWB77_RS26745	COG4585	Histidine kinase
DWB77_RS26755	COG1131	(ABC) transporter
DWB77_RS26760	COG2030	dehydratase
DWB77_RS26770	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS26780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB77_RS26795	COG0800	Aldolase
DWB77_RS26800	COG3022	response to hydroperoxide
DWB77_RS26810	COG0557	exoribonuclease II activity
DWB77_RS26820	COG0789	Transcriptional regulator
DWB77_RS26840	COG0384	phenazine biosynthesis protein PhzF
DWB77_RS26850	COG2814	Major facilitator Superfamily
DWB77_RS26860	COG1834	amidinotransferase
DWB77_RS26885	COG0672	)-iron permease
DWB77_RS26890	COG2837	iron assimilation
DWB77_RS26935	COG1994	Peptidase M50
DWB77_RS26955	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWB77_RS26960	COG0477	Major facilitator Superfamily
DWB77_RS26975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB77_RS26975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWB77_RS26980	COG0531	amino acid
DWB77_RS26990	COG2267	carboxylic ester hydrolase activity
DWB77_RS27015	COG0174	glutamine synthetase
DWB77_RS27020	COG4974	Belongs to the 'phage' integrase family
DWB77_RS27080	COG0546	phosphoglycolate phosphatase activity
DWB77_RS27115	COG3511	phospholipase C
DWB77_RS27120	COG3594	Acyltransferase
DWB77_RS27130	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DWB77_RS27140	COG1609	Transcriptional regulator
DWB77_RS27145	COG0366	Alpha amylase catalytic
DWB77_RS27155	COG1175	transmembrane transport
DWB77_RS27160	COG3833	ABC-type maltose transport systems, permease component
DWB77_RS27165	COG0366	Alpha amylase catalytic
DWB77_RS27235	COG2365	Tyrosine phosphatase family
DWB77_RS27255	COG2813	Specifically methylates the guanine in position
DWB77_RS27260	COG2197	response regulator
DWB77_RS27265	COG4585	Histidine kinase
DWB77_RS27270	COG0745	RESPONSE REGULATOR receiver
DWB77_RS27340	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB77_RS27345	COG0583	DNA-binding transcription factor activity
DWB77_RS27390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWB77_RS27395	COG0321	lipoyl(octanoyl) transferase activity
DWB77_RS27415	COG0454	-acetyltransferase
DWB77_RS27415	COG0456	acetyltransferase
DWB77_RS27425	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS27445	COG2186	Transcriptional regulator
DWB77_RS27455	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DWB77_RS27465	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB77_RS27470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB77_RS27475	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB77_RS27485	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS27505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DWB77_RS27525	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DWB77_RS27540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB77_RS27565	COG4585	Histidine kinase
DWB77_RS27570	COG2197	response regulator
DWB77_RS27575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB77_RS27580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DWB77_RS27600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB77_RS27610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB77_RS27615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWB77_RS27625	COG1376	ErfK ybiS ycfS ynhG family protein
DWB77_RS27635	COG1845	cytochrome c oxidase, subunit III
DWB77_RS27640	COG2010	Cytochrome c
DWB77_RS27645	COG0723	plastoquinol--plastocyanin reductase activity
DWB77_RS27650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DWB77_RS27655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB77_RS27660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB77_RS27690	COG0791	NLP P60 protein
DWB77_RS27690	COG3883	PFAM NLP P60 protein
DWB77_RS27705	COG0534	Mate efflux family protein
DWB77_RS27715	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS27720	COG1022	Amp-dependent synthetase and ligase
DWB77_RS27735	COG0003	Pfam Anion-transporting ATPase
DWB77_RS27745	COG1940	carbohydrate kinase activity
DWB77_RS27775	COG4585	Histidine kinase
DWB77_RS27780	COG2197	response regulator
DWB77_RS27785	COG0205	6-phosphofructokinase activity
DWB77_RS27790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB77_RS27810	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWB77_RS27820	COG2193	ferroxidase activity
DWB77_RS27825	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB77_RS27830	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWB77_RS27835	COG2815	serine threonine protein kinase
DWB77_RS27835	COG0515	serine threonine protein kinase
DWB77_RS27840	COG2022	thiamine diphosphate biosynthetic process
DWB77_RS27850	COG2022	thiamine diphosphate biosynthetic process
DWB77_RS27850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS27865	COG0352	thiamine-phosphate diphosphorylase activity
DWB77_RS27880	COG1233	COG1233 Phytoene dehydrogenase and related
