locus-tag	class	description
SHXM_RS00010	COG2271	Major facilitator Superfamily
SHXM_RS00015	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SHXM_RS00040	COG2226	methyltransferase
SHXM_RS00135	COG3621	Patatin-like phospholipase
SHXM_RS00160	COG4974	Belongs to the 'phage' integrase family
SHXM_RS00165	COG4584	PFAM Integrase catalytic
SHXM_RS00170	COG1484	DNA-dependent DNA replication
SHXM_RS00190	COG1309	transcriptional regulator
SHXM_RS00205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS00320	COG0789	Transcriptional regulator
SHXM_RS00340	COG1414	Transcriptional regulator
SHXM_RS00375	COG0477	Major facilitator Superfamily
SHXM_RS00405	COG2319	Wd-40 repeat
SHXM_RS00410	COG2319	Wd-40 repeat
SHXM_RS00435	COG3328	transposase activity
SHXM_RS00460	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS00470	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS00515	COG0583	DNA-binding transcription factor activity
SHXM_RS00520	COG1024	Enoyl-CoA hydratase
SHXM_RS00525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS00530	COG0477	Major facilitator Superfamily
SHXM_RS00585	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS00645	COG2826	transposase and inactivated derivatives, IS30 family
SHXM_RS00650	COG0667	Aldo Keto reductase
SHXM_RS00675	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS00695	COG0667	Aldo Keto reductase
SHXM_RS00700	COG1309	transcriptional regulator
SHXM_RS00745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS00750	COG1024	Enoyl-CoA hydratase
SHXM_RS00795	COG2816	NAD+ diphosphatase activity
SHXM_RS00800	COG3415	Transposase
SHXM_RS00800	COG2801	Transposase and inactivated derivatives
SHXM_RS00845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS00855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SHXM_RS00860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHXM_RS00860	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS00890	COG3693	PFAM glycoside hydrolase, family 10
SHXM_RS00895	COG1609	Transcriptional regulator
SHXM_RS00925	COG0583	DNA-binding transcription factor activity
SHXM_RS00965	COG1396	sequence-specific DNA binding
SHXM_RS00970	COG1247	-acetyltransferase
SHXM_RS01000	COG1414	Transcriptional regulator
SHXM_RS01015	COG1129	ABC transporter
SHXM_RS01020	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS01040	COG1129	ABC transporter
SHXM_RS01045	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS01050	COG1879	ABC-type sugar transport system periplasmic component
SHXM_RS01070	COG3959	Transketolase, thiamine diphosphate binding domain
SHXM_RS01075	COG3958	Transketolase
SHXM_RS01080	COG1414	Transcriptional regulator
SHXM_RS01125	COG2801	Transposase and inactivated derivatives
SHXM_RS01140	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS01145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS01150	COG2197	response regulator
SHXM_RS01175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS01235	COG0300	oxidoreductase activity
SHXM_RS01240	COG0300	oxidoreductase activity
SHXM_RS01255	COG0657	acetylesterase activity
SHXM_RS01270	COG0596	Alpha beta hydrolase
SHXM_RS01320	COG0596	Alpha beta hydrolase
SHXM_RS01340	COG0596	Alpha beta hydrolase
SHXM_RS01345	COG1335	isochorismatase
SHXM_RS01370	COG0477	Major facilitator Superfamily
SHXM_RS01375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS01380	COG2309	aminopeptidase activity
SHXM_RS01385	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHXM_RS01445	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SHXM_RS01450	COG2226	methyltransferase
SHXM_RS01485	COG1653	transport
SHXM_RS01490	COG0395	ABC-type sugar transport system, permease component
SHXM_RS01495	COG4209	transmembrane transport
SHXM_RS01500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS01510	COG0673	inositol 2-dehydrogenase activity
SHXM_RS01560	COG2986	histidine ammonia-lyase
SHXM_RS01600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHXM_RS01605	COG0596	Alpha beta hydrolase
SHXM_RS01610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01630	COG0531	amino acid
SHXM_RS01645	COG0494	nUDIX hydrolase
SHXM_RS01665	COG3842	ATPase activity
SHXM_RS01675	COG1177	transmembrane transport
SHXM_RS01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01740	COG1914	H( )-stimulated, divalent metal cation uptake system
SHXM_RS01745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHXM_RS01755	COG0667	Aldo Keto reductase
SHXM_RS01765	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SHXM_RS01770	COG2124	cytochrome p450
SHXM_RS01775	COG0402	S-adenosylhomocysteine deaminase activity
SHXM_RS01785	COG0626	cystathionine gamma-synthase activity
SHXM_RS01810	COG1175	transmembrane transport
SHXM_RS01815	COG0395	ABC-type sugar transport system, permease component
SHXM_RS01830	COG3661	Belongs to the glycosyl hydrolase 67 family
SHXM_RS01845	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
SHXM_RS01875	COG1301	dicarboxylic acid transport
SHXM_RS01880	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHXM_RS01885	COG1733	regulation of RNA biosynthetic process
SHXM_RS01900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01920	COG0477	Major facilitator Superfamily
SHXM_RS01935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS01940	COG0601	transmembrane transport
SHXM_RS01945	COG0747	negative chemotaxis
SHXM_RS01955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS01960	COG0277	FAD linked oxidase domain protein
SHXM_RS01965	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHXM_RS01970	COG2011	ABC-type metal ion transport system permease component
SHXM_RS01975	COG1464	Belongs to the NlpA lipoprotein family
SHXM_RS01985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS01995	COG0667	Aldo Keto reductase
SHXM_RS02000	COG1116	anion transmembrane transporter activity
SHXM_RS02005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS02020	COG1733	regulation of RNA biosynthetic process
SHXM_RS02040	COG0747	negative chemotaxis
SHXM_RS02045	COG0601	transmembrane transport
SHXM_RS02050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS02055	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS02060	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS02135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS02140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS02145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS02155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHXM_RS02160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHXM_RS02170	COG2423	ornithine cyclodeaminase activity
SHXM_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS02215	COG1891	lyase activity
SHXM_RS02230	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SHXM_RS02255	COG1509	lysine 2,3-aminomutase activity
SHXM_RS02305	COG4221	oxidoreductase activity
SHXM_RS02330	COG3961	Belongs to the TPP enzyme family
SHXM_RS02345	COG1131	(ABC) transporter
SHXM_RS02350	COG0142	geranyltranstransferase activity
SHXM_RS02355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SHXM_RS02365	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS02370	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS02375	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS02385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS02390	COG0601	transmembrane transport
SHXM_RS02415	COG0789	Transcriptional regulator
SHXM_RS02425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SHXM_RS02430	COG4977	sequence-specific DNA binding
SHXM_RS02445	COG1073	alpha beta
SHXM_RS02465	COG3454	Phosphonate metabolism
SHXM_RS02535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHXM_RS02550	COG1024	Enoyl-CoA hydratase
SHXM_RS02565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SHXM_RS02575	COG2192	nodulation
SHXM_RS02595	COG0300	oxidoreductase activity
SHXM_RS02595	COG3321	synthase
SHXM_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS02595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS02595	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS02630	COG4977	sequence-specific DNA binding
SHXM_RS02635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHXM_RS02660	COG2814	Major facilitator Superfamily
SHXM_RS02685	COG0604	alcohol dehydrogenase
SHXM_RS02695	COG2226	methyltransferase
SHXM_RS02735	COG1733	regulation of RNA biosynthetic process
SHXM_RS02745	COG2353	YceI-like domain
SHXM_RS02805	COG1846	Transcriptional regulator
SHXM_RS02810	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHXM_RS02825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS02835	COG2084	Dehydrogenase
SHXM_RS02840	COG3395	kinase activity
SHXM_RS02845	COG0235	Class ii aldolase
SHXM_RS02850	COG2271	Major facilitator Superfamily
SHXM_RS02855	COG3622	Belongs to the hyi family
SHXM_RS02860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHXM_RS02875	COG2318	DinB family
SHXM_RS02880	COG0667	Aldo Keto reductase
SHXM_RS02905	COG1959	2 iron, 2 sulfur cluster binding
SHXM_RS02910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SHXM_RS02910	COG1017	nitric oxide dioxygenase activity
SHXM_RS02915	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SHXM_RS02920	COG2345	Transcriptional regulator
SHXM_RS02930	COG0789	Transcriptional regulator
SHXM_RS02935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS02945	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHXM_RS02950	COG0436	Aminotransferase
SHXM_RS02955	COG4221	oxidoreductase activity
SHXM_RS02960	COG0477	Major facilitator Superfamily
SHXM_RS02965	COG1984	allophanate hydrolase subunit 2
SHXM_RS02970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS02975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS02985	COG1609	Transcriptional regulator
SHXM_RS02995	COG0673	inositol 2-dehydrogenase activity
SHXM_RS03000	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS03025	COG0542	response to heat
SHXM_RS03030	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS03035	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS03040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS03055	COG2124	cytochrome p450
SHXM_RS03095	COG1309	transcriptional regulator
SHXM_RS03115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS03125	COG0604	alcohol dehydrogenase
SHXM_RS03125	COG3321	synthase
SHXM_RS03135	COG0328	RNA-DNA hybrid ribonuclease activity
SHXM_RS03140	COG2356	endonuclease I
SHXM_RS03220	COG3511	phospholipase C
SHXM_RS03260	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SHXM_RS03270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS03320	COG1357	PFAM Pentapeptide repeats (8 copies)
SHXM_RS03330	COG0306	phosphate transporter
SHXM_RS03345	COG0583	DNA-binding transcription factor activity
SHXM_RS03350	COG2175	clavaminate synthase activity
SHXM_RS03355	COG3629	intracellular signal transduction
SHXM_RS03355	COG3903	Transcriptional regulator
SHXM_RS03370	COG2267	carboxylic ester hydrolase activity
SHXM_RS03380	COG0114	fumarate hydratase activity
SHXM_RS03385	COG0726	polysaccharide deacetylase
SHXM_RS03405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SHXM_RS03410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS03420	COG3290	protein histidine kinase activity
SHXM_RS03425	COG4565	transcriptional regulatory protein
SHXM_RS03435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHXM_RS03470	COG2376	Dihydroxyacetone kinase
SHXM_RS03475	COG2376	Dihydroxyacetone kinase
SHXM_RS03480	COG3594	Acyltransferase
SHXM_RS03485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS03515	COG0747	negative chemotaxis
SHXM_RS03540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS03550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS03555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS03560	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS03565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHXM_RS03595	COG3250	beta-galactosidase activity
SHXM_RS03610	COG2815	serine threonine protein kinase
SHXM_RS03610	COG0515	serine threonine protein kinase
SHXM_RS03630	COG0412	Dienelactone hydrolase
SHXM_RS03645	COG0326	Molecular chaperone. Has ATPase activity
SHXM_RS03670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHXM_RS03680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS03695	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS03705	COG2508	Transcriptional regulator
SHXM_RS03725	COG0739	heme binding
SHXM_RS03735	COG2175	clavaminate synthase activity
SHXM_RS03740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS03750	COG0109	protoheme IX farnesyltransferase activity
SHXM_RS03755	COG0142	geranyltranstransferase activity
SHXM_RS03760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHXM_RS03785	COG0668	transmembrane transport
SHXM_RS03815	COG3387	PFAM Glycoside hydrolase 15-related
SHXM_RS03830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SHXM_RS03835	COG1309	transcriptional regulator
SHXM_RS03845	COG0477	Major facilitator Superfamily
SHXM_RS03875	COG3537	Alpha-1,2-mannosidase
SHXM_RS03895	COG1175	transmembrane transport
SHXM_RS03905	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS03910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS03915	COG0583	DNA-binding transcription factor activity
SHXM_RS03945	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS03950	COG2610	gluconate transmembrane transporter activity
SHXM_RS03985	COG1414	Transcriptional regulator
SHXM_RS03990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS04000	COG1968	undecaprenyl-diphosphatase activity
SHXM_RS04010	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS04030	COG0477	Major facilitator Superfamily
SHXM_RS04035	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHXM_RS04040	COG1396	sequence-specific DNA binding
SHXM_RS04050	COG4221	oxidoreductase activity
SHXM_RS04110	COG1309	transcriptional regulator
SHXM_RS04125	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SHXM_RS04125	COG3291	Pkd domain containing protein
SHXM_RS04155	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SHXM_RS04170	COG1064	alcohol dehydrogenase
SHXM_RS04215	COG0435	Glutathione S-transferase
SHXM_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS04270	COG1819	glycosyl
SHXM_RS04295	COG0488	(ABC) transporter
SHXM_RS04320	COG0656	L-ascorbic acid biosynthetic process
SHXM_RS04340	COG3321	synthase
SHXM_RS04340	COG0604	alcohol dehydrogenase
SHXM_RS04350	COG3321	synthase
SHXM_RS04350	COG0604	alcohol dehydrogenase
SHXM_RS04355	COG3321	synthase
SHXM_RS04355	COG0604	alcohol dehydrogenase
SHXM_RS04375	COG0156	8-amino-7-oxononanoate synthase activity
SHXM_RS04385	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS04395	COG3509	depolymerase
SHXM_RS04410	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS04435	COG3835	regulator
SHXM_RS04440	COG2226	methyltransferase
SHXM_RS04450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHXM_RS04460	COG2271	Major facilitator Superfamily
SHXM_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS04505	COG0129	dihydroxy-acid dehydratase activity
SHXM_RS04520	COG0701	Predicted permease
SHXM_RS04545	COG4585	Histidine kinase
SHXM_RS04550	COG2197	response regulator
SHXM_RS04570	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS04575	COG0492	ferredoxin-NADP+ reductase activity
SHXM_RS04590	COG0475	glutathione-regulated potassium exporter activity
SHXM_RS04595	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS04605	COG2197	response regulator
SHXM_RS04630	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
SHXM_RS04635	COG2828	Protein conserved in bacteria
SHXM_RS04640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHXM_RS04655	COG0531	amino acid
SHXM_RS04705	COG3119	arylsulfatase activity
SHXM_RS04710	COG3507	Belongs to the glycosyl hydrolase 43 family
SHXM_RS04730	COG1175	transmembrane transport
SHXM_RS04735	COG0395	ABC-type sugar transport system, permease component
SHXM_RS04740	COG1609	Transcriptional regulator
SHXM_RS04745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SHXM_RS04765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS04770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS04785	COG2226	methyltransferase
SHXM_RS04790	COG0673	inositol 2-dehydrogenase activity
SHXM_RS04795	COG3622	Belongs to the hyi family
SHXM_RS04800	COG1609	Transcriptional regulator
SHXM_RS04830	COG2197	response regulator
SHXM_RS04835	COG4585	Histidine kinase
SHXM_RS04840	COG0577	efflux transmembrane transporter activity
SHXM_RS04850	COG2815	serine threonine protein kinase
SHXM_RS04850	COG0515	serine threonine protein kinase
SHXM_RS04855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SHXM_RS04915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHXM_RS04925	COG1942	4-Oxalocrotonate Tautomerase
SHXM_RS04990	COG0542	response to heat
SHXM_RS05000	COG0515	serine threonine protein kinase
SHXM_RS05000	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS05035	COG0789	Transcriptional regulator
SHXM_RS05050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHXM_RS05065	COG0546	phosphoglycolate phosphatase activity
SHXM_RS05095	COG3290	protein histidine kinase activity
SHXM_RS05100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHXM_RS05130	COG1063	alcohol dehydrogenase
SHXM_RS05140	COG2072	flavoprotein involved in K transport
SHXM_RS05155	COG1053	succinate dehydrogenase
SHXM_RS05160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHXM_RS05215	COG0477	Major facilitator Superfamily
SHXM_RS05220	COG0789	Transcriptional regulator
SHXM_RS05235	COG2197	response regulator
SHXM_RS05250	COG5006	permease, DMT superfamily
SHXM_RS05290	COG3321	synthase
SHXM_RS05290	COG3321	synthase
SHXM_RS05290	COG0604	alcohol dehydrogenase
SHXM_RS05290	COG0604	alcohol dehydrogenase
SHXM_RS05295	COG0604	alcohol dehydrogenase
SHXM_RS05295	COG3321	synthase
SHXM_RS05305	COG0604	alcohol dehydrogenase
SHXM_RS05305	COG3321	synthase
SHXM_RS05310	COG3321	synthase
SHXM_RS05310	COG0604	alcohol dehydrogenase
SHXM_RS05320	COG0604	alcohol dehydrogenase
SHXM_RS05320	COG3321	synthase
SHXM_RS05415	COG0587	DNA-directed DNA polymerase activity
SHXM_RS05430	COG1175	transmembrane transport
SHXM_RS05435	COG0395	ABC-type sugar transport system, permease component
SHXM_RS05440	COG0366	Alpha amylase catalytic
SHXM_RS05450	COG0137	argininosuccinate synthase activity
SHXM_RS05465	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS05490	COG2353	YceI-like domain
SHXM_RS05505	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SHXM_RS05510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHXM_RS05515	COG0583	DNA-binding transcription factor activity
SHXM_RS05525	COG0277	FAD linked oxidase domain protein
SHXM_RS05540	COG4585	Histidine kinase
SHXM_RS05545	COG2197	response regulator
SHXM_RS05555	COG1136	(ABC) transporter
SHXM_RS05555	COG0577	efflux transmembrane transporter activity
SHXM_RS05560	COG0577	efflux transmembrane transporter activity
SHXM_RS05560	COG1136	(ABC) transporter
SHXM_RS05565	COG2197	response regulator
SHXM_RS05570	COG4585	Histidine kinase
SHXM_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS05695	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS05720	COG0483	inositol monophosphate 1-phosphatase activity
SHXM_RS05730	COG1316	TRANSCRIPTIONal
SHXM_RS05735	COG2261	transglycosylase associated protein
SHXM_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS05755	COG1819	glycosyl
SHXM_RS05760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SHXM_RS05765	COG1309	transcriptional regulator
SHXM_RS05840	COG1222	aaa ATPase
SHXM_RS05875	COG0583	DNA-binding transcription factor activity
SHXM_RS05885	COG2318	DinB family
SHXM_RS05905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHXM_RS05930	COG0640	Transcriptional regulator
SHXM_RS05945	COG1609	Transcriptional regulator
SHXM_RS05955	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS05960	COG0246	Mannitol dehydrogenase
SHXM_RS05965	COG0477	Major facilitator Superfamily
SHXM_RS05970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHXM_RS05980	COG0254	rRNA binding
SHXM_RS05985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHXM_RS05990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SHXM_RS05995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHXM_RS06000	COG1024	Enoyl-CoA hydratase
SHXM_RS06050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS06060	COG0747	negative chemotaxis
SHXM_RS06100	COG1113	amino acid transport
SHXM_RS06105	COG2186	Transcriptional regulator
SHXM_RS06125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SHXM_RS06130	COG0673	inositol 2-dehydrogenase activity
SHXM_RS06145	COG2318	DinB family
SHXM_RS06180	COG2378	regulation of single-species biofilm formation
SHXM_RS06190	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHXM_RS06245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SHXM_RS06260	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS06265	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS06270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS06295	COG1215	transferase activity, transferring glycosyl groups
SHXM_RS06310	COG1131	(ABC) transporter
SHXM_RS06365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS06430	COG2945	thiolester hydrolase activity
