locus-tag	class	description
HOK021_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HOK021_RS00010	COG0592	DNA-directed DNA polymerase activity
HOK021_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HOK021_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HOK021_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HOK021_RS00030	COG0187	DNA topoisomerase II activity
HOK021_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOK021_RS00065	COG0515	serine threonine protein kinase
HOK021_RS00090	COG0705	Rhomboid family
HOK021_RS00105	COG3764	Sortase (surface protein transpeptidase)
HOK021_RS00120	COG3764	Sortase (surface protein transpeptidase)
HOK021_RS00125	COG3764	Sortase (surface protein transpeptidase)
HOK021_RS00130	COG0515	serine threonine protein kinase
HOK021_RS00135	COG0768	penicillin binding
HOK021_RS00150	COG1716	ATPase activity
HOK021_RS00155	COG1716	ATPase activity
HOK021_RS00165	COG0583	DNA-binding transcription factor activity
HOK021_RS00175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HOK021_RS00180	COG1733	regulation of RNA biosynthetic process
HOK021_RS00215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HOK021_RS00220	COG2151	metal-sulfur cluster biosynthetic enzyme
HOK021_RS00225	COG3396	Phenylacetate-CoA oxygenase
HOK021_RS00230	COG3460	Phenylacetate-CoA oxygenase
HOK021_RS00235	COG3396	Phenylacetate-CoA oxygenase
HOK021_RS00260	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS00265	COG1309	transcriptional regulator
HOK021_RS00270	COG1522	sequence-specific DNA binding
HOK021_RS00300	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HOK021_RS00320	COG0515	serine threonine protein kinase
HOK021_RS00325	COG0515	serine threonine protein kinase
HOK021_RS00350	COG0022	dehydrogenase e1 component
HOK021_RS00355	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOK021_RS00375	COG0456	acetyltransferase
HOK021_RS00425	COG3903	Transcriptional regulator
HOK021_RS00425	COG3629	intracellular signal transduction
HOK021_RS00430	COG1362	aminopeptidase activity
HOK021_RS00435	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS00460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HOK021_RS00470	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOK021_RS00505	COG1174	glycine betaine transport
HOK021_RS00510	COG1174	glycine betaine transport
HOK021_RS00515	COG1732	Glycine betaine
HOK021_RS00520	COG0517	IMP dehydrogenase activity
HOK021_RS00520	COG1125	glycine betaine transport
HOK021_RS00525	COG0745	RESPONSE REGULATOR receiver
HOK021_RS00575	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HOK021_RS00650	COG1316	TRANSCRIPTIONal
HOK021_RS00690	COG2197	response regulator
HOK021_RS00695	COG4585	Histidine kinase
HOK021_RS00705	COG1131	(ABC) transporter
HOK021_RS00720	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS00725	COG2030	dehydratase
HOK021_RS00735	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOK021_RS00755	COG0028	Belongs to the TPP enzyme family
HOK021_RS00780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS00790	COG0515	serine threonine protein kinase
HOK021_RS00805	COG2197	response regulator
HOK021_RS00865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HOK021_RS00875	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOK021_RS00880	COG1051	belongs to the nudix hydrolase family
HOK021_RS00900	COG2815	serine threonine protein kinase
HOK021_RS00900	COG0515	serine threonine protein kinase
HOK021_RS00905	COG0515	serine threonine protein kinase
HOK021_RS00910	COG0577	efflux transmembrane transporter activity
HOK021_RS00910	COG1136	(ABC) transporter
HOK021_RS00935	COG0789	Transcriptional regulator
HOK021_RS00940	COG0659	secondary active sulfate transmembrane transporter activity
HOK021_RS00960	COG1902	pentaerythritol trinitrate reductase activity
HOK021_RS00965	COG1846	Transcriptional regulator
HOK021_RS00970	COG2267	carboxylic ester hydrolase activity
HOK021_RS00975	COG3226	Transcriptional regulator
HOK021_RS00985	COG0640	Transcriptional regulator
HOK021_RS00990	COG0798	PFAM Bile acid sodium symporter
HOK021_RS00995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOK021_RS01085	COG0305	Participates in initiation and elongation during chromosome replication
HOK021_RS01120	COG0717	Belongs to the dCTP deaminase family
HOK021_RS01150	COG2181	nitrate reductase activity
HOK021_RS01150	COG0247	lactate metabolic process
HOK021_RS01155	COG0443	Heat shock 70 kDa protein
HOK021_RS01160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOK021_RS01165	COG0484	heat shock protein binding
HOK021_RS01170	COG0789	Transcriptional regulator
HOK021_RS01190	COG0542	response to heat
HOK021_RS01230	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HOK021_RS01245	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOK021_RS01250	COG0191	fructose-bisphosphate aldolase activity
HOK021_RS01255	COG0477	Major facilitator Superfamily
HOK021_RS01265	COG3483	tryptophan 2,3-dioxygenase activity
HOK021_RS01280	COG4585	Histidine kinase
HOK021_RS01285	COG2197	response regulator
HOK021_RS01295	COG3559	Exporter of polyketide antibiotics
HOK021_RS01300	COG1131	(ABC) transporter
HOK021_RS01315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOK021_RS01335	COG0693	protein deglycase activity
HOK021_RS01345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOK021_RS01350	COG1802	Transcriptional regulator
HOK021_RS01365	COG0151	Belongs to the GarS family
HOK021_RS01380	COG0583	DNA-binding transcription factor activity
HOK021_RS01390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HOK021_RS01400	COG2197	response regulator
HOK021_RS01435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOK021_RS01440	COG0047	phosphoribosylformylglycinamidine synthase activity
HOK021_RS01445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HOK021_RS01470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HOK021_RS01505	COG1643	Atp-dependent helicase
HOK021_RS01550	COG0513	Belongs to the DEAD box helicase family
HOK021_RS01620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HOK021_RS01625	COG0579	oxidoreductase
HOK021_RS01670	COG1846	Transcriptional regulator
HOK021_RS01690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOK021_RS01700	COG0123	including yeast histone deacetylase and acetoin utilization protein
HOK021_RS01750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HOK021_RS01755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HOK021_RS01760	COG0181	hydroxymethylbilane synthase activity
HOK021_RS01765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOK021_RS01765	COG1648	precorrin-2 dehydrogenase activity
HOK021_RS01790	COG0113	porphobilinogen synthase activity
HOK021_RS01795	COG3237	CsbD-like
HOK021_RS01805	COG0018	arginyl-trna synthetase
HOK021_RS01810	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HOK021_RS01835	COG1690	Belongs to the RtcB family
HOK021_RS01845	COG1742	UPF0060 membrane protein
HOK021_RS01850	COG4181	ATPase activity
HOK021_RS01855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS01890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HOK021_RS01895	COG0406	alpha-ribazole phosphatase activity
HOK021_RS01910	COG0785	Cytochrome C biogenesis protein
HOK021_RS01920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HOK021_RS01950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HOK021_RS01955	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HOK021_RS01975	COG0163	prenyltransferase activity
HOK021_RS01985	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOK021_RS02000	COG1301	dicarboxylic acid transport
HOK021_RS02015	COG1309	transcriptional regulator
HOK021_RS02065	COG1404	Belongs to the peptidase S8 family
HOK021_RS02080	COG1404	Belongs to the peptidase S8 family
HOK021_RS02095	COG1674	ftsk spoiiie
HOK021_RS02100	COG1278	Cold shock
HOK021_RS02105	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOK021_RS02115	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOK021_RS02125	COG2226	methyltransferase
HOK021_RS02145	COG0791	NLP P60 protein
HOK021_RS02145	COG1388	LysM domain
HOK021_RS02145	COG3103	Sh3 type 3 domain protein
HOK021_RS02155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02165	COG0649	NAD binding
HOK021_RS02175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HOK021_RS02180	COG1034	ATP synthesis coupled electron transport
HOK021_RS02185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HOK021_RS02190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02195	COG0839	Belongs to the complex I subunit 6 family
HOK021_RS02200	COG0713	ATP synthesis coupled electron transport
HOK021_RS02205	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HOK021_RS02215	COG1007	ATP synthesis coupled electron transport
HOK021_RS02245	COG0142	geranyltranstransferase activity
HOK021_RS02255	COG1131	(ABC) transporter
HOK021_RS02270	COG0702	epimerase
HOK021_RS02275	COG1013	pyruvate-flavodoxin oxidoreductase activity
HOK021_RS02280	COG0674	pyruvate-flavodoxin oxidoreductase activity
HOK021_RS02280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HOK021_RS02290	COG4585	Histidine kinase
HOK021_RS02295	COG4585	Histidine kinase
HOK021_RS02310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02320	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02325	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HOK021_RS02330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HOK021_RS02335	COG0839	Belongs to the complex I subunit 6 family
HOK021_RS02340	COG0713	ATP synthesis coupled electron transport
HOK021_RS02345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HOK021_RS02355	COG1007	ATP synthesis coupled electron transport
HOK021_RS02360	COG0501	Belongs to the peptidase M48B family
HOK021_RS02365	COG3304	Inner membrane component domain
HOK021_RS02375	COG1666	GTP binding
HOK021_RS02395	COG0402	S-adenosylhomocysteine deaminase activity
HOK021_RS02410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HOK021_RS02415	COG2030	dehydratase
HOK021_RS02425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HOK021_RS02430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOK021_RS02435	COG0436	Aminotransferase
HOK021_RS02450	COG0250	Participates in transcription elongation, termination and antitermination
HOK021_RS02455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HOK021_RS02460	COG0081	regulation of translation
HOK021_RS02470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HOK021_RS02475	COG0222	ribosome binding
HOK021_RS02480	COG0085	RNA polymerase activity
HOK021_RS02485	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HOK021_RS02495	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HOK021_RS02500	COG0049	tRNA binding
HOK021_RS02505	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HOK021_RS02510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOK021_RS02515	COG0051	transcription antitermination factor activity, RNA binding
HOK021_RS02520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HOK021_RS02525	COG0088	Forms part of the polypeptide exit tunnel
HOK021_RS02530	COG0089	rRNA binding
HOK021_RS02535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HOK021_RS02540	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HOK021_RS02545	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HOK021_RS02550	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HOK021_RS02555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HOK021_RS02560	COG0255	Belongs to the universal ribosomal protein uL29 family
HOK021_RS02565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HOK021_RS02570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HOK021_RS02575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HOK021_RS02580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HOK021_RS02585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOK021_RS02590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HOK021_RS02595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HOK021_RS02600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HOK021_RS02605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HOK021_RS02610	COG1841	ribosomal large subunit assembly
HOK021_RS02615	COG0200	Binds to the 23S rRNA
HOK021_RS02625	COG0563	adenylate kinase activity
HOK021_RS02635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HOK021_RS02640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HOK021_RS02645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HOK021_RS02650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HOK021_RS02655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOK021_RS02660	COG0202	RNA polymerase activity
HOK021_RS02665	COG0203	ribosomal protein L17
HOK021_RS02670	COG0101	tRNA pseudouridine synthase activity
HOK021_RS02680	COG0488	(ABC) transporter
HOK021_RS02685	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HOK021_RS02690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HOK021_RS02695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOK021_RS02705	COG1072	(Pantothenic acid kinase))
HOK021_RS02715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOK021_RS02720	COG0736	holo-[acyl-carrier-protein] synthase activity
HOK021_RS02735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HOK021_RS02745	COG0802	atpase or kinase
HOK021_RS02770	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOK021_RS02790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HOK021_RS02800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOK021_RS02810	COG4221	oxidoreductase activity
HOK021_RS02820	COG0583	DNA-binding transcription factor activity
HOK021_RS02835	COG1595	DNA-templated transcription, initiation
HOK021_RS02845	COG0516	GMP reductase activity
HOK021_RS02855	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HOK021_RS02890	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS02895	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS02915	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOK021_RS02945	COG1024	Enoyl-CoA hydratase
HOK021_RS02975	COG0259	pyridoxamine-phosphate oxidase activity
HOK021_RS03020	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS03035	COG0515	serine threonine protein kinase
HOK021_RS03035	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOK021_RS03050	COG1024	Enoyl-CoA hydratase
HOK021_RS03115	COG2319	Wd-40 repeat
HOK021_RS03125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS03180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HOK021_RS03190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOK021_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS03210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS03245	COG1686	Belongs to the peptidase S11 family
HOK021_RS03275	COG2205	protein histidine kinase activity
HOK021_RS03280	COG0514	ATP-dependent DNA helicase (RecQ)
HOK021_RS03300	COG1674	ftsk spoiiie
HOK021_RS03350	COG1309	transcriptional regulator
HOK021_RS03370	COG1846	Transcriptional regulator
HOK021_RS03375	COG3384	dioxygenase
HOK021_RS03395	COG1247	-acetyltransferase
HOK021_RS03405	COG1349	DNA-binding transcription factor activity
HOK021_RS03410	COG1105	Belongs to the carbohydrate kinase PfkB family
HOK021_RS03415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOK021_RS03415	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HOK021_RS03415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOK021_RS03440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS03500	COG2188	Transcriptional regulator
HOK021_RS03505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HOK021_RS03510	COG0477	Major facilitator Superfamily
HOK021_RS03540	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HOK021_RS03555	COG3263	regulation of cellular component size
HOK021_RS03565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HOK021_RS03570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HOK021_RS03580	COG0315	cyclic pyranopterin monophosphate synthase activity
HOK021_RS03585	COG0315	cyclic pyranopterin monophosphate synthase activity
HOK021_RS03585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HOK021_RS03590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOK021_RS03605	COG0596	Alpha beta hydrolase
HOK021_RS03625	COG0789	Transcriptional regulator
HOK021_RS03630	COG1725	Transcriptional regulator
HOK021_RS03650	COG0708	Exodeoxyribonuclease III
HOK021_RS03665	COG3903	Transcriptional regulator
HOK021_RS03665	COG3629	intracellular signal transduction
HOK021_RS03675	COG2072	flavoprotein involved in K transport
HOK021_RS03680	COG2267	carboxylic ester hydrolase activity
HOK021_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS03700	COG0793	Belongs to the peptidase S41A family
HOK021_RS03700	COG4946	Tricorn protease homolog
HOK021_RS03710	COG2409	Drug exporters of the RND superfamily
HOK021_RS03715	COG0310	cobalt ion transport
HOK021_RS03725	COG1122	ATPase activity
HOK021_RS03735	COG1090	epimerase
HOK021_RS03750	COG0768	penicillin binding
HOK021_RS03770	COG0084	hydrolase, TatD family'
HOK021_RS03780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HOK021_RS03785	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HOK021_RS03830	COG0488	(ABC) transporter
HOK021_RS03900	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HOK021_RS03905	COG2197	response regulator
HOK021_RS03925	COG4106	trans-aconitate 2-methyltransferase activity
HOK021_RS03935	COG1309	transcriptional regulator
HOK021_RS03945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HOK021_RS03955	COG0193	aminoacyl-tRNA hydrolase activity
HOK021_RS03960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HOK021_RS03965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOK021_RS03970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HOK021_RS03985	COG4585	Histidine kinase
HOK021_RS04010	COG1316	TRANSCRIPTIONal
HOK021_RS04020	COG2814	Major facilitator Superfamily
HOK021_RS04070	COG2814	Major facilitator Superfamily
HOK021_RS04080	COG2124	cytochrome p450
HOK021_RS04095	COG0148	phosphopyruvate hydratase activity
HOK021_RS04120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HOK021_RS04125	COG0577	efflux transmembrane transporter activity
HOK021_RS04125	COG1136	(ABC) transporter
HOK021_RS04130	COG1136	(ABC) transporter