DWB77_RS27890	COG1309	transcriptional regulator
DWB77_RS27895	COG1511	domain protein
DWB77_RS27900	COG1121	(ABC) transporter
DWB77_RS27930	COG0714	Associated with various cellular activities
DWB77_RS27940	COG0275	rRNA processing
DWB77_RS27950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB77_RS27955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB77_RS27960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB77_RS27965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB77_RS27975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB77_RS27980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DWB77_RS27995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB77_RS28000	COG1799	cell septum assembly
DWB77_RS28010	COG3599	regulation of cell shape
DWB77_RS28015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB77_RS28025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DWB77_RS28065	COG0587	DNA-directed DNA polymerase activity
DWB77_RS28075	COG1432	Conserved Protein
DWB77_RS28080	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS28105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DWB77_RS28120	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DWB77_RS28125	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB77_RS28130	COG0131	Imidazoleglycerol-phosphate dehydratase
DWB77_RS28135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DWB77_RS28140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DWB77_RS28145	COG0251	oxidation-reduction process
DWB77_RS28150	COG0107	imidazoleglycerol-phosphate synthase activity
DWB77_RS28170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DWB77_RS28175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB77_RS28195	COG0134	indole-3-glycerol-phosphate synthase activity
DWB77_RS28200	COG0133	tryptophan synthase activity
DWB77_RS28205	COG0159	tryptophan synthase activity
DWB77_RS28215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB77_RS28220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB77_RS28230	COG0070	glutamate synthase
DWB77_RS28230	COG0067	glutamate synthase
DWB77_RS28230	COG0069	glutamate synthase activity
DWB77_RS28245	COG2304	oxidoreductase activity
DWB77_RS28255	COG4221	oxidoreductase activity
DWB77_RS28260	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS28265	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS28270	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS28275	COG1309	transcriptional regulator
DWB77_RS28280	COG0183	Belongs to the thiolase family
DWB77_RS28285	COG1278	Cold shock
DWB77_RS28295	COG2365	Tyrosine phosphatase family
DWB77_RS28315	COG1024	Enoyl-CoA hydratase
DWB77_RS28325	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS28345	COG2197	response regulator
DWB77_RS28350	COG3851	Histidine kinase
DWB77_RS28365	COG0287	Prephenate dehydrogenase
DWB77_RS28365	COG1605	Chorismate mutase
DWB77_RS28385	COG0737	Belongs to the 5'-nucleotidase family
DWB77_RS28390	COG2968	Membrane
DWB77_RS28430	COG0559	Belongs to the binding-protein-dependent transport system permease family
DWB77_RS28445	COG2050	protein possibly involved in aromatic compounds catabolism
DWB77_RS28475	COG1643	Atp-dependent helicase
DWB77_RS28480	COG2226	methyltransferase
DWB77_RS28500	COG0237	dephospho-CoA kinase activity
DWB77_RS28535	COG0596	Alpha beta hydrolase
DWB77_RS28545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWB77_RS28590	COG2313	pseudouridylate synthase activity
DWB77_RS28605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB77_RS28615	COG0556	nucleotide-excision repair
DWB77_RS28635	COG0477	Major facilitator Superfamily
DWB77_RS28650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB77_RS28680	COG0322	excinuclease ABC activity
DWB77_RS28685	COG1660	Displays ATPase and GTPase activities
DWB77_RS28690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB77_RS28695	COG1481	regulation of sporulation
DWB77_RS28705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB77_RS28710	COG0126	phosphoglycerate kinase activity
DWB77_RS28715	COG0149	triose-phosphate isomerase activity
DWB77_RS28720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB77_RS28735	COG0166	Belongs to the GPI family
DWB77_RS28740	COG0363	glucosamine-6-phosphate deaminase activity
DWB77_RS28755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB77_RS28765	COG0109	protoheme IX farnesyltransferase activity
DWB77_RS28780	COG1612	heme a metabolic process
DWB77_RS28790	COG1131	(ABC) transporter
DWB77_RS28795	COG2746	aminoglycoside 3-N-acetyltransferase activity
DWB77_RS28810	COG0719	Fe-S assembly protein
DWB77_RS28820	COG0396	ATPase activity
DWB77_RS28825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB77_RS28830	COG0822	iron-sulfur transferase activity
DWB77_RS28835	COG2151	metal-sulfur cluster biosynthetic enzyme
DWB77_RS28875	COG2171	N-acyltransferase activity