SHXM_RS06430	COG0596	Alpha beta hydrolase
SHXM_RS06440	COG3321	synthase
SHXM_RS06440	COG0604	alcohol dehydrogenase
SHXM_RS06445	COG0604	alcohol dehydrogenase
SHXM_RS06445	COG3321	synthase
SHXM_RS06450	COG3321	synthase
SHXM_RS06450	COG0604	alcohol dehydrogenase
SHXM_RS06480	COG2936	dipeptidyl-peptidase activity
SHXM_RS06495	COG0542	response to heat
SHXM_RS06505	COG1595	DNA-templated transcription, initiation
SHXM_RS06515	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS06520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS06525	COG0747	negative chemotaxis
SHXM_RS06555	COG0384	phenazine biosynthesis protein PhzF
SHXM_RS06560	COG2313	pseudouridylate synthase activity
SHXM_RS06565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS06565	COG1522	sequence-specific DNA binding
SHXM_RS06570	COG0189	ligase activity
SHXM_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS06605	COG2207	Transcriptional regulator
SHXM_RS06615	COG3290	protein histidine kinase activity
SHXM_RS06625	COG0673	inositol 2-dehydrogenase activity
SHXM_RS06635	COG3321	synthase
SHXM_RS06635	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS06635	COG0604	alcohol dehydrogenase
SHXM_RS06640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS06650	COG1834	amidinotransferase
SHXM_RS06655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHXM_RS06660	COG3224	Antibiotic biosynthesis monooxygenase
SHXM_RS06670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS06680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS06690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS06710	COG0477	Major facilitator Superfamily
SHXM_RS06715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SHXM_RS06730	COG0443	Heat shock 70 kDa protein
SHXM_RS06760	COG1522	sequence-specific DNA binding
SHXM_RS06775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS06795	COG0596	Alpha beta hydrolase
SHXM_RS06800	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS06805	COG1802	Transcriptional regulator
SHXM_RS06810	COG1802	Transcriptional regulator
SHXM_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS06840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS06860	COG3250	beta-galactosidase activity
SHXM_RS06870	COG1796	DNA polymerase
SHXM_RS06870	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHXM_RS06890	COG2273	Hydrolase Family 16
SHXM_RS06895	COG2723	6-phospho-beta-galactosidase activity
SHXM_RS06900	COG0395	ABC-type sugar transport system, permease component
SHXM_RS06905	COG1175	transmembrane transport
SHXM_RS06910	COG2182	Extracellular solute-binding protein
SHXM_RS06915	COG1940	carbohydrate kinase activity
SHXM_RS06940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHXM_RS06945	COG1349	DNA-binding transcription factor activity
SHXM_RS06950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHXM_RS06955	COG0191	fructose-bisphosphate aldolase activity
SHXM_RS06980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SHXM_RS07005	COG0745	RESPONSE REGULATOR receiver
SHXM_RS07010	COG2205	protein histidine kinase activity
SHXM_RS07015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS07025	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHXM_RS07040	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHXM_RS07090	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS07095	COG1024	Enoyl-CoA hydratase
SHXM_RS07115	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SHXM_RS07125	COG3360	Dodecin
SHXM_RS07140	COG3959	Transketolase, thiamine diphosphate binding domain
SHXM_RS07145	COG1252	NADH dehydrogenase
SHXM_RS07155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHXM_RS07175	COG0667	Aldo Keto reductase
SHXM_RS07185	COG2197	response regulator
SHXM_RS07190	COG3851	Histidine kinase
SHXM_RS07200	COG1131	(ABC) transporter
SHXM_RS07250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
SHXM_RS07320	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
SHXM_RS07335	COG0110	maltose O-acetyltransferase activity
SHXM_RS07380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS07395	COG0671	phosphoesterase, PA-phosphatase related
SHXM_RS07405	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHXM_RS07410	COG1733	regulation of RNA biosynthetic process
SHXM_RS07415	COG0477	Major facilitator Superfamily
SHXM_RS07440	COG2205	protein histidine kinase activity
SHXM_RS07445	COG0745	RESPONSE REGULATOR receiver
SHXM_RS07450	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS07470	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
SHXM_RS07475	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SHXM_RS07490	COG3345	alpha-galactosidase
SHXM_RS07500	COG2133	pyrroloquinoline quinone binding
SHXM_RS07510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS07515	COG2271	Major facilitator Superfamily
SHXM_RS07520	COG3835	regulator
SHXM_RS07525	COG4607	ABC-type enterochelin transport system periplasmic component
SHXM_RS07530	COG0174	glutamine synthetase
SHXM_RS07565	COG2815	serine threonine protein kinase
SHXM_RS07565	COG0515	serine threonine protein kinase
SHXM_RS07580	COG4221	oxidoreductase activity
SHXM_RS07585	COG3537	Alpha-1,2-mannosidase
SHXM_RS07590	COG1064	alcohol dehydrogenase
SHXM_RS07595	COG2851	Citrate transporter
SHXM_RS07600	COG0583	DNA-binding transcription factor activity
SHXM_RS07605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS07630	COG2197	response regulator
SHXM_RS07635	COG1595	DNA-templated transcription, initiation
SHXM_RS07645	COG0386	Belongs to the glutathione peroxidase family
SHXM_RS07655	COG2353	YceI-like domain
SHXM_RS07730	COG0395	ABC-type sugar transport system, permease component
SHXM_RS07735	COG1175	transmembrane transport
SHXM_RS07740	COG1653	transport
SHXM_RS07745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS07755	COG1486	melibiose metabolic process
SHXM_RS07775	COG0395	ABC-type sugar transport system, permease component
SHXM_RS07780	COG1063	alcohol dehydrogenase
SHXM_RS07805	COG0514	ATP-dependent DNA helicase (RecQ)
SHXM_RS07830	COG2186	Transcriptional regulator
SHXM_RS07855	COG3250	beta-galactosidase activity
SHXM_RS07880	COG0765	amino acid transport
SHXM_RS07885	COG1126	abc transporter atp-binding protein
SHXM_RS07965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS07975	COG0277	FAD linked oxidase domain protein
SHXM_RS07980	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SHXM_RS08005	COG1063	alcohol dehydrogenase
SHXM_RS08055	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS08075	COG0242	peptide deformylase activity
SHXM_RS08110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS08115	COG0395	ABC-type sugar transport system, permease component
SHXM_RS08140	COG3629	intracellular signal transduction
SHXM_RS08140	COG3903	Transcriptional regulator
SHXM_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS08210	COG0667	Aldo Keto reductase
SHXM_RS08215	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS08225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS08230	COG0601	transmembrane transport
SHXM_RS08235	COG0747	negative chemotaxis
SHXM_RS08240	COG3395	kinase activity
SHXM_RS08245	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
SHXM_RS08250	COG1349	DNA-binding transcription factor activity
SHXM_RS08255	COG1132	(ABC) transporter
SHXM_RS08260	COG1132	(ABC) transporter
SHXM_RS08280	COG1191	sigma factor activity
SHXM_RS08290	COG1793	dna ligase
SHXM_RS08305	COG0252	asparaginase activity
SHXM_RS08325	COG3631	Ketosteroid isomerase-related protein
SHXM_RS08330	COG0702	epimerase
SHXM_RS08375	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHXM_RS08380	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS08390	COG0242	peptide deformylase activity
SHXM_RS08400	COG3442	glutamine amidotransferase
SHXM_RS08405	COG0205	6-phosphofructokinase activity
SHXM_RS08445	COG0596	Alpha beta hydrolase
SHXM_RS08450	COG0829	nickel cation binding
SHXM_RS08455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SHXM_RS08460	COG0830	nickel cation binding
SHXM_RS08465	COG0804	urea catabolic process
SHXM_RS08470	COG0832	Belongs to the urease beta subunit family
SHXM_RS08475	COG0831	urea catabolic process
SHXM_RS08480	COG4935	Belongs to the peptidase S8 family
SHXM_RS08480	COG2234	aminopeptidase activity
SHXM_RS08490	COG0740	serine-type endopeptidase activity
SHXM_RS08500	COG0791	NLP P60 protein
SHXM_RS08500	COG0741	lytic transglycosylase activity
SHXM_RS08535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SHXM_RS08540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHXM_RS08545	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SHXM_RS08550	COG2226	methyltransferase
SHXM_RS08555	COG0577	efflux transmembrane transporter activity
SHXM_RS08555	COG1136	(ABC) transporter
SHXM_RS08595	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHXM_RS08600	COG3663	DNA glycosylase
SHXM_RS08610	COG1940	carbohydrate kinase activity
SHXM_RS08615	COG2188	Transcriptional regulator
SHXM_RS08620	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS08660	COG0626	cystathionine gamma-synthase activity
SHXM_RS08675	COG0419	ATPase involved in DNA repair
SHXM_RS08680	COG0420	3'-5' exonuclease activity
SHXM_RS08685	COG0659	secondary active sulfate transmembrane transporter activity
SHXM_RS08695	COG0745	RESPONSE REGULATOR receiver
SHXM_RS08700	COG0642	Histidine kinase
SHXM_RS08705	COG1739	Uncharacterized protein family UPF0029
SHXM_RS08715	COG4585	Histidine kinase
SHXM_RS08720	COG2197	response regulator
SHXM_RS08735	COG0583	DNA-binding transcription factor activity
SHXM_RS08840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SHXM_RS08945	COG2066	Belongs to the glutaminase family
SHXM_RS08950	COG1027	Aspartate ammonia-lyase
SHXM_RS09135	COG1222	aaa ATPase
SHXM_RS09145	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS09165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHXM_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS09175	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS09185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS09195	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
SHXM_RS09200	COG3104	oligopeptide transport
SHXM_RS09210	COG0022	dehydrogenase e1 component
SHXM_RS09215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SHXM_RS09345	COG1113	amino acid transport
SHXM_RS09375	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS09385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS09505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS09510	COG2267	carboxylic ester hydrolase activity
SHXM_RS09515	COG4221	oxidoreductase activity
SHXM_RS09520	COG1414	Transcriptional regulator
SHXM_RS09530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS09590	COG4974	Belongs to the 'phage' integrase family
SHXM_RS09595	COG4584	PFAM Integrase catalytic
SHXM_RS09600	COG1484	DNA-dependent DNA replication
SHXM_RS09615	COG1309	transcriptional regulator
SHXM_RS09650	COG2130	NADP-dependent
SHXM_RS09730	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SHXM_RS09785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHXM_RS09830	COG2963	transposase activity
SHXM_RS09945	COG0596	Alpha beta hydrolase
SHXM_RS10190	COG2226	methyltransferase
SHXM_RS10240	COG0105	UTP biosynthetic process
SHXM_RS10260	COG0667	Aldo Keto reductase
SHXM_RS10265	COG3903	Transcriptional regulator
SHXM_RS10265	COG3629	intracellular signal transduction
SHXM_RS10280	COG3903	Transcriptional regulator
SHXM_RS10280	COG3629	intracellular signal transduction
SHXM_RS10345	COG1832	CoA-binding protein
SHXM_RS10350	COG1832	CoA-binding protein
SHXM_RS10380	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS10385	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS10390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS10410	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS10425	COG3336	cytochrome c oxidase
SHXM_RS10470	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SHXM_RS10485	COG2814	Major facilitator Superfamily
SHXM_RS10490	COG1968	undecaprenyl-diphosphatase activity
SHXM_RS10500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS10505	COG0154	amidase activity
SHXM_RS10540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHXM_RS10545	COG1522	sequence-specific DNA binding
SHXM_RS10565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SHXM_RS10570	COG0640	Transcriptional regulator
SHXM_RS10575	COG0154	amidase activity
SHXM_RS10595	COG2267	carboxylic ester hydrolase activity
SHXM_RS10600	COG2226	methyltransferase
SHXM_RS10605	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SHXM_RS10620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHXM_RS10650	COG0183	Belongs to the thiolase family
SHXM_RS10655	COG1024	Enoyl-CoA hydratase
SHXM_RS10660	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS10665	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS10670	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS10680	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS10685	COG0183	Belongs to the thiolase family
SHXM_RS10695	COG1024	Enoyl-CoA hydratase
SHXM_RS10700	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS10720	COG0477	Major facilitator Superfamily
SHXM_RS10725	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS10740	COG1053	succinate dehydrogenase
SHXM_RS10740	COG3976	FMN-binding domain protein
SHXM_RS10745	COG1070	Carbohydrate kinase
SHXM_RS10775	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SHXM_RS10775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS10775	COG3321	synthase
SHXM_RS10805	COG3290	protein histidine kinase activity
SHXM_RS10810	COG4565	transcriptional regulatory protein
SHXM_RS10815	COG1609	Transcriptional regulator
SHXM_RS10830	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS10890	COG0583	DNA-binding transcription factor activity
SHXM_RS10910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS10915	COG1116	anion transmembrane transporter activity
SHXM_RS10920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SHXM_RS10925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS10940	COG0277	FAD linked oxidase domain protein
SHXM_RS10945	COG0431	NADPH-dependent FMN reductase
SHXM_RS10955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS10960	COG0395	ABC-type sugar transport system, permease component
SHXM_RS10985	COG2018	Roadblock/LC7 domain
SHXM_RS10990	COG0642	Histidine kinase
SHXM_RS11005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS11075	COG3321	synthase
SHXM_RS11075	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS11075	COG0604	alcohol dehydrogenase
SHXM_RS11115	COG0604	alcohol dehydrogenase
SHXM_RS11125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHXM_RS11175	COG0154	amidase activity
SHXM_RS11185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS11205	COG1874	Beta-galactosidase
SHXM_RS11215	COG0395	ABC-type sugar transport system, permease component
SHXM_RS11220	COG1175	transmembrane transport
SHXM_RS11250	COG0477	Major facilitator Superfamily
SHXM_RS11260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHXM_RS11265	COG4569	acetaldehyde dehydrogenase (acetylating) activity
SHXM_RS11270	COG3971	2-oxopent-4-enoate hydratase activity
SHXM_RS11280	COG2264	protein methyltransferase activity
SHXM_RS11305	COG0596	Alpha beta hydrolase
SHXM_RS11310	COG0500	methyltransferase
SHXM_RS11335	COG2072	flavoprotein involved in K transport
SHXM_RS11340	COG1609	Transcriptional regulator
SHXM_RS11345	COG2814	Major facilitator Superfamily
SHXM_RS11350	COG0589	response to stress
SHXM_RS11370	COG3254	rhamnose metabolic process
SHXM_RS11385	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS11390	COG1129	ABC transporter
SHXM_RS11395	COG3250	beta-galactosidase activity
SHXM_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS11405	COG3347	Dehydrogenase
SHXM_RS11410	COG1070	Carbohydrate kinase
SHXM_RS11415	COG0247	lactate metabolic process
SHXM_RS11420	COG1139	Iron-sulfur cluster binding protein
SHXM_RS11425	COG1556	Lactate utilization protein
SHXM_RS11440	COG1940	carbohydrate kinase activity
SHXM_RS11460	COG0154	amidase activity
SHXM_RS11465	COG2207	Transcriptional regulator
SHXM_RS11490	COG1940	carbohydrate kinase activity
SHXM_RS11510	COG2186	Transcriptional regulator
SHXM_RS11515	COG2364	Membrane
SHXM_RS11525	COG3030	protein affecting phage T7 exclusion by the F plasmid
SHXM_RS11545	COG1006	Multisubunit Na H antiporter MnhC subunit
SHXM_RS11550	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS11560	COG0463	Glycosyl transferase, family 2
SHXM_RS11585	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS11680	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS11690	COG1175	transmembrane transport
SHXM_RS11700	COG2188	Transcriptional regulator
SHXM_RS11705	COG1408	metallophosphoesterase
SHXM_RS11750	COG1335	isochorismatase
SHXM_RS11755	COG0583	DNA-binding transcription factor activity
SHXM_RS11760	COG0667	Aldo Keto reductase
SHXM_RS11835	COG5001	Diguanylate cyclase
SHXM_RS11840	COG3835	regulator
SHXM_RS11855	COG2205	protein histidine kinase activity
SHXM_RS11860	COG0745	RESPONSE REGULATOR receiver
SHXM_RS11875	COG0577	efflux transmembrane transporter activity
SHXM_RS11875	COG1136	(ABC) transporter
SHXM_RS11880	COG1136	(ABC) transporter
SHXM_RS11880	COG0577	efflux transmembrane transporter activity
SHXM_RS11905	COG0436	Aminotransferase
SHXM_RS11930	COG2315	Protein conserved in bacteria
SHXM_RS11935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS11990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS12005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHXM_RS12020	COG0673	inositol 2-dehydrogenase activity
SHXM_RS12035	COG1021	2,3-dihydroxybenzoate-AMP ligase
SHXM_RS12070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS12075	COG0601	transmembrane transport
SHXM_RS12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS12085	COG1802	Transcriptional regulator
SHXM_RS12095	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS12100	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS12140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SHXM_RS12145	COG0140	phosphoribosyl-ATP diphosphatase activity
SHXM_RS12150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SHXM_RS12155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHXM_RS12155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHXM_RS12175	COG1846	Transcriptional regulator
SHXM_RS12175	COG1940	carbohydrate kinase activity
SHXM_RS12180	COG0738	Major facilitator superfamily
SHXM_RS12190	COG2084	Dehydrogenase
SHXM_RS12205	COG1609	Transcriptional regulator
SHXM_RS12210	COG2233	PERMEase
SHXM_RS12220	COG0702	epimerase
SHXM_RS12235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHXM_RS12245	COG0531	amino acid
SHXM_RS12275	COG2390	Transcriptional regulator
SHXM_RS12280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SHXM_RS12295	COG1132	(ABC) transporter
SHXM_RS12300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SHXM_RS12320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SHXM_RS12335	COG0194	GDP metabolic process
SHXM_RS12345	COG0284	orotidine-5'-phosphate decarboxylase activity
SHXM_RS12350	COG0167	dihydroorotate dehydrogenase activity
SHXM_RS12355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHXM_RS12360	COG0505	Belongs to the CarA family
SHXM_RS12370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHXM_RS12375	COG0540	Belongs to the ATCase OTCase family
SHXM_RS12380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SHXM_RS12390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHXM_RS12395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SHXM_RS12400	COG0006	proline dipeptidase activity
SHXM_RS12410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SHXM_RS12415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SHXM_RS12420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SHXM_RS12425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SHXM_RS12435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SHXM_RS12440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHXM_RS12455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHXM_RS12485	COG4585	Histidine kinase
SHXM_RS12490	COG2197	response regulator
SHXM_RS12495	COG0124	histidyl-tRNA synthetase
SHXM_RS12505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SHXM_RS12510	COG1196	nuclear chromosome segregation
SHXM_RS12515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SHXM_RS12520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHXM_RS12525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHXM_RS12530	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHXM_RS12540	COG2255	four-way junction helicase activity
SHXM_RS12545	COG0632	four-way junction helicase activity
SHXM_RS12550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SHXM_RS12555	COG0217	transcriptional regulatory protein
SHXM_RS12560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SHXM_RS12565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SHXM_RS12575	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS12580	COG1560	Kdo2-lipid A biosynthetic process