HOK021_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS04160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HOK021_RS04185	COG0300	oxidoreductase activity
HOK021_RS04195	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HOK021_RS04225	COG2030	dehydratase
HOK021_RS04235	COG2124	cytochrome p450
HOK021_RS04285	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOK021_RS04290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOK021_RS04305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS04320	COG0183	Belongs to the thiolase family
HOK021_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS04330	COG2188	Transcriptional regulator
HOK021_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS04340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS04345	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS04355	COG0477	Major facilitator Superfamily
HOK021_RS04370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HOK021_RS04395	COG0183	Belongs to the thiolase family
HOK021_RS04400	COG2755	lipolytic protein G-D-S-L family
HOK021_RS04415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HOK021_RS04430	COG1609	Transcriptional regulator
HOK021_RS04460	COG1174	glycine betaine transport
HOK021_RS04465	COG1174	glycine betaine transport
HOK021_RS04475	COG2986	histidine ammonia-lyase
HOK021_RS04515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HOK021_RS04520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOK021_RS04530	COG1228	amidohydrolase
HOK021_RS04535	COG1191	sigma factor activity
HOK021_RS04540	COG1366	Belongs to the anti-sigma-factor antagonist family
HOK021_RS04570	COG3104	oligopeptide transport
HOK021_RS04575	COG0745	RESPONSE REGULATOR receiver
HOK021_RS04580	COG5002	protein histidine kinase activity
HOK021_RS04615	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HOK021_RS04625	COG1316	TRANSCRIPTIONal
HOK021_RS04645	COG1316	TRANSCRIPTIONal
HOK021_RS04690	COG0778	Nitroreductase
HOK021_RS04690	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HOK021_RS04695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HOK021_RS04735	COG2835	tetraacyldisaccharide 4'-kinase activity
HOK021_RS04745	COG1482	cell wall glycoprotein biosynthetic process
HOK021_RS04755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOK021_RS04755	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOK021_RS04755	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HOK021_RS04760	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HOK021_RS04800	COG0714	Associated with various cellular activities
HOK021_RS04820	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HOK021_RS04825	COG0745	RESPONSE REGULATOR receiver
HOK021_RS04830	COG5002	protein histidine kinase activity
HOK021_RS04830	COG5000	phosphorelay sensor kinase activity
HOK021_RS04835	COG0823	Involved in the tonB-independent uptake of proteins
HOK021_RS04845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HOK021_RS04850	COG2197	response regulator
HOK021_RS04855	COG3214	Protein conserved in bacteria
HOK021_RS04865	COG0653	protein targeting
HOK021_RS04880	COG0546	phosphoglycolate phosphatase activity
HOK021_RS04885	COG2902	Dehydrogenase
HOK021_RS04890	COG1134	teichoic acid transport
HOK021_RS04900	COG1309	transcriptional regulator
HOK021_RS04915	COG0463	Glycosyl transferase, family 2
HOK021_RS04940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HOK021_RS04940	COG1215	transferase activity, transferring glycosyl groups
HOK021_RS04945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HOK021_RS04960	COG0395	ABC-type sugar transport system, permease component
HOK021_RS04965	COG1175	transmembrane transport
HOK021_RS04970	COG1653	transport
HOK021_RS04980	COG0515	serine threonine protein kinase
HOK021_RS04985	COG0515	serine threonine protein kinase
HOK021_RS04990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HOK021_RS05005	COG2884	Cell division ATP-binding protein ftsE
HOK021_RS05010	COG2177	Part of the ABC transporter FtsEX involved in
HOK021_RS05015	COG0793	Belongs to the peptidase S41A family
HOK021_RS05020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HOK021_RS05050	COG0583	DNA-binding transcription factor activity
HOK021_RS05105	COG3973	AAA domain
HOK021_RS05115	COG0776	regulation of translation
HOK021_RS05125	COG2186	Transcriptional regulator
HOK021_RS05140	COG1176	ABC-type spermidine putrescine transport system, permease component I
HOK021_RS05145	COG3842	ATPase activity
HOK021_RS05155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOK021_RS05160	COG1678	Uncharacterized ACR, COG1678
HOK021_RS05180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HOK021_RS05195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS05215	COG0477	Major facilitator Superfamily
HOK021_RS05240	COG1174	glycine betaine transport
HOK021_RS05250	COG1174	glycine betaine transport
HOK021_RS05260	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HOK021_RS05265	COG0277	FAD linked oxidase domain protein
HOK021_RS05275	COG2080	2 iron, 2 sulfur cluster binding
HOK021_RS05275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS05290	COG0222	ribosome binding
HOK021_RS05295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOK021_RS05335	COG1335	isochorismatase
HOK021_RS05345	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HOK021_RS05355	COG1113	amino acid transport
HOK021_RS05380	COG1234	tRNA 3'-trailer cleavage
HOK021_RS05385	COG1263	PTS System
HOK021_RS05390	COG1263	PTS System
HOK021_RS05395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOK021_RS05400	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HOK021_RS05415	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HOK021_RS05435	COG0477	Major facilitator Superfamily
HOK021_RS05450	COG2205	protein histidine kinase activity
HOK021_RS05465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HOK021_RS05475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOK021_RS05490	COG1131	(ABC) transporter
HOK021_RS05505	COG2733	membrane
HOK021_RS05510	COG3764	Sortase (surface protein transpeptidase)
HOK021_RS05520	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOK021_RS05575	COG4702	Belongs to the UPF0303 family
HOK021_RS05580	COG0673	inositol 2-dehydrogenase activity
HOK021_RS05590	COG2188	Transcriptional regulator
HOK021_RS05595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOK021_RS05690	COG3397	chitin binding
HOK021_RS05725	COG1126	abc transporter atp-binding protein
HOK021_RS05730	COG0765	amino acid transport
HOK021_RS05735	COG0765	amino acid transport
HOK021_RS05750	COG0154	amidase activity
HOK021_RS05770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS05830	COG0492	ferredoxin-NADP+ reductase activity
HOK021_RS05845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HOK021_RS05850	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS05885	COG3979	chitinase
HOK021_RS05895	COG2910	NAD(P)H-binding
HOK021_RS05905	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HOK021_RS05910	COG4977	sequence-specific DNA binding
HOK021_RS05920	COG0589	response to stress
HOK021_RS05925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOK021_RS05940	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS05955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS05960	COG1309	transcriptional regulator
HOK021_RS05970	COG1946	Acyl-CoA thioesterase
HOK021_RS06010	COG0028	Belongs to the TPP enzyme family
HOK021_RS06015	COG1309	transcriptional regulator
HOK021_RS06025	COG1129	ABC transporter
HOK021_RS06025	COG0842	Transport permease protein
HOK021_RS06035	COG2826	transposase and inactivated derivatives, IS30 family
HOK021_RS06050	COG1472	Belongs to the glycosyl hydrolase 3 family
HOK021_RS06065	COG0673	inositol 2-dehydrogenase activity
HOK021_RS06080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOK021_RS06105	COG0673	inositol 2-dehydrogenase activity
HOK021_RS06115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HOK021_RS06125	COG3409	Peptidoglycan-binding domain 1 protein
HOK021_RS06130	COG2814	Major facilitator Superfamily
HOK021_RS06135	COG0673	inositol 2-dehydrogenase activity
HOK021_RS06155	COG3718	enzyme involved in inositol metabolism
HOK021_RS06160	COG3962	Belongs to the TPP enzyme family
HOK021_RS06175	COG1131	(ABC) transporter
HOK021_RS06190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HOK021_RS06200	COG1077	Cell shape determining protein MreB Mrl
HOK021_RS06205	COG0596	Alpha beta hydrolase
HOK021_RS06240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS06245	COG3321	synthase
HOK021_RS06245	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS06245	COG0604	alcohol dehydrogenase
HOK021_RS06260	COG1278	Cold shock
HOK021_RS06265	COG0513	Belongs to the DEAD box helicase family
HOK021_RS06325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HOK021_RS06330	COG0629	single-stranded DNA binding
HOK021_RS06355	COG2346	COG2346, Truncated hemoglobins
HOK021_RS06385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS06395	COG2186	Transcriptional regulator
HOK021_RS06405	COG1486	melibiose metabolic process
HOK021_RS06410	COG0395	ABC-type sugar transport system, permease component
HOK021_RS06415	COG1175	transmembrane transport
HOK021_RS06425	COG1846	Transcriptional regulator
HOK021_RS06425	COG1940	carbohydrate kinase activity
HOK021_RS06450	COG0668	transmembrane transport
HOK021_RS06495	COG4266	Belongs to the allantoicase family
HOK021_RS06530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HOK021_RS06535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HOK021_RS06540	COG1113	amino acid transport
HOK021_RS06545	COG1113	amino acid transport
HOK021_RS06555	COG1113	amino acid transport
HOK021_RS06560	COG0698	ribose 5-phosphate isomerase
HOK021_RS06570	COG4552	Acetyltransferase involved in intracellular survival and related
HOK021_RS06580	COG3594	Acyltransferase
HOK021_RS06605	COG0544	peptidyl-prolyl cis-trans isomerase activity
HOK021_RS06610	COG0740	serine-type endopeptidase activity
HOK021_RS06615	COG0740	serine-type endopeptidase activity
HOK021_RS06620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HOK021_RS06630	COG0525	valine-tRNA ligase activity
HOK021_RS06640	COG0768	penicillin binding
HOK021_RS06645	COG0285	dihydrofolate synthase activity
HOK021_RS06655	COG0105	UTP biosynthetic process
HOK021_RS06660	COG1077	Cell shape determining protein MreB Mrl
HOK021_RS06675	COG0768	penicillin binding
HOK021_RS06680	COG0772	Belongs to the SEDS family
HOK021_RS06715	COG1530	ribonuclease E activity
HOK021_RS06720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HOK021_RS06725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HOK021_RS06730	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HOK021_RS06740	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HOK021_RS06750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HOK021_RS06765	COG0501	Belongs to the peptidase M48B family
HOK021_RS06780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HOK021_RS06790	COG0799	negative regulation of ribosome biogenesis
HOK021_RS06795	COG0588	phosphoglycerate mutase activity
HOK021_RS06845	COG0495	leucyl-tRNA aminoacylation
HOK021_RS06855	COG1307	EDD domain protein, DegV family
HOK021_RS06870	COG1234	tRNA 3'-trailer cleavage
HOK021_RS06875	COG1959	2 iron, 2 sulfur cluster binding
HOK021_RS06880	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HOK021_RS06900	COG0268	Binds directly to 16S ribosomal RNA
HOK021_RS06905	COG0481	GTPase activity
HOK021_RS06940	COG1420	regulation of RNA biosynthetic process
HOK021_RS06945	COG0484	heat shock protein binding
HOK021_RS06950	COG2070	2-Nitropropane dioxygenase
HOK021_RS06965	COG0537	adenosine 5'-monophosphoramidase activity
HOK021_RS06970	COG1234	tRNA 3'-trailer cleavage
HOK021_RS06980	COG4948	Mandelate Racemase Muconate Lactonizing
HOK021_RS07000	COG1486	melibiose metabolic process
HOK021_RS07005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS07015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HOK021_RS07040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HOK021_RS07050	COG2723	6-phospho-beta-galactosidase activity
HOK021_RS07065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOK021_RS07070	COG2755	lipolytic protein G-D-S-L family
HOK021_RS07125	COG1381	Involved in DNA repair and RecF pathway recombination
HOK021_RS07130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOK021_RS07155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HOK021_RS07160	COG1121	(ABC) transporter
HOK021_RS07170	COG0423	glycine-tRNA ligase activity
HOK021_RS07185	COG2197	response regulator
HOK021_RS07220	COG1309	transcriptional regulator
HOK021_RS07225	COG0667	Aldo Keto reductase
HOK021_RS07230	COG0477	Major facilitator Superfamily
HOK021_RS07255	COG0574	Belongs to the PEP-utilizing enzyme family
HOK021_RS07255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOK021_RS07265	COG2175	clavaminate synthase activity
HOK021_RS07270	COG0395	ABC-type sugar transport system, permease component
HOK021_RS07275	COG1175	transmembrane transport
HOK021_RS07280	COG2182	Extracellular solute-binding protein
HOK021_RS07335	COG0531	amino acid
HOK021_RS07345	COG0640	Transcriptional regulator
HOK021_RS07360	COG2146	nitrite reductase [NAD(P)H] activity
HOK021_RS07360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOK021_RS07390	COG0667	Aldo Keto reductase
HOK021_RS07400	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HOK021_RS07430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOK021_RS07440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HOK021_RS07455	COG0358	DNA primase activity
HOK021_RS07460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HOK021_RS07465	COG1070	Carbohydrate kinase
HOK021_RS07500	COG0515	serine threonine protein kinase
HOK021_RS07500	COG2815	serine threonine protein kinase
HOK021_RS07540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HOK021_RS07545	COG0588	phosphoglycerate mutase activity
HOK021_RS07550	COG1077	Cell shape determining protein MreB Mrl
HOK021_RS07565	COG0477	Major facilitator Superfamily
HOK021_RS07575	COG2130	NADP-dependent
HOK021_RS07580	COG1764	response to oxidative stress
HOK021_RS07585	COG1609	Transcriptional regulator
HOK021_RS07590	COG1129	ABC transporter
HOK021_RS07595	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS07605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS07630	COG1309	transcriptional regulator
HOK021_RS07665	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS07670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOK021_RS07675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOK021_RS07680	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HOK021_RS07700	COG0789	Transcriptional regulator
HOK021_RS07705	COG0667	Aldo Keto reductase
HOK021_RS07720	COG2197	response regulator
HOK021_RS07725	COG4585	Histidine kinase
HOK021_RS07740	COG1309	transcriptional regulator
HOK021_RS07745	COG0477	Major facilitator Superfamily
HOK021_RS07755	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HOK021_RS07800	COG1358	cellular component organization or biogenesis
HOK021_RS07825	COG0800	Aldolase
HOK021_RS07830	COG4948	Mandelate Racemase Muconate Lactonizing
HOK021_RS07835	COG2186	Transcriptional regulator
HOK021_RS07855	COG2188	Transcriptional regulator
HOK021_RS07865	COG0583	DNA-binding transcription factor activity
HOK021_RS07885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS07890	COG1024	Enoyl-CoA hydratase
HOK021_RS07905	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HOK021_RS07910	COG0596	Alpha beta hydrolase
HOK021_RS08015	COG0477	Major facilitator Superfamily
HOK021_RS08055	COG2124	cytochrome p450
HOK021_RS08060	COG0183	Belongs to the thiolase family
HOK021_RS08070	COG3845	ABC transporter
HOK021_RS08105	COG1309	transcriptional regulator
HOK021_RS08110	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS08130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS08140	COG0860	N-Acetylmuramoyl-L-alanine amidase
HOK021_RS08145	COG3510	cephalosporin hydroxylase
HOK021_RS08150	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS08155	COG0183	Belongs to the thiolase family
HOK021_RS08165	COG2197	response regulator
HOK021_RS08170	COG4585	Histidine kinase
HOK021_RS08180	COG1131	(ABC) transporter
HOK021_RS08185	COG2030	dehydratase
HOK021_RS08195	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS08210	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HOK021_RS08225	COG0800	Aldolase
HOK021_RS08230	COG3022	response to hydroperoxide
HOK021_RS08235	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
HOK021_RS08320	COG0210	DNA helicase
HOK021_RS08350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HOK021_RS08430	COG0159	tryptophan synthase activity
HOK021_RS08435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOK021_RS08470	COG2124	cytochrome p450
HOK021_RS08475	COG0587	DNA-directed DNA polymerase activity
HOK021_RS08560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HOK021_RS08565	COG1088	dTDP-glucose 4,6-dehydratase activity
HOK021_RS08585	COG0587	DNA-directed DNA polymerase activity
HOK021_RS08590	COG1793	dna ligase
HOK021_RS08590	COG3285	dna ligase
HOK021_RS08630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS08655	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS08665	COG3540	Alkaline phosphatase
HOK021_RS08670	COG2814	Major facilitator Superfamily
HOK021_RS08675	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HOK021_RS08685	COG1834	amidinotransferase
HOK021_RS08710	COG0672	)-iron permease
HOK021_RS08715	COG2837	iron assimilation
HOK021_RS08755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOK021_RS08760	COG2186	Transcriptional regulator
HOK021_RS08775	COG1175	transmembrane transport
HOK021_RS08795	COG1994	Peptidase M50
HOK021_RS08815	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HOK021_RS08820	COG0477	Major facilitator Superfamily
HOK021_RS08825	COG1309	transcriptional regulator
HOK021_RS08835	COG2814	Major facilitator Superfamily
HOK021_RS08840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HOK021_RS08840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOK021_RS08845	COG2132	Multicopper oxidase
HOK021_RS08850	COG2267	carboxylic ester hydrolase activity
HOK021_RS08855	COG0174	glutamine synthetase