DWB77_RS28885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB77_RS28915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS28925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DWB77_RS28930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB77_RS28945	COG0768	penicillin binding
DWB77_RS28950	COG2197	response regulator
DWB77_RS28955	COG4585	Histidine kinase
DWB77_RS28960	COG1414	Transcriptional regulator
DWB77_RS28970	COG0477	Major facilitator Superfamily
DWB77_RS28995	COG5285	phytanoyl-CoA dioxygenase
DWB77_RS29010	COG0456	acetyltransferase
DWB77_RS29015	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWB77_RS29045	COG1797	cobyrinic acid a,c-diamide synthase activity
DWB77_RS29060	COG1492	cobalamin metabolic process
DWB77_RS29065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DWB77_RS29085	COG0235	Class ii aldolase
DWB77_RS29110	COG0488	(ABC) transporter
DWB77_RS29160	COG3387	PFAM Glycoside hydrolase 15-related
DWB77_RS29175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB77_RS29235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB77_RS29240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB77_RS29260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DWB77_RS29275	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS29280	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DWB77_RS29290	COG2186	Transcriptional regulator
DWB77_RS29310	COG3830	Belongs to the UPF0237 family
DWB77_RS29310	COG0560	Phosphoserine phosphatase
DWB77_RS29320	COG0842	Transport permease protein
DWB77_RS29320	COG1716	ATPase activity
DWB77_RS29320	COG1131	(ABC) transporter
DWB77_RS29335	COG4221	oxidoreductase activity
DWB77_RS29340	COG4585	Histidine kinase
DWB77_RS29345	COG2197	response regulator
DWB77_RS29355	COG1119	ATPase activity
DWB77_RS29380	COG1881	PFAM PEBP family protein
DWB77_RS29390	COG2094	Belongs to the DNA glycosylase MPG family
DWB77_RS29435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB77_RS29440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB77_RS29445	COG1120	ATPase activity
DWB77_RS29465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWB77_RS29470	COG0497	DNA recombination
DWB77_RS29480	COG0297	glycogen (starch) synthase activity
DWB77_RS29490	COG3387	PFAM Glycoside hydrolase 15-related
DWB77_RS29495	COG0504	CTP synthase activity
DWB77_RS29500	COG0494	nUDIX hydrolase
DWB77_RS29510	COG0686	Belongs to the AlaDH PNT family
DWB77_RS29525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB77_RS29530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB77_RS29535	COG1187	pseudouridine synthase activity
DWB77_RS29555	COG1397	ADP-ribosylglycohydrolase
DWB77_RS29560	COG3541	Predicted nucleotidyltransferase
DWB77_RS29585	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB77_RS29595	COG1160	GTP binding
DWB77_RS29610	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS29620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DWB77_RS29630	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS29635	COG0477	Major facilitator Superfamily
DWB77_RS29640	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS29645	COG1799	cell septum assembly
DWB77_RS29665	COG0641	radical SAM
DWB77_RS29675	COG0330	HflC and HflK could
DWB77_RS29690	COG0587	DNA-directed DNA polymerase activity
DWB77_RS29720	COG2226	methyltransferase
DWB77_RS29730	COG1725	Transcriptional regulator
DWB77_RS29740	COG2755	lipolytic protein G-D-S-L family
DWB77_RS29755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DWB77_RS29785	COG2188	Transcriptional regulator
DWB77_RS29790	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
DWB77_RS29795	COG1309	transcriptional regulator
DWB77_RS29800	COG0243	molybdopterin cofactor binding
DWB77_RS29805	COG2851	Citrate transporter
DWB77_RS29820	COG0697	spore germination
DWB77_RS29830	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS29880	COG3876	Protein conserved in bacteria
DWB77_RS29900	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS29915	COG2149	membrane
DWB77_RS29920	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DWB77_RS29955	COG3265	gluconokinase activity
DWB77_RS29960	COG2186	Transcriptional regulator
DWB77_RS29965	COG1113	amino acid transport
DWB77_RS30010	COG0564	pseudouridine synthase activity
DWB77_RS30015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS30055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB77_RS30080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB77_RS30085	COG0667	Aldo Keto reductase
DWB77_RS30090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS30100	COG0598	Magnesium transport protein CorA
DWB77_RS30120	COG0215	cysteine-tRNA ligase activity
DWB77_RS30130	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS30140	COG4948	Mandelate Racemase Muconate Lactonizing
DWB77_RS30145	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS30155	COG1129	ABC transporter