SHXM_RS12585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SHXM_RS12605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHXM_RS12620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SHXM_RS12650	COG0395	ABC-type sugar transport system, permease component
SHXM_RS12655	COG1175	transmembrane transport
SHXM_RS12660	COG1653	transport
SHXM_RS12705	COG0512	Glutamine amidotransferase of anthranilate synthase
SHXM_RS12705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SHXM_RS12750	COG1309	transcriptional regulator
SHXM_RS12760	COG2814	Major facilitator Superfamily
SHXM_RS12790	COG1648	precorrin-2 dehydrogenase activity
SHXM_RS12790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHXM_RS12795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SHXM_RS12810	COG1464	Belongs to the NlpA lipoprotein family
SHXM_RS12815	COG2011	ABC-type metal ion transport system permease component
SHXM_RS12855	COG0204	Acyl-transferase
SHXM_RS12855	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS12870	COG0165	Argininosuccinate lyase
SHXM_RS12875	COG0137	argininosuccinate synthase activity
SHXM_RS12905	COG1477	protein flavinylation
SHXM_RS12935	COG0385	Bile acid
SHXM_RS12940	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SHXM_RS12955	COG3842	ATPase activity
SHXM_RS12960	COG4149	molybdate abc transporter
SHXM_RS12965	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHXM_RS12970	COG1609	Transcriptional regulator
SHXM_RS12975	COG1438	arginine binding
SHXM_RS12980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHXM_RS12985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SHXM_RS12990	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SHXM_RS12995	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SHXM_RS13045	COG0697	spore germination
SHXM_RS13055	COG1649	PFAM Uncharacterised BCR, COG1649
SHXM_RS13085	COG1285	pathogenesis
SHXM_RS13115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHXM_RS13115	COG0072	phenylalanine-tRNA ligase activity
SHXM_RS13120	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SHXM_RS13125	COG5002	protein histidine kinase activity
SHXM_RS13130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SHXM_RS13135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SHXM_RS13140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SHXM_RS13145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SHXM_RS13155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHXM_RS13195	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS13210	COG0531	amino acid
SHXM_RS13215	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SHXM_RS13220	COG0596	Alpha beta hydrolase
SHXM_RS13280	COG2755	lipolytic protein G-D-S-L family
SHXM_RS13305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHXM_RS13310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHXM_RS13325	COG1657	PFAM Prenyltransferase squalene oxidase
SHXM_RS13335	COG1233	COG1233 Phytoene dehydrogenase and related
SHXM_RS13345	COG1562	ergosterol biosynthetic process
SHXM_RS13355	COG2124	cytochrome p450
SHXM_RS13360	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS13380	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SHXM_RS13385	COG0644	oxidoreductase
SHXM_RS13405	COG1134	teichoic acid transport
SHXM_RS13450	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SHXM_RS13460	COG1024	Enoyl-CoA hydratase
SHXM_RS13470	COG2183	response to ionizing radiation
SHXM_RS13480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SHXM_RS13490	COG2936	dipeptidyl-peptidase activity
SHXM_RS13505	COG3250	beta-galactosidase activity
SHXM_RS13510	COG0789	Transcriptional regulator
SHXM_RS13520	COG0583	DNA-binding transcription factor activity
SHXM_RS13525	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS13525	COG1024	Enoyl-CoA hydratase
SHXM_RS13530	COG0183	Belongs to the thiolase family
SHXM_RS13535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS13545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHXM_RS13555	COG1515	deoxyribonuclease V activity
SHXM_RS13610	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS13615	COG0531	amino acid
SHXM_RS13625	COG1404	Belongs to the peptidase S8 family
SHXM_RS13665	COG0431	NADPH-dependent FMN reductase
SHXM_RS13670	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS13675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS13710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS13715	COG0601	transmembrane transport
SHXM_RS13755	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SHXM_RS13760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SHXM_RS13765	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SHXM_RS13775	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS13795	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS13815	COG0519	Catalyzes the synthesis of GMP from XMP
SHXM_RS13820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SHXM_RS13825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SHXM_RS13840	COG1733	regulation of RNA biosynthetic process
SHXM_RS13855	COG0596	Alpha beta hydrolase
SHXM_RS13860	COG0667	Aldo Keto reductase
SHXM_RS13870	COG1609	Transcriptional regulator
SHXM_RS13875	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SHXM_RS13880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHXM_RS13885	COG0789	Transcriptional regulator
SHXM_RS13890	COG2226	methyltransferase
SHXM_RS13890	COG1073	alpha beta
SHXM_RS13900	COG2890	protein-(glutamine-N5) methyltransferase activity
SHXM_RS13910	COG0248	Ppx GppA phosphatase
SHXM_RS13915	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS13930	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS13950	COG1802	Transcriptional regulator
SHXM_RS13965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHXM_RS13970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHXM_RS13995	COG3408	Glycogen debranching enzyme
SHXM_RS13995	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SHXM_RS14020	COG4585	Histidine kinase
SHXM_RS14025	COG2197	response regulator
SHXM_RS14035	COG0667	Aldo Keto reductase
SHXM_RS14040	COG0583	DNA-binding transcription factor activity
SHXM_RS14045	COG0402	S-adenosylhomocysteine deaminase activity
SHXM_RS14085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHXM_RS14115	COG0045	succinate-CoA ligase (ADP-forming) activity
SHXM_RS14125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS14195	COG0673	inositol 2-dehydrogenase activity
SHXM_RS14200	COG1879	ABC-type sugar transport system periplasmic component
SHXM_RS14205	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS14210	COG1129	ABC transporter
SHXM_RS14215	COG1940	carbohydrate kinase activity
SHXM_RS14235	COG3383	formate dehydrogenase (NAD+) activity
SHXM_RS14250	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SHXM_RS14255	COG1309	transcriptional regulator
SHXM_RS14265	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS14275	COG0789	Transcriptional regulator
SHXM_RS14290	COG2226	methyltransferase
SHXM_RS14300	COG0583	DNA-binding transcription factor activity
SHXM_RS14320	COG0656	L-ascorbic acid biosynthetic process
SHXM_RS14330	COG1595	DNA-templated transcription, initiation
SHXM_RS14345	COG2154	pterin-4-alpha-carbinolamine dehydratase
SHXM_RS14385	COG0531	amino acid
SHXM_RS14395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS14400	COG3842	ATPase activity
SHXM_RS14440	COG4214	carbohydrate transport
SHXM_RS14450	COG4213	ABC transporter substrate-binding protein
SHXM_RS14490	COG2267	carboxylic ester hydrolase activity
SHXM_RS14500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHXM_RS14520	COG0662	Cupin 2, conserved barrel domain protein
SHXM_RS14535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS14540	COG2867	negative regulation of translational initiation
SHXM_RS14595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS14600	COG0028	Belongs to the TPP enzyme family
SHXM_RS14605	COG0693	protein deglycase activity
SHXM_RS14630	COG0516	GMP reductase activity
SHXM_RS14630	COG0517	IMP dehydrogenase activity
SHXM_RS14635	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS14670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHXM_RS14675	COG2362	D-Aminopeptidase
SHXM_RS14715	COG1309	transcriptional regulator
SHXM_RS14720	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS14735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS14735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS14740	COG2301	Belongs to the HpcH HpaI aldolase family
SHXM_RS14750	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS14755	COG0688	phosphatidylethanolamine metabolic process
SHXM_RS14775	COG1929	Belongs to the glycerate kinase type-1 family
SHXM_RS14795	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SHXM_RS14830	COG0181	hydroxymethylbilane synthase activity
SHXM_RS14840	COG0483	inositol monophosphate 1-phosphatase activity
SHXM_RS14860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHXM_RS14865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHXM_RS14885	COG0477	Major facilitator Superfamily
SHXM_RS14890	COG1335	isochorismatase
SHXM_RS14895	COG0405	Gamma-glutamyltransferase
SHXM_RS14930	COG0765	amino acid transport
SHXM_RS14935	COG0765	amino acid transport
SHXM_RS14940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS14955	COG1131	(ABC) transporter
SHXM_RS14965	COG2197	response regulator
SHXM_RS14985	COG1846	Transcriptional regulator
SHXM_RS14990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS14995	COG0028	Belongs to the TPP enzyme family
SHXM_RS15060	COG1335	isochorismatase
SHXM_RS15075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHXM_RS15095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS15110	COG4770	biotin carboxylase activity
SHXM_RS15125	COG1301	dicarboxylic acid transport
SHXM_RS15135	COG0583	DNA-binding transcription factor activity
SHXM_RS15140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SHXM_RS15210	COG0649	NAD binding
SHXM_RS15265	COG1802	Transcriptional regulator
SHXM_RS15280	COG0702	epimerase
SHXM_RS15285	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS15290	COG4221	oxidoreductase activity
SHXM_RS15305	COG0436	Aminotransferase
SHXM_RS15310	COG0531	amino acid
SHXM_RS15325	COG1802	Transcriptional regulator
SHXM_RS15400	COG0577	efflux transmembrane transporter activity
SHXM_RS15400	COG1136	(ABC) transporter
SHXM_RS15405	COG3629	intracellular signal transduction
SHXM_RS15405	COG3903	Transcriptional regulator
SHXM_RS15410	COG1132	(ABC) transporter
SHXM_RS15415	COG1132	(ABC) transporter
SHXM_RS15420	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS15440	COG1132	(ABC) transporter
SHXM_RS15475	COG0402	S-adenosylhomocysteine deaminase activity
SHXM_RS15485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS15490	COG0351	phosphomethylpyrimidine kinase
SHXM_RS15500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SHXM_RS15565	COG0477	Major facilitator Superfamily
SHXM_RS15570	COG1414	Transcriptional regulator
SHXM_RS15580	COG0800	Aldolase
SHXM_RS15590	COG1609	Transcriptional regulator
SHXM_RS15605	COG0673	inositol 2-dehydrogenase activity
SHXM_RS15665	COG1487	ribonuclease activity
SHXM_RS15680	COG0649	NAD binding
SHXM_RS15765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHXM_RS15770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS15785	COG3959	Transketolase, thiamine diphosphate binding domain
SHXM_RS15790	COG3958	Transketolase
SHXM_RS15795	COG2267	carboxylic ester hydrolase activity
SHXM_RS15800	COG1228	amidohydrolase
SHXM_RS15825	COG0517	IMP dehydrogenase activity
SHXM_RS15825	COG4175	Glycine betaine
SHXM_RS15830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHXM_RS15855	COG0805	protein transport
SHXM_RS15860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHXM_RS15880	COG2378	regulation of single-species biofilm formation
SHXM_RS15890	COG0545	Peptidyl-prolyl cis-trans isomerase
SHXM_RS15895	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHXM_RS15905	COG1609	Transcriptional regulator
SHXM_RS15910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHXM_RS15915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHXM_RS15925	COG4122	O-methyltransferase activity
SHXM_RS15930	COG1222	aaa ATPase
SHXM_RS15950	COG1994	Peptidase M50
SHXM_RS15950	COG0517	IMP dehydrogenase activity
SHXM_RS15960	COG2197	response regulator
SHXM_RS15975	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHXM_RS15980	COG0646	methionine synthase
SHXM_RS15980	COG1410	methionine synthase
SHXM_RS15985	COG1414	Transcriptional regulator
SHXM_RS15990	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHXM_RS15995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS16000	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHXM_RS16010	COG2186	Transcriptional regulator
SHXM_RS16025	COG4211	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS16030	COG1129	ABC transporter
SHXM_RS16040	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS16045	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS16055	COG0215	cysteine-tRNA ligase activity
SHXM_RS16075	COG0598	Magnesium transport protein CorA
SHXM_RS16085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS16090	COG0667	Aldo Keto reductase
SHXM_RS16145	COG1309	transcriptional regulator
SHXM_RS16160	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SHXM_RS16165	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SHXM_RS16170	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SHXM_RS16190	COG4221	oxidoreductase activity
SHXM_RS16210	COG0297	glycogen (starch) synthase activity
SHXM_RS16230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHXM_RS16235	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS16240	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS16245	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS16265	COG0702	epimerase
SHXM_RS16275	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS16310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SHXM_RS16315	COG2149	membrane
SHXM_RS16340	COG1733	regulation of RNA biosynthetic process
SHXM_RS16350	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS16375	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS16420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHXM_RS16425	COG0142	geranyltranstransferase activity
SHXM_RS16430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHXM_RS16435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHXM_RS16450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS16465	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHXM_RS16470	COG2409	Drug exporters of the RND superfamily
SHXM_RS16495	COG2851	Citrate transporter
SHXM_RS16500	COG3383	formate dehydrogenase (NAD+) activity
SHXM_RS16505	COG1309	transcriptional regulator
SHXM_RS16510	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SHXM_RS16515	COG2188	Transcriptional regulator
SHXM_RS16560	COG0463	Glycosyl transferase, family 2
SHXM_RS16595	COG1834	amidinotransferase
SHXM_RS16600	COG1725	Transcriptional regulator
SHXM_RS16610	COG2226	methyltransferase
SHXM_RS16665	COG2197	response regulator
SHXM_RS16670	COG4585	Histidine kinase
SHXM_RS16675	COG2409	Drug exporters of the RND superfamily
SHXM_RS16695	COG0604	alcohol dehydrogenase
SHXM_RS16695	COG3321	synthase
SHXM_RS16700	COG0604	alcohol dehydrogenase
SHXM_RS16700	COG3321	synthase
SHXM_RS16705	COG0604	alcohol dehydrogenase
SHXM_RS16705	COG3321	synthase
SHXM_RS16715	COG3321	synthase
SHXM_RS16715	COG0604	alcohol dehydrogenase
SHXM_RS16760	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS16770	COG4221	oxidoreductase activity
SHXM_RS16790	COG0519	Catalyzes the synthesis of GMP from XMP
SHXM_RS16790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHXM_RS16810	COG4977	sequence-specific DNA binding
SHXM_RS16820	COG0019	diaminopimelate decarboxylase activity
SHXM_RS16825	COG4264	IucA IucC family
SHXM_RS16855	COG1846	Transcriptional regulator
SHXM_RS16860	COG1764	response to oxidative stress
SHXM_RS16870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHXM_RS16875	COG0587	DNA-directed DNA polymerase activity
SHXM_RS16880	COG3467	pyridoxamine 5'-phosphate
SHXM_RS16895	COG0330	HflC and HflK could
SHXM_RS16905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS16910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS16915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS16920	COG1126	abc transporter atp-binding protein
SHXM_RS16940	COG1799	cell septum assembly
SHXM_RS16945	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS16950	COG0477	Major facilitator Superfamily
SHXM_RS16960	COG0671	phosphoesterase, PA-phosphatase related
SHXM_RS17020	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS17035	COG1160	GTP binding
SHXM_RS17045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SHXM_RS17060	COG1187	pseudouridine synthase activity
SHXM_RS17065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SHXM_RS17070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SHXM_RS17085	COG0686	Belongs to the AlaDH PNT family
SHXM_RS17090	COG3629	intracellular signal transduction
SHXM_RS17090	COG3903	Transcriptional regulator
SHXM_RS17095	COG0494	nUDIX hydrolase
SHXM_RS17100	COG0504	CTP synthase activity
SHXM_RS17105	COG3387	PFAM Glycoside hydrolase 15-related
SHXM_RS17120	COG0297	glycogen (starch) synthase activity
SHXM_RS17125	COG0497	DNA recombination
SHXM_RS17130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHXM_RS17150	COG1120	ATPase activity
SHXM_RS17155	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS17160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS17165	COG0647	UMP catabolic process
SHXM_RS17200	COG2094	Belongs to the DNA glycosylase MPG family
SHXM_RS17215	COG1881	PFAM PEBP family protein
SHXM_RS17235	COG1119	ATPase activity
SHXM_RS17250	COG2197	response regulator
SHXM_RS17265	COG1716	ATPase activity
SHXM_RS17265	COG0842	Transport permease protein
SHXM_RS17265	COG1131	(ABC) transporter
SHXM_RS17275	COG0560	Phosphoserine phosphatase
SHXM_RS17275	COG3830	Belongs to the UPF0237 family
SHXM_RS17290	COG2807	transmembrane transport
SHXM_RS17295	COG2186	Transcriptional regulator
SHXM_RS17305	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SHXM_RS17310	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS17315	COG1846	Transcriptional regulator
SHXM_RS17345	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SHXM_RS17365	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHXM_RS17370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS17380	COG1404	Belongs to the peptidase S8 family
SHXM_RS17405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHXM_RS17420	COG3387	PFAM Glycoside hydrolase 15-related
SHXM_RS17425	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS17465	COG3850	Histidine kinase
SHXM_RS17465	COG4999	Histidine kinase
SHXM_RS17465	COG2205	protein histidine kinase activity
SHXM_RS17465	COG3437	response regulator, receiver
SHXM_RS17485	COG0488	(ABC) transporter
SHXM_RS17500	COG0235	Class ii aldolase
SHXM_RS17515	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SHXM_RS17520	COG1492	cobalamin metabolic process
SHXM_RS17535	COG1797	cobyrinic acid a,c-diamide synthase activity
SHXM_RS17575	COG0456	acetyltransferase
SHXM_RS17585	COG1917	Cupin 2, conserved barrel domain protein
SHXM_RS17590	COG5285	phytanoyl-CoA dioxygenase
SHXM_RS17595	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS17605	COG1414	Transcriptional regulator
SHXM_RS17615	COG4585	Histidine kinase
SHXM_RS17625	COG0667	Aldo Keto reductase
SHXM_RS17635	COG0726	polysaccharide deacetylase
SHXM_RS17655	COG0395	ABC-type sugar transport system, permease component
SHXM_RS17660	COG1175	transmembrane transport
SHXM_RS17670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHXM_RS17675	COG1802	Transcriptional regulator
SHXM_RS17685	COG2223	nitrite transmembrane transporter activity
SHXM_RS17695	COG1802	Transcriptional regulator
SHXM_RS17715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHXM_RS17720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHXM_RS17735	COG1335	isochorismatase
SHXM_RS17745	COG0515	serine threonine protein kinase
SHXM_RS17745	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS17765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS17785	COG2171	N-acyltransferase activity
SHXM_RS17790	COG3226	Transcriptional regulator
SHXM_RS17795	COG2076	Multidrug Resistance protein
SHXM_RS17805	COG0822	iron-sulfur transferase activity
SHXM_RS17810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS17815	COG0396	ATPase activity
SHXM_RS17825	COG0719	Fe-S assembly protein
SHXM_RS17850	COG1612	heme a metabolic process
SHXM_RS17865	COG0109	protoheme IX farnesyltransferase activity
SHXM_RS17870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
SHXM_RS17875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHXM_RS17890	COG0363	glucosamine-6-phosphate deaminase activity
SHXM_RS17895	COG0166	Belongs to the GPI family
SHXM_RS17910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SHXM_RS17915	COG0149	triose-phosphate isomerase activity
SHXM_RS17920	COG0126	phosphoglycerate kinase activity
SHXM_RS17925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SHXM_RS17935	COG1481	regulation of sporulation