HOK021_RS08860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HOK021_RS08870	COG1609	Transcriptional regulator
HOK021_RS08875	COG0366	Alpha amylase catalytic
HOK021_RS08880	COG2182	Extracellular solute-binding protein
HOK021_RS08885	COG1175	transmembrane transport
HOK021_RS08890	COG0395	ABC-type sugar transport system, permease component
HOK021_RS08895	COG0366	Alpha amylase catalytic
HOK021_RS08940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HOK021_RS09030	COG0745	RESPONSE REGULATOR receiver
HOK021_RS09060	COG1695	Transcriptional regulator
HOK021_RS09065	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOK021_RS09065	COG1902	pentaerythritol trinitrate reductase activity
HOK021_RS09080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HOK021_RS09115	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HOK021_RS09120	COG0321	lipoyl(octanoyl) transferase activity
HOK021_RS09150	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS09160	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HOK021_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOK021_RS09175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOK021_RS09180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HOK021_RS09185	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HOK021_RS09200	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HOK021_RS09200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HOK021_RS09205	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HOK021_RS09240	COG4585	Histidine kinase
HOK021_RS09245	COG2197	response regulator
HOK021_RS09250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HOK021_RS09255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HOK021_RS09265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HOK021_RS09285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS09295	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HOK021_RS09300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HOK021_RS09310	COG1376	ErfK ybiS ycfS ynhG family protein
HOK021_RS09320	COG1845	cytochrome c oxidase, subunit III
HOK021_RS09325	COG2010	Cytochrome c
HOK021_RS09330	COG0723	plastoquinol--plastocyanin reductase activity
HOK021_RS09335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HOK021_RS09340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOK021_RS09390	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS09410	COG0003	Pfam Anion-transporting ATPase
HOK021_RS09420	COG1940	carbohydrate kinase activity
HOK021_RS09450	COG2197	response regulator
HOK021_RS09455	COG0205	6-phosphofructokinase activity
HOK021_RS09460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOK021_RS09470	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HOK021_RS09480	COG2193	ferroxidase activity
HOK021_RS09485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HOK021_RS09490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HOK021_RS09495	COG0515	serine threonine protein kinase
HOK021_RS09495	COG2815	serine threonine protein kinase
HOK021_RS09500	COG2022	thiamine diphosphate biosynthetic process
HOK021_RS09510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOK021_RS09510	COG2022	thiamine diphosphate biosynthetic process
HOK021_RS09525	COG0352	thiamine-phosphate diphosphorylase activity
HOK021_RS09540	COG1233	COG1233 Phytoene dehydrogenase and related
HOK021_RS09550	COG1309	transcriptional regulator
HOK021_RS09570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOK021_RS09590	COG0714	Associated with various cellular activities
HOK021_RS09600	COG0275	rRNA processing
HOK021_RS09615	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HOK021_RS09625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HOK021_RS09630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HOK021_RS09640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HOK021_RS09645	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HOK021_RS09665	COG1799	cell septum assembly
HOK021_RS09675	COG3599	regulation of cell shape
HOK021_RS09680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HOK021_RS09690	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HOK021_RS09745	COG0587	DNA-directed DNA polymerase activity
HOK021_RS09755	COG1432	Conserved Protein
HOK021_RS09775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HOK021_RS09790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HOK021_RS09795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOK021_RS09800	COG0131	Imidazoleglycerol-phosphate dehydratase
HOK021_RS09810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HOK021_RS09815	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HOK021_RS09820	COG0251	oxidation-reduction process
HOK021_RS09825	COG0107	imidazoleglycerol-phosphate synthase activity
HOK021_RS09840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HOK021_RS09845	COG1053	succinate dehydrogenase
HOK021_RS09855	COG0583	DNA-binding transcription factor activity
HOK021_RS09870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HOK021_RS09875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOK021_RS09895	COG0134	indole-3-glycerol-phosphate synthase activity
HOK021_RS09900	COG0133	tryptophan synthase activity
HOK021_RS09905	COG0159	tryptophan synthase activity
HOK021_RS09915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HOK021_RS09925	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS09955	COG0070	glutamate synthase
HOK021_RS09955	COG0067	glutamate synthase
HOK021_RS09955	COG0069	glutamate synthase activity
HOK021_RS09970	COG0640	Transcriptional regulator
HOK021_RS09980	COG3467	pyridoxamine 5'-phosphate
HOK021_RS09990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOK021_RS10015	COG2197	response regulator
HOK021_RS10025	COG1470	cell adhesion involved in biofilm formation
HOK021_RS10025	COG0366	Alpha amylase catalytic
HOK021_RS10110	COG2050	protein possibly involved in aromatic compounds catabolism
HOK021_RS10150	COG1643	Atp-dependent helicase
HOK021_RS10170	COG0237	dephospho-CoA kinase activity
HOK021_RS10195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HOK021_RS10250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOK021_RS10255	COG0584	glycerophosphoryl diester phosphodiesterase
HOK021_RS10260	COG0556	nucleotide-excision repair
HOK021_RS10300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOK021_RS10310	COG1609	Transcriptional regulator
HOK021_RS10315	COG1063	alcohol dehydrogenase
HOK021_RS10345	COG3844	kynureninase activity
HOK021_RS10350	COG0322	excinuclease ABC activity
HOK021_RS10355	COG1660	Displays ATPase and GTPase activities
HOK021_RS10360	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HOK021_RS10365	COG1481	regulation of sporulation
HOK021_RS10370	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HOK021_RS10375	COG0126	phosphoglycerate kinase activity
HOK021_RS10380	COG0149	triose-phosphate isomerase activity
HOK021_RS10385	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HOK021_RS10395	COG0166	Belongs to the GPI family
HOK021_RS10400	COG0363	glucosamine-6-phosphate deaminase activity
HOK021_RS10415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HOK021_RS10425	COG0109	protoheme IX farnesyltransferase activity
HOK021_RS10440	COG1612	heme a metabolic process
HOK021_RS10450	COG1131	(ABC) transporter
HOK021_RS10475	COG0396	ATPase activity
HOK021_RS10480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HOK021_RS10485	COG0822	iron-sulfur transferase activity
HOK021_RS10495	COG2076	Multidrug Resistance protein
HOK021_RS10500	COG3226	Transcriptional regulator
HOK021_RS10505	COG2171	N-acyltransferase activity
HOK021_RS10515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOK021_RS10540	COG2226	methyltransferase
HOK021_RS10555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HOK021_RS10560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOK021_RS10575	COG4585	Histidine kinase
HOK021_RS10585	COG1414	Transcriptional regulator
HOK021_RS10615	COG1902	pentaerythritol trinitrate reductase activity
HOK021_RS10625	COG1917	Cupin 2, conserved barrel domain protein
HOK021_RS10630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOK021_RS10675	COG1797	cobyrinic acid a,c-diamide synthase activity
HOK021_RS10690	COG1492	cobalamin metabolic process
HOK021_RS10695	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HOK021_RS10710	COG1653	transport
HOK021_RS10725	COG0235	Class ii aldolase
HOK021_RS10740	COG0488	(ABC) transporter
HOK021_RS10760	COG1302	Protein conserved in bacteria
HOK021_RS10790	COG3387	PFAM Glycoside hydrolase 15-related
HOK021_RS10805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOK021_RS10835	COG3340	Belongs to the peptidase S51 family
HOK021_RS10875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOK021_RS10880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HOK021_RS10895	COG2261	transglycosylase associated protein
HOK021_RS10900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HOK021_RS10915	COG3655	Transcriptional regulator
HOK021_RS10940	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS10945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HOK021_RS10950	COG2186	Transcriptional regulator
HOK021_RS10970	COG0560	Phosphoserine phosphatase
HOK021_RS10970	COG3830	Belongs to the UPF0237 family
HOK021_RS10975	COG0842	Transport permease protein
HOK021_RS10975	COG1131	(ABC) transporter
HOK021_RS10975	COG1716	ATPase activity
HOK021_RS10995	COG4585	Histidine kinase
HOK021_RS11000	COG2197	response regulator
HOK021_RS11020	COG1119	ATPase activity
HOK021_RS11045	COG1881	PFAM PEBP family protein
HOK021_RS11055	COG2094	Belongs to the DNA glycosylase MPG family
HOK021_RS11095	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HOK021_RS11110	COG0647	UMP catabolic process
HOK021_RS11125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS11130	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS11135	COG1120	ATPase activity
HOK021_RS11155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HOK021_RS11160	COG0497	DNA recombination
HOK021_RS11175	COG3415	Transposase
HOK021_RS11175	COG2801	Transposase and inactivated derivatives
HOK021_RS11210	COG3387	PFAM Glycoside hydrolase 15-related
HOK021_RS11215	COG0504	CTP synthase activity
HOK021_RS11220	COG0494	nUDIX hydrolase
HOK021_RS11230	COG0686	Belongs to the AlaDH PNT family
HOK021_RS11245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HOK021_RS11250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HOK021_RS11255	COG1187	pseudouridine synthase activity
HOK021_RS11265	COG3541	Predicted nucleotidyltransferase
HOK021_RS11285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HOK021_RS11295	COG1160	GTP binding
HOK021_RS11315	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS11330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HOK021_RS11340	COG0671	phosphoesterase, PA-phosphatase related
HOK021_RS11350	COG0477	Major facilitator Superfamily
HOK021_RS11355	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS11360	COG1799	cell septum assembly
HOK021_RS11375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS11380	COG0765	amino acid transport
HOK021_RS11400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS11415	COG0330	HflC and HflK could
HOK021_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS11460	COG0587	DNA-directed DNA polymerase activity
HOK021_RS11465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOK021_RS11485	COG0531	amino acid
HOK021_RS11490	COG1522	sequence-specific DNA binding
HOK021_RS11510	COG0456	acetyltransferase
HOK021_RS11515	COG1725	Transcriptional regulator
HOK021_RS11520	COG1834	amidinotransferase
HOK021_RS11550	COG0726	polysaccharide deacetylase
HOK021_RS11550	COG1649	PFAM Uncharacterised BCR, COG1649
HOK021_RS11595	COG0477	Major facilitator Superfamily
HOK021_RS11595	COG2814	Major facilitator Superfamily
HOK021_RS11600	COG2188	Transcriptional regulator
HOK021_RS11605	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HOK021_RS11610	COG1309	transcriptional regulator
HOK021_RS11615	COG0243	molybdopterin cofactor binding
HOK021_RS11620	COG2851	Citrate transporter
HOK021_RS11640	COG1473	amidohydrolase
HOK021_RS11645	COG0477	Major facilitator Superfamily
HOK021_RS11655	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS11705	COG0477	Major facilitator Superfamily
HOK021_RS11710	COG3876	Protein conserved in bacteria
HOK021_RS11715	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS11720	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS11725	COG1309	transcriptional regulator
HOK021_RS11730	COG3963	phosphatidate phosphatase activity
HOK021_RS11740	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS11765	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HOK021_RS11805	COG2205	protein histidine kinase activity
HOK021_RS11810	COG0745	RESPONSE REGULATOR receiver
HOK021_RS11820	COG2124	cytochrome p450
HOK021_RS11830	COG0488	(ABC) transporter
HOK021_RS11860	COG0515	serine threonine protein kinase
HOK021_RS11860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HOK021_RS11870	COG0564	pseudouridine synthase activity
HOK021_RS11880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOK021_RS11910	COG0667	Aldo Keto reductase
HOK021_RS11915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS11925	COG0598	Magnesium transport protein CorA
HOK021_RS11945	COG0215	cysteine-tRNA ligase activity
HOK021_RS11960	COG4948	Mandelate Racemase Muconate Lactonizing
HOK021_RS11965	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS11975	COG1129	ABC transporter
HOK021_RS11980	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS12000	COG2186	Transcriptional regulator
HOK021_RS12010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HOK021_RS12015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOK021_RS12020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HOK021_RS12025	COG1414	Transcriptional regulator
HOK021_RS12030	COG0646	methionine synthase
HOK021_RS12030	COG1410	methionine synthase
HOK021_RS12035	COG0546	phosphoglycolate phosphatase activity
HOK021_RS12050	COG2197	response regulator
HOK021_RS12060	COG1994	Peptidase M50
HOK021_RS12060	COG0517	IMP dehydrogenase activity
HOK021_RS12080	COG1222	aaa ATPase
HOK021_RS12085	COG4122	O-methyltransferase activity
HOK021_RS12100	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HOK021_RS12105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HOK021_RS12110	COG1609	Transcriptional regulator
HOK021_RS12120	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HOK021_RS12125	COG0545	Peptidyl-prolyl cis-trans isomerase
HOK021_RS12135	COG2378	regulation of single-species biofilm formation
HOK021_RS12155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOK021_RS12160	COG0805	protein transport
HOK021_RS12175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS12180	COG3254	rhamnose metabolic process
HOK021_RS12195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HOK021_RS12200	COG4175	Glycine betaine
HOK021_RS12200	COG0517	IMP dehydrogenase activity
HOK021_RS12235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HOK021_RS12240	COG0531	amino acid
HOK021_RS12245	COG2186	Transcriptional regulator
HOK021_RS12290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HOK021_RS12300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HOK021_RS12305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HOK021_RS12310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HOK021_RS12315	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HOK021_RS12320	COG5002	protein histidine kinase activity
HOK021_RS12325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HOK021_RS12330	COG0072	phenylalanine-tRNA ligase activity
HOK021_RS12330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HOK021_RS12370	COG1649	PFAM Uncharacterised BCR, COG1649
HOK021_RS12380	COG0697	spore germination
HOK021_RS12385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS12430	COG4106	trans-aconitate 2-methyltransferase activity
HOK021_RS12460	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HOK021_RS12465	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HOK021_RS12470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HOK021_RS12475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOK021_RS12480	COG1438	arginine binding
HOK021_RS12485	COG0668	transmembrane transport
HOK021_RS12500	COG0137	argininosuccinate synthase activity
HOK021_RS12505	COG0165	Argininosuccinate lyase
HOK021_RS12515	COG0477	Major facilitator Superfamily
HOK021_RS12525	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS12525	COG0204	Acyl-transferase
HOK021_RS12530	COG0584	glycerophosphoryl diester phosphodiesterase
HOK021_RS12555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HOK021_RS12560	COG2011	ABC-type metal ion transport system permease component
HOK021_RS12565	COG1464	Belongs to the NlpA lipoprotein family
HOK021_RS12580	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HOK021_RS12585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HOK021_RS12585	COG1648	precorrin-2 dehydrogenase activity
HOK021_RS12650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HOK021_RS12660	COG0456	acetyltransferase
HOK021_RS12660	COG0454	-acetyltransferase
HOK021_RS12710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HOK021_RS12725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HOK021_RS12760	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HOK021_RS12765	COG1560	Kdo2-lipid A biosynthetic process
HOK021_RS12770	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS12780	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HOK021_RS12785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HOK021_RS12790	COG0217	transcriptional regulatory protein
HOK021_RS12795	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HOK021_RS12800	COG0632	four-way junction helicase activity
HOK021_RS12805	COG2255	four-way junction helicase activity
HOK021_RS12815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOK021_RS12820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HOK021_RS12825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HOK021_RS12830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOK021_RS12835	COG1196	nuclear chromosome segregation