DWB77_RS30160	COG1172	Belongs to the binding-protein-dependent transport system permease family
DWB77_RS30170	COG2186	Transcriptional regulator
DWB77_RS30175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DWB77_RS30180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWB77_RS30185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DWB77_RS30190	COG1414	Transcriptional regulator
DWB77_RS30220	COG2197	response regulator
DWB77_RS30230	COG0517	IMP dehydrogenase activity
DWB77_RS30230	COG1994	Peptidase M50
DWB77_RS30250	COG1222	aaa ATPase
DWB77_RS30255	COG4122	O-methyltransferase activity
DWB77_RS30270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWB77_RS30275	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWB77_RS30280	COG1609	Transcriptional regulator
DWB77_RS30290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
DWB77_RS30305	COG2378	regulation of single-species biofilm formation
DWB77_RS30325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB77_RS30330	COG0805	protein transport
DWB77_RS30350	COG2197	response regulator
DWB77_RS30355	COG4585	Histidine kinase
DWB77_RS30360	COG2409	Drug exporters of the RND superfamily
DWB77_RS30370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB77_RS30390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB77_RS30410	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DWB77_RS30415	COG1113	amino acid transport
DWB77_RS30420	COG2186	Transcriptional regulator
DWB77_RS30425	COG0174	glutamine synthetase
DWB77_RS30430	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS30480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB77_RS30485	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWB77_RS30495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB77_RS30500	COG5002	protein histidine kinase activity
DWB77_RS30505	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB77_RS30510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB77_RS30510	COG0072	phenylalanine-tRNA ligase activity
DWB77_RS30520	COG1051	belongs to the nudix hydrolase family
DWB77_RS30535	COG1649	PFAM Uncharacterised BCR, COG1649
DWB77_RS30540	COG0697	spore germination
DWB77_RS30545	COG1609	Transcriptional regulator
DWB77_RS30560	COG4941	Belongs to the sigma-70 factor family
DWB77_RS30565	COG1252	NADH dehydrogenase
DWB77_RS30570	COG1595	DNA-templated transcription, initiation
DWB77_RS30580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWB77_RS30585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWB77_RS30590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWB77_RS30595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWB77_RS30600	COG1438	arginine binding
DWB77_RS30610	COG0165	Argininosuccinate lyase
DWB77_RS30620	COG0477	Major facilitator Superfamily
DWB77_RS30625	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS30625	COG0204	Acyl-transferase
DWB77_RS30660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB77_RS30665	COG2011	ABC-type metal ion transport system permease component
DWB77_RS30670	COG1464	Belongs to the NlpA lipoprotein family
DWB77_RS30685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DWB77_RS30690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DWB77_RS30690	COG1648	precorrin-2 dehydrogenase activity
DWB77_RS30750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB77_RS30755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB77_RS30805	COG2176	DNA-directed DNA polymerase activity
DWB77_RS30805	COG5002	protein histidine kinase activity
DWB77_RS30820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB77_RS30840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DWB77_RS30845	COG1560	Kdo2-lipid A biosynthetic process
DWB77_RS30850	COG0438	transferase activity, transferring glycosyl groups
DWB77_RS30860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB77_RS30865	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWB77_RS30870	COG0217	transcriptional regulatory protein
DWB77_RS30875	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
DWB77_RS30880	COG0632	four-way junction helicase activity
DWB77_RS30885	COG2255	four-way junction helicase activity
DWB77_RS30895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB77_RS30900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB77_RS30905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB77_RS30910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB77_RS30920	COG1196	nuclear chromosome segregation
DWB77_RS30935	COG0124	histidyl-tRNA synthetase
DWB77_RS30940	COG2197	response regulator
DWB77_RS30945	COG4585	Histidine kinase
DWB77_RS30975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB77_RS30995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWB77_RS31000	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DWB77_RS31010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DWB77_RS31015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWB77_RS31020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB77_RS31025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB77_RS31030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB77_RS31035	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DWB77_RS31045	COG0006	proline dipeptidase activity