SHXM_RS17945	COG1660	Displays ATPase and GTPase activities
SHXM_RS17950	COG0322	excinuclease ABC activity
SHXM_RS17960	COG1609	Transcriptional regulator
SHXM_RS17970	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHXM_RS17985	COG0477	Major facilitator Superfamily
SHXM_RS18005	COG0556	nucleotide-excision repair
SHXM_RS18010	COG0584	glycerophosphoryl diester phosphodiesterase
SHXM_RS18015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHXM_RS18070	COG0237	dephospho-CoA kinase activity
SHXM_RS18100	COG1643	Atp-dependent helicase
SHXM_RS18140	COG2050	protein possibly involved in aromatic compounds catabolism
SHXM_RS18165	COG0411	ABC transporter
SHXM_RS18200	COG0737	Belongs to the 5'-nucleotidase family
SHXM_RS18210	COG0076	glutamate decarboxylase activity
SHXM_RS18230	COG1605	Chorismate mutase
SHXM_RS18230	COG0287	Prephenate dehydrogenase
SHXM_RS18250	COG3467	pyridoxamine 5'-phosphate
SHXM_RS18270	COG1131	(ABC) transporter
SHXM_RS18275	COG1725	Transcriptional regulator
SHXM_RS18285	COG0067	glutamate synthase
SHXM_RS18285	COG0070	glutamate synthase
SHXM_RS18285	COG0069	glutamate synthase activity
SHXM_RS18295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SHXM_RS18305	COG0159	tryptophan synthase activity
SHXM_RS18310	COG0133	tryptophan synthase activity
SHXM_RS18315	COG0134	indole-3-glycerol-phosphate synthase activity
SHXM_RS18340	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SHXM_RS18360	COG4221	oxidoreductase activity
SHXM_RS18370	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS18375	COG0789	Transcriptional regulator
SHXM_RS18390	COG0107	imidazoleglycerol-phosphate synthase activity
SHXM_RS18395	COG0251	oxidation-reduction process
SHXM_RS18400	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SHXM_RS18405	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SHXM_RS18410	COG0131	Imidazoleglycerol-phosphate dehydratase
SHXM_RS18415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHXM_RS18420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SHXM_RS18430	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SHXM_RS18435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SHXM_RS18465	COG0587	DNA-directed DNA polymerase activity
SHXM_RS18515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SHXM_RS18525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SHXM_RS18540	COG1799	cell septum assembly
SHXM_RS18550	COG1496	oxidoreductase activity
SHXM_RS18555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SHXM_RS18560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SHXM_RS18565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SHXM_RS18575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SHXM_RS18580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHXM_RS18590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SHXM_RS18605	COG0275	rRNA processing
SHXM_RS18615	COG0714	Associated with various cellular activities
SHXM_RS18645	COG1129	ABC transporter
SHXM_RS18655	COG1309	transcriptional regulator
SHXM_RS18660	COG1233	COG1233 Phytoene dehydrogenase and related
SHXM_RS18675	COG0352	thiamine-phosphate diphosphorylase activity
SHXM_RS18690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS18690	COG2022	thiamine diphosphate biosynthetic process
SHXM_RS18700	COG2022	thiamine diphosphate biosynthetic process
SHXM_RS18710	COG2815	serine threonine protein kinase
SHXM_RS18710	COG0515	serine threonine protein kinase
SHXM_RS18715	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SHXM_RS18725	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHXM_RS18730	COG2193	ferroxidase activity
SHXM_RS18735	COG0243	molybdopterin cofactor binding
SHXM_RS18740	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SHXM_RS18755	COG0205	6-phosphofructokinase activity
SHXM_RS18760	COG2197	response regulator
SHXM_RS18790	COG1940	carbohydrate kinase activity
SHXM_RS18800	COG0003	Pfam Anion-transporting ATPase
SHXM_RS18860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS18865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHXM_RS18870	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SHXM_RS18875	COG0723	plastoquinol--plastocyanin reductase activity
SHXM_RS18880	COG2010	Cytochrome c
SHXM_RS18885	COG1845	cytochrome c oxidase, subunit III
SHXM_RS18895	COG1376	ErfK ybiS ycfS ynhG family protein
SHXM_RS18905	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHXM_RS18910	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SHXM_RS18915	COG1104	cysteine desulfurase activity
SHXM_RS18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS18940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SHXM_RS18945	COG2197	response regulator
SHXM_RS18950	COG4585	Histidine kinase
SHXM_RS18970	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS18995	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SHXM_RS19000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SHXM_RS19005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SHXM_RS19010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHXM_RS19015	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHXM_RS19025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SHXM_RS19070	COG0640	Transcriptional regulator
SHXM_RS19080	COG0321	lipoyl(octanoyl) transferase activity
SHXM_RS19085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SHXM_RS19125	COG1280	lysine exporter protein (LysE YggA)
SHXM_RS19135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SHXM_RS19150	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SHXM_RS19170	COG0477	Major facilitator Superfamily
SHXM_RS19195	COG0745	RESPONSE REGULATOR receiver
SHXM_RS19230	COG2197	response regulator
SHXM_RS19265	COG3833	ABC-type maltose transport systems, permease component
SHXM_RS19270	COG1175	transmembrane transport
SHXM_RS19275	COG2182	Extracellular solute-binding protein
SHXM_RS19280	COG0366	Alpha amylase catalytic
SHXM_RS19285	COG1609	Transcriptional regulator
SHXM_RS19295	COG0561	phosphatase activity
SHXM_RS19300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHXM_RS19340	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SHXM_RS19350	COG0174	glutamine synthetase
SHXM_RS19355	COG2132	Multicopper oxidase
SHXM_RS19360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SHXM_RS19360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHXM_RS19365	COG2267	carboxylic ester hydrolase activity
SHXM_RS19370	COG2814	Major facilitator Superfamily
SHXM_RS19380	COG1309	transcriptional regulator
SHXM_RS19385	COG0477	Major facilitator Superfamily
SHXM_RS19390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SHXM_RS19410	COG1994	Peptidase M50
SHXM_RS19425	COG0395	ABC-type sugar transport system, permease component
SHXM_RS19430	COG1175	transmembrane transport
SHXM_RS19490	COG2822	iron ion transport
SHXM_RS19495	COG2837	iron assimilation
SHXM_RS19500	COG0672	)-iron permease
SHXM_RS19530	COG1309	transcriptional regulator
SHXM_RS19535	COG2814	Major facilitator Superfamily
SHXM_RS19545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHXM_RS19550	COG2814	Major facilitator Superfamily
SHXM_RS19560	COG3540	Alkaline phosphatase
SHXM_RS19600	COG0443	Heat shock 70 kDa protein
SHXM_RS19605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHXM_RS19620	COG0542	response to heat
SHXM_RS19640	COG1414	Transcriptional regulator
SHXM_RS19650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS19655	COG0477	Major facilitator Superfamily
SHXM_RS19660	COG0596	Alpha beta hydrolase
SHXM_RS19665	COG0583	DNA-binding transcription factor activity
SHXM_RS19670	COG0473	3-isopropylmalate dehydrogenase activity
SHXM_RS19695	COG3022	response to hydroperoxide
SHXM_RS19700	COG0800	Aldolase
SHXM_RS19715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SHXM_RS19720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHXM_RS19730	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS19735	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SHXM_RS19740	COG2030	dehydratase
SHXM_RS19745	COG4585	Histidine kinase
SHXM_RS19750	COG2197	response regulator
SHXM_RS19760	COG0860	N-Acetylmuramoyl-L-alanine amidase
SHXM_RS19770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS19790	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS19795	COG1309	transcriptional regulator
SHXM_RS19800	COG2197	response regulator
SHXM_RS19850	COG3845	ABC transporter
SHXM_RS19860	COG0183	Belongs to the thiolase family
SHXM_RS19865	COG2124	cytochrome p450
SHXM_RS19885	COG2207	Transcriptional regulator
SHXM_RS19905	COG0667	Aldo Keto reductase
SHXM_RS19930	COG0745	RESPONSE REGULATOR receiver
SHXM_RS19935	COG5002	protein histidine kinase activity
SHXM_RS20045	COG1396	sequence-specific DNA binding
SHXM_RS20050	COG0740	serine-type endopeptidase activity
SHXM_RS20055	COG0740	serine-type endopeptidase activity
SHXM_RS20070	COG0300	oxidoreductase activity
SHXM_RS20080	COG1959	2 iron, 2 sulfur cluster binding
SHXM_RS20090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SHXM_RS20095	COG1846	Transcriptional regulator
SHXM_RS20105	COG1073	alpha beta
SHXM_RS20110	COG0604	alcohol dehydrogenase
SHXM_RS20135	COG2197	response regulator
SHXM_RS20140	COG4585	Histidine kinase
SHXM_RS20190	COG1358	cellular component organization or biogenesis
SHXM_RS20235	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SHXM_RS20245	COG0477	Major facilitator Superfamily
SHXM_RS20250	COG1309	transcriptional regulator
SHXM_RS20265	COG4585	Histidine kinase
SHXM_RS20270	COG2197	response regulator
SHXM_RS20285	COG0789	Transcriptional regulator
SHXM_RS20310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS20315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS20320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS20345	COG1309	transcriptional regulator
SHXM_RS20390	COG4214	carbohydrate transport
SHXM_RS20445	COG5520	Belongs to the glycosyl hydrolase 30 family
SHXM_RS20450	COG2130	NADP-dependent
SHXM_RS20465	COG3386	PFAM SMP-30 Gluconolaconase
SHXM_RS20470	COG1414	Transcriptional regulator
SHXM_RS20485	COG0588	phosphoglycerate mutase activity
SHXM_RS20490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHXM_RS20535	COG0745	RESPONSE REGULATOR receiver
SHXM_RS20560	COG1131	(ABC) transporter
SHXM_RS20565	COG1725	Transcriptional regulator
SHXM_RS20595	COG1070	Carbohydrate kinase
SHXM_RS20605	COG0358	DNA primase activity
SHXM_RS20615	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SHXM_RS20625	COG0243	molybdopterin cofactor binding
SHXM_RS20630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHXM_RS20640	COG2949	membrane
SHXM_RS20675	COG0745	RESPONSE REGULATOR receiver
SHXM_RS20680	COG5002	protein histidine kinase activity
SHXM_RS20705	COG2124	cytochrome p450
SHXM_RS20715	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHXM_RS20720	COG2146	nitrite reductase [NAD(P)H] activity
SHXM_RS20720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHXM_RS20725	COG2146	nitrite reductase [NAD(P)H] activity
SHXM_RS20725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHXM_RS20745	COG1609	Transcriptional regulator
SHXM_RS20755	COG1175	transmembrane transport
SHXM_RS20775	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS20815	COG2890	protein-(glutamine-N5) methyltransferase activity
SHXM_RS20820	COG1846	Transcriptional regulator
SHXM_RS20825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SHXM_RS20830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SHXM_RS20835	COG0183	Belongs to the thiolase family
SHXM_RS20840	COG3485	protocatechuate 3,4-dioxygenase
SHXM_RS20845	COG3485	protocatechuate 3,4-dioxygenase
SHXM_RS20850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHXM_RS20855	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS20860	COG2182	Extracellular solute-binding protein
SHXM_RS20870	COG0395	ABC-type sugar transport system, permease component
SHXM_RS20890	COG2188	Transcriptional regulator
SHXM_RS20895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS20900	COG0531	amino acid
SHXM_RS20910	COG4585	Histidine kinase
SHXM_RS20915	COG2197	response regulator
SHXM_RS20945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHXM_RS20945	COG0574	Belongs to the PEP-utilizing enzyme family
SHXM_RS20985	COG0477	Major facilitator Superfamily
SHXM_RS20995	COG2197	response regulator
SHXM_RS21015	COG0423	glycine-tRNA ligase activity
SHXM_RS21025	COG1121	(ABC) transporter
SHXM_RS21030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SHXM_RS21085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHXM_RS21090	COG1381	Involved in DNA repair and RecF pathway recombination
SHXM_RS21135	COG1846	Transcriptional regulator
SHXM_RS21150	COG2315	Protein conserved in bacteria
SHXM_RS21160	COG0454	-acetyltransferase
SHXM_RS21160	COG0456	acetyltransferase
SHXM_RS21180	COG3422	double-strand break repair
SHXM_RS21190	COG2197	response regulator
SHXM_RS21195	COG4585	Histidine kinase
SHXM_RS21200	COG2409	Drug exporters of the RND superfamily
SHXM_RS21210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHXM_RS21230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SHXM_RS21250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SHXM_RS21260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS21265	COG1234	tRNA 3'-trailer cleavage
SHXM_RS21270	COG0537	adenosine 5'-monophosphoramidase activity
SHXM_RS21290	COG0484	heat shock protein binding
SHXM_RS21295	COG1420	regulation of RNA biosynthetic process
SHXM_RS21320	COG1022	Amp-dependent synthetase and ligase
SHXM_RS21325	COG0481	GTPase activity
SHXM_RS21330	COG0268	Binds directly to 16S ribosomal RNA
SHXM_RS21500	COG1555	photosystem II stabilization
SHXM_RS21505	COG1307	EDD domain protein, DegV family
SHXM_RS21515	COG0495	leucyl-tRNA aminoacylation
SHXM_RS21540	COG0588	phosphoglycerate mutase activity
SHXM_RS21545	COG0799	negative regulation of ribosome biogenesis
SHXM_RS21555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SHXM_RS21560	COG0501	Belongs to the peptidase M48B family
SHXM_RS21575	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SHXM_RS21585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SHXM_RS21595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHXM_RS21600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SHXM_RS21605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SHXM_RS21610	COG1530	ribonuclease E activity
SHXM_RS21630	COG0772	Belongs to the SEDS family
SHXM_RS21635	COG0768	penicillin binding
SHXM_RS21650	COG1077	Cell shape determining protein MreB Mrl
SHXM_RS21655	COG0105	UTP biosynthetic process
SHXM_RS21665	COG0285	dihydrofolate synthase activity
SHXM_RS21670	COG0768	penicillin binding
SHXM_RS21675	COG0525	valine-tRNA ligase activity
SHXM_RS21695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SHXM_RS21700	COG0740	serine-type endopeptidase activity
SHXM_RS21705	COG0740	serine-type endopeptidase activity
SHXM_RS21710	COG0544	peptidyl-prolyl cis-trans isomerase activity
SHXM_RS21730	COG3594	Acyltransferase
SHXM_RS21740	COG1136	(ABC) transporter
SHXM_RS21750	COG4552	Acetyltransferase involved in intracellular survival and related
SHXM_RS21765	COG1113	amino acid transport
SHXM_RS21795	COG3345	alpha-galactosidase
SHXM_RS21800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SHXM_RS21815	COG1113	amino acid transport
SHXM_RS21825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHXM_RS21890	COG3291	Pkd domain containing protein
SHXM_RS21890	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SHXM_RS21900	COG0668	transmembrane transport
SHXM_RS21910	COG1846	Transcriptional regulator
SHXM_RS21910	COG1940	carbohydrate kinase activity
SHXM_RS21920	COG1175	transmembrane transport
SHXM_RS21925	COG0395	ABC-type sugar transport system, permease component
SHXM_RS21930	COG1486	melibiose metabolic process
SHXM_RS21945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS21975	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS22010	COG0629	single-stranded DNA binding
SHXM_RS22035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHXM_RS22070	COG3251	PFAM MbtH domain protein
SHXM_RS22075	COG0142	geranyltranstransferase activity
SHXM_RS22080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SHXM_RS22085	COG1993	acr, cog1993
SHXM_RS22090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SHXM_RS22095	COG0583	DNA-binding transcription factor activity
SHXM_RS22115	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS22125	COG1131	(ABC) transporter
SHXM_RS22140	COG0604	alcohol dehydrogenase
SHXM_RS22140	COG3321	synthase
SHXM_RS22145	COG0604	alcohol dehydrogenase
SHXM_RS22145	COG3321	synthase
SHXM_RS22175	COG0604	alcohol dehydrogenase
SHXM_RS22175	COG3321	synthase
SHXM_RS22190	COG3402	PFAM membrane-flanked domain
SHXM_RS22200	COG4585	Histidine kinase
SHXM_RS22205	COG2197	response regulator
SHXM_RS22245	COG3962	Belongs to the TPP enzyme family
SHXM_RS22250	COG3718	enzyme involved in inositol metabolism
SHXM_RS22260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS22270	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS22285	COG0673	inositol 2-dehydrogenase activity
SHXM_RS22295	COG2409	Drug exporters of the RND superfamily
SHXM_RS22320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHXM_RS22330	COG1129	ABC transporter
SHXM_RS22335	COG1879	ABC-type sugar transport system periplasmic component
SHXM_RS22340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS22345	COG1869	D-ribose catabolic process
SHXM_RS22355	COG1595	DNA-templated transcription, initiation
SHXM_RS22365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS22380	COG0673	inositol 2-dehydrogenase activity
SHXM_RS22395	COG0395	ABC-type sugar transport system, permease component
SHXM_RS22400	COG1175	transmembrane transport
SHXM_RS22425	COG1609	Transcriptional regulator
SHXM_RS22445	COG0456	acetyltransferase
SHXM_RS22445	COG1846	Transcriptional regulator
SHXM_RS22485	COG1472	Belongs to the glycosyl hydrolase 3 family
SHXM_RS22490	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS22530	COG2197	response regulator
SHXM_RS22535	COG4585	Histidine kinase
SHXM_RS22570	COG1278	Cold shock
SHXM_RS22585	COG1946	Acyl-CoA thioesterase
SHXM_RS22595	COG1309	transcriptional regulator
SHXM_RS22600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS22620	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS22640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHXM_RS22645	COG0589	response to stress
SHXM_RS22660	COG4977	sequence-specific DNA binding
SHXM_RS22665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SHXM_RS22745	COG1215	transferase activity, transferring glycosyl groups
SHXM_RS22750	COG5297	Belongs to the glycosyl hydrolase family 6
SHXM_RS22750	COG4733	cellulase activity
SHXM_RS22760	COG5297	Belongs to the glycosyl hydrolase family 6
SHXM_RS22790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SHXM_RS22800	COG0577	efflux transmembrane transporter activity
SHXM_RS22915	COG4585	Histidine kinase
SHXM_RS22920	COG2197	response regulator
SHXM_RS22925	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS22925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS22925	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS22925	COG0300	oxidoreductase activity
SHXM_RS22925	COG3321	synthase
SHXM_RS22940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS22960	COG3473	Maleate cis-trans isomerase
SHXM_RS22975	COG0154	amidase activity
SHXM_RS22985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS22990	COG0765	amino acid transport
SHXM_RS22995	COG0765	amino acid transport
SHXM_RS23000	COG1126	abc transporter atp-binding protein
SHXM_RS23020	COG2267	carboxylic ester hydrolase activity
SHXM_RS23025	COG2091	lysine biosynthetic process via aminoadipic acid
SHXM_RS23035	COG4770	biotin carboxylase activity
SHXM_RS23050	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS23055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHXM_RS23065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS23070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
SHXM_RS23095	COG0300	oxidoreductase activity
SHXM_RS23120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS23125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS23130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS23140	COG0477	Major facilitator Superfamily
SHXM_RS23145	COG1063	alcohol dehydrogenase
SHXM_RS23160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SHXM_RS23165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS23200	COG3397	chitin binding
SHXM_RS23220	COG3548	integral membrane protein
SHXM_RS23240	COG2186	Transcriptional regulator
SHXM_RS23290	COG0673	inositol 2-dehydrogenase activity
SHXM_RS23295	COG4702	Belongs to the UPF0303 family
SHXM_RS23305	COG0706	membrane insertase activity
SHXM_RS23315	COG3764	Sortase (surface protein transpeptidase)
SHXM_RS23320	COG2733	membrane
SHXM_RS23350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS23355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SHXM_RS23375	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SHXM_RS23385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SHXM_RS23390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SHXM_RS23395	COG1263	PTS System