HOK021_RS12850	COG0124	histidyl-tRNA synthetase
HOK021_RS12870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HOK021_RS12890	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HOK021_RS12895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HOK021_RS12905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HOK021_RS12910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HOK021_RS12915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HOK021_RS12920	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HOK021_RS12925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HOK021_RS12935	COG0006	proline dipeptidase activity
HOK021_RS12940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HOK021_RS12945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HOK021_RS12955	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HOK021_RS12960	COG0540	Belongs to the ATCase OTCase family
HOK021_RS12965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HOK021_RS12975	COG0505	Belongs to the CarA family
HOK021_RS12980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOK021_RS12985	COG0167	dihydroorotate dehydrogenase activity
HOK021_RS12990	COG0284	orotidine-5'-phosphate decarboxylase activity
HOK021_RS13015	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOK021_RS13030	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOK021_RS13060	COG0456	acetyltransferase
HOK021_RS13065	COG5285	phytanoyl-CoA dioxygenase
HOK021_RS13075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOK021_RS13080	COG2390	Transcriptional regulator
HOK021_RS13100	COG0531	amino acid
HOK021_RS13115	COG0477	Major facilitator Superfamily
HOK021_RS13135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOK021_RS13155	COG2233	PERMEase
HOK021_RS13165	COG2223	nitrite transmembrane transporter activity
HOK021_RS13170	COG1940	carbohydrate kinase activity
HOK021_RS13170	COG1846	Transcriptional regulator
HOK021_RS13175	COG1090	epimerase
HOK021_RS13190	COG3201	nicotinamide mononucleotide transporter
HOK021_RS13195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOK021_RS13195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOK021_RS13200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HOK021_RS13205	COG0140	phosphoribosyl-ATP diphosphatase activity
HOK021_RS13210	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HOK021_RS13285	COG1674	ftsk spoiiie
HOK021_RS13310	COG2814	Major facilitator Superfamily
HOK021_RS13315	COG2910	NAD(P)H-binding
HOK021_RS13325	COG1733	regulation of RNA biosynthetic process
HOK021_RS13365	COG1231	oxidoreductase activity
HOK021_RS13395	COG2018	Roadblock/LC7 domain
HOK021_RS13430	COG2197	response regulator
HOK021_RS13435	COG3850	Histidine kinase
HOK021_RS13455	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS13475	COG0671	phosphoesterase, PA-phosphatase related
HOK021_RS13505	COG0765	amino acid transport
HOK021_RS13515	COG0584	glycerophosphoryl diester phosphodiesterase
HOK021_RS13570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HOK021_RS13575	COG2318	DinB family
HOK021_RS13600	COG3345	alpha-galactosidase
HOK021_RS13610	COG1175	transmembrane transport
HOK021_RS13615	COG0395	ABC-type sugar transport system, permease component
HOK021_RS13635	COG4585	Histidine kinase
HOK021_RS13640	COG2197	response regulator
HOK021_RS13655	COG2223	nitrite transmembrane transporter activity
HOK021_RS13660	COG1940	carbohydrate kinase activity
HOK021_RS13725	COG1349	DNA-binding transcription factor activity
HOK021_RS13735	COG0464	growth
HOK021_RS13755	COG0633	Ferredoxin
HOK021_RS13755	COG3217	Mosc domain protein beta barrel domain protein
HOK021_RS13770	COG0463	Glycosyl transferase, family 2
HOK021_RS13775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HOK021_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS13910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HOK021_RS13945	COG0590	tRNA wobble adenosine to inosine editing
HOK021_RS13950	COG3224	Antibiotic biosynthesis monooxygenase
HOK021_RS13960	COG1793	dna ligase
HOK021_RS13975	COG1063	alcohol dehydrogenase
HOK021_RS13980	COG0395	ABC-type sugar transport system, permease component
HOK021_RS14025	COG1461	Dihydroxyacetone kinase
HOK021_RS14030	COG2376	Dihydroxyacetone kinase
HOK021_RS14045	COG2124	cytochrome p450
HOK021_RS14105	COG0735	belongs to the Fur family
HOK021_RS14125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HOK021_RS14145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HOK021_RS14150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HOK021_RS14155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOK021_RS14160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HOK021_RS14175	COG1609	Transcriptional regulator
HOK021_RS14180	COG2814	Major facilitator Superfamily
HOK021_RS14200	COG1335	isochorismatase
HOK021_RS14215	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HOK021_RS14225	COG1609	Transcriptional regulator
HOK021_RS14315	COG0783	Belongs to the Dps family
HOK021_RS14350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HOK021_RS14370	COG3285	dna ligase
HOK021_RS14370	COG1793	dna ligase
HOK021_RS14385	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HOK021_RS14400	COG0243	molybdopterin cofactor binding
HOK021_RS14415	COG0019	diaminopimelate decarboxylase activity
HOK021_RS14420	COG4264	IucA IucC family
HOK021_RS14425	COG2814	Major facilitator Superfamily
HOK021_RS14435	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOK021_RS14440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HOK021_RS14445	COG1120	ATPase activity
HOK021_RS14450	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS14455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS14480	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS14485	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS14495	COG0515	serine threonine protein kinase
HOK021_RS14510	COG2070	2-Nitropropane dioxygenase
HOK021_RS14520	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS14545	COG1605	Chorismate mutase
HOK021_RS14555	COG1024	Enoyl-CoA hydratase
HOK021_RS14635	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS14650	COG1984	allophanate hydrolase subunit 2
HOK021_RS14655	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HOK021_RS14660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HOK021_RS14680	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HOK021_RS14710	COG2146	nitrite reductase [NAD(P)H] activity
HOK021_RS14735	COG0596	Alpha beta hydrolase
HOK021_RS14750	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HOK021_RS14755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HOK021_RS14785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HOK021_RS14790	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HOK021_RS14800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOK021_RS14810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOK021_RS14840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HOK021_RS14860	COG1716	ATPase activity
HOK021_RS14880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HOK021_RS14890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HOK021_RS14890	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HOK021_RS14925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HOK021_RS15005	COG0697	spore germination
HOK021_RS15010	COG0583	DNA-binding transcription factor activity
HOK021_RS15015	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HOK021_RS15015	COG0825	malonyl-CoA metabolic process
HOK021_RS15020	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS15130	COG3629	intracellular signal transduction
HOK021_RS15130	COG3903	Transcriptional regulator
HOK021_RS15145	COG0602	queuosine metabolic process
HOK021_RS15150	COG0720	synthase
HOK021_RS15155	COG0302	gtp cyclohydrolase
HOK021_RS15165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HOK021_RS15210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS15230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOK021_RS15250	COG0596	Alpha beta hydrolase
HOK021_RS15280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOK021_RS15305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HOK021_RS15315	COG1132	(ABC) transporter
HOK021_RS15335	COG0386	Belongs to the glutathione peroxidase family
HOK021_RS15365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS15370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HOK021_RS15425	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS15450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HOK021_RS15480	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HOK021_RS15555	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HOK021_RS15580	COG3835	regulator
HOK021_RS15585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HOK021_RS15590	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS15605	COG3585	molybdate ion transport
HOK021_RS15640	COG2814	Major facilitator Superfamily
HOK021_RS15660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HOK021_RS15660	COG1024	Enoyl-CoA hydratase
HOK021_RS15665	COG0745	RESPONSE REGULATOR receiver
HOK021_RS15690	COG2318	DinB family
HOK021_RS15715	COG1063	alcohol dehydrogenase
HOK021_RS15720	COG0156	8-amino-7-oxononanoate synthase activity
HOK021_RS15725	COG0583	DNA-binding transcription factor activity
HOK021_RS15740	COG1796	DNA polymerase
HOK021_RS15740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HOK021_RS15755	COG2274	protein secretion by the type I secretion system
HOK021_RS15760	COG2274	protein secretion by the type I secretion system
HOK021_RS15820	COG2423	ornithine cyclodeaminase activity
HOK021_RS15830	COG0626	cystathionine gamma-synthase activity
HOK021_RS15835	COG3135	benzoate transporter
HOK021_RS15840	COG2268	Band 7 protein
HOK021_RS15860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOK021_RS15865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOK021_RS15885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOK021_RS15900	COG1620	l-lactate permease
HOK021_RS15905	COG0247	lactate metabolic process
HOK021_RS15910	COG1139	Iron-sulfur cluster binding protein
HOK021_RS15915	COG1556	Lactate utilization protein
HOK021_RS15930	COG0477	Major facilitator Superfamily
HOK021_RS15950	COG1113	amino acid transport
HOK021_RS15955	COG2186	Transcriptional regulator
HOK021_RS15965	COG4565	transcriptional regulatory protein
HOK021_RS15970	COG3290	protein histidine kinase activity
HOK021_RS15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOK021_RS15995	COG3591	Belongs to the peptidase S1B family
HOK021_RS15995	COG1864	DNA RNA non-specific endonuclease
HOK021_RS16015	COG0542	response to heat
HOK021_RS16020	COG2770	Histidine kinase
HOK021_RS16020	COG2208	phosphoserine phosphatase activity
HOK021_RS16040	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS16045	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS16050	COG0183	Belongs to the thiolase family
HOK021_RS16070	COG1024	Enoyl-CoA hydratase
HOK021_RS16080	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS16085	COG2814	Major facilitator Superfamily
HOK021_RS16095	COG0477	Major facilitator Superfamily
HOK021_RS16100	COG0702	epimerase
HOK021_RS16130	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOK021_RS16140	COG3938	Belongs to the proline racemase family
HOK021_RS16145	COG1802	Transcriptional regulator
HOK021_RS16150	COG0006	proline dipeptidase activity
HOK021_RS16175	COG2326	polyphosphate kinase activity
HOK021_RS16190	COG0589	response to stress
HOK021_RS16195	COG0701	Predicted permease
HOK021_RS16200	COG4214	carbohydrate transport
HOK021_RS16210	COG4213	ABC transporter substrate-binding protein
HOK021_RS16245	COG1113	amino acid transport
HOK021_RS16265	COG3594	Acyltransferase
HOK021_RS16270	COG1968	undecaprenyl-diphosphatase activity
HOK021_RS16300	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HOK021_RS16405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HOK021_RS16410	COG0443	Heat shock 70 kDa protein
HOK021_RS16415	COG3424	synthase
HOK021_RS16430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HOK021_RS16460	COG0513	Belongs to the DEAD box helicase family
HOK021_RS16465	COG1278	Cold shock
HOK021_RS16475	COG0517	IMP dehydrogenase activity
HOK021_RS16475	COG0516	GMP reductase activity
HOK021_RS16505	COG0384	phenazine biosynthesis protein PhzF
HOK021_RS16510	COG0534	Mate efflux family protein
HOK021_RS16515	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOK021_RS16520	COG0019	diaminopimelate decarboxylase activity
HOK021_RS16535	COG4166	transmembrane transport
HOK021_RS16540	COG0601	transmembrane transport
HOK021_RS16545	COG4171	peptide transport system, permease
HOK021_RS16550	COG4172	Belongs to the ABC transporter superfamily
HOK021_RS16610	COG3739	integral membrane protein
HOK021_RS16615	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HOK021_RS16655	COG2124	cytochrome p450
HOK021_RS16690	COG1231	oxidoreductase activity
HOK021_RS16740	COG1063	alcohol dehydrogenase
HOK021_RS16755	COG0300	oxidoreductase activity
HOK021_RS16795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS16815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS16820	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HOK021_RS16825	COG3251	PFAM MbtH domain protein
HOK021_RS16830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS16835	COG3903	Transcriptional regulator
HOK021_RS16835	COG3629	intracellular signal transduction
HOK021_RS16840	COG0789	Transcriptional regulator
HOK021_RS16875	COG2267	carboxylic ester hydrolase activity
HOK021_RS16880	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HOK021_RS16895	COG0137	argininosuccinate synthase activity
HOK021_RS16905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS16920	COG3973	AAA domain
HOK021_RS16940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HOK021_RS16945	COG0477	Major facilitator Superfamily
HOK021_RS16955	COG2382	esterase
HOK021_RS16970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS16970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS16975	COG3433	isochorismatase activity
HOK021_RS16975	COG1535	isochorismatase
HOK021_RS16980	COG3433	isochorismatase activity
HOK021_RS16980	COG1535	isochorismatase
HOK021_RS16985	COG1021	2,3-dihydroxybenzoate-AMP ligase
HOK021_RS16990	COG1169	isochorismate synthase
HOK021_RS16995	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS17005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS17010	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS17015	COG1120	ATPase activity
HOK021_RS17030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HOK021_RS17055	COG2197	response regulator
HOK021_RS17060	COG1136	(ABC) transporter
HOK021_RS17065	COG0577	efflux transmembrane transporter activity
HOK021_RS17065	COG1136	(ABC) transporter
HOK021_RS17090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS17095	COG0601	transmembrane transport
HOK021_RS17140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOK021_RS17170	COG0137	argininosuccinate synthase activity
HOK021_RS17190	COG4221	oxidoreductase activity
HOK021_RS17235	COG2814	Major facilitator Superfamily
HOK021_RS17245	COG1309	transcriptional regulator
HOK021_RS17285	COG0583	DNA-binding transcription factor activity
HOK021_RS17290	COG0596	Alpha beta hydrolase
HOK021_RS17290	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOK021_RS17295	COG2135	peptidase activity
HOK021_RS17330	COG2226	methyltransferase
HOK021_RS17335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOK021_RS17355	COG0531	amino acid
HOK021_RS17400	COG0492	ferredoxin-NADP+ reductase activity
HOK021_RS17430	COG2814	Major facilitator Superfamily
HOK021_RS17445	COG0513	Belongs to the DEAD box helicase family
HOK021_RS17500	COG2124	cytochrome p450
HOK021_RS17520	COG1309	transcriptional regulator
HOK021_RS17525	COG0586	Pfam SNARE associated Golgi protein
HOK021_RS17545	COG2353	YceI-like domain
HOK021_RS17575	COG0583	DNA-binding transcription factor activity
HOK021_RS17600	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS17615	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS17620	COG1024	Enoyl-CoA hydratase
HOK021_RS17635	COG0301	tRNA thio-modification
HOK021_RS17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS17640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS17645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS17650	COG3251	PFAM MbtH domain protein
HOK021_RS17665	COG0583	DNA-binding transcription factor activity
HOK021_RS17725	COG0738	Major facilitator superfamily
HOK021_RS17755	COG3896	Chloramphenicol phosphotransferase-like protein
HOK021_RS17760	COG0702	epimerase
HOK021_RS17765	COG1733	regulation of RNA biosynthetic process
HOK021_RS17775	COG0069	glutamate synthase activity
HOK021_RS17820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOK021_RS17845	COG2133	pyrroloquinoline quinone binding
HOK021_RS17880	COG1794	racemase activity, acting on amino acids and derivatives
HOK021_RS17920	COG0181	hydroxymethylbilane synthase activity
HOK021_RS17925	COG4221	oxidoreductase activity
HOK021_RS17935	COG4552	Acetyltransferase involved in intracellular survival and related
HOK021_RS18000	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HOK021_RS18025	COG3387	PFAM Glycoside hydrolase 15-related
HOK021_RS18050	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HOK021_RS18065	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS18095	COG2885	chlorophyll binding
HOK021_RS18125	COG1720	tRNA m6t6A37 methyltransferase activity
HOK021_RS18140	COG0789	Transcriptional regulator
HOK021_RS18165	COG1022	Amp-dependent synthetase and ligase
HOK021_RS18185	COG0402	S-adenosylhomocysteine deaminase activity
HOK021_RS18200	COG2340	Cysteine-rich secretory protein family
HOK021_RS18250	COG1271	oxidase subunit
HOK021_RS18315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HOK021_RS18340	COG0667	Aldo Keto reductase
HOK021_RS18350	COG2814	Major facilitator Superfamily
HOK021_RS18355	COG1063	alcohol dehydrogenase
HOK021_RS18360	COG1349	DNA-binding transcription factor activity
HOK021_RS18385	COG5504	Zn-dependent protease
HOK021_RS18395	COG0395	ABC-type sugar transport system, permease component
HOK021_RS18400	COG1175	transmembrane transport
HOK021_RS18405	COG1653	transport
HOK021_RS18410	COG0366	Alpha amylase catalytic