DWB77_RS31050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB77_RS31055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB77_RS31065	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB77_RS31070	COG0540	Belongs to the ATCase OTCase family
DWB77_RS31075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB77_RS31085	COG0505	Belongs to the CarA family
DWB77_RS31090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB77_RS31095	COG0167	dihydroorotate dehydrogenase activity
DWB77_RS31100	COG0284	orotidine-5'-phosphate decarboxylase activity
DWB77_RS31110	COG0194	GDP metabolic process
DWB77_RS31125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB77_RS31140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB77_RS31150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB77_RS31155	COG2390	Transcriptional regulator
DWB77_RS31165	COG0174	glutamine synthetase
DWB77_RS31170	COG1793	dna ligase
DWB77_RS31195	COG0531	amino acid
DWB77_RS31205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DWB77_RS31220	COG2233	PERMEase
DWB77_RS31230	COG0738	Major facilitator superfamily
DWB77_RS31235	COG1846	Transcriptional regulator
DWB77_RS31235	COG1940	carbohydrate kinase activity
DWB77_RS31255	COG3201	nicotinamide mononucleotide transporter
DWB77_RS31260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB77_RS31260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB77_RS31265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB77_RS31270	COG0140	phosphoribosyl-ATP diphosphatase activity
DWB77_RS31275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DWB77_RS31335	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS31370	COG0463	Glycosyl transferase, family 2
DWB77_RS31385	COG2270	Major facilitator Superfamily
DWB77_RS31395	COG2364	Membrane
DWB77_RS31400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS31425	COG1984	allophanate hydrolase subunit 2
DWB77_RS31430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB77_RS31435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DWB77_RS31440	COG4336	lyase activity
DWB77_RS31445	COG2814	Major facilitator Superfamily
DWB77_RS31480	COG2018	Roadblock/LC7 domain
DWB77_RS31495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DWB77_RS31500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB77_RS31515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
DWB77_RS31530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB77_RS31535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DWB77_RS31550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB77_RS31585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DWB77_RS31605	COG1716	ATPase activity
DWB77_RS31625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB77_RS31635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB77_RS31635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DWB77_RS31675	COG1695	Transcriptional regulator
DWB77_RS31715	COG0697	spore germination
DWB77_RS31760	COG0747	negative chemotaxis
DWB77_RS31765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB77_RS31775	COG2318	DinB family
DWB77_RS31795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DWB77_RS31805	COG1024	Enoyl-CoA hydratase
DWB77_RS31825	COG1968	undecaprenyl-diphosphatase activity
DWB77_RS31840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB77_RS31850	COG2814	Major facilitator Superfamily
DWB77_RS31905	COG0641	radical SAM
DWB77_RS31920	COG2267	carboxylic ester hydrolase activity
DWB77_RS31925	COG1832	CoA-binding protein
DWB77_RS31935	COG5492	domain, Protein
DWB77_RS31940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DWB77_RS31945	COG1739	Uncharacterized protein family UPF0029
DWB77_RS31950	COG0420	3'-5' exonuclease activity
DWB77_RS31955	COG0419	ATPase involved in DNA repair
DWB77_RS31960	COG1522	sequence-specific DNA binding
DWB77_RS31985	COG2188	Transcriptional regulator
DWB77_RS31990	COG1940	carbohydrate kinase activity
DWB77_RS31995	COG2197	response regulator
DWB77_RS32000	COG4585	Histidine kinase
DWB77_RS32025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DWB77_RS32030	COG0242	peptide deformylase activity
DWB77_RS32060	COG2226	methyltransferase
DWB77_RS32070	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DWB77_RS32075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DWB77_RS32080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DWB77_RS32115	COG0740	serine-type endopeptidase activity
DWB77_RS32120	COG0204	Acyl-transferase
DWB77_RS32120	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS32130	COG0831	urea catabolic process