SHXM_RS23400	COG1234	tRNA 3'-trailer cleavage
SHXM_RS23420	COG1113	amino acid transport
SHXM_RS23430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SHXM_RS23440	COG1335	isochorismatase
SHXM_RS23480	COG1064	alcohol dehydrogenase
SHXM_RS23505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS23510	COG0277	FAD linked oxidase domain protein
SHXM_RS23540	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SHXM_RS23580	COG3654	unkown
SHXM_RS23595	COG2855	membrane
SHXM_RS23605	COG0583	DNA-binding transcription factor activity
SHXM_RS23625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS23640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS23655	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SHXM_RS23660	COG0395	ABC-type sugar transport system, permease component
SHXM_RS23665	COG1175	transmembrane transport
SHXM_RS23685	COG1678	Uncharacterized ACR, COG1678
SHXM_RS23690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHXM_RS23695	COG0776	regulation of translation
SHXM_RS23705	COG1278	Cold shock
SHXM_RS23710	COG3973	AAA domain
SHXM_RS23710	COG3973	AAA domain
SHXM_RS23740	COG2223	nitrite transmembrane transporter activity
SHXM_RS23755	COG0583	DNA-binding transcription factor activity
SHXM_RS23770	COG0583	DNA-binding transcription factor activity
SHXM_RS23785	COG0395	ABC-type sugar transport system, permease component
SHXM_RS23790	COG1501	Belongs to the glycosyl hydrolase 31 family
SHXM_RS23795	COG2027	D-alanyl-D-alanine carboxypeptidase
SHXM_RS23835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SHXM_RS23840	COG0793	Belongs to the peptidase S41A family
SHXM_RS23850	COG2884	Cell division ATP-binding protein ftsE
SHXM_RS23865	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SHXM_RS23870	COG0515	serine threonine protein kinase
SHXM_RS23875	COG0515	serine threonine protein kinase
SHXM_RS23885	COG1653	transport
SHXM_RS23890	COG1175	transmembrane transport
SHXM_RS23895	COG0395	ABC-type sugar transport system, permease component
SHXM_RS23955	COG0697	spore germination
SHXM_RS23970	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SHXM_RS23975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS23990	COG0463	Glycosyl transferase, family 2
SHXM_RS23990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHXM_RS23995	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS24010	COG1309	transcriptional regulator
SHXM_RS24045	COG0463	Glycosyl transferase, family 2
SHXM_RS24045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHXM_RS24050	COG2902	Dehydrogenase
SHXM_RS24055	COG0693	protein deglycase activity
SHXM_RS24080	COG0653	protein targeting
SHXM_RS24090	COG3214	Protein conserved in bacteria
SHXM_RS24095	COG2197	response regulator
SHXM_RS24100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SHXM_RS24110	COG0823	Involved in the tonB-independent uptake of proteins
SHXM_RS24115	COG5002	protein histidine kinase activity
SHXM_RS24115	COG5000	phosphorelay sensor kinase activity
SHXM_RS24120	COG0745	RESPONSE REGULATOR receiver
SHXM_RS24125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SHXM_RS24155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SHXM_RS24160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHXM_RS24160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHXM_RS24160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS24170	COG1482	cell wall glycoprotein biosynthetic process
SHXM_RS24180	COG2835	tetraacyldisaccharide 4'-kinase activity
SHXM_RS24185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHXM_RS24190	COG1620	l-lactate permease
SHXM_RS24225	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SHXM_RS24230	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SHXM_RS24230	COG0778	Nitroreductase
SHXM_RS24255	COG1316	TRANSCRIPTIONal
SHXM_RS24260	COG1316	TRANSCRIPTIONal
SHXM_RS24275	COG1316	TRANSCRIPTIONal
SHXM_RS24280	COG1607	acyl-coa hydrolase
SHXM_RS24285	COG1316	TRANSCRIPTIONal
SHXM_RS24295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SHXM_RS24325	COG2205	protein histidine kinase activity
SHXM_RS24330	COG0745	RESPONSE REGULATOR receiver
SHXM_RS24335	COG3104	oligopeptide transport
SHXM_RS24365	COG1366	Belongs to the anti-sigma-factor antagonist family
SHXM_RS24370	COG1191	sigma factor activity
SHXM_RS24375	COG1228	amidohydrolase
SHXM_RS24390	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SHXM_RS24395	COG0604	alcohol dehydrogenase
SHXM_RS24420	COG2986	histidine ammonia-lyase
SHXM_RS24430	COG1174	glycine betaine transport
SHXM_RS24435	COG1174	glycine betaine transport
SHXM_RS24445	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SHXM_RS24465	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS24480	COG2755	lipolytic protein G-D-S-L family
SHXM_RS24485	COG0183	Belongs to the thiolase family
SHXM_RS24515	COG1136	(ABC) transporter
SHXM_RS24520	COG0577	efflux transmembrane transporter activity
SHXM_RS24525	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SHXM_RS24530	COG1252	NADH dehydrogenase
SHXM_RS24550	COG0148	phosphopyruvate hydratase activity
SHXM_RS24565	COG2124	cytochrome p450
SHXM_RS24600	COG3033	Beta-eliminating lyase
SHXM_RS24650	COG2986	histidine ammonia-lyase
SHXM_RS24660	COG1024	Enoyl-CoA hydratase
SHXM_RS24670	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SHXM_RS24680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS24690	COG0424	maF-like protein
SHXM_RS24700	COG4770	biotin carboxylase activity
SHXM_RS24735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHXM_RS24755	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS24760	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS24765	COG2159	amidohydrolase
SHXM_RS24775	COG0477	Major facilitator Superfamily
SHXM_RS24775	COG2814	Major facilitator Superfamily
SHXM_RS24785	COG1595	DNA-templated transcription, initiation
SHXM_RS24790	COG0745	RESPONSE REGULATOR receiver
SHXM_RS24795	COG2205	protein histidine kinase activity
SHXM_RS24820	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHXM_RS24830	COG2814	Major facilitator Superfamily
SHXM_RS24835	COG0583	DNA-binding transcription factor activity
SHXM_RS24850	COG1079	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS24855	COG4603	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS24860	COG3845	ABC transporter
SHXM_RS24865	COG1744	ABC transporter substrate-binding protein PnrA-like
SHXM_RS24925	COG1473	amidohydrolase
SHXM_RS24925	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SHXM_RS24935	COG2089	acid synthase
SHXM_RS24940	COG1083	cytidylyl-transferase
SHXM_RS24950	COG1216	Glycosyl transferase, family 2
SHXM_RS24960	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
SHXM_RS24980	COG1063	alcohol dehydrogenase
SHXM_RS24985	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS24995	COG3265	gluconokinase activity
SHXM_RS25000	COG2186	Transcriptional regulator
SHXM_RS25005	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS25010	COG1309	transcriptional regulator
SHXM_RS25035	COG1316	TRANSCRIPTIONal
SHXM_RS25040	COG1215	transferase activity, transferring glycosyl groups
SHXM_RS25070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS25070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS25085	COG1595	DNA-templated transcription, initiation
SHXM_RS25105	COG2009	succinate dehydrogenase
SHXM_RS25120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHXM_RS25135	COG1686	Belongs to the peptidase S11 family
SHXM_RS25140	COG1295	ribonuclease BN
SHXM_RS25155	COG0180	Tryptophanyl-tRNA synthetase
SHXM_RS25165	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHXM_RS25170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHXM_RS25175	COG0754	glutathionylspermidine amidase activity
SHXM_RS25185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS25190	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS25205	COG4176	ABC-type proline glycine betaine transport system permease component
SHXM_RS25210	COG4175	Glycine betaine
SHXM_RS25210	COG0517	IMP dehydrogenase activity
SHXM_RS25220	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS25245	COG0039	L-malate dehydrogenase activity
SHXM_RS25260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SHXM_RS25265	COG0138	bifunctional purine biosynthesis protein purh
SHXM_RS25290	COG0045	succinate-CoA ligase (ADP-forming) activity
SHXM_RS25305	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SHXM_RS25315	COG0714	Associated with various cellular activities
SHXM_RS25330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS25340	COG0739	heme binding
SHXM_RS25375	COG2197	response regulator
SHXM_RS25395	COG0515	serine threonine protein kinase
SHXM_RS25420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHXM_RS25420	COG0519	Catalyzes the synthesis of GMP from XMP
SHXM_RS25445	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS25455	COG0515	serine threonine protein kinase
SHXM_RS25475	COG2197	response regulator
SHXM_RS25480	COG4585	Histidine kinase
SHXM_RS25485	COG1366	Belongs to the anti-sigma-factor antagonist family
SHXM_RS25555	COG0596	Alpha beta hydrolase
SHXM_RS25565	COG4821	SIS domain
SHXM_RS25575	COG0259	pyridoxamine-phosphate oxidase activity
SHXM_RS25585	COG1309	transcriptional regulator
SHXM_RS25590	COG1024	Enoyl-CoA hydratase
SHXM_RS25595	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS25610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS25640	COG2442	InterPro IPR007367
SHXM_RS25645	COG0247	lactate metabolic process
SHXM_RS25645	COG0277	FAD linked oxidase domain protein
SHXM_RS25650	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SHXM_RS25665	COG0667	Aldo Keto reductase
SHXM_RS25685	COG2252	PERMEase
SHXM_RS25715	COG2814	Major facilitator Superfamily
SHXM_RS25725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHXM_RS25730	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHXM_RS25735	COG1278	Cold shock
SHXM_RS25750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS25755	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS25760	COG1120	ATPase activity
SHXM_RS25785	COG1061	Type III restriction enzyme res subunit
SHXM_RS25795	COG3973	AAA domain
SHXM_RS25805	COG3142	Participates in the control of copper homeostasis
SHXM_RS25835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SHXM_RS25840	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SHXM_RS25845	COG0459	protein refolding
SHXM_RS25850	COG1278	Cold shock
SHXM_RS25865	COG0463	Glycosyl transferase, family 2
SHXM_RS25875	COG1877	trehalose-phosphatase activity
SHXM_RS25875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHXM_RS25890	COG1940	carbohydrate kinase activity
SHXM_RS25900	COG1105	Belongs to the carbohydrate kinase PfkB family
SHXM_RS25915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS25920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SHXM_RS25935	COG1309	transcriptional regulator
SHXM_RS25940	COG1064	alcohol dehydrogenase
SHXM_RS25955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHXM_RS25985	COG3842	ATPase activity
SHXM_RS25995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SHXM_RS26010	COG0215	cysteine-tRNA ligase activity
SHXM_RS26015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SHXM_RS26020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SHXM_RS26025	COG1329	Transcriptional regulator
SHXM_RS26045	COG5002	protein histidine kinase activity
SHXM_RS26060	COG2319	Wd-40 repeat
SHXM_RS26060	COG4249	Peptidase C14 caspase catalytic subunit p20
SHXM_RS26075	COG1215	transferase activity, transferring glycosyl groups
SHXM_RS26080	COG2188	Transcriptional regulator
SHXM_RS26110	COG0745	RESPONSE REGULATOR receiver
SHXM_RS26115	COG1404	Belongs to the peptidase S8 family
SHXM_RS26125	COG0588	phosphoglycerate mutase activity
SHXM_RS26160	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS26170	COG0531	amino acid
SHXM_RS26180	COG0667	Aldo Keto reductase
SHXM_RS26195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHXM_RS26225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SHXM_RS26230	COG0454	-acetyltransferase
SHXM_RS26230	COG0456	acetyltransferase
SHXM_RS26240	COG0737	Belongs to the 5'-nucleotidase family
SHXM_RS26300	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SHXM_RS26320	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SHXM_RS26330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SHXM_RS26335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SHXM_RS26355	COG0640	Transcriptional regulator
SHXM_RS26360	COG0640	Transcriptional regulator
SHXM_RS26365	COG2197	response regulator
SHXM_RS26380	COG0649	NAD binding
SHXM_RS26390	COG1732	Glycine betaine
SHXM_RS26395	COG1174	glycine betaine transport
SHXM_RS26400	COG1174	glycine betaine transport
SHXM_RS26405	COG1125	glycine betaine transport
SHXM_RS26405	COG0517	IMP dehydrogenase activity
SHXM_RS26415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHXM_RS26415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SHXM_RS26430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SHXM_RS26435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SHXM_RS26445	COG0302	gtp cyclohydrolase
SHXM_RS26460	COG0037	tRNA processing
SHXM_RS26470	COG2027	D-alanyl-D-alanine carboxypeptidase
SHXM_RS26475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SHXM_RS26485	COG0586	Pfam SNARE associated Golgi protein
SHXM_RS26490	COG0789	Transcriptional regulator
SHXM_RS26500	COG0076	glutamate decarboxylase activity
SHXM_RS26520	COG2318	DinB family
SHXM_RS26525	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS26550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHXM_RS26550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHXM_RS26555	COG1077	Cell shape determining protein MreB Mrl
SHXM_RS26570	COG1595	DNA-templated transcription, initiation
SHXM_RS26585	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SHXM_RS26590	COG2197	response regulator
SHXM_RS26650	COG4585	Histidine kinase
SHXM_RS26680	COG1191	sigma factor activity
SHXM_RS26690	COG0640	Transcriptional regulator
SHXM_RS26700	COG2197	response regulator
SHXM_RS26715	COG3629	intracellular signal transduction
SHXM_RS26715	COG3903	Transcriptional regulator
SHXM_RS26730	COG2186	Transcriptional regulator
SHXM_RS26735	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SHXM_RS26740	COG2816	NAD+ diphosphatase activity
SHXM_RS26855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SHXM_RS26860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SHXM_RS26865	COG1754	DNA topoisomerase type I activity
SHXM_RS26865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SHXM_RS26875	COG2890	protein-(glutamine-N5) methyltransferase activity
SHXM_RS26885	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SHXM_RS26890	COG2172	sigma factor antagonist activity
SHXM_RS26895	COG1366	Belongs to the anti-sigma-factor antagonist family
SHXM_RS26960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS26965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SHXM_RS26975	COG2267	carboxylic ester hydrolase activity
SHXM_RS27005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHXM_RS27025	COG0003	Pfam Anion-transporting ATPase
SHXM_RS27040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS27050	COG1408	metallophosphoesterase
SHXM_RS27100	COG2124	cytochrome p450
SHXM_RS27145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SHXM_RS27155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SHXM_RS27210	COG4585	Histidine kinase
SHXM_RS27215	COG2197	response regulator
SHXM_RS27230	COG0577	efflux transmembrane transporter activity
SHXM_RS27230	COG1136	(ABC) transporter
SHXM_RS27235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHXM_RS27270	COG3594	Acyltransferase
SHXM_RS27290	COG2124	cytochrome p450
SHXM_RS27295	COG0702	epimerase
SHXM_RS27310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SHXM_RS27355	COG0205	6-phosphofructokinase activity
SHXM_RS27360	COG1191	sigma factor activity
SHXM_RS27365	COG1191	sigma factor activity
SHXM_RS27400	COG0477	Major facilitator Superfamily
SHXM_RS27405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SHXM_RS27405	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SHXM_RS27415	COG2205	protein histidine kinase activity
SHXM_RS27420	COG0745	RESPONSE REGULATOR receiver
SHXM_RS27455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS27495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHXM_RS27495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHXM_RS27540	COG5000	phosphorelay sensor kinase activity
SHXM_RS27545	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS27550	COG1595	DNA-templated transcription, initiation
SHXM_RS27600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHXM_RS27615	COG0653	protein targeting
SHXM_RS27630	COG0006	proline dipeptidase activity
SHXM_RS27635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS27660	COG1999	signal sequence binding
SHXM_RS27670	COG2372	response to copper ion
SHXM_RS27675	COG2837	iron assimilation
SHXM_RS27685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SHXM_RS27690	COG0561	phosphatase activity
SHXM_RS27720	COG2807	transmembrane transport
SHXM_RS27745	COG1131	(ABC) transporter
SHXM_RS27760	COG0501	Belongs to the peptidase M48B family
SHXM_RS27770	COG0561	phosphatase activity
SHXM_RS27790	COG4988	ABC transporter
SHXM_RS27795	COG1294	oxidase, subunit
SHXM_RS27800	COG1271	oxidase subunit
SHXM_RS27805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHXM_RS27810	COG1609	Transcriptional regulator
SHXM_RS27835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SHXM_RS27855	COG0662	Cupin 2, conserved barrel domain protein
SHXM_RS27860	COG1950	PFAM Membrane protein of
SHXM_RS27865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHXM_RS27870	COG0626	cystathionine gamma-synthase activity
SHXM_RS27935	COG0242	peptide deformylase activity
SHXM_RS27940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS27950	COG1414	Transcriptional regulator
SHXM_RS27965	COG0305	Participates in initiation and elongation during chromosome replication
SHXM_RS27975	COG0359	binds to the 23S rRNA
SHXM_RS27980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHXM_RS27985	COG0629	single-stranded DNA binding
SHXM_RS27990	COG0360	Binds together with S18 to 16S ribosomal RNA
SHXM_RS28015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS28025	COG1260	myo-inositol-1-phosphate synthase
SHXM_RS28035	COG0617	tRNA 3'-terminal CCA addition
SHXM_RS28050	COG0515	serine threonine protein kinase
SHXM_RS28050	COG2815	serine threonine protein kinase
SHXM_RS28055	COG1595	DNA-templated transcription, initiation
SHXM_RS28065	COG0492	ferredoxin-NADP+ reductase activity
SHXM_RS28070	COG3118	belongs to the thioredoxin family
SHXM_RS28085	COG1192	Involved in chromosome partitioning
SHXM_RS28090	COG0357	Ribosomal RNA small subunit methyltransferase G
SHXM_RS28100	COG0706	membrane insertase activity
SHXM_RS28105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SHXM_RS28110	COG0594	ribonuclease P activity
SHXM_RS28115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
SHXM_RS28130	COG0592	DNA-directed DNA polymerase activity
SHXM_RS28135	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SHXM_RS28140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SHXM_RS28145	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SHXM_RS28150	COG0187	DNA topoisomerase II activity
SHXM_RS28155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHXM_RS28180	COG0515	serine threonine protein kinase
SHXM_RS28210	COG0705	Rhomboid family
SHXM_RS28225	COG3764	Sortase (surface protein transpeptidase)
SHXM_RS28235	COG3764	Sortase (surface protein transpeptidase)
SHXM_RS28240	COG3764	Sortase (surface protein transpeptidase)
SHXM_RS28245	COG0515	serine threonine protein kinase
SHXM_RS28250	COG0768	penicillin binding
SHXM_RS28265	COG1716	ATPase activity
SHXM_RS28270	COG1716	ATPase activity
SHXM_RS28280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SHXM_RS28285	COG1733	regulation of RNA biosynthetic process
SHXM_RS28300	COG0425	Belongs to the sulfur carrier protein TusA family
SHXM_RS28300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHXM_RS28310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SHXM_RS28315	COG2151	metal-sulfur cluster biosynthetic enzyme
SHXM_RS28320	COG3396	Phenylacetate-CoA oxygenase
SHXM_RS28325	COG3460	Phenylacetate-CoA oxygenase
SHXM_RS28330	COG3396	Phenylacetate-CoA oxygenase
SHXM_RS28355	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS28360	COG1309	transcriptional regulator
SHXM_RS28365	COG1522	sequence-specific DNA binding
SHXM_RS28395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SHXM_RS28400	COG3321	synthase
SHXM_RS28400	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS28400	COG0604	alcohol dehydrogenase
SHXM_RS28415	COG0515	serine threonine protein kinase
SHXM_RS28420	COG0515	serine threonine protein kinase
SHXM_RS28440	COG0022	dehydrogenase e1 component
SHXM_RS28445	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHXM_RS28490	COG1362	aminopeptidase activity
SHXM_RS28505	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS28515	COG1741	Belongs to the pirin family