HOK021_RS18415	COG1653	transport
HOK021_RS18425	COG1136	(ABC) transporter
HOK021_RS18425	COG0577	efflux transmembrane transporter activity
HOK021_RS18440	COG2340	Cysteine-rich secretory protein family
HOK021_RS18465	COG3647	Membrane
HOK021_RS18485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HOK021_RS18500	COG2197	response regulator
HOK021_RS18505	COG4585	Histidine kinase
HOK021_RS18525	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HOK021_RS18535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOK021_RS18540	COG4948	Mandelate Racemase Muconate Lactonizing
HOK021_RS18550	COG1073	alpha beta
HOK021_RS18550	COG2226	methyltransferase
HOK021_RS18555	COG0747	negative chemotaxis
HOK021_RS18560	COG0601	transmembrane transport
HOK021_RS18565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS18590	COG3548	integral membrane protein
HOK021_RS18635	COG4941	Belongs to the sigma-70 factor family
HOK021_RS18670	COG2814	Major facilitator Superfamily
HOK021_RS18675	COG0583	DNA-binding transcription factor activity
HOK021_RS18730	COG0515	serine threonine protein kinase
HOK021_RS18745	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HOK021_RS18755	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HOK021_RS18820	COG2205	protein histidine kinase activity
HOK021_RS18825	COG1191	sigma factor activity
HOK021_RS18920	COG0142	geranyltranstransferase activity
HOK021_RS18930	COG0829	nickel cation binding
HOK021_RS18935	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HOK021_RS18945	COG0804	urea catabolic process
HOK021_RS18950	COG0831	urea catabolic process
HOK021_RS18950	COG0832	Belongs to the urease beta subunit family
HOK021_RS18960	COG2267	carboxylic ester hydrolase activity
HOK021_RS18970	COG1335	isochorismatase
HOK021_RS18995	COG0702	epimerase
HOK021_RS19000	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HOK021_RS19070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOK021_RS19075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HOK021_RS19085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HOK021_RS19090	COG2211	Major facilitator Superfamily
HOK021_RS19105	COG2197	response regulator
HOK021_RS19120	COG0789	Transcriptional regulator
HOK021_RS19130	COG1051	belongs to the nudix hydrolase family
HOK021_RS19135	COG1132	(ABC) transporter
HOK021_RS19140	COG0494	nUDIX hydrolase
HOK021_RS19150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS19185	COG3511	phospholipase C
HOK021_RS19235	COG5651	PPE family
HOK021_RS19235	COG3391	amine dehydrogenase activity
HOK021_RS19265	COG0179	Fumarylacetoacetate (FAA) hydrolase
HOK021_RS19275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOK021_RS19305	COG2205	protein histidine kinase activity
HOK021_RS19310	COG0745	RESPONSE REGULATOR receiver
HOK021_RS19315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HOK021_RS19315	COG1017	nitric oxide dioxygenase activity
HOK021_RS19410	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HOK021_RS19470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS19475	COG1120	ATPase activity
HOK021_RS19485	COG0477	Major facilitator Superfamily
HOK021_RS19490	COG0367	asparagine synthase
HOK021_RS19495	COG2124	cytochrome p450
HOK021_RS19520	COG1595	DNA-templated transcription, initiation
HOK021_RS19530	COG1131	(ABC) transporter
HOK021_RS19665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOK021_RS19705	COG3321	synthase
HOK021_RS19705	COG0604	alcohol dehydrogenase
HOK021_RS19720	COG4257	antibiotic catabolic process
HOK021_RS19725	COG0110	maltose O-acetyltransferase activity
HOK021_RS19730	COG0583	DNA-binding transcription factor activity
HOK021_RS19770	COG0024	Methionine aminopeptidase
HOK021_RS19785	COG0604	alcohol dehydrogenase
HOK021_RS19920	COG0531	amino acid
HOK021_RS19925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOK021_RS19935	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HOK021_RS19955	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS19960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOK021_RS19960	COG0045	succinate-CoA ligase (ADP-forming) activity
HOK021_RS19960	COG1042	CoA-binding domain protein
HOK021_RS19990	COG1176	ABC-type spermidine putrescine transport system, permease component I
HOK021_RS19995	COG1177	transmembrane transport
HOK021_RS20000	COG3842	ATPase activity
HOK021_RS20010	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS20020	COG2188	Transcriptional regulator
HOK021_RS20035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOK021_RS20075	COG2124	cytochrome p450
HOK021_RS20100	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HOK021_RS20105	COG3395	kinase activity
HOK021_RS20110	COG1349	DNA-binding transcription factor activity
HOK021_RS20120	COG3290	protein histidine kinase activity
HOK021_RS20140	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS20160	COG1793	dna ligase
HOK021_RS20175	COG0531	amino acid
HOK021_RS20195	COG2837	iron assimilation
HOK021_RS20200	COG0309	Hydrogenase expression formation protein (HypE)
HOK021_RS20205	COG0409	Hydrogenase expression formation protein
HOK021_RS20210	COG0298	carbon dioxide binding
HOK021_RS20215	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HOK021_RS20225	COG0375	protein maturation
HOK021_RS20255	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HOK021_RS20270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOK021_RS20275	COG0477	Major facilitator Superfamily
HOK021_RS20290	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS20300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HOK021_RS20320	COG2124	cytochrome p450
HOK021_RS20325	COG2084	Dehydrogenase
HOK021_RS20330	COG3960	tartronate-semialdehyde synthase activity
HOK021_RS20335	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS20345	COG0242	peptide deformylase activity
HOK021_RS20355	COG3442	glutamine amidotransferase
HOK021_RS20360	COG0205	6-phosphofructokinase activity
HOK021_RS20365	COG3336	cytochrome c oxidase
HOK021_RS20435	COG0829	nickel cation binding
HOK021_RS20440	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HOK021_RS20450	COG0804	urea catabolic process
HOK021_RS20455	COG0832	Belongs to the urease beta subunit family
HOK021_RS20460	COG0831	urea catabolic process
HOK021_RS20465	COG4935	Belongs to the peptidase S8 family
HOK021_RS20465	COG2234	aminopeptidase activity
HOK021_RS20500	COG0142	geranyltranstransferase activity
HOK021_RS20560	COG0740	serine-type endopeptidase activity
HOK021_RS20570	COG0791	NLP P60 protein
HOK021_RS20575	COG1280	lysine exporter protein (LysE YggA)
HOK021_RS20580	COG0583	DNA-binding transcription factor activity
HOK021_RS20590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HOK021_RS20595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HOK021_RS20600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HOK021_RS20605	COG2226	methyltransferase
HOK021_RS20640	COG2367	Beta-lactamase
HOK021_RS20725	COG1309	transcriptional regulator
HOK021_RS20735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOK021_RS20745	COG3511	phospholipase C
HOK021_RS20775	COG4585	Histidine kinase
HOK021_RS20780	COG2197	response regulator
HOK021_RS20785	COG1940	carbohydrate kinase activity
HOK021_RS20790	COG2188	Transcriptional regulator
HOK021_RS20800	COG1595	DNA-templated transcription, initiation
HOK021_RS20805	COG2267	carboxylic ester hydrolase activity
HOK021_RS20845	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS20855	COG1522	sequence-specific DNA binding
HOK021_RS20860	COG0419	ATPase involved in DNA repair
HOK021_RS20865	COG0420	3'-5' exonuclease activity
HOK021_RS20870	COG0531	amino acid
HOK021_RS20875	COG1739	Uncharacterized protein family UPF0029
HOK021_RS20885	COG1832	CoA-binding protein
HOK021_RS20925	COG1024	Enoyl-CoA hydratase
HOK021_RS20930	COG2124	cytochrome p450
HOK021_RS20935	COG2124	cytochrome p450
HOK021_RS21005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HOK021_RS21015	COG1968	undecaprenyl-diphosphatase activity
HOK021_RS21020	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS21055	COG2208	phosphoserine phosphatase activity
HOK021_RS21075	COG1940	carbohydrate kinase activity
HOK021_RS21080	COG2182	Extracellular solute-binding protein
HOK021_RS21085	COG1175	transmembrane transport
HOK021_RS21090	COG1175	transmembrane transport
HOK021_RS21095	COG0395	ABC-type sugar transport system, permease component
HOK021_RS21100	COG2723	6-phospho-beta-galactosidase activity
HOK021_RS21105	COG1764	response to oxidative stress
HOK021_RS21110	COG1846	Transcriptional regulator
HOK021_RS21120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS21125	COG2267	carboxylic ester hydrolase activity
HOK021_RS21165	COG0739	heme binding
HOK021_RS21170	COG0702	epimerase
HOK021_RS21175	COG1609	Transcriptional regulator
HOK021_RS21185	COG1175	transmembrane transport
HOK021_RS21190	COG0395	ABC-type sugar transport system, permease component
HOK021_RS21225	COG1278	Cold shock
HOK021_RS21230	COG1686	Belongs to the peptidase S11 family
HOK021_RS21235	COG2356	endonuclease I
HOK021_RS21250	COG1793	dna ligase
HOK021_RS21250	COG3285	dna ligase
HOK021_RS21255	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HOK021_RS21270	COG3012	SEC-C Motif Domain Protein
HOK021_RS21290	COG2364	Membrane
HOK021_RS21300	COG2270	Major facilitator Superfamily
HOK021_RS21315	COG1216	Glycosyl transferase, family 2
HOK021_RS21325	COG1228	amidohydrolase
HOK021_RS21345	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS21360	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS21370	COG0148	phosphopyruvate hydratase activity
HOK021_RS21380	COG0778	Nitroreductase
HOK021_RS21385	COG1309	transcriptional regulator
HOK021_RS21445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOK021_RS21465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HOK021_RS21465	COG0574	Belongs to the PEP-utilizing enzyme family
HOK021_RS21490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HOK021_RS21515	COG2080	2 iron, 2 sulfur cluster binding
HOK021_RS21520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HOK021_RS21525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS21580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS21620	COG0367	asparagine synthase
HOK021_RS21635	COG3284	Transcriptional regulator
HOK021_RS21640	COG1129	ABC transporter
HOK021_RS21645	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS21660	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HOK021_RS21695	COG0475	glutathione-regulated potassium exporter activity
HOK021_RS21705	COG2197	response regulator
HOK021_RS21710	COG1280	lysine exporter protein (LysE YggA)
HOK021_RS21715	COG0009	L-threonylcarbamoyladenylate synthase
HOK021_RS21760	COG0494	nUDIX hydrolase
HOK021_RS21780	COG1609	Transcriptional regulator
HOK021_RS21785	COG1957	nucleoside hydrolase
HOK021_RS21790	COG0477	Major facilitator Superfamily
HOK021_RS21815	COG3383	formate dehydrogenase (NAD+) activity
HOK021_RS21815	COG0243	molybdopterin cofactor binding
HOK021_RS21820	COG0437	4 iron, 4 sulfur cluster binding
HOK021_RS21830	COG1252	NADH dehydrogenase
HOK021_RS21865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HOK021_RS21910	COG1309	transcriptional regulator
HOK021_RS21940	COG1902	pentaerythritol trinitrate reductase activity
HOK021_RS21950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HOK021_RS21975	COG2706	6-phosphogluconolactonase activity
HOK021_RS21995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS22005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS22030	COG2197	response regulator
HOK021_RS22040	COG0604	alcohol dehydrogenase
HOK021_RS22040	COG3321	synthase
HOK021_RS22050	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS22070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOK021_RS22075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOK021_RS22085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS22100	COG0596	Alpha beta hydrolase
HOK021_RS22140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HOK021_RS22155	COG2130	NADP-dependent
HOK021_RS22160	COG2318	DinB family
HOK021_RS22170	COG2124	cytochrome p450
HOK021_RS22190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HOK021_RS22200	COG0477	Major facilitator Superfamily
HOK021_RS22250	COG0596	Alpha beta hydrolase
HOK021_RS22255	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HOK021_RS22260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HOK021_RS22265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS22270	COG0646	methionine synthase
HOK021_RS22270	COG1410	methionine synthase
HOK021_RS22300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HOK021_RS22320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HOK021_RS22325	COG4213	ABC transporter substrate-binding protein
HOK021_RS22330	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS22345	COG1304	FMN binding
HOK021_RS22350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HOK021_RS22355	COG2271	Major facilitator Superfamily
HOK021_RS22365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HOK021_RS22385	COG1254	Belongs to the acylphosphatase family
HOK021_RS22410	COG1595	DNA-templated transcription, initiation
HOK021_RS22425	COG3608	succinylglutamate desuccinylase aspartoacylase
HOK021_RS22425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HOK021_RS22430	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS22435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HOK021_RS22440	COG2080	2 iron, 2 sulfur cluster binding
HOK021_RS22450	COG2226	methyltransferase
HOK021_RS22460	COG3511	phospholipase C
HOK021_RS22540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HOK021_RS22540	COG2124	cytochrome p450
HOK021_RS22555	COG1309	transcriptional regulator
HOK021_RS22570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HOK021_RS22595	COG0492	ferredoxin-NADP+ reductase activity
HOK021_RS22635	COG0431	NADPH-dependent FMN reductase
HOK021_RS22640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS22695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS22715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HOK021_RS22760	COG0432	Pfam Uncharacterised protein family UPF0047
HOK021_RS22765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOK021_RS22770	COG1116	anion transmembrane transporter activity
HOK021_RS22785	COG2072	flavoprotein involved in K transport
HOK021_RS22790	COG0477	Major facilitator Superfamily
HOK021_RS22795	COG0247	lactate metabolic process
HOK021_RS22800	COG1139	Iron-sulfur cluster binding protein
HOK021_RS22805	COG1556	Lactate utilization protein
HOK021_RS22835	COG0300	oxidoreductase activity
HOK021_RS22855	COG1132	(ABC) transporter
HOK021_RS22890	COG1132	(ABC) transporter
HOK021_RS22895	COG1132	(ABC) transporter
HOK021_RS22910	COG1946	Acyl-CoA thioesterase
HOK021_RS22920	COG2018	Roadblock/LC7 domain
HOK021_RS22940	COG2226	methyltransferase
HOK021_RS22965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HOK021_RS22990	COG0431	NADPH-dependent FMN reductase
HOK021_RS23000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS23010	COG2040	homocysteine
HOK021_RS23015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS23020	COG0765	amino acid transport
HOK021_RS23035	COG3458	cephalosporin-C deacetylase activity
HOK021_RS23045	COG1070	Carbohydrate kinase
HOK021_RS23050	COG1940	carbohydrate kinase activity
HOK021_RS23055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOK021_RS23060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOK021_RS23060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOK021_RS23065	COG3023	N-Acetylmuramoyl-L-alanine amidase
HOK021_RS23090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HOK021_RS23090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HOK021_RS23095	COG3511	phospholipase C
HOK021_RS23130	COG3321	synthase
HOK021_RS23130	COG0604	alcohol dehydrogenase
HOK021_RS23145	COG0588	phosphoglycerate mutase activity
HOK021_RS23150	COG1070	Carbohydrate kinase
HOK021_RS23155	COG1070	Carbohydrate kinase
HOK021_RS23160	COG2814	Major facilitator Superfamily
HOK021_RS23195	COG0445	tRNA wobble uridine modification
HOK021_RS23205	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS23210	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS23220	COG1024	Enoyl-CoA hydratase
HOK021_RS23230	COG0583	DNA-binding transcription factor activity
HOK021_RS23260	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS23265	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS23280	COG1388	LysM domain
HOK021_RS23280	COG3858	chitin binding
HOK021_RS23300	COG3572	ergothioneine biosynthetic process
HOK021_RS23305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HOK021_RS23315	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HOK021_RS23355	COG3360	Dodecin
HOK021_RS23360	COG0531	amino acid
HOK021_RS23370	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOK021_RS23395	COG3537	Alpha-1,2-mannosidase
HOK021_RS23445	COG2226	methyltransferase
HOK021_RS23460	COG2378	regulation of single-species biofilm formation
HOK021_RS23475	COG0149	triose-phosphate isomerase activity
HOK021_RS23480	COG0698	ribose 5-phosphate isomerase
HOK021_RS23485	COG1063	alcohol dehydrogenase
HOK021_RS23490	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HOK021_RS23505	COG5183	chlorophyll binding
HOK021_RS23505	COG2133	pyrroloquinoline quinone binding
HOK021_RS23530	COG2706	6-phosphogluconolactonase activity
HOK021_RS23535	COG1113	amino acid transport
HOK021_RS23545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HOK021_RS23550	COG2205	protein histidine kinase activity
HOK021_RS23570	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS23575	COG1024	Enoyl-CoA hydratase
HOK021_RS23580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HOK021_RS23585	COG0154	amidase activity
HOK021_RS23620	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS23635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS23645	COG0747	negative chemotaxis
HOK021_RS23650	COG1940	carbohydrate kinase activity
HOK021_RS23670	COG0174	glutamine synthetase
HOK021_RS23685	COG3246	L-lysine catabolic process to acetate
HOK021_RS23690	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS23710	COG1686	Belongs to the peptidase S11 family
HOK021_RS23715	COG2124	cytochrome p450