DWB77_RS32135	COG0832	Belongs to the urease beta subunit family
DWB77_RS32140	COG0804	urea catabolic process
DWB77_RS32150	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DWB77_RS32155	COG0829	nickel cation binding
DWB77_RS32180	COG0205	6-phosphofructokinase activity
DWB77_RS32185	COG3442	glutamine amidotransferase
DWB77_RS32195	COG0242	peptide deformylase activity
DWB77_RS32205	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS32215	COG0386	Belongs to the glutathione peroxidase family
DWB77_RS32220	COG1946	Acyl-CoA thioesterase
DWB77_RS32235	COG1132	(ABC) transporter
DWB77_RS32240	COG1132	(ABC) transporter
DWB77_RS32260	COG1132	(ABC) transporter
DWB77_RS32270	COG2072	flavoprotein involved in K transport
DWB77_RS32275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB77_RS32285	COG1116	anion transmembrane transporter activity
DWB77_RS32290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DWB77_RS32295	COG0432	Pfam Uncharacterised protein family UPF0047
DWB77_RS32365	COG2706	6-phosphogluconolactonase activity
DWB77_RS32380	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DWB77_RS32390	COG1309	transcriptional regulator
DWB77_RS32400	COG1902	pentaerythritol trinitrate reductase activity
DWB77_RS32405	COG0640	Transcriptional regulator
DWB77_RS32415	COG1309	transcriptional regulator
DWB77_RS32425	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS32450	COG0584	glycerophosphoryl diester phosphodiesterase
DWB77_RS32485	COG0204	Acyl-transferase
DWB77_RS32505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DWB77_RS32515	COG0515	serine threonine protein kinase
DWB77_RS32515	COG2815	serine threonine protein kinase
DWB77_RS32525	COG1940	carbohydrate kinase activity
DWB77_RS32530	COG1653	transport
DWB77_RS32535	COG1175	transmembrane transport
DWB77_RS32540	COG0395	ABC-type sugar transport system, permease component
DWB77_RS32560	COG1660	Displays ATPase and GTPase activities
DWB77_RS32575	COG0445	tRNA wobble uridine modification
DWB77_RS32590	COG4585	Histidine kinase
DWB77_RS32595	COG2197	response regulator
DWB77_RS32610	COG2223	nitrite transmembrane transporter activity
DWB77_RS32615	COG1940	carbohydrate kinase activity
DWB77_RS32655	COG0589	response to stress
DWB77_RS32660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS32670	COG1349	DNA-binding transcription factor activity
DWB77_RS32680	COG0464	growth
DWB77_RS32690	COG3217	Mosc domain protein beta barrel domain protein
DWB77_RS32690	COG0633	Ferredoxin
DWB77_RS32705	COG1215	transferase activity, transferring glycosyl groups
DWB77_RS32730	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS32780	COG0668	transmembrane transport
DWB77_RS32790	COG2838	Isocitrate dehydrogenase
DWB77_RS32810	COG3345	alpha-galactosidase
DWB77_RS32815	COG1940	carbohydrate kinase activity
DWB77_RS32845	COG2233	PERMEase
DWB77_RS32870	COG1902	pentaerythritol trinitrate reductase activity
DWB77_RS32870	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB77_RS32885	COG1461	Dihydroxyacetone kinase
DWB77_RS32890	COG2376	Dihydroxyacetone kinase
DWB77_RS32895	COG0584	glycerophosphoryl diester phosphodiesterase
DWB77_RS32900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DWB77_RS32905	COG0254	rRNA binding
DWB77_RS32915	COG1090	epimerase
DWB77_RS32930	COG3189	MarR family transcriptional regulator
DWB77_RS32935	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS32940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DWB77_RS32945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DWB77_RS32955	COG1960	acyl-CoA dehydrogenase activity
DWB77_RS32965	COG2815	serine threonine protein kinase
DWB77_RS32965	COG0515	serine threonine protein kinase
DWB77_RS32975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB77_RS32980	COG2070	2-Nitropropane dioxygenase
DWB77_RS32990	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS33010	COG1024	Enoyl-CoA hydratase
DWB77_RS33035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB77_RS33040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWB77_RS33040	COG1672	PFAM Archaeal ATPase
DWB77_RS33090	COG2124	cytochrome p450
DWB77_RS33150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS33165	COG0583	DNA-binding transcription factor activity
DWB77_RS33170	COG1686	Belongs to the peptidase S11 family
DWB77_RS33175	COG3469	chitinase activity
DWB77_RS33185	COG1191	sigma factor activity
DWB77_RS33200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DWB77_RS33210	COG3345	alpha-galactosidase
DWB77_RS33220	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS33235	COG1522	sequence-specific DNA binding
DWB77_RS33240	COG0626	cystathionine gamma-synthase activity
DWB77_RS33275	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS33280	COG1846	Transcriptional regulator
DWB77_RS33285	COG1764	response to oxidative stress