SHXM_RS28530	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SHXM_RS28545	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHXM_RS28575	COG1793	dna ligase
SHXM_RS28585	COG3290	protein histidine kinase activity
SHXM_RS28595	COG2018	Roadblock/LC7 domain
SHXM_RS28610	COG2124	cytochrome p450
SHXM_RS28650	COG0535	radical SAM domain protein
SHXM_RS28720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHXM_RS28725	COG3938	Belongs to the proline racemase family
SHXM_RS28750	COG0725	ABC transporter, periplasmic molybdate-binding protein
SHXM_RS28780	COG0546	phosphoglycolate phosphatase activity
SHXM_RS28790	COG2409	Drug exporters of the RND superfamily
SHXM_RS28795	COG4585	Histidine kinase
SHXM_RS28800	COG2197	response regulator
SHXM_RS28810	COG0583	DNA-binding transcription factor activity
SHXM_RS28820	COG2268	Band 7 protein
SHXM_RS28845	COG0515	serine threonine protein kinase
SHXM_RS28845	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS28890	COG2197	response regulator
SHXM_RS28895	COG4585	Histidine kinase
SHXM_RS28955	COG0596	Alpha beta hydrolase
SHXM_RS29005	COG3391	amine dehydrogenase activity
SHXM_RS29055	COG0717	Belongs to the dCTP deaminase family
SHXM_RS29060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SHXM_RS29075	COG3290	protein histidine kinase activity
SHXM_RS29080	COG2181	nitrate reductase activity
SHXM_RS29080	COG0247	lactate metabolic process
SHXM_RS29085	COG0443	Heat shock 70 kDa protein
SHXM_RS29090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHXM_RS29095	COG0484	heat shock protein binding
SHXM_RS29100	COG0789	Transcriptional regulator
SHXM_RS29120	COG0542	response to heat
SHXM_RS29220	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SHXM_RS29235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SHXM_RS29240	COG0191	fructose-bisphosphate aldolase activity
SHXM_RS29245	COG0477	Major facilitator Superfamily
SHXM_RS29260	COG3844	kynureninase activity
SHXM_RS29270	COG4585	Histidine kinase
SHXM_RS29275	COG2197	response regulator
SHXM_RS29285	COG3559	Exporter of polyketide antibiotics
SHXM_RS29290	COG1131	(ABC) transporter
SHXM_RS29305	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SHXM_RS29310	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS29310	COG0515	serine threonine protein kinase
SHXM_RS29320	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHXM_RS29325	COG1802	Transcriptional regulator
SHXM_RS29340	COG0151	Belongs to the GarS family
SHXM_RS29355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SHXM_RS29385	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHXM_RS29390	COG0047	phosphoribosylformylglycinamidine synthase activity
SHXM_RS29395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHXM_RS29405	COG2318	DinB family
SHXM_RS29415	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SHXM_RS29425	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHXM_RS29450	COG1643	Atp-dependent helicase
SHXM_RS29465	COG0477	Major facilitator Superfamily
SHXM_RS29480	COG0494	nUDIX hydrolase
SHXM_RS29490	COG2186	Transcriptional regulator
SHXM_RS29560	COG0582	viral genome integration into host DNA
SHXM_RS29580	COG2188	Transcriptional regulator
SHXM_RS29630	COG0582	viral genome integration into host DNA
SHXM_RS29670	COG0513	Belongs to the DEAD box helicase family
SHXM_RS29715	COG0667	Aldo Keto reductase
SHXM_RS29730	COG0270	DNA (cytosine-5-)-methyltransferase activity
SHXM_RS29745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHXM_RS29770	COG1376	ErfK ybiS ycfS ynhG family protein
SHXM_RS29785	COG1595	DNA-templated transcription, initiation
SHXM_RS29795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SHXM_RS29800	COG0579	oxidoreductase
SHXM_RS29825	COG1252	NADH dehydrogenase
SHXM_RS29840	COG1846	Transcriptional regulator
SHXM_RS29900	COG0739	heme binding
SHXM_RS29900	COG0741	lytic transglycosylase activity
SHXM_RS29900	COG1196	nuclear chromosome segregation
SHXM_RS29905	COG0671	phosphoesterase, PA-phosphatase related
SHXM_RS29910	COG0277	FAD linked oxidase domain protein
SHXM_RS29930	COG1937	Protein conserved in bacteria
SHXM_RS29940	COG0306	phosphate transporter
SHXM_RS29945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SHXM_RS29970	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SHXM_RS30000	COG4941	Belongs to the sigma-70 factor family
SHXM_RS30005	COG0667	Aldo Keto reductase
SHXM_RS30015	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHXM_RS30040	COG0789	Transcriptional regulator
SHXM_RS30045	COG4552	Acetyltransferase involved in intracellular survival and related
SHXM_RS30055	COG1490	D-aminoacyl-tRNA deacylase activity
SHXM_RS30060	COG0354	folic acid binding
SHXM_RS30065	COG0735	belongs to the Fur family
SHXM_RS30070	COG3485	protocatechuate 3,4-dioxygenase
SHXM_RS30090	COG2897	thiosulfate sulfurtransferase activity
SHXM_RS30130	COG0745	RESPONSE REGULATOR receiver
SHXM_RS30135	COG1609	Transcriptional regulator
SHXM_RS30140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHXM_RS30155	COG1132	(ABC) transporter
SHXM_RS30160	COG0577	efflux transmembrane transporter activity
SHXM_RS30160	COG1136	(ABC) transporter
SHXM_RS30165	COG1136	(ABC) transporter
SHXM_RS30180	COG0745	RESPONSE REGULATOR receiver
SHXM_RS30185	COG2205	protein histidine kinase activity
SHXM_RS30195	COG0724	RNA recognition motif
SHXM_RS30205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS30240	COG0739	heme binding
SHXM_RS30255	COG2207	Transcriptional regulator
SHXM_RS30260	COG0346	lactoylglutathione lyase activity
SHXM_RS30265	COG2205	protein histidine kinase activity
SHXM_RS30270	COG0745	RESPONSE REGULATOR receiver
SHXM_RS30280	COG1595	DNA-templated transcription, initiation
SHXM_RS30285	COG1194	a g-specific adenine glycosylase
SHXM_RS30295	COG0583	DNA-binding transcription factor activity
SHXM_RS30300	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS30305	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SHXM_RS30325	COG0248	Ppx GppA phosphatase
SHXM_RS30330	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS30335	COG1309	transcriptional regulator
SHXM_RS30340	COG0129	dihydroxy-acid dehydratase activity
SHXM_RS30350	COG0515	serine threonine protein kinase
SHXM_RS30350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS30370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SHXM_RS30375	COG0180	Tryptophanyl-tRNA synthetase
SHXM_RS30405	COG0123	including yeast histone deacetylase and acetoin utilization protein
SHXM_RS30455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SHXM_RS30460	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SHXM_RS30465	COG0181	hydroxymethylbilane synthase activity
SHXM_RS30470	COG1648	precorrin-2 dehydrogenase activity
SHXM_RS30470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHXM_RS30475	COG0113	porphobilinogen synthase activity
SHXM_RS30505	COG1072	(Pantothenic acid kinase))
SHXM_RS30525	COG0018	arginyl-trna synthetase
SHXM_RS30530	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SHXM_RS30550	COG1690	Belongs to the RtcB family
SHXM_RS30555	COG2124	cytochrome p450
SHXM_RS30580	COG1742	UPF0060 membrane protein
SHXM_RS30595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHXM_RS30600	COG0406	alpha-ribazole phosphatase activity
SHXM_RS30615	COG0785	Cytochrome C biogenesis protein
SHXM_RS30620	COG1333	cytochrome c biogenesis protein
SHXM_RS30625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHXM_RS30635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SHXM_RS30640	COG0109	protoheme IX farnesyltransferase activity
SHXM_RS30645	COG0163	prenyltransferase activity
SHXM_RS30655	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHXM_RS30670	COG1301	dicarboxylic acid transport
SHXM_RS30685	COG1309	transcriptional regulator
SHXM_RS30695	COG2207	Transcriptional regulator
SHXM_RS30705	COG1278	Cold shock
SHXM_RS30710	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHXM_RS30720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHXM_RS30730	COG2226	methyltransferase
SHXM_RS30760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30765	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30770	COG0649	NAD binding
SHXM_RS30780	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SHXM_RS30785	COG1034	ATP synthesis coupled electron transport
SHXM_RS30790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHXM_RS30795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30800	COG0839	Belongs to the complex I subunit 6 family
SHXM_RS30805	COG0713	ATP synthesis coupled electron transport
SHXM_RS30810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHXM_RS30820	COG1007	ATP synthesis coupled electron transport
SHXM_RS30855	COG0492	ferredoxin-NADP+ reductase activity
SHXM_RS30860	COG0142	geranyltranstransferase activity
SHXM_RS30890	COG0702	epimerase
SHXM_RS30895	COG0531	amino acid
SHXM_RS30900	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHXM_RS30905	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHXM_RS30905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHXM_RS30915	COG4585	Histidine kinase
SHXM_RS30920	COG4585	Histidine kinase
SHXM_RS30925	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHXM_RS30945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHXM_RS30950	COG0839	Belongs to the complex I subunit 6 family
SHXM_RS30955	COG0713	ATP synthesis coupled electron transport
SHXM_RS30960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHXM_RS30970	COG1007	ATP synthesis coupled electron transport
SHXM_RS30975	COG0501	Belongs to the peptidase M48B family
SHXM_RS30980	COG3304	Inner membrane component domain
SHXM_RS30985	COG1666	GTP binding
SHXM_RS31000	COG1970	mechanosensitive ion channel activity
SHXM_RS31020	COG0702	epimerase
SHXM_RS31040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHXM_RS31045	COG2030	dehydratase
SHXM_RS31055	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SHXM_RS31060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHXM_RS31065	COG0436	Aminotransferase
SHXM_RS31085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SHXM_RS31090	COG0081	regulation of translation
SHXM_RS31100	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SHXM_RS31105	COG0222	ribosome binding
SHXM_RS31115	COG0085	RNA polymerase activity
SHXM_RS31120	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHXM_RS31125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SHXM_RS31130	COG0049	tRNA binding
SHXM_RS31135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SHXM_RS31140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SHXM_RS31160	COG0051	transcription antitermination factor activity, RNA binding
SHXM_RS31165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHXM_RS31170	COG0088	Forms part of the polypeptide exit tunnel
SHXM_RS31175	COG0089	rRNA binding
SHXM_RS31180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SHXM_RS31185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SHXM_RS31190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SHXM_RS31195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SHXM_RS31200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SHXM_RS31205	COG0255	Belongs to the universal ribosomal protein uL29 family
SHXM_RS31210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SHXM_RS31215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SHXM_RS31220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SHXM_RS31225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SHXM_RS31230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHXM_RS31240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SHXM_RS31245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SHXM_RS31250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SHXM_RS31255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SHXM_RS31265	COG0200	Binds to the 23S rRNA
SHXM_RS31275	COG0563	adenylate kinase activity
SHXM_RS31285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SHXM_RS31290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SHXM_RS31295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SHXM_RS31300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SHXM_RS31305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHXM_RS31310	COG0202	RNA polymerase activity
SHXM_RS31315	COG0203	ribosomal protein L17
SHXM_RS31320	COG0101	tRNA pseudouridine synthase activity
SHXM_RS31325	COG1366	Belongs to the anti-sigma-factor antagonist family
SHXM_RS31330	COG1366	Belongs to the anti-sigma-factor antagonist family
SHXM_RS31335	COG2172	sigma factor antagonist activity
SHXM_RS31345	COG2770	Histidine kinase
SHXM_RS31345	COG2208	phosphoserine phosphatase activity
SHXM_RS31355	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS31370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SHXM_RS31375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHXM_RS31380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHXM_RS31390	COG1072	(Pantothenic acid kinase))
SHXM_RS31395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHXM_RS31400	COG0736	holo-[acyl-carrier-protein] synthase activity
SHXM_RS31410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHXM_RS31425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SHXM_RS31430	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHXM_RS31435	COG0802	atpase or kinase
SHXM_RS31460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SHXM_RS31470	COG3903	Transcriptional regulator
SHXM_RS31470	COG3629	intracellular signal transduction
SHXM_RS31475	COG0596	Alpha beta hydrolase
SHXM_RS31530	COG0726	polysaccharide deacetylase
SHXM_RS31535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SHXM_RS31540	COG0459	protein refolding
SHXM_RS31545	COG4221	oxidoreductase activity
SHXM_RS31555	COG0583	DNA-binding transcription factor activity
SHXM_RS31565	COG2197	response regulator
SHXM_RS31570	COG1595	DNA-templated transcription, initiation
SHXM_RS31580	COG0516	GMP reductase activity
SHXM_RS31595	COG1077	Cell shape determining protein MreB Mrl
SHXM_RS31610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHXM_RS31630	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS31635	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS31640	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS31655	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS31660	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS31665	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS31690	COG1175	transmembrane transport
SHXM_RS31695	COG0395	ABC-type sugar transport system, permease component
SHXM_RS31710	COG4977	sequence-specific DNA binding
SHXM_RS31720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS31725	COG1024	Enoyl-CoA hydratase
SHXM_RS31735	COG2072	flavoprotein involved in K transport
SHXM_RS31750	COG0259	pyridoxamine-phosphate oxidase activity
SHXM_RS31760	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS31770	COG1309	transcriptional regulator
SHXM_RS31780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHXM_RS31780	COG0515	serine threonine protein kinase
SHXM_RS31795	COG1024	Enoyl-CoA hydratase
SHXM_RS31855	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SHXM_RS31860	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS31880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHXM_RS31930	COG1686	Belongs to the peptidase S11 family
SHXM_RS31940	COG1653	transport
SHXM_RS31955	COG0515	serine threonine protein kinase
SHXM_RS31985	COG1309	transcriptional regulator
SHXM_RS31995	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SHXM_RS32000	COG3285	dna ligase
SHXM_RS32000	COG1793	dna ligase
SHXM_RS32005	COG1793	dna ligase
SHXM_RS32010	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SHXM_RS32025	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS32025	COG0824	Thioesterase
SHXM_RS32030	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS32035	COG3246	L-lysine catabolic process to acetate
SHXM_RS32040	COG1309	transcriptional regulator
SHXM_RS32045	COG0515	serine threonine protein kinase
SHXM_RS32055	COG0596	Alpha beta hydrolase
SHXM_RS32110	COG1802	Transcriptional regulator
SHXM_RS32120	COG0436	Aminotransferase
SHXM_RS32160	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS32185	COG0582	viral genome integration into host DNA
SHXM_RS32215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHXM_RS32225	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHXM_RS32230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SHXM_RS32270	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SHXM_RS32310	COG1309	transcriptional regulator
SHXM_RS32330	COG1846	Transcriptional regulator
SHXM_RS32335	COG3384	dioxygenase
SHXM_RS32355	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS32360	COG1349	DNA-binding transcription factor activity
SHXM_RS32365	COG1105	Belongs to the carbohydrate kinase PfkB family
SHXM_RS32370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHXM_RS32370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHXM_RS32375	COG3634	alkyl hydroperoxide reductase activity
SHXM_RS32385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS32395	COG1970	mechanosensitive ion channel activity
SHXM_RS32405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SHXM_RS32415	COG3263	regulation of cellular component size
SHXM_RS32425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SHXM_RS32430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SHXM_RS32440	COG0315	cyclic pyranopterin monophosphate synthase activity
SHXM_RS32445	COG0521	Mo-molybdopterin cofactor biosynthetic process
SHXM_RS32445	COG0315	cyclic pyranopterin monophosphate synthase activity
SHXM_RS32450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHXM_RS32470	COG0277	FAD linked oxidase domain protein
SHXM_RS32475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHXM_RS32480	COG0798	PFAM Bile acid sodium symporter
SHXM_RS32485	COG0640	Transcriptional regulator
SHXM_RS32500	COG0783	Belongs to the Dps family
SHXM_RS32515	COG0708	Exodeoxyribonuclease III
SHXM_RS32525	COG2072	flavoprotein involved in K transport
SHXM_RS32530	COG2267	carboxylic ester hydrolase activity
SHXM_RS32545	COG4946	Tricorn protease homolog
SHXM_RS32545	COG0793	Belongs to the peptidase S41A family
SHXM_RS32555	COG2409	Drug exporters of the RND superfamily
SHXM_RS32560	COG0310	cobalt ion transport
SHXM_RS32570	COG1122	ATPase activity
SHXM_RS32600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHXM_RS32610	COG4166	transmembrane transport
SHXM_RS32670	COG0084	hydrolase, TatD family'
SHXM_RS32675	COG3584	3D domain protein
SHXM_RS32675	COG3583	domain protein
SHXM_RS32680	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SHXM_RS32685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SHXM_RS32690	COG0488	(ABC) transporter
SHXM_RS32725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SHXM_RS32730	COG2197	response regulator
SHXM_RS32740	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS32770	COG1309	transcriptional regulator
SHXM_RS32780	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SHXM_RS32790	COG0193	aminoacyl-tRNA hydrolase activity
SHXM_RS32795	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SHXM_RS32800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHXM_RS32805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SHXM_RS32820	COG4585	Histidine kinase
SHXM_RS32850	COG0477	Major facilitator Superfamily
SHXM_RS32855	COG1136	(ABC) transporter
SHXM_RS32860	COG0577	efflux transmembrane transporter activity
SHXM_RS32870	COG0667	Aldo Keto reductase
SHXM_RS32885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
SHXM_RS32965	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS32970	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS32975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS33000	COG0583	DNA-binding transcription factor activity
SHXM_RS33010	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHXM_RS33015	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS33020	COG0583	DNA-binding transcription factor activity
SHXM_RS33035	COG5002	protein histidine kinase activity
SHXM_RS33040	COG2018	Roadblock/LC7 domain
SHXM_RS33075	COG2378	regulation of single-species biofilm formation
SHXM_RS33085	COG0789	Transcriptional regulator
SHXM_RS33100	COG2304	oxidoreductase activity
SHXM_RS33130	COG2770	Histidine kinase
SHXM_RS33130	COG2208	phosphoserine phosphatase activity
SHXM_RS33165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHXM_RS33195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHXM_RS33210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SHXM_RS33220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHXM_RS33235	COG0583	DNA-binding transcription factor activity
SHXM_RS33245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHXM_RS33255	COG1331	Highly conserved protein containing a thioredoxin domain
SHXM_RS33260	COG1309	transcriptional regulator
SHXM_RS33265	COG1272	protein, Hemolysin III
SHXM_RS33270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SHXM_RS33290	COG0601	transmembrane transport
SHXM_RS33295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS33320	COG1595	DNA-templated transcription, initiation