HOK021_RS23735	COG2207	Transcriptional regulator
HOK021_RS23740	COG2223	nitrite transmembrane transporter activity
HOK021_RS23760	COG3959	Transketolase, thiamine diphosphate binding domain
HOK021_RS23765	COG3958	Transketolase
HOK021_RS23770	COG2267	carboxylic ester hydrolase activity
HOK021_RS23775	COG0402	S-adenosylhomocysteine deaminase activity
HOK021_RS23780	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS23805	COG2018	Roadblock/LC7 domain
HOK021_RS23845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS23870	COG2755	lipolytic protein G-D-S-L family
HOK021_RS23875	COG2365	Tyrosine phosphatase family
HOK021_RS23890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOK021_RS23905	COG1657	PFAM Prenyltransferase squalene oxidase
HOK021_RS23915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HOK021_RS23925	COG1562	ergosterol biosynthetic process
HOK021_RS23930	COG1134	teichoic acid transport
HOK021_RS23965	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HOK021_RS23995	COG4977	sequence-specific DNA binding
HOK021_RS24005	COG2183	response to ionizing radiation
HOK021_RS24040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HOK021_RS24050	COG2936	dipeptidyl-peptidase activity
HOK021_RS24080	COG1113	amino acid transport
HOK021_RS24095	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS24095	COG1024	Enoyl-CoA hydratase
HOK021_RS24100	COG0183	Belongs to the thiolase family
HOK021_RS24105	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS24110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS24120	COG1285	pathogenesis
HOK021_RS24130	COG3268	Saccharopine dehydrogenase
HOK021_RS24135	COG1515	deoxyribonuclease V activity
HOK021_RS24140	COG0154	amidase activity
HOK021_RS24150	COG2814	Major facilitator Superfamily
HOK021_RS24155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HOK021_RS24165	COG1349	DNA-binding transcription factor activity
HOK021_RS24175	COG1309	transcriptional regulator
HOK021_RS24180	COG1289	transmembrane transporter activity
HOK021_RS24185	COG1846	Transcriptional regulator
HOK021_RS24200	COG3226	Transcriptional regulator
HOK021_RS24225	COG0745	RESPONSE REGULATOR receiver
HOK021_RS24230	COG2205	protein histidine kinase activity
HOK021_RS24265	COG0583	DNA-binding transcription factor activity
HOK021_RS24310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HOK021_RS24315	COG1846	Transcriptional regulator
HOK021_RS24320	COG1309	transcriptional regulator
HOK021_RS24345	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS24370	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS24375	COG0287	Prephenate dehydrogenase
HOK021_RS24375	COG1605	Chorismate mutase
HOK021_RS24410	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HOK021_RS24435	COG0673	inositol 2-dehydrogenase activity
HOK021_RS24440	COG1879	ABC-type sugar transport system periplasmic component
HOK021_RS24445	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS24450	COG1129	ABC transporter
HOK021_RS24455	COG1940	carbohydrate kinase activity
HOK021_RS24460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS24465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HOK021_RS24475	COG1063	alcohol dehydrogenase
HOK021_RS24490	COG0583	DNA-binding transcription factor activity
HOK021_RS24505	COG0656	L-ascorbic acid biosynthetic process
HOK021_RS24515	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HOK021_RS24530	COG1295	ribonuclease BN
HOK021_RS24535	COG2154	pterin-4-alpha-carbinolamine dehydratase
HOK021_RS24610	COG2362	D-Aminopeptidase
HOK021_RS24635	COG0531	amino acid
HOK021_RS24645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HOK021_RS24665	COG0456	acetyltransferase
HOK021_RS24670	COG1597	lipid kinase activity
HOK021_RS24675	COG2226	methyltransferase
HOK021_RS24700	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS24710	COG0010	Belongs to the arginase family
HOK021_RS24730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HOK021_RS24745	COG2124	cytochrome p450
HOK021_RS24760	COG1619	proteins homologs of microcin C7 resistance protein MccF
HOK021_RS24775	COG2362	D-Aminopeptidase
HOK021_RS24825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOK021_RS24825	COG0456	acetyltransferase
HOK021_RS24835	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS24850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS24850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS24855	COG2301	Belongs to the HpcH HpaI aldolase family
HOK021_RS24865	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS24870	COG0688	phosphatidylethanolamine metabolic process
HOK021_RS24880	COG1929	Belongs to the glycerate kinase type-1 family
HOK021_RS24915	COG2267	carboxylic ester hydrolase activity
HOK021_RS24920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HOK021_RS24930	COG0483	inositol monophosphate 1-phosphatase activity
HOK021_RS24940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HOK021_RS24945	COG1953	Uracil, thiamine, allantoin
HOK021_RS24955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HOK021_RS24985	COG1335	isochorismatase
HOK021_RS24995	COG0405	Gamma-glutamyltransferase
HOK021_RS25005	COG0387	Pfam Sodium calcium exchanger
HOK021_RS25020	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS25025	COG2409	Drug exporters of the RND superfamily
HOK021_RS25035	COG0435	Glutathione S-transferase
HOK021_RS25045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS25055	COG2226	methyltransferase
HOK021_RS25080	COG0765	amino acid transport
HOK021_RS25085	COG0765	amino acid transport
HOK021_RS25090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS25095	COG1126	abc transporter atp-binding protein
HOK021_RS25120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOK021_RS25135	COG1940	carbohydrate kinase activity
HOK021_RS25145	COG1172	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS25160	COG2188	Transcriptional regulator
HOK021_RS25180	COG0800	Aldolase
HOK021_RS25215	COG4266	Belongs to the allantoicase family
HOK021_RS25220	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HOK021_RS25225	COG1953	Uracil, thiamine, allantoin
HOK021_RS25235	COG1414	Transcriptional regulator
HOK021_RS25245	COG0515	serine threonine protein kinase
HOK021_RS25245	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOK021_RS25260	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HOK021_RS25265	COG0789	Transcriptional regulator
HOK021_RS25295	COG2233	PERMEase
HOK021_RS25305	COG2233	PERMEase
HOK021_RS25315	COG2351	hydroxyisourate hydrolase activity
HOK021_RS25335	COG3622	Belongs to the hyi family
HOK021_RS25340	COG2084	Dehydrogenase
HOK021_RS25345	COG0028	Belongs to the TPP enzyme family
HOK021_RS25350	COG0753	catalase activity
HOK021_RS25365	COG2315	Protein conserved in bacteria
HOK021_RS25370	COG1309	transcriptional regulator
HOK021_RS25385	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS25390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOK021_RS25395	COG2197	response regulator
HOK021_RS25400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HOK021_RS25405	COG4552	Acetyltransferase involved in intracellular survival and related
HOK021_RS25415	COG2252	PERMEase
HOK021_RS25420	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS25450	COG1802	Transcriptional regulator
HOK021_RS25500	COG0028	Belongs to the TPP enzyme family
HOK021_RS25520	COG1162	GTPase activity
HOK021_RS25525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HOK021_RS25530	COG2318	DinB family
HOK021_RS25565	COG3226	Transcriptional regulator
HOK021_RS25570	COG2755	lipolytic protein G-D-S-L family
HOK021_RS25570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HOK021_RS25575	COG1215	transferase activity, transferring glycosyl groups
HOK021_RS25585	COG2233	PERMEase
HOK021_RS25590	COG1131	(ABC) transporter
HOK021_RS25590	COG1716	ATPase activity
HOK021_RS25590	COG0842	Transport permease protein
HOK021_RS25615	COG1376	ErfK ybiS ycfS ynhG family protein
HOK021_RS25625	COG0667	Aldo Keto reductase
HOK021_RS25630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HOK021_RS25635	COG0531	amino acid
HOK021_RS25640	COG0019	diaminopimelate decarboxylase activity
HOK021_RS25650	COG3511	phospholipase C
HOK021_RS25655	COG0529	Catalyzes the synthesis of activated sulfate
HOK021_RS25665	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HOK021_RS25670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HOK021_RS25675	COG2080	2 iron, 2 sulfur cluster binding
HOK021_RS25695	COG1846	Transcriptional regulator
HOK021_RS25710	COG2154	pterin-4-alpha-carbinolamine dehydratase
HOK021_RS25735	COG2208	phosphoserine phosphatase activity
HOK021_RS25735	COG2770	Histidine kinase
HOK021_RS25745	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HOK021_RS25750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HOK021_RS25755	COG3485	protocatechuate 3,4-dioxygenase
HOK021_RS25760	COG3485	protocatechuate 3,4-dioxygenase
HOK021_RS25775	COG1414	Transcriptional regulator
HOK021_RS25785	COG2814	Major facilitator Superfamily
HOK021_RS25795	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS25805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS25830	COG0175	sulfate reduction
HOK021_RS25835	COG0529	Catalyzes the synthesis of activated sulfate
HOK021_RS25855	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HOK021_RS25860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HOK021_RS25870	COG0366	Alpha amylase catalytic
HOK021_RS25890	COG1609	Transcriptional regulator
HOK021_RS25895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HOK021_RS25915	COG0596	Alpha beta hydrolase
HOK021_RS25925	COG0306	phosphate transporter
HOK021_RS25980	COG1442	glycosyl transferase family 8
HOK021_RS25980	COG1216	Glycosyl transferase, family 2
HOK021_RS26055	COG0583	DNA-binding transcription factor activity
HOK021_RS26060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HOK021_RS26080	COG0693	protein deglycase activity
HOK021_RS26090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HOK021_RS26105	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOK021_RS26110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HOK021_RS26115	COG2197	response regulator
HOK021_RS26120	COG4585	Histidine kinase
HOK021_RS26125	COG0577	efflux transmembrane transporter activity
HOK021_RS26130	COG0577	efflux transmembrane transporter activity
HOK021_RS26130	COG1136	(ABC) transporter
HOK021_RS26160	COG1116	anion transmembrane transporter activity
HOK021_RS26205	COG3253	May function as heme-dependent peroxidase
HOK021_RS26210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HOK021_RS26215	COG0183	Belongs to the thiolase family
HOK021_RS26220	COG0446	pyridine nucleotide-disulphide oxidoreductase
HOK021_RS26225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HOK021_RS26240	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HOK021_RS26250	COG0183	Belongs to the thiolase family
HOK021_RS26255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS26255	COG1024	Enoyl-CoA hydratase
HOK021_RS26265	COG0531	amino acid
HOK021_RS26270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HOK021_RS26275	COG4214	carbohydrate transport
HOK021_RS26285	COG4213	ABC transporter substrate-binding protein
HOK021_RS26290	COG1940	carbohydrate kinase activity
HOK021_RS26295	COG0395	ABC-type sugar transport system, permease component
HOK021_RS26300	COG1175	transmembrane transport
HOK021_RS26305	COG1653	transport
HOK021_RS26315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HOK021_RS26325	COG1595	DNA-templated transcription, initiation
HOK021_RS26340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HOK021_RS26370	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HOK021_RS26370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HOK021_RS26450	COG1222	aaa ATPase
HOK021_RS26470	COG0484	heat shock protein binding
HOK021_RS26505	COG0546	phosphoglycolate phosphatase activity
HOK021_RS26535	COG1024	Enoyl-CoA hydratase
HOK021_RS26550	COG0531	amino acid
HOK021_RS26555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HOK021_RS26565	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HOK021_RS26595	COG1799	cell septum assembly
HOK021_RS26600	COG0598	Magnesium transport protein CorA
HOK021_RS26685	COG0492	ferredoxin-NADP+ reductase activity
HOK021_RS26720	COG4122	O-methyltransferase activity
HOK021_RS26740	COG0436	Aminotransferase
HOK021_RS26780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOK021_RS26800	COG0583	DNA-binding transcription factor activity
HOK021_RS26835	COG1191	sigma factor activity
HOK021_RS26845	COG1191	sigma factor activity
HOK021_RS26860	COG3387	PFAM Glycoside hydrolase 15-related
HOK021_RS26885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HOK021_RS26890	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS26925	COG3239	Fatty acid desaturase
HOK021_RS26940	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HOK021_RS26945	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HOK021_RS26955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HOK021_RS26960	COG0154	amidase activity
HOK021_RS26965	COG1136	(ABC) transporter
HOK021_RS26965	COG0577	efflux transmembrane transporter activity
HOK021_RS26970	COG0577	efflux transmembrane transporter activity
HOK021_RS26995	COG4585	Histidine kinase
HOK021_RS27000	COG2197	response regulator
HOK021_RS27030	COG3629	intracellular signal transduction
HOK021_RS27030	COG3903	Transcriptional regulator
HOK021_RS27040	COG2175	clavaminate synthase activity
HOK021_RS27045	COG3251	PFAM MbtH domain protein
HOK021_RS27050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HOK021_RS27070	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HOK021_RS27080	COG0512	Glutamine amidotransferase of anthranilate synthase
HOK021_RS27090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HOK021_RS27095	COG0134	indole-3-glycerol-phosphate synthase activity
HOK021_RS27110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HOK021_RS27160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HOK021_RS27165	COG0531	amino acid
HOK021_RS27175	COG0569	domain protein
HOK021_RS27215	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HOK021_RS27220	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HOK021_RS27225	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HOK021_RS27240	COG0756	dUTP diphosphatase activity
HOK021_RS27265	COG2205	protein histidine kinase activity
HOK021_RS27270	COG0745	RESPONSE REGULATOR receiver
HOK021_RS27280	COG0483	inositol monophosphate 1-phosphatase activity
HOK021_RS27285	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HOK021_RS27320	COG1435	thymidine kinase activity
HOK021_RS27340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HOK021_RS27345	COG1802	Transcriptional regulator
HOK021_RS27360	COG0612	Peptidase, M16
HOK021_RS27365	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HOK021_RS27375	COG0372	Belongs to the citrate synthase family
HOK021_RS27390	COG3290	protein histidine kinase activity
HOK021_RS27395	COG4565	transcriptional regulatory protein
HOK021_RS27400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HOK021_RS27410	COG2197	response regulator
HOK021_RS27415	COG4585	Histidine kinase
HOK021_RS27425	COG0187	DNA topoisomerase II activity
HOK021_RS27440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HOK021_RS27445	COG2186	Transcriptional regulator
HOK021_RS27450	COG0494	nUDIX hydrolase
HOK021_RS27480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HOK021_RS27495	COG0488	(ABC) transporter
HOK021_RS27510	COG0154	amidase activity
HOK021_RS27515	COG3226	Transcriptional regulator
HOK021_RS27525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOK021_RS27530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HOK021_RS27535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HOK021_RS27570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HOK021_RS27580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HOK021_RS27585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HOK021_RS27595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HOK021_RS27610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOK021_RS27625	COG1278	Cold shock
HOK021_RS27630	COG2205	protein histidine kinase activity
HOK021_RS27640	COG1126	abc transporter atp-binding protein
HOK021_RS27645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS27650	COG0765	amino acid transport
HOK021_RS27655	COG0765	amino acid transport
HOK021_RS27660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS27680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HOK021_RS27685	COG0628	permease
HOK021_RS27730	COG2208	phosphoserine phosphatase activity
HOK021_RS27740	COG2172	sigma factor antagonist activity
HOK021_RS27745	COG1366	Belongs to the anti-sigma-factor antagonist family
HOK021_RS27750	COG1366	Belongs to the anti-sigma-factor antagonist family
HOK021_RS27780	COG1917	Cupin 2, conserved barrel domain protein
HOK021_RS27780	COG2207	Transcriptional regulator
HOK021_RS27785	COG1201	RNA secondary structure unwinding
HOK021_RS27790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HOK021_RS27795	COG1028	Short-chain dehydrogenase reductase Sdr
HOK021_RS27805	COG0783	Belongs to the Dps family
HOK021_RS27810	COG1396	sequence-specific DNA binding
HOK021_RS27815	COG1058	Belongs to the CinA family
HOK021_RS27815	COG1546	Belongs to the CinA family
HOK021_RS27825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HOK021_RS27835	COG1674	ftsk spoiiie
HOK021_RS27845	COG3850	Histidine kinase
HOK021_RS27845	COG3437	response regulator, receiver
HOK021_RS27845	COG4999	Histidine kinase
HOK021_RS27845	COG2205	protein histidine kinase activity
HOK021_RS27850	COG2770	Histidine kinase
HOK021_RS27850	COG2208	phosphoserine phosphatase activity
HOK021_RS27885	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HOK021_RS27890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HOK021_RS27895	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HOK021_RS27915	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HOK021_RS27920	COG0612	Peptidase, M16
HOK021_RS27925	COG1185	polyribonucleotide nucleotidyltransferase activity
HOK021_RS27930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HOK021_RS27940	COG1674	ftsk spoiiie