DWB77_RS33300	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB77_RS33330	COG4249	Peptidase C14 caspase catalytic subunit p20
DWB77_RS33330	COG2319	Wd-40 repeat
DWB77_RS33350	COG1796	DNA polymerase
DWB77_RS33350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DWB77_RS33365	COG0328	RNA-DNA hybrid ribonuclease activity
DWB77_RS33375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWB77_RS33410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS33460	COG3118	belongs to the thioredoxin family
DWB77_RS33505	COG1309	transcriptional regulator
DWB77_RS33520	COG0009	L-threonylcarbamoyladenylate synthase
DWB77_RS33525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DWB77_RS33540	COG2226	methyltransferase
DWB77_RS33555	COG0667	Aldo Keto reductase
DWB77_RS33575	COG1132	(ABC) transporter
DWB77_RS33610	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
DWB77_RS33645	COG2124	cytochrome p450
DWB77_RS33655	COG2124	cytochrome p450
DWB77_RS33675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DWB77_RS33680	COG2080	2 iron, 2 sulfur cluster binding
DWB77_RS33695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB77_RS33705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DWB77_RS33765	COG3483	tryptophan 2,3-dioxygenase activity
DWB77_RS33770	COG0436	Aminotransferase
DWB77_RS33775	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB77_RS33805	COG3433	isochorismatase activity
DWB77_RS33805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS33805	COG2226	methyltransferase
DWB77_RS33810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS33810	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DWB77_RS33815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS33830	COG2267	carboxylic ester hydrolase activity
DWB77_RS33835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS33885	COG2124	cytochrome p450
DWB77_RS33915	COG2815	serine threonine protein kinase
DWB77_RS33915	COG0515	serine threonine protein kinase
DWB77_RS33920	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS33940	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DWB77_RS33955	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS33965	COG2267	carboxylic ester hydrolase activity
DWB77_RS33975	COG3321	synthase
DWB77_RS33975	COG0604	alcohol dehydrogenase
DWB77_RS33980	COG0477	Major facilitator Superfamily
DWB77_RS33985	COG0183	Belongs to the thiolase family
DWB77_RS34045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS34070	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS34110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DWB77_RS34115	COG3239	Fatty acid desaturase
DWB77_RS34130	COG1720	tRNA m6t6A37 methyltransferase activity
DWB77_RS34160	COG2018	Roadblock/LC7 domain
DWB77_RS34170	COG0189	ligase activity
DWB77_RS34180	COG0588	phosphoglycerate mutase activity
DWB77_RS34210	COG1686	Belongs to the peptidase S11 family
DWB77_RS34220	COG1609	Transcriptional regulator
DWB77_RS34225	COG3537	Alpha-1,2-mannosidase
DWB77_RS34305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DWB77_RS34315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB77_RS34320	COG1993	acr, cog1993
DWB77_RS34325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB77_RS34330	COG0671	phosphoesterase, PA-phosphatase related
DWB77_RS34335	COG0215	cysteine-tRNA ligase activity
DWB77_RS34340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB77_RS34390	COG1131	(ABC) transporter
DWB77_RS34410	COG2124	cytochrome p450
DWB77_RS34410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB77_RS34440	COG0531	amino acid
DWB77_RS34465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DWB77_RS34485	COG2066	Belongs to the glutaminase family
DWB77_RS34505	COG1012	belongs to the aldehyde dehydrogenase family
DWB77_RS34515	COG0583	DNA-binding transcription factor activity
DWB77_RS34535	COG3237	CsbD-like
DWB77_RS34545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB77_RS34605	COG1131	(ABC) transporter
DWB77_RS34615	COG1725	Transcriptional regulator
DWB77_RS34625	COG0596	Alpha beta hydrolase
DWB77_RS34665	COG2723	6-phospho-beta-galactosidase activity
DWB77_RS34670	COG0395	ABC-type sugar transport system, permease component
DWB77_RS34675	COG1175	transmembrane transport
DWB77_RS34680	COG2182	Extracellular solute-binding protein
DWB77_RS34730	COG0142	geranyltranstransferase activity
DWB77_RS34750	COG1191	sigma factor activity
DWB77_RS34765	COG0454	-acetyltransferase
DWB77_RS34785	COG0596	Alpha beta hydrolase
DWB77_RS34855	COG3903	Transcriptional regulator
DWB77_RS34855	COG3629	intracellular signal transduction
DWB77_RS34860	COG2366	antibiotic biosynthetic process
DWB77_RS34875	COG2267	carboxylic ester hydrolase activity
DWB77_RS34920	COG2197	response regulator
DWB77_RS34935	COG0437	4 iron, 4 sulfur cluster binding
DWB77_RS34940	COG0243	molybdopterin cofactor binding
DWB77_RS34940	COG3383	formate dehydrogenase (NAD+) activity
DWB77_RS34945	COG1335	isochorismatase