SHXM_RS33355	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SHXM_RS33370	COG1414	Transcriptional regulator
SHXM_RS33380	COG2610	gluconate transmembrane transporter activity
SHXM_RS33385	COG1131	(ABC) transporter
SHXM_RS33450	COG2894	cell division
SHXM_RS33490	COG2885	chlorophyll binding
SHXM_RS33495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SHXM_RS33500	COG1278	Cold shock
SHXM_RS33515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHXM_RS33520	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SHXM_RS33535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS33540	COG0450	alkyl hydroperoxide reductase
SHXM_RS33555	COG1136	(ABC) transporter
SHXM_RS33575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS33590	COG1309	transcriptional regulator
SHXM_RS33600	COG2226	methyltransferase
SHXM_RS33610	COG0114	fumarate hydratase activity
SHXM_RS33625	COG3469	chitinase activity
SHXM_RS33630	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SHXM_RS33630	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SHXM_RS33655	COG0778	Nitroreductase
SHXM_RS33660	COG1722	exodeoxyribonuclease VII activity
SHXM_RS33665	COG1570	exodeoxyribonuclease VII activity
SHXM_RS33670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHXM_RS33685	COG0012	GTP binding
SHXM_RS33720	COG4221	oxidoreductase activity
SHXM_RS33725	COG2814	Major facilitator Superfamily
SHXM_RS33730	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS33740	COG0583	DNA-binding transcription factor activity
SHXM_RS33795	COG0531	amino acid
SHXM_RS33820	COG1053	succinate dehydrogenase
SHXM_RS33840	COG1217	gtp-binding protein TYPA
SHXM_RS33850	COG0601	transmembrane transport
SHXM_RS33855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS33860	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS33865	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS33895	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS33905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS33910	COG0601	transmembrane transport
SHXM_RS33915	COG4166	transmembrane transport
SHXM_RS33945	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS33950	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS33960	COG0747	negative chemotaxis
SHXM_RS33965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS33985	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHXM_RS34005	COG1131	(ABC) transporter
SHXM_RS34015	COG4585	Histidine kinase
SHXM_RS34020	COG2197	response regulator
SHXM_RS34060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHXM_RS34065	COG1611	Belongs to the LOG family
SHXM_RS34070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SHXM_RS34080	COG0519	Catalyzes the synthesis of GMP from XMP
SHXM_RS34085	COG1024	Enoyl-CoA hydratase
SHXM_RS34100	COG1595	DNA-templated transcription, initiation
SHXM_RS34110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHXM_RS34115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHXM_RS34155	COG0598	Magnesium transport protein CorA
SHXM_RS34175	COG2095	MarC family integral membrane protein
SHXM_RS34180	COG1432	Conserved Protein
SHXM_RS34185	COG0596	Alpha beta hydrolase
SHXM_RS34220	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHXM_RS34220	COG0596	Alpha beta hydrolase
SHXM_RS34285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHXM_RS34320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SHXM_RS34375	COG3480	Lon protease (S16) C-terminal proteolytic domain
SHXM_RS34385	COG1615	UPF0182 protein
SHXM_RS34410	COG0753	catalase activity
SHXM_RS34420	COG0483	inositol monophosphate 1-phosphatase activity
SHXM_RS34430	COG2076	Multidrug Resistance protein
SHXM_RS34435	COG1162	GTPase activity
SHXM_RS34440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SHXM_RS34450	COG2135	peptidase activity
SHXM_RS34460	COG1595	DNA-templated transcription, initiation
SHXM_RS34465	COG5662	AntiSigma factor
SHXM_RS34470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHXM_RS34470	COG2199	diguanylate cyclase activity
SHXM_RS34490	COG0242	peptide deformylase activity
SHXM_RS34495	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHXM_RS34580	COG2188	Transcriptional regulator
SHXM_RS34585	COG2182	Extracellular solute-binding protein
SHXM_RS34590	COG1175	transmembrane transport
SHXM_RS34595	COG0395	ABC-type sugar transport system, permease component
SHXM_RS34600	COG1472	Belongs to the glycosyl hydrolase 3 family
SHXM_RS34605	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHXM_RS34620	COG1597	lipid kinase activity
SHXM_RS34660	COG2066	Belongs to the glutaminase family
SHXM_RS34680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS34705	COG5640	endopeptidase activity
SHXM_RS34710	COG0583	DNA-binding transcription factor activity
SHXM_RS34725	COG0702	epimerase
SHXM_RS34760	COG0765	amino acid transport
SHXM_RS34770	COG0281	malic enzyme
SHXM_RS34795	COG0300	oxidoreductase activity
SHXM_RS34795	COG3321	synthase
SHXM_RS34795	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS34795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS34795	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS34810	COG0778	Nitroreductase
SHXM_RS34835	COG0789	Transcriptional regulator
SHXM_RS34845	COG0567	Dehydrogenase, E1 component
SHXM_RS34845	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHXM_RS34850	COG2205	protein histidine kinase activity
SHXM_RS34855	COG0745	RESPONSE REGULATOR receiver
SHXM_RS34870	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SHXM_RS34880	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS34885	COG2249	NAD(P)H dehydrogenase (quinone) activity
SHXM_RS34890	COG1309	transcriptional regulator
SHXM_RS34935	COG0791	NLP P60 protein
SHXM_RS34935	COG3103	Sh3 type 3 domain protein
SHXM_RS34935	COG1388	LysM domain
SHXM_RS34965	COG0583	DNA-binding transcription factor activity
SHXM_RS34980	COG0477	Major facilitator Superfamily
SHXM_RS35025	COG3629	intracellular signal transduction
SHXM_RS35025	COG3903	Transcriptional regulator
SHXM_RS35120	COG1725	Transcriptional regulator
SHXM_RS35150	COG0745	RESPONSE REGULATOR receiver
SHXM_RS35155	COG0018	arginyl-trna synthetase
SHXM_RS35155	COG0018	arginyl-trna synthetase
SHXM_RS35160	COG0019	diaminopimelate decarboxylase activity
SHXM_RS35165	COG0460	homoserine dehydrogenase
SHXM_RS35170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHXM_RS35175	COG0083	homoserine kinase activity
SHXM_RS35185	COG1316	TRANSCRIPTIONal
SHXM_RS35190	COG0254	rRNA binding
SHXM_RS35195	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SHXM_RS35200	COG2890	protein-(glutamine-N5) methyltransferase activity
SHXM_RS35210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHXM_RS35215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHXM_RS35235	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHXM_RS35240	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SHXM_RS35245	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHXM_RS35250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SHXM_RS35255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SHXM_RS35260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SHXM_RS35265	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SHXM_RS35275	COG2197	response regulator
SHXM_RS35280	COG4585	Histidine kinase
SHXM_RS35310	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS35325	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SHXM_RS35375	COG0183	Belongs to the thiolase family
SHXM_RS35390	COG0745	RESPONSE REGULATOR receiver
SHXM_RS35400	COG4413	Urea transporter
SHXM_RS35405	COG0831	urea catabolic process
SHXM_RS35410	COG0832	Belongs to the urease beta subunit family
SHXM_RS35410	COG0831	urea catabolic process
SHXM_RS35415	COG0804	urea catabolic process
SHXM_RS35420	COG0830	nickel cation binding
SHXM_RS35425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SHXM_RS35430	COG0829	nickel cation binding
SHXM_RS35485	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS35485	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS35525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SHXM_RS35530	COG0280	phosphate acetyltransferase
SHXM_RS35530	COG0857	belongs to the CobB CobQ family
SHXM_RS35535	COG0205	6-phosphofructokinase activity
SHXM_RS35550	COG3833	ABC-type maltose transport systems, permease component
SHXM_RS35555	COG1316	TRANSCRIPTIONal
SHXM_RS35575	COG1309	transcriptional regulator
SHXM_RS35610	COG3903	Transcriptional regulator
SHXM_RS35610	COG3629	intracellular signal transduction
SHXM_RS35635	COG1309	transcriptional regulator
SHXM_RS35640	COG1175	transmembrane transport
SHXM_RS35650	COG3469	chitinase activity
SHXM_RS35665	COG4565	transcriptional regulatory protein
SHXM_RS35675	COG3290	protein histidine kinase activity
SHXM_RS35680	COG1301	dicarboxylic acid transport
SHXM_RS35690	COG3903	Transcriptional regulator
SHXM_RS35690	COG3629	intracellular signal transduction
SHXM_RS35695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SHXM_RS35700	COG3281	Trehalose synthase
SHXM_RS35710	COG0366	Alpha amylase catalytic
SHXM_RS35730	COG3401	FG-GAP repeat protein
SHXM_RS35735	COG0058	SHG alpha-glucan phosphorylase activity
SHXM_RS35785	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SHXM_RS35805	COG2318	DinB family
SHXM_RS35810	COG3340	Belongs to the peptidase S51 family
SHXM_RS35840	COG1132	(ABC) transporter
SHXM_RS35845	COG1132	(ABC) transporter
SHXM_RS35905	COG1597	lipid kinase activity
SHXM_RS35915	COG3209	COG3209 Rhs family protein
SHXM_RS35935	COG1595	DNA-templated transcription, initiation
SHXM_RS35945	COG1760	l-serine dehydratase
SHXM_RS35950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHXM_RS35955	COG0509	glycine decarboxylation via glycine cleavage system
SHXM_RS35960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SHXM_RS35985	COG4166	transmembrane transport
SHXM_RS35995	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS36000	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS36005	COG2860	membrane
SHXM_RS36045	COG0482	sulfurtransferase activity
SHXM_RS36055	COG0789	Transcriptional regulator
SHXM_RS36060	COG1819	glycosyl
SHXM_RS36070	COG0300	oxidoreductase activity
SHXM_RS36080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHXM_RS36090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHXM_RS36095	COG0154	amidase activity
SHXM_RS36105	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHXM_RS36115	COG2409	Drug exporters of the RND superfamily
SHXM_RS36130	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SHXM_RS36130	COG1672	PFAM Archaeal ATPase
SHXM_RS36135	COG2133	pyrroloquinoline quinone binding
SHXM_RS36140	COG0667	Aldo Keto reductase
SHXM_RS36150	COG5001	Diguanylate cyclase
SHXM_RS36150	COG3300	MHYT domain
SHXM_RS36160	COG0440	acetolactate synthase activity
SHXM_RS36165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SHXM_RS36170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHXM_RS36205	COG0477	Major facilitator Superfamily
SHXM_RS36220	COG0506	proline dehydrogenase activity
SHXM_RS36225	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS36235	COG0473	3-isopropylmalate dehydrogenase activity
SHXM_RS36240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SHXM_RS36245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHXM_RS36250	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS36270	COG2018	Roadblock/LC7 domain
SHXM_RS36290	COG2018	Roadblock/LC7 domain
SHXM_RS36295	COG5002	protein histidine kinase activity
SHXM_RS36305	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHXM_RS36310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHXM_RS36350	COG1414	Transcriptional regulator
SHXM_RS36355	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHXM_RS36360	COG0066	3-isopropylmalate dehydratase activity
SHXM_RS36370	COG0776	regulation of translation
SHXM_RS36375	COG1920	GTP binding
SHXM_RS36385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHXM_RS36390	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHXM_RS36410	COG0351	phosphomethylpyrimidine kinase
SHXM_RS36415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SHXM_RS36420	COG1461	Dihydroxyacetone kinase
SHXM_RS36425	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SHXM_RS36430	COG0742	ribosomal rna small subunit methyltransferase
SHXM_RS36435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHXM_RS36450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SHXM_RS36455	COG0571	ribonuclease III activity
SHXM_RS36460	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHXM_RS36465	COG1733	regulation of RNA biosynthetic process
SHXM_RS36470	COG2340	Cysteine-rich secretory protein family
SHXM_RS36475	COG1254	Belongs to the acylphosphatase family
SHXM_RS36485	COG1196	nuclear chromosome segregation
SHXM_RS36490	COG0477	Major facilitator Superfamily
SHXM_RS36510	COG4585	Histidine kinase
SHXM_RS36545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SHXM_RS36560	COG0442	prolyl-tRNA aminoacylation
SHXM_RS36570	COG0228	four-way junction DNA binding
SHXM_RS36575	COG1837	Belongs to the UPF0109 family
SHXM_RS36580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SHXM_RS36585	COG0336	Belongs to the RNA methyltransferase TrmD family
SHXM_RS36590	COG0335	large ribosomal subunit rRNA binding
SHXM_RS36595	COG0681	Belongs to the peptidase S26 family
SHXM_RS36600	COG0681	Belongs to the peptidase S26 family
SHXM_RS36605	COG0681	Belongs to the peptidase S26 family
SHXM_RS36615	COG1051	belongs to the nudix hydrolase family
SHXM_RS36625	COG0792	nuclease activity
SHXM_RS36640	COG1191	sigma factor activity
SHXM_RS36655	COG0052	Belongs to the universal ribosomal protein uS2 family
SHXM_RS36660	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SHXM_RS36665	COG0528	UMP kinase activity
SHXM_RS36670	COG0233	cytoplasmic translational termination
SHXM_RS36675	COG0575	Belongs to the CDS family
SHXM_RS36680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SHXM_RS36690	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SHXM_RS36695	COG3842	ATPase activity
SHXM_RS36710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHXM_RS36715	COG0028	Belongs to the TPP enzyme family
SHXM_RS36730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHXM_RS36740	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS36755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHXM_RS36770	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS36780	COG3842	ATPase activity
SHXM_RS36785	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHXM_RS36790	COG1177	transmembrane transport
SHXM_RS36795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS36815	COG2508	Transcriptional regulator
SHXM_RS36820	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS36825	COG1472	Belongs to the glycosyl hydrolase 3 family
SHXM_RS36835	COG4209	transmembrane transport
SHXM_RS36840	COG0395	ABC-type sugar transport system, permease component
SHXM_RS36865	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SHXM_RS36870	COG0750	zinc metalloprotease
SHXM_RS36875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHXM_RS36890	COG0442	prolyl-tRNA aminoacylation
SHXM_RS36910	COG0779	Required for maturation of 30S ribosomal subunits
SHXM_RS36925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SHXM_RS36935	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SHXM_RS36940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SHXM_RS36950	COG0455	bacterial-type flagellum organization
SHXM_RS36980	COG1404	Belongs to the peptidase S8 family
SHXM_RS37035	COG1674	ftsk spoiiie
SHXM_RS37065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SHXM_RS37070	COG1185	polyribonucleotide nucleotidyltransferase activity
SHXM_RS37075	COG0612	Peptidase, M16
SHXM_RS37080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SHXM_RS37100	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SHXM_RS37105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHXM_RS37110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHXM_RS37145	COG2770	Histidine kinase
SHXM_RS37145	COG2208	phosphoserine phosphatase activity
SHXM_RS37160	COG1674	ftsk spoiiie
SHXM_RS37170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHXM_RS37180	COG1058	Belongs to the CinA family
SHXM_RS37180	COG1546	Belongs to the CinA family
SHXM_RS37185	COG1396	sequence-specific DNA binding
SHXM_RS37200	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHXM_RS37205	COG1201	RNA secondary structure unwinding
SHXM_RS37250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHXM_RS37260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS37265	COG0765	amino acid transport
SHXM_RS37270	COG0765	amino acid transport
SHXM_RS37275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
SHXM_RS37280	COG1126	abc transporter atp-binding protein
SHXM_RS37290	COG2205	protein histidine kinase activity
SHXM_RS37295	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS37305	COG1414	Transcriptional regulator
SHXM_RS37310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHXM_RS37330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SHXM_RS37340	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SHXM_RS37345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SHXM_RS37355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SHXM_RS37385	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SHXM_RS37390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SHXM_RS37395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHXM_RS37410	COG0488	(ABC) transporter
SHXM_RS37425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHXM_RS37460	COG1802	Transcriptional regulator
SHXM_RS37465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHXM_RS37480	COG0187	DNA topoisomerase II activity
SHXM_RS37485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS37490	COG4565	transcriptional regulatory protein
SHXM_RS37495	COG3290	protein histidine kinase activity
SHXM_RS37510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHXM_RS37515	COG0612	Peptidase, M16
SHXM_RS37530	COG1802	Transcriptional regulator
SHXM_RS37535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS37540	COG0045	succinate-CoA ligase (ADP-forming) activity
SHXM_RS37540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHXM_RS37540	COG1042	CoA-binding domain protein
SHXM_RS37555	COG1435	thymidine kinase activity
SHXM_RS37590	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SHXM_RS37600	COG0745	RESPONSE REGULATOR receiver
SHXM_RS37605	COG2205	protein histidine kinase activity
SHXM_RS37630	COG0756	dUTP diphosphatase activity
SHXM_RS37670	COG0569	domain protein
SHXM_RS37700	COG0531	amino acid
SHXM_RS37705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SHXM_RS37740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS37745	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS37750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS37755	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS37775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS37780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHXM_RS37785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SHXM_RS37790	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS37800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS37810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS37820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS37825	COG2124	cytochrome p450
SHXM_RS37850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS37870	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SHXM_RS37880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS37895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SHXM_RS37905	COG2409	Drug exporters of the RND superfamily
SHXM_RS37935	COG2040	homocysteine
SHXM_RS37945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SHXM_RS37950	COG4977	sequence-specific DNA binding
SHXM_RS37955	COG0477	Major facilitator Superfamily
SHXM_RS37980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHXM_RS38005	COG0800	Aldolase
SHXM_RS38015	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS38020	COG2186	Transcriptional regulator
SHXM_RS38035	COG0395	ABC-type sugar transport system, permease component
SHXM_RS38040	COG1175	transmembrane transport
SHXM_RS38050	COG3345	alpha-galactosidase
SHXM_RS38090	COG1309	transcriptional regulator
SHXM_RS38100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHXM_RS38115	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SHXM_RS38125	COG3537	Alpha-1,2-mannosidase
SHXM_RS38135	COG2409	Drug exporters of the RND superfamily
SHXM_RS38145	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHXM_RS38150	COG0702	epimerase
SHXM_RS38155	COG1733	regulation of RNA biosynthetic process
SHXM_RS38170	COG1653	transport
SHXM_RS38175	COG1175	transmembrane transport
SHXM_RS38180	COG0395	ABC-type sugar transport system, permease component
SHXM_RS38185	COG1940	carbohydrate kinase activity
SHXM_RS38190	COG4213	ABC transporter substrate-binding protein
SHXM_RS38200	COG4214	carbohydrate transport
SHXM_RS38205	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHXM_RS38210	COG0531	amino acid