HOK021_RS28010	COG1404	Belongs to the peptidase S8 family
HOK021_RS28025	COG3266	domain, Protein
HOK021_RS28040	COG0455	bacterial-type flagellum organization
HOK021_RS28055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HOK021_RS28060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HOK021_RS28070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HOK021_RS28085	COG0779	Required for maturation of 30S ribosomal subunits
HOK021_RS28100	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
HOK021_RS28105	COG0442	prolyl-tRNA aminoacylation
HOK021_RS28120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HOK021_RS28125	COG0750	zinc metalloprotease
HOK021_RS28130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HOK021_RS28140	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS28165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HOK021_RS28170	COG1177	transmembrane transport
HOK021_RS28175	COG1176	ABC-type spermidine putrescine transport system, permease component I
HOK021_RS28180	COG3842	ATPase activity
HOK021_RS28190	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS28200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOK021_RS28210	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS28220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HOK021_RS28225	COG4181	ATPase activity
HOK021_RS28250	COG3842	ATPase activity
HOK021_RS28255	COG4208	sulfate ABC transporter
HOK021_RS28265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HOK021_RS28280	COG0233	cytoplasmic translational termination
HOK021_RS28285	COG0528	UMP kinase activity
HOK021_RS28290	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HOK021_RS28295	COG0052	Belongs to the universal ribosomal protein uS2 family
HOK021_RS28310	COG1191	sigma factor activity
HOK021_RS28325	COG0792	nuclease activity
HOK021_RS28340	COG0681	Belongs to the peptidase S26 family
HOK021_RS28345	COG0681	Belongs to the peptidase S26 family
HOK021_RS28355	COG0681	Belongs to the peptidase S26 family
HOK021_RS28360	COG0335	large ribosomal subunit rRNA binding
HOK021_RS28365	COG0336	Belongs to the RNA methyltransferase TrmD family
HOK021_RS28370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HOK021_RS28375	COG1837	Belongs to the UPF0109 family
HOK021_RS28380	COG0228	four-way junction DNA binding
HOK021_RS28395	COG2188	Transcriptional regulator
HOK021_RS28415	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HOK021_RS28420	COG0626	cystathionine gamma-synthase activity
HOK021_RS28425	COG3457	Alanine racemase
HOK021_RS28435	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HOK021_RS28470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HOK021_RS28485	COG0477	Major facilitator Superfamily
HOK021_RS28490	COG1196	nuclear chromosome segregation
HOK021_RS28500	COG1254	Belongs to the acylphosphatase family
HOK021_RS28505	COG2340	Cysteine-rich secretory protein family
HOK021_RS28515	COG1733	regulation of RNA biosynthetic process
HOK021_RS28520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HOK021_RS28525	COG0571	ribonuclease III activity
HOK021_RS28530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HOK021_RS28545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HOK021_RS28550	COG0742	ribosomal rna small subunit methyltransferase
HOK021_RS28560	COG1461	Dihydroxyacetone kinase
HOK021_RS28565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HOK021_RS28570	COG0351	phosphomethylpyrimidine kinase
HOK021_RS28590	COG1181	Belongs to the D-alanine--D-alanine ligase family
HOK021_RS28595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HOK021_RS28605	COG1920	GTP binding
HOK021_RS28615	COG0776	regulation of translation
HOK021_RS28625	COG0066	3-isopropylmalate dehydratase activity
HOK021_RS28630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HOK021_RS28675	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
HOK021_RS28680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HOK021_RS28685	COG0179	Fumarylacetoacetate (FAA) hydrolase
HOK021_RS28700	COG2018	Roadblock/LC7 domain
HOK021_RS28720	COG2018	Roadblock/LC7 domain
HOK021_RS28735	COG2376	Dihydroxyacetone kinase
HOK021_RS28750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS28755	COG5492	domain, Protein
HOK021_RS28760	COG2353	YceI-like domain
HOK021_RS28765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HOK021_RS28775	COG0477	Major facilitator Superfamily
HOK021_RS28785	COG1309	transcriptional regulator
HOK021_RS28790	COG2957	Belongs to the agmatine deiminase family
HOK021_RS28795	COG0804	urea catabolic process
HOK021_RS28800	COG0831	urea catabolic process
HOK021_RS28800	COG0832	Belongs to the urease beta subunit family
HOK021_RS28810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HOK021_RS28815	COG0473	3-isopropylmalate dehydrogenase activity
HOK021_RS28830	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS28835	COG0506	proline dehydrogenase activity
HOK021_RS28855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HOK021_RS28860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HOK021_RS28865	COG0440	acetolactate synthase activity
HOK021_RS28875	COG3300	MHYT domain
HOK021_RS28875	COG5001	Diguanylate cyclase
HOK021_RS28885	COG0667	Aldo Keto reductase
HOK021_RS28890	COG2133	pyrroloquinoline quinone binding
HOK021_RS28900	COG1672	PFAM Archaeal ATPase
HOK021_RS28900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HOK021_RS28915	COG2409	Drug exporters of the RND superfamily
HOK021_RS28920	COG3511	phospholipase C
HOK021_RS28925	COG0667	Aldo Keto reductase
HOK021_RS28935	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOK021_RS28945	COG0154	amidase activity
HOK021_RS28950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HOK021_RS28965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HOK021_RS28975	COG0477	Major facilitator Superfamily
HOK021_RS28985	COG4221	oxidoreductase activity
HOK021_RS28995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HOK021_RS29005	COG0482	sulfurtransferase activity
HOK021_RS29030	COG2860	membrane
HOK021_RS29035	COG0308	aminopeptidase N
HOK021_RS29040	COG4608	Belongs to the ABC transporter superfamily
HOK021_RS29045	COG0444	Belongs to the ABC transporter superfamily
HOK021_RS29055	COG0747	negative chemotaxis
HOK021_RS29060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS29080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HOK021_RS29085	COG0509	glycine decarboxylation via glycine cleavage system
HOK021_RS29090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOK021_RS29095	COG1760	l-serine dehydratase
HOK021_RS29115	COG0586	Pfam SNARE associated Golgi protein
HOK021_RS29130	COG2205	protein histidine kinase activity
HOK021_RS29130	COG2972	Histidine kinase
HOK021_RS29135	COG0745	RESPONSE REGULATOR receiver
HOK021_RS29140	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS29150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HOK021_RS29160	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HOK021_RS29165	COG0785	Cytochrome C biogenesis protein
HOK021_RS29170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HOK021_RS29170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HOK021_RS29195	COG1376	ErfK ybiS ycfS ynhG family protein
HOK021_RS29205	COG1132	(ABC) transporter
HOK021_RS29210	COG1132	(ABC) transporter
HOK021_RS29215	COG1132	(ABC) transporter
HOK021_RS29220	COG1132	(ABC) transporter
HOK021_RS29235	COG0366	Alpha amylase catalytic
HOK021_RS29250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HOK021_RS29255	COG1301	dicarboxylic acid transport
HOK021_RS29260	COG3290	protein histidine kinase activity
HOK021_RS29265	COG4565	transcriptional regulatory protein
HOK021_RS29280	COG0395	ABC-type sugar transport system, permease component
HOK021_RS29290	COG0577	efflux transmembrane transporter activity
HOK021_RS29290	COG1136	(ABC) transporter
HOK021_RS29295	COG0577	efflux transmembrane transporter activity
HOK021_RS29300	COG0205	6-phosphofructokinase activity
HOK021_RS29305	COG0280	phosphate acetyltransferase
HOK021_RS29305	COG0857	belongs to the CobB CobQ family
HOK021_RS29310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HOK021_RS29345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HOK021_RS29350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HOK021_RS29355	COG0745	RESPONSE REGULATOR receiver
HOK021_RS29360	COG2205	protein histidine kinase activity
HOK021_RS29385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS29385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS29440	COG3850	Histidine kinase
HOK021_RS29440	COG0642	Histidine kinase
HOK021_RS29445	COG0745	RESPONSE REGULATOR receiver
HOK021_RS29460	COG0183	Belongs to the thiolase family
HOK021_RS29515	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HOK021_RS29530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HOK021_RS29560	COG3850	Histidine kinase
HOK021_RS29565	COG2197	response regulator
HOK021_RS29575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HOK021_RS29580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HOK021_RS29585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HOK021_RS29590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HOK021_RS29595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOK021_RS29600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HOK021_RS29605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HOK021_RS29625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOK021_RS29630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOK021_RS29640	COG2890	protein-(glutamine-N5) methyltransferase activity
HOK021_RS29645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOK021_RS29650	COG0254	rRNA binding
HOK021_RS29665	COG0083	homoserine kinase activity
HOK021_RS29670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HOK021_RS29675	COG0460	homoserine dehydrogenase
HOK021_RS29680	COG0019	diaminopimelate decarboxylase activity
HOK021_RS29685	COG0018	arginyl-trna synthetase
HOK021_RS29710	COG0210	DNA helicase
HOK021_RS29720	COG0515	serine threonine protein kinase
HOK021_RS29720	COG2815	serine threonine protein kinase
HOK021_RS29755	COG2124	cytochrome p450
HOK021_RS29775	COG0768	penicillin binding
HOK021_RS29785	COG1119	ATPase activity
HOK021_RS29860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HOK021_RS29865	COG1357	PFAM Pentapeptide repeats (8 copies)
HOK021_RS29885	COG0745	RESPONSE REGULATOR receiver
HOK021_RS29890	COG2205	protein histidine kinase activity
HOK021_RS29895	COG0508	dehydrogenase complex catalyzes the overall conversion of
HOK021_RS29895	COG0567	Dehydrogenase, E1 component
HOK021_RS29920	COG2255	four-way junction helicase activity
HOK021_RS29985	COG0604	alcohol dehydrogenase
HOK021_RS29990	COG0281	malic enzyme
HOK021_RS29995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HOK021_RS30000	COG0765	amino acid transport
HOK021_RS30005	COG1126	abc transporter atp-binding protein
HOK021_RS30010	COG4106	trans-aconitate 2-methyltransferase activity
HOK021_RS30045	COG0577	efflux transmembrane transporter activity
HOK021_RS30045	COG1136	(ABC) transporter
HOK021_RS30065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOK021_RS30070	COG1993	acr, cog1993
HOK021_RS30075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HOK021_RS30080	COG2186	Transcriptional regulator
HOK021_RS30085	COG2807	transmembrane transport
HOK021_RS30090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HOK021_RS30095	COG0598	Magnesium transport protein CorA
HOK021_RS30100	COG0477	Major facilitator Superfamily
HOK021_RS30115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HOK021_RS30130	COG2066	Belongs to the glutaminase family
HOK021_RS30185	COG1597	lipid kinase activity
HOK021_RS30200	COG1309	transcriptional regulator
HOK021_RS30210	COG0363	glucosamine-6-phosphate deaminase activity
HOK021_RS30215	COG1472	Belongs to the glycosyl hydrolase 3 family
HOK021_RS30220	COG0395	ABC-type sugar transport system, permease component
HOK021_RS30225	COG1175	transmembrane transport
HOK021_RS30230	COG2182	Extracellular solute-binding protein
HOK021_RS30235	COG2188	Transcriptional regulator
HOK021_RS30260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HOK021_RS30265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOK021_RS30270	COG0242	peptide deformylase activity
HOK021_RS30290	COG5662	AntiSigma factor
HOK021_RS30295	COG1595	DNA-templated transcription, initiation
HOK021_RS30305	COG2135	peptidase activity
HOK021_RS30315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HOK021_RS30325	COG2076	Multidrug Resistance protein
HOK021_RS30335	COG0483	inositol monophosphate 1-phosphatase activity
HOK021_RS30340	COG0517	IMP dehydrogenase activity
HOK021_RS30340	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HOK021_RS30345	COG0753	catalase activity
HOK021_RS30350	COG0735	belongs to the Fur family
HOK021_RS30385	COG1615	UPF0182 protein
HOK021_RS30395	COG3480	Lon protease (S16) C-terminal proteolytic domain
HOK021_RS30450	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HOK021_RS30490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOK021_RS30545	COG2267	carboxylic ester hydrolase activity
HOK021_RS30575	COG0513	Belongs to the DEAD box helicase family
HOK021_RS30590	COG1432	Conserved Protein
HOK021_RS30600	COG2095	MarC family integral membrane protein
HOK021_RS30615	COG2814	Major facilitator Superfamily
HOK021_RS30625	COG0598	Magnesium transport protein CorA
HOK021_RS30660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOK021_RS30665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HOK021_RS30675	COG1595	DNA-templated transcription, initiation
HOK021_RS30690	COG1024	Enoyl-CoA hydratase
HOK021_RS30695	COG0519	Catalyzes the synthesis of GMP from XMP
HOK021_RS30705	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HOK021_RS30710	COG1611	Belongs to the LOG family
HOK021_RS30715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HOK021_RS30755	COG2197	response regulator
HOK021_RS30760	COG4585	Histidine kinase
HOK021_RS30770	COG1131	(ABC) transporter
HOK021_RS30785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HOK021_RS30805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS30810	COG4166	transmembrane transport
HOK021_RS30815	COG0601	transmembrane transport
HOK021_RS30820	COG0444	Belongs to the ABC transporter superfamily
HOK021_RS30825	COG4608	Belongs to the ABC transporter superfamily
HOK021_RS30830	COG4608	Belongs to the ABC transporter superfamily
HOK021_RS30835	COG0444	Belongs to the ABC transporter superfamily
HOK021_RS30840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HOK021_RS30845	COG0601	transmembrane transport
HOK021_RS30850	COG4166	transmembrane transport
HOK021_RS30855	COG2329	Antibiotic biosynthesis monooxygenase
HOK021_RS30860	COG1217	gtp-binding protein TYPA
HOK021_RS30880	COG1053	succinate dehydrogenase
HOK021_RS30910	COG0531	amino acid
HOK021_RS30935	COG0012	GTP binding
HOK021_RS30945	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HOK021_RS30955	COG1570	exodeoxyribonuclease VII activity
HOK021_RS30960	COG1722	exodeoxyribonuclease VII activity
HOK021_RS30965	COG0778	Nitroreductase
HOK021_RS30990	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HOK021_RS30990	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HOK021_RS30995	COG2318	DinB family
HOK021_RS31020	COG0114	fumarate hydratase activity
HOK021_RS31045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOK021_RS31070	COG1136	(ABC) transporter
HOK021_RS31085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HOK021_RS31100	COG0450	alkyl hydroperoxide reductase
HOK021_RS31105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOK021_RS31120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HOK021_RS31125	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HOK021_RS31130	COG0667	Aldo Keto reductase
HOK021_RS31205	COG2894	cell division
HOK021_RS31260	COG2610	gluconate transmembrane transporter activity
HOK021_RS31265	COG0251	oxidation-reduction process
HOK021_RS31270	COG1414	Transcriptional regulator
HOK021_RS31275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HOK021_RS31285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HOK021_RS31295	COG0436	Aminotransferase
HOK021_RS31310	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HOK021_RS31320	COG1846	Transcriptional regulator
HOK021_RS31335	COG0789	Transcriptional regulator
HOK021_RS31340	COG0154	amidase activity
HOK021_RS31350	COG1331	Highly conserved protein containing a thioredoxin domain
HOK021_RS31365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HOK021_RS31375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HOK021_RS31390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HOK021_RS31395	COG2255	four-way junction helicase activity
HOK021_RS31420	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HOK021_RS31455	COG1113	amino acid transport
HOK021_RS31485	COG2197	response regulator
HOK021_RS31510	COG2986	histidine ammonia-lyase
HOK021_RS31520	COG1024	Enoyl-CoA hydratase
HOK021_RS31525	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HOK021_RS31535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS31545	COG0768	penicillin binding
HOK021_RS31550	COG0424	maF-like protein
HOK021_RS31560	COG0693	protein deglycase activity
HOK021_RS31565	COG0515	serine threonine protein kinase
HOK021_RS31565	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOK021_RS31585	COG4770	biotin carboxylase activity
HOK021_RS31620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HOK021_RS31630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HOK021_RS31635	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS31640	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS31675	COG1595	DNA-templated transcription, initiation
HOK021_RS31680	COG0745	RESPONSE REGULATOR receiver
HOK021_RS31685	COG2205	protein histidine kinase activity
HOK021_RS31710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HOK021_RS31720	COG0583	DNA-binding transcription factor activity
HOK021_RS31725	COG2814	Major facilitator Superfamily
HOK021_RS31755	COG0494	nUDIX hydrolase
HOK021_RS31770	COG1079	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS31775	COG4603	Belongs to the binding-protein-dependent transport system permease family