DWB77_RS34965	COG1231	oxidoreductase activity
DWB77_RS35000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DWB77_RS35000	COG0723	plastoquinol--plastocyanin reductase activity
DWB77_RS35005	COG3547	Transposase (IS116 IS110 IS902 family)
DWB77_RS35060	COG0297	glycogen (starch) synthase activity
DWB77_RS35080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
DWB77_RS35095	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35115	COG1982	Orn Lys Arg decarboxylase major
DWB77_RS35135	COG1309	transcriptional regulator
DWB77_RS35140	COG0667	Aldo Keto reductase
DWB77_RS35150	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35210	COG2197	response regulator
DWB77_RS35230	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB77_RS35300	COG5297	Belongs to the glycosyl hydrolase family 6
DWB77_RS35310	COG5297	Belongs to the glycosyl hydrolase family 6
DWB77_RS35310	COG4733	cellulase activity
DWB77_RS35320	COG1653	transport
DWB77_RS35335	COG0395	ABC-type sugar transport system, permease component
DWB77_RS35340	COG1175	transmembrane transport
DWB77_RS35350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB77_RS35355	COG1802	Transcriptional regulator
DWB77_RS35365	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS35415	COG0475	glutathione-regulated potassium exporter activity
DWB77_RS35425	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DWB77_RS35430	COG1605	Chorismate mutase
DWB77_RS35435	COG0287	Prephenate dehydrogenase
DWB77_RS35440	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB77_RS35440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB77_RS35450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB77_RS35470	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35485	COG0667	Aldo Keto reductase
DWB77_RS35500	COG0583	DNA-binding transcription factor activity
DWB77_RS35510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB77_RS35555	COG1595	DNA-templated transcription, initiation
DWB77_RS35595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB77_RS35695	COG0069	glutamate synthase activity
DWB77_RS35700	COG0028	Belongs to the TPP enzyme family
DWB77_RS35705	COG4989	oxidoreductase activity
DWB77_RS35710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB77_RS35740	COG1408	metallophosphoesterase
DWB77_RS35750	COG1397	ADP-ribosylglycohydrolase
DWB77_RS35775	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35780	COG1846	Transcriptional regulator
DWB77_RS35860	COG1278	Cold shock
DWB77_RS35890	COG0326	Molecular chaperone. Has ATPase activity
DWB77_RS35905	COG2249	NAD(P)H dehydrogenase (quinone) activity
DWB77_RS35920	COG2378	regulation of single-species biofilm formation
DWB77_RS35925	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS35950	COG1051	belongs to the nudix hydrolase family
DWB77_RS36060	COG0501	Belongs to the peptidase M48B family
DWB77_RS36115	COG2318	DinB family
DWB77_RS36160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB77_RS36165	COG1120	ATPase activity
DWB77_RS36265	COG2226	methyltransferase
DWB77_RS36285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB77_RS36310	COG3152	Membrane
DWB77_RS36390	COG3251	PFAM MbtH domain protein
DWB77_RS36500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB77_RS36505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DWB77_RS36545	COG1846	Transcriptional regulator
DWB77_RS36555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB77_RS36565	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
DWB77_RS36565	COG1672	PFAM Archaeal ATPase
DWB77_RS36655	COG1113	amino acid transport
DWB77_RS36665	COG0667	Aldo Keto reductase
DWB77_RS36675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB77_RS36695	COG0318	PFAM AMP-dependent synthetase and ligase
DWB77_RS36700	COG0028	Belongs to the TPP enzyme family
DWB77_RS36705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DWB77_RS36715	COG0156	8-amino-7-oxononanoate synthase activity
DWB77_RS36720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB77_RS36730	COG2211	Major facilitator Superfamily
DWB77_RS36750	COG0667	Aldo Keto reductase
DWB77_RS36810	COG2770	Histidine kinase
DWB77_RS36810	COG2208	phosphoserine phosphatase activity
DWB77_RS36845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB77_RS36855	COG1028	Short-chain dehydrogenase reductase Sdr
DWB77_RS36855	COG0604	alcohol dehydrogenase
DWB77_RS36855	COG3321	synthase
DWB77_RS36860	COG1309	transcriptional regulator
DWB77_RS36875	COG3693	PFAM glycoside hydrolase, family 10
DWB77_RS36885	COG1595	DNA-templated transcription, initiation
DWB77_RS36945	COG2130	NADP-dependent
DWB77_RS36950	COG0583	DNA-binding transcription factor activity
DWB77_RS37150	COG3479	Phenolic acid decarboxylase
DWB77_RS37155	COG1280	lysine exporter protein (LysE YggA)
DWB77_RS37180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DWB77_RS37375	COG0113	porphobilinogen synthase activity