HOK021_RS31780	COG3845	ABC transporter
HOK021_RS31785	COG1744	ABC transporter substrate-binding protein PnrA-like
HOK021_RS31790	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HOK021_RS31790	COG1473	amidohydrolase
HOK021_RS31800	COG2089	acid synthase
HOK021_RS31815	COG1216	Glycosyl transferase, family 2
HOK021_RS31825	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HOK021_RS31855	COG3265	gluconokinase activity
HOK021_RS31860	COG2186	Transcriptional regulator
HOK021_RS31875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS31875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS31890	COG1595	DNA-templated transcription, initiation
HOK021_RS31920	COG1720	tRNA m6t6A37 methyltransferase activity
HOK021_RS31940	COG2205	protein histidine kinase activity
HOK021_RS32000	COG2301	Belongs to the HpcH HpaI aldolase family
HOK021_RS32030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HOK021_RS32060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HOK021_RS32070	COG1051	belongs to the nudix hydrolase family
HOK021_RS32085	COG3547	Transposase (IS116 IS110 IS902 family)
HOK021_RS32105	COG0641	radical SAM
HOK021_RS32400	COG0714	Associated with various cellular activities
HOK021_RS32415	COG4974	Belongs to the 'phage' integrase family
HOK021_RS32530	COG0159	tryptophan synthase activity
HOK021_RS32550	COG0305	Participates in initiation and elongation during chromosome replication
HOK021_RS32575	COG2009	succinate dehydrogenase
HOK021_RS32585	COG1053	succinate dehydrogenase
HOK021_RS32590	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HOK021_RS32610	COG1404	Belongs to the peptidase S8 family
HOK021_RS32625	COG1408	metallophosphoesterase
HOK021_RS32635	COG1686	Belongs to the peptidase S11 family
HOK021_RS32640	COG1295	ribonuclease BN
HOK021_RS32650	COG0180	Tryptophanyl-tRNA synthetase
HOK021_RS32660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HOK021_RS32665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOK021_RS32670	COG0754	glutathionylspermidine amidase activity
HOK021_RS32690	COG0456	acetyltransferase
HOK021_RS32695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS32700	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOK021_RS32710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HOK021_RS32715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS32720	COG3708	Transcriptional regulator
HOK021_RS32720	COG2207	Transcriptional regulator
HOK021_RS32745	COG0640	Transcriptional regulator
HOK021_RS32765	COG2197	response regulator
HOK021_RS32785	COG4176	ABC-type proline glycine betaine transport system permease component
HOK021_RS32795	COG4175	Glycine betaine
HOK021_RS32795	COG0517	IMP dehydrogenase activity
HOK021_RS32805	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS32855	COG0039	L-malate dehydrogenase activity
HOK021_RS32870	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HOK021_RS32885	COG0138	bifunctional purine biosynthesis protein purh
HOK021_RS32925	COG0045	succinate-CoA ligase (ADP-forming) activity
HOK021_RS32945	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HOK021_RS32950	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HOK021_RS32955	COG0714	Associated with various cellular activities
HOK021_RS32970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HOK021_RS33010	COG2197	response regulator
HOK021_RS33020	COG0515	serine threonine protein kinase
HOK021_RS33020	COG2815	serine threonine protein kinase
HOK021_RS33075	COG2423	ornithine cyclodeaminase activity
HOK021_RS33080	COG0436	Aminotransferase
HOK021_RS33090	COG0519	Catalyzes the synthesis of GMP from XMP
HOK021_RS33090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HOK021_RS33110	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS33200	COG1131	(ABC) transporter
HOK021_RS33210	COG0596	Alpha beta hydrolase
HOK021_RS33210	COG2945	thiolester hydrolase activity
HOK021_RS33220	COG4821	SIS domain
HOK021_RS33230	COG0259	pyridoxamine-phosphate oxidase activity
HOK021_RS33250	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS33265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HOK021_RS33280	COG5006	permease, DMT superfamily
HOK021_RS33285	COG0583	DNA-binding transcription factor activity
HOK021_RS33305	COG0247	lactate metabolic process
HOK021_RS33305	COG0277	FAD linked oxidase domain protein
HOK021_RS33320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HOK021_RS33340	COG0667	Aldo Keto reductase
HOK021_RS33365	COG2252	PERMEase
HOK021_RS33375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HOK021_RS33405	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HOK021_RS33435	COG2814	Major facilitator Superfamily
HOK021_RS33445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HOK021_RS33450	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HOK021_RS33480	COG1061	Type III restriction enzyme res subunit
HOK021_RS33495	COG3973	AAA domain
HOK021_RS33500	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOK021_RS33500	COG0515	serine threonine protein kinase
HOK021_RS33540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HOK021_RS33545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HOK021_RS33545	COG1263	PTS System
HOK021_RS33580	COG0459	protein refolding
HOK021_RS33585	COG1278	Cold shock
HOK021_RS33600	COG0463	Glycosyl transferase, family 2
HOK021_RS33610	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HOK021_RS33665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HOK021_RS33720	COG0745	RESPONSE REGULATOR receiver
HOK021_RS33725	COG2205	protein histidine kinase activity
HOK021_RS33735	COG1191	sigma factor activity
HOK021_RS33755	COG2770	Histidine kinase
HOK021_RS33755	COG2208	phosphoserine phosphatase activity
HOK021_RS33760	COG0596	Alpha beta hydrolase
HOK021_RS33770	COG1191	sigma factor activity
HOK021_RS33785	COG1278	Cold shock
HOK021_RS33790	COG1278	Cold shock
HOK021_RS33800	COG1733	regulation of RNA biosynthetic process
HOK021_RS33895	COG1201	RNA secondary structure unwinding
HOK021_RS33915	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS33995	COG4974	Belongs to the 'phage' integrase family
HOK021_RS34005	COG3842	ATPase activity
HOK021_RS34030	COG0215	cysteine-tRNA ligase activity
HOK021_RS34040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HOK021_RS34045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HOK021_RS34050	COG1329	Transcriptional regulator
HOK021_RS34065	COG5002	protein histidine kinase activity
HOK021_RS34090	COG0588	phosphoglycerate mutase activity
HOK021_RS34100	COG4106	trans-aconitate 2-methyltransferase activity
HOK021_RS34110	COG0438	transferase activity, transferring glycosyl groups
HOK021_RS34125	COG0667	Aldo Keto reductase
HOK021_RS34135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS34140	COG0494	nUDIX hydrolase
HOK021_RS34140	COG0406	alpha-ribazole phosphatase activity
HOK021_RS34150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HOK021_RS34160	COG1131	(ABC) transporter
HOK021_RS34170	COG0456	acetyltransferase
HOK021_RS34175	COG0737	Belongs to the 5'-nucleotidase family
HOK021_RS34220	COG0702	epimerase
HOK021_RS34240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HOK021_RS34245	COG1609	Transcriptional regulator
HOK021_RS34250	COG0745	RESPONSE REGULATOR receiver
HOK021_RS34285	COG2897	thiosulfate sulfurtransferase activity
HOK021_RS34305	COG3485	protocatechuate 3,4-dioxygenase
HOK021_RS34310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HOK021_RS34315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HOK021_RS34325	COG0735	belongs to the Fur family
HOK021_RS34330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HOK021_RS34335	COG1490	D-aminoacyl-tRNA deacylase activity
HOK021_RS34355	COG0431	NADPH-dependent FMN reductase
HOK021_RS34380	COG0667	Aldo Keto reductase
HOK021_RS34385	COG2890	protein-(glutamine-N5) methyltransferase activity
HOK021_RS34425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HOK021_RS34445	COG0306	phosphate transporter
HOK021_RS34455	COG1937	Protein conserved in bacteria
HOK021_RS34475	COG0277	FAD linked oxidase domain protein
HOK021_RS34480	COG0671	phosphoesterase, PA-phosphatase related
HOK021_RS34485	COG0739	heme binding
HOK021_RS34485	COG1196	nuclear chromosome segregation
HOK021_RS34485	COG0741	lytic transglycosylase activity
HOK021_RS34545	COG0180	Tryptophanyl-tRNA synthetase
HOK021_RS34550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HOK021_RS34560	COG1129	ABC transporter
HOK021_RS34560	COG0842	Transport permease protein
HOK021_RS34590	COG4991	sh3 domain protein
HOK021_RS34595	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HOK021_RS34595	COG0515	serine threonine protein kinase
HOK021_RS34620	COG0129	dihydroxy-acid dehydratase activity
HOK021_RS34630	COG1082	Xylose isomerase domain protein TIM barrel
HOK021_RS34635	COG0248	Ppx GppA phosphatase
HOK021_RS34655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HOK021_RS34670	COG1194	a g-specific adenine glycosylase
HOK021_RS34675	COG1595	DNA-templated transcription, initiation
HOK021_RS34685	COG0745	RESPONSE REGULATOR receiver
HOK021_RS34690	COG2205	protein histidine kinase activity
HOK021_RS34735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HOK021_RS34755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HOK021_RS34760	COG0157	Belongs to the NadC ModD family
HOK021_RS34765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HOK021_RS34770	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HOK021_RS34790	COG0640	Transcriptional regulator
HOK021_RS34810	COG0649	NAD binding
HOK021_RS34825	COG1174	glycine betaine transport
HOK021_RS34830	COG1174	glycine betaine transport
HOK021_RS34835	COG1125	glycine betaine transport
HOK021_RS34835	COG0517	IMP dehydrogenase activity
HOK021_RS34845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HOK021_RS34850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HOK021_RS34875	COG0302	gtp cyclohydrolase
HOK021_RS34890	COG0037	tRNA processing
HOK021_RS34900	COG2027	D-alanyl-D-alanine carboxypeptidase
HOK021_RS34905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HOK021_RS34915	COG0586	Pfam SNARE associated Golgi protein
HOK021_RS34920	COG0789	Transcriptional regulator
HOK021_RS34930	COG0655	NAD(P)H dehydrogenase (quinone) activity
HOK021_RS34935	COG0076	glutamate decarboxylase activity
HOK021_RS34955	COG2318	DinB family
HOK021_RS34960	COG1012	belongs to the aldehyde dehydrogenase family
HOK021_RS34980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOK021_RS34990	COG0254	rRNA binding
HOK021_RS34995	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HOK021_RS35000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HOK021_RS35005	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HOK021_RS35010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HOK021_RS35015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HOK021_RS35015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HOK021_RS35065	COG1309	transcriptional regulator
HOK021_RS35075	COG1349	DNA-binding transcription factor activity
HOK021_RS35085	COG3594	Acyltransferase
HOK021_RS35090	COG0584	glycerophosphoryl diester phosphodiesterase
HOK021_RS35095	COG2197	response regulator
HOK021_RS35120	COG0745	RESPONSE REGULATOR receiver
HOK021_RS35125	COG2205	protein histidine kinase activity
HOK021_RS35165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HOK021_RS35260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HOK021_RS35265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HOK021_RS35270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HOK021_RS35270	COG1754	DNA topoisomerase type I activity
HOK021_RS35295	COG2890	protein-(glutamine-N5) methyltransferase activity
HOK021_RS35305	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HOK021_RS35310	COG2172	sigma factor antagonist activity
HOK021_RS35315	COG1366	Belongs to the anti-sigma-factor antagonist family
HOK021_RS35320	COG1205	dead DEAH box helicase
HOK021_RS35320	COG1111	helicase
HOK021_RS35380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HOK021_RS35385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HOK021_RS35395	COG2267	carboxylic ester hydrolase activity
HOK021_RS35430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HOK021_RS35455	COG0003	Pfam Anion-transporting ATPase
HOK021_RS35465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOK021_RS35475	COG1408	metallophosphoesterase
HOK021_RS35490	COG1316	TRANSCRIPTIONal
HOK021_RS35495	COG1215	transferase activity, transferring glycosyl groups
HOK021_RS35500	COG1309	transcriptional regulator
HOK021_RS35505	COG2124	cytochrome p450
HOK021_RS35535	COG1595	DNA-templated transcription, initiation
HOK021_RS35555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HOK021_RS35560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HOK021_RS35585	COG4585	Histidine kinase
HOK021_RS35590	COG2197	response regulator
HOK021_RS35600	COG3629	intracellular signal transduction
HOK021_RS35605	COG3469	chitinase activity
HOK021_RS35610	COG0531	amino acid
HOK021_RS35615	COG1132	(ABC) transporter
HOK021_RS35620	COG0477	Major facilitator Superfamily
HOK021_RS35630	COG1136	(ABC) transporter
HOK021_RS35630	COG0577	efflux transmembrane transporter activity
HOK021_RS35635	COG0577	efflux transmembrane transporter activity
HOK021_RS35635	COG1136	(ABC) transporter
HOK021_RS35650	COG0745	RESPONSE REGULATOR receiver
HOK021_RS35655	COG2205	protein histidine kinase activity
HOK021_RS35700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HOK021_RS35710	COG3631	Ketosteroid isomerase-related protein
HOK021_RS35715	COG0702	epimerase
HOK021_RS35735	COG0189	ligase activity
HOK021_RS35735	COG0569	domain protein
HOK021_RS35745	COG0402	S-adenosylhomocysteine deaminase activity
HOK021_RS35755	COG1834	amidinotransferase
HOK021_RS35760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HOK021_RS35765	COG0659	secondary active sulfate transmembrane transporter activity
HOK021_RS35775	COG0596	Alpha beta hydrolase
HOK021_RS35785	COG2514	catechol 2,3-dioxygenase activity
HOK021_RS35805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HOK021_RS35810	COG2226	methyltransferase
HOK021_RS35820	COG0477	Major facilitator Superfamily
HOK021_RS35835	COG2268	Band 7 protein
HOK021_RS35870	COG1064	alcohol dehydrogenase
HOK021_RS35880	COG0523	cobalamin synthesis protein
HOK021_RS35915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HOK021_RS35965	COG1191	sigma factor activity
HOK021_RS35970	COG1191	sigma factor activity
HOK021_RS35990	COG0402	S-adenosylhomocysteine deaminase activity
HOK021_RS36010	COG0477	Major facilitator Superfamily
HOK021_RS36015	COG2353	YceI-like domain
HOK021_RS36025	COG0477	Major facilitator Superfamily
HOK021_RS36030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOK021_RS36030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HOK021_RS36040	COG2205	protein histidine kinase activity
HOK021_RS36045	COG0745	RESPONSE REGULATOR receiver
HOK021_RS36075	COG2249	NAD(P)H dehydrogenase (quinone) activity
HOK021_RS36130	COG0318	PFAM AMP-dependent synthetase and ligase
HOK021_RS36145	COG2205	protein histidine kinase activity
HOK021_RS36145	COG3437	response regulator, receiver
HOK021_RS36145	COG3850	Histidine kinase
HOK021_RS36145	COG4999	Histidine kinase
HOK021_RS36150	COG3437	response regulator, receiver
HOK021_RS36185	COG0662	Cupin 2, conserved barrel domain protein
HOK021_RS36210	COG1595	DNA-templated transcription, initiation
HOK021_RS36230	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS36240	COG1960	acyl-CoA dehydrogenase activity
HOK021_RS36285	COG0494	nUDIX hydrolase
HOK021_RS36365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HOK021_RS36400	COG0006	proline dipeptidase activity
HOK021_RS36485	COG2372	response to copper ion
HOK021_RS36490	COG2837	iron assimilation
HOK021_RS36495	COG0077	Prephenate dehydratase
HOK021_RS36500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HOK021_RS36505	COG0561	phosphatase activity
HOK021_RS36545	COG2186	Transcriptional regulator
HOK021_RS36550	COG2807	transmembrane transport
HOK021_RS36555	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HOK021_RS36575	COG1131	(ABC) transporter
HOK021_RS36595	COG0789	Transcriptional regulator
HOK021_RS36600	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HOK021_RS36615	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
HOK021_RS36625	COG0501	Belongs to the peptidase M48B family
HOK021_RS36635	COG0561	phosphatase activity
HOK021_RS36645	COG4988	ABC transporter
HOK021_RS36650	COG1294	oxidase, subunit
HOK021_RS36655	COG1271	oxidase subunit
HOK021_RS36660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HOK021_RS36665	COG1609	Transcriptional regulator
HOK021_RS36680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HOK021_RS36705	COG0662	Cupin 2, conserved barrel domain protein
HOK021_RS36710	COG1950	PFAM Membrane protein of
HOK021_RS36715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HOK021_RS36720	COG0626	cystathionine gamma-synthase activity
HOK021_RS36760	COG2814	Major facilitator Superfamily
HOK021_RS36795	COG4977	sequence-specific DNA binding
HOK021_RS36810	COG0305	Participates in initiation and elongation during chromosome replication
HOK021_RS36825	COG0359	binds to the 23S rRNA
HOK021_RS36830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HOK021_RS36835	COG0629	single-stranded DNA binding
HOK021_RS36840	COG0360	Binds together with S18 to 16S ribosomal RNA
HOK021_RS36870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HOK021_RS36870	COG4499	WXG100 protein secretion system (Wss), protein YukC
HOK021_RS36895	COG0617	tRNA 3'-terminal CCA addition
HOK021_RS36910	COG2815	serine threonine protein kinase
HOK021_RS36910	COG0515	serine threonine protein kinase
HOK021_RS36915	COG1595	DNA-templated transcription, initiation
HOK021_RS36925	COG0492	ferredoxin-NADP+ reductase activity
HOK021_RS36930	COG3118	belongs to the thioredoxin family
HOK021_RS36945	COG1192	Involved in chromosome partitioning
HOK021_RS36950	COG0357	Ribosomal RNA small subunit methyltransferase G
HOK021_RS36960	COG0706	membrane insertase activity
HOK021_RS36965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HOK021_RS36975	COG0230	Belongs to the bacterial ribosomal protein bL34 family