SHXM_RS38225	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS38225	COG1024	Enoyl-CoA hydratase
SHXM_RS38230	COG0183	Belongs to the thiolase family
SHXM_RS38250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SHXM_RS38260	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHXM_RS38265	COG2271	Major facilitator Superfamily
SHXM_RS38280	COG1414	Transcriptional regulator
SHXM_RS38285	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHXM_RS38290	COG3253	May function as heme-dependent peroxidase
SHXM_RS38310	COG3220	belongs to the UPF0276 family
SHXM_RS38315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHXM_RS38360	COG0745	RESPONSE REGULATOR receiver
SHXM_RS38365	COG5002	protein histidine kinase activity
SHXM_RS38390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHXM_RS38400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS38410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SHXM_RS38420	COG0596	Alpha beta hydrolase
SHXM_RS38455	COG1136	(ABC) transporter
SHXM_RS38490	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SHXM_RS38495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHXM_RS38545	COG1119	ATPase activity
SHXM_RS38550	COG2188	Transcriptional regulator
SHXM_RS38565	COG0583	DNA-binding transcription factor activity
SHXM_RS38585	COG1175	transmembrane transport
SHXM_RS38630	COG2409	Drug exporters of the RND superfamily
SHXM_RS38685	COG1309	transcriptional regulator
SHXM_RS38690	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS38710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS38715	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
SHXM_RS38735	COG0529	Catalyzes the synthesis of activated sulfate
SHXM_RS38740	COG0175	sulfate reduction
SHXM_RS38750	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHXM_RS38775	COG0604	alcohol dehydrogenase
SHXM_RS38775	COG3321	synthase
SHXM_RS38790	COG1162	GTPase activity
SHXM_RS38810	COG0028	Belongs to the TPP enzyme family
SHXM_RS38840	COG1802	Transcriptional regulator
SHXM_RS38850	COG3835	regulator
SHXM_RS38860	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS38865	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS38895	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS38905	COG0598	Magnesium transport protein CorA
SHXM_RS38910	COG2197	response regulator
SHXM_RS38915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS38920	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS38950	COG2351	hydroxyisourate hydrolase activity
SHXM_RS38970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SHXM_RS38975	COG0746	molybdenum cofactor guanylyltransferase activity
SHXM_RS38985	COG1414	Transcriptional regulator
SHXM_RS38995	COG1953	Uracil, thiamine, allantoin
SHXM_RS39000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHXM_RS39005	COG4266	Belongs to the allantoicase family
SHXM_RS39065	COG0800	Aldolase
SHXM_RS39085	COG2188	Transcriptional regulator
SHXM_RS39105	COG1940	carbohydrate kinase activity
SHXM_RS39115	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS39140	COG1126	abc transporter atp-binding protein
SHXM_RS39150	COG3903	Transcriptional regulator
SHXM_RS39150	COG3629	intracellular signal transduction
SHXM_RS39155	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS39205	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS39285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS39285	COG0723	plastoquinol--plastocyanin reductase activity
SHXM_RS39305	COG1278	Cold shock
SHXM_RS39335	COG0667	Aldo Keto reductase
SHXM_RS39350	COG0477	Major facilitator Superfamily
SHXM_RS39370	COG1609	Transcriptional regulator
SHXM_RS39380	COG0800	Aldolase
SHXM_RS39385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SHXM_RS39385	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SHXM_RS39400	COG0583	DNA-binding transcription factor activity
SHXM_RS39405	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS39415	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS39460	COG4585	Histidine kinase
SHXM_RS39465	COG2197	response regulator
SHXM_RS39500	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SHXM_RS39530	COG0513	Belongs to the DEAD box helicase family
SHXM_RS39570	COG0604	alcohol dehydrogenase
SHXM_RS39575	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS39600	COG3321	synthase
SHXM_RS39600	COG0604	alcohol dehydrogenase
SHXM_RS39600	COG3321	synthase
SHXM_RS39600	COG0604	alcohol dehydrogenase
SHXM_RS39620	COG0604	alcohol dehydrogenase
SHXM_RS39620	COG3321	synthase
SHXM_RS39635	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SHXM_RS39640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SHXM_RS39655	COG0546	phosphoglycolate phosphatase activity
SHXM_RS39665	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS39680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHXM_RS39695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS39710	COG1802	Transcriptional regulator
SHXM_RS39715	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHXM_RS39725	COG2814	Major facilitator Superfamily
SHXM_RS39730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS39750	COG0583	DNA-binding transcription factor activity
SHXM_RS39755	COG2828	Protein conserved in bacteria
SHXM_RS39760	COG1301	dicarboxylic acid transport
SHXM_RS39765	COG1053	succinate dehydrogenase
SHXM_RS39780	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS39790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS39820	COG0667	Aldo Keto reductase
SHXM_RS39830	COG1309	transcriptional regulator
SHXM_RS39835	COG1309	transcriptional regulator
SHXM_RS39845	COG1683	Conserved Protein
SHXM_RS39880	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS39895	COG1309	transcriptional regulator
SHXM_RS39915	COG1278	Cold shock
SHXM_RS39920	COG1278	Cold shock
SHXM_RS39925	COG0513	Belongs to the DEAD box helicase family
SHXM_RS39950	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SHXM_RS39955	COG2814	Major facilitator Superfamily
SHXM_RS39960	COG0640	Transcriptional regulator
SHXM_RS40010	COG0443	Heat shock 70 kDa protein
SHXM_RS40015	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHXM_RS40030	COG0542	response to heat
SHXM_RS40045	COG3118	belongs to the thioredoxin family
SHXM_RS40045	COG0492	ferredoxin-NADP+ reductase activity
SHXM_RS40050	COG0071	Belongs to the small heat shock protein (HSP20) family
SHXM_RS40065	COG0531	amino acid
SHXM_RS40075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHXM_RS40105	COG2205	protein histidine kinase activity
SHXM_RS40110	COG0745	RESPONSE REGULATOR receiver
SHXM_RS40115	COG0577	efflux transmembrane transporter activity
SHXM_RS40155	COG2264	protein methyltransferase activity
SHXM_RS40160	COG0494	nUDIX hydrolase
SHXM_RS40170	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHXM_RS40205	COG0515	serine threonine protein kinase
SHXM_RS40205	COG2815	serine threonine protein kinase
SHXM_RS40235	COG0657	acetylesterase activity
SHXM_RS40240	COG0604	alcohol dehydrogenase
SHXM_RS40240	COG3321	synthase
SHXM_RS40240	COG4221	oxidoreductase activity
SHXM_RS40240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS40300	COG2197	response regulator
SHXM_RS40310	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS40320	COG0604	alcohol dehydrogenase
SHXM_RS40345	COG0577	efflux transmembrane transporter activity
SHXM_RS40365	COG2188	Transcriptional regulator
SHXM_RS40370	COG2182	Extracellular solute-binding protein
SHXM_RS40375	COG1175	transmembrane transport
SHXM_RS40380	COG0395	ABC-type sugar transport system, permease component
SHXM_RS40400	COG0583	DNA-binding transcription factor activity
SHXM_RS40405	COG2130	NADP-dependent
SHXM_RS40420	COG0583	DNA-binding transcription factor activity
SHXM_RS40425	COG0110	maltose O-acetyltransferase activity
SHXM_RS40430	COG4257	antibiotic catabolic process
SHXM_RS40460	COG2223	nitrite transmembrane transporter activity
SHXM_RS40470	COG0667	Aldo Keto reductase
SHXM_RS40510	COG0831	urea catabolic process
SHXM_RS40510	COG0832	Belongs to the urease beta subunit family
SHXM_RS40515	COG0804	urea catabolic process
SHXM_RS40520	COG0477	Major facilitator Superfamily
SHXM_RS40525	COG0028	Belongs to the TPP enzyme family
SHXM_RS40530	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS40535	COG0477	Major facilitator Superfamily
SHXM_RS40540	COG0251	oxidation-reduction process
SHXM_RS40545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHXM_RS40595	COG1309	transcriptional regulator
SHXM_RS40635	COG0531	amino acid
SHXM_RS40645	COG0247	lactate metabolic process
SHXM_RS40645	COG0277	FAD linked oxidase domain protein
SHXM_RS40655	COG0583	DNA-binding transcription factor activity
SHXM_RS40665	COG3971	2-oxopent-4-enoate hydratase activity
SHXM_RS40680	COG1917	Cupin 2, conserved barrel domain protein
SHXM_RS40695	COG1234	tRNA 3'-trailer cleavage
SHXM_RS40715	COG0277	FAD linked oxidase domain protein
SHXM_RS40720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHXM_RS40725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS40750	COG3321	synthase
SHXM_RS40750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS40770	COG1819	glycosyl
SHXM_RS40775	COG1132	(ABC) transporter
SHXM_RS40780	COG2755	lipolytic protein G-D-S-L family
SHXM_RS40815	COG0583	DNA-binding transcription factor activity
SHXM_RS40825	COG1063	alcohol dehydrogenase
SHXM_RS40840	COG3903	Transcriptional regulator
SHXM_RS40840	COG3629	intracellular signal transduction
SHXM_RS40890	COG1929	Belongs to the glycerate kinase type-1 family
SHXM_RS40895	COG4266	Belongs to the allantoicase family
SHXM_RS40900	COG3960	tartronate-semialdehyde synthase activity
SHXM_RS40905	COG2084	Dehydrogenase
SHXM_RS40910	COG3622	Belongs to the hyi family
SHXM_RS40925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS40935	COG2226	methyltransferase
SHXM_RS40940	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS40940	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHXM_RS40945	COG1703	isobutyryl-CoA mutase activity
SHXM_RS40945	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS40945	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHXM_RS40975	COG0395	ABC-type sugar transport system, permease component
SHXM_RS40980	COG1175	transmembrane transport
SHXM_RS40985	COG1653	transport
SHXM_RS41015	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SHXM_RS41030	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS41035	COG0477	Major facilitator Superfamily
SHXM_RS41050	COG0583	DNA-binding transcription factor activity
SHXM_RS41085	COG0154	amidase activity
SHXM_RS41110	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHXM_RS41115	COG1309	transcriptional regulator
SHXM_RS41120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SHXM_RS41170	COG2207	Transcriptional regulator
SHXM_RS41185	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS41190	COG0583	DNA-binding transcription factor activity
SHXM_RS41200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS41205	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS41230	COG3384	dioxygenase
SHXM_RS41275	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
SHXM_RS41285	COG0667	Aldo Keto reductase
SHXM_RS41290	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHXM_RS41300	COG0436	Aminotransferase
SHXM_RS41305	COG0300	oxidoreductase activity
SHXM_RS41320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS41325	COG0477	Major facilitator Superfamily
SHXM_RS41330	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHXM_RS41335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS41345	COG0702	epimerase
SHXM_RS41375	COG0009	L-threonylcarbamoyladenylate synthase
SHXM_RS41390	COG1609	Transcriptional regulator
SHXM_RS41410	COG0142	geranyltranstransferase activity
SHXM_RS41420	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS41430	COG0574	Belongs to the PEP-utilizing enzyme family
SHXM_RS41430	COG3848	Pyruvate phosphate dikinase
SHXM_RS41475	COG2207	Transcriptional regulator
SHXM_RS41475	COG1609	Transcriptional regulator
SHXM_RS41515	COG0477	Major facilitator Superfamily
SHXM_RS41535	COG0604	alcohol dehydrogenase
SHXM_RS41545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS41550	COG0473	3-isopropylmalate dehydrogenase activity
SHXM_RS41550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
SHXM_RS41560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHXM_RS41565	COG0515	serine threonine protein kinase
SHXM_RS41585	COG2814	Major facilitator Superfamily
SHXM_RS41590	COG1349	DNA-binding transcription factor activity
SHXM_RS41595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHXM_RS41605	COG1070	Carbohydrate kinase
SHXM_RS41610	COG2376	Dihydroxyacetone kinase
SHXM_RS41615	COG0698	ribose 5-phosphate isomerase
SHXM_RS41635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SHXM_RS41645	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS41665	COG0842	Transport permease protein
SHXM_RS41665	COG1716	ATPase activity
SHXM_RS41665	COG1131	(ABC) transporter
SHXM_RS41670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHXM_RS41685	COG3469	chitinase activity
SHXM_RS41695	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS41700	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS41710	COG1129	ABC transporter
SHXM_RS41750	COG3469	chitinase activity
SHXM_RS41760	COG2409	Drug exporters of the RND superfamily
SHXM_RS41770	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHXM_RS41815	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS41865	COG0300	oxidoreductase activity
SHXM_RS41895	COG0477	Major facilitator Superfamily
SHXM_RS41920	COG3971	2-oxopent-4-enoate hydratase activity
SHXM_RS41930	COG1309	transcriptional regulator
SHXM_RS41935	COG1414	Transcriptional regulator
SHXM_RS41940	COG0667	Aldo Keto reductase
SHXM_RS41970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHXM_RS41975	COG1595	DNA-templated transcription, initiation
SHXM_RS41985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS41990	COG1120	ATPase activity
SHXM_RS41995	COG2197	response regulator
SHXM_RS42025	COG0596	Alpha beta hydrolase
SHXM_RS42050	COG0251	oxidation-reduction process
SHXM_RS42065	COG3961	Belongs to the TPP enzyme family
SHXM_RS42070	COG1231	oxidoreductase activity
SHXM_RS42080	COG1609	Transcriptional regulator
SHXM_RS42105	COG2814	Major facilitator Superfamily
SHXM_RS42115	COG0656	L-ascorbic acid biosynthetic process
SHXM_RS42125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHXM_RS42130	COG1414	Transcriptional regulator
SHXM_RS42160	COG0800	Aldolase
SHXM_RS42165	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS42170	COG1063	alcohol dehydrogenase
SHXM_RS42175	COG1063	alcohol dehydrogenase
SHXM_RS42180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS42190	COG2140	Oxalate decarboxylase
SHXM_RS42195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS42200	COG1737	Transcriptional regulator
SHXM_RS42210	COG0583	DNA-binding transcription factor activity
SHXM_RS42225	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS42230	COG1522	sequence-specific DNA binding
SHXM_RS42240	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS42270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SHXM_RS42285	COG0366	Alpha amylase catalytic
SHXM_RS42285	COG1470	cell adhesion involved in biofilm formation
SHXM_RS42295	COG0745	RESPONSE REGULATOR receiver
SHXM_RS42300	COG2972	Histidine kinase
SHXM_RS42300	COG2205	protein histidine kinase activity
SHXM_RS42330	COG1959	2 iron, 2 sulfur cluster binding
SHXM_RS42335	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS42355	COG2226	methyltransferase
SHXM_RS42370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHXM_RS42375	COG0395	ABC-type sugar transport system, permease component
SHXM_RS42380	COG1414	Transcriptional regulator
SHXM_RS42385	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS42405	COG1940	carbohydrate kinase activity
SHXM_RS42440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHXM_RS42445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS42450	COG2188	Transcriptional regulator
SHXM_RS42455	COG4689	acetoacetate decarboxylase
SHXM_RS42465	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHXM_RS42480	COG1846	Transcriptional regulator
SHXM_RS42485	COG0174	glutamine synthetase
SHXM_RS42500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHXM_RS42510	COG0842	Transport permease protein
SHXM_RS42515	COG3850	Histidine kinase
SHXM_RS42525	COG0596	Alpha beta hydrolase
SHXM_RS42530	COG2132	Multicopper oxidase
SHXM_RS42545	COG2326	polyphosphate kinase activity
SHXM_RS42550	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SHXM_RS42555	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SHXM_RS42565	COG3940	Belongs to the glycosyl hydrolase 43 family
SHXM_RS42570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHXM_RS42580	COG3119	arylsulfatase activity
SHXM_RS42585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS42660	COG1116	anion transmembrane transporter activity
SHXM_RS42665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS42675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHXM_RS42680	COG2027	D-alanyl-D-alanine carboxypeptidase
SHXM_RS42720	COG2706	6-phosphogluconolactonase activity
SHXM_RS42740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHXM_RS42750	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS42755	COG0640	Transcriptional regulator
SHXM_RS42760	COG2233	PERMEase
SHXM_RS42765	COG0493	'glutamate synthase
SHXM_RS42820	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHXM_RS42860	COG0604	alcohol dehydrogenase
SHXM_RS42860	COG3321	synthase
SHXM_RS42870	COG3321	synthase
SHXM_RS42870	COG0604	alcohol dehydrogenase
SHXM_RS42895	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SHXM_RS42950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS42955	COG1120	ATPase activity
SHXM_RS42960	COG2814	Major facilitator Superfamily
SHXM_RS42965	COG0367	asparagine synthase
SHXM_RS43000	COG0789	Transcriptional regulator
SHXM_RS43005	COG0659	secondary active sulfate transmembrane transporter activity
SHXM_RS43040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SHXM_RS43040	COG1017	nitric oxide dioxygenase activity
SHXM_RS43045	COG0745	RESPONSE REGULATOR receiver
SHXM_RS43050	COG2205	protein histidine kinase activity
SHXM_RS43065	COG0671	phosphoesterase, PA-phosphatase related
SHXM_RS43095	COG0584	glycerophosphoryl diester phosphodiesterase
SHXM_RS43135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SHXM_RS43175	COG3345	alpha-galactosidase
SHXM_RS43185	COG1175	transmembrane transport
SHXM_RS43190	COG0395	ABC-type sugar transport system, permease component
SHXM_RS43195	COG1660	Displays ATPase and GTPase activities
SHXM_RS43205	COG0445	tRNA wobble uridine modification
SHXM_RS43210	COG4585	Histidine kinase
SHXM_RS43215	COG2197	response regulator
SHXM_RS43245	COG1940	carbohydrate kinase activity
SHXM_RS43280	COG1349	DNA-binding transcription factor activity
SHXM_RS43290	COG0464	growth
SHXM_RS43335	COG0463	Glycosyl transferase, family 2
SHXM_RS43340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SHXM_RS43355	COG0494	nUDIX hydrolase
SHXM_RS43360	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS43385	COG2124	cytochrome p450
SHXM_RS43390	COG2124	cytochrome p450
SHXM_RS43400	COG0142	geranyltranstransferase activity
SHXM_RS43405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHXM_RS43405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHXM_RS43405	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SHXM_RS43410	COG1461	Dihydroxyacetone kinase
SHXM_RS43415	COG2376	Dihydroxyacetone kinase
SHXM_RS43425	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS43470	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SHXM_RS43475	COG0298	carbon dioxide binding
SHXM_RS43485	COG0309	Hydrogenase expression formation protein (HypE)
SHXM_RS43490	COG0516	GMP reductase activity
SHXM_RS43490	COG0517	IMP dehydrogenase activity
SHXM_RS43505	COG0589	response to stress
SHXM_RS43515	COG2326	polyphosphate kinase activity
SHXM_RS43530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SHXM_RS43540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHXM_RS43565	COG0515	serine threonine protein kinase
SHXM_RS43575	COG2070	2-Nitropropane dioxygenase
SHXM_RS43595	COG1024	Enoyl-CoA hydratase
SHXM_RS43670	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS43690	COG1984	allophanate hydrolase subunit 2
SHXM_RS43695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS43700	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS43720	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SHXM_RS43750	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS43755	COG4638	Rieske (2fe-2S)
SHXM_RS43775	COG2146	nitrite reductase [NAD(P)H] activity
SHXM_RS43795	COG2018	Roadblock/LC7 domain
SHXM_RS43810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS43815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHXM_RS43820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS43830	COG3842	ATPase activity
SHXM_RS43835	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SHXM_RS43840	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHXM_RS43845	COG1177	transmembrane transport
SHXM_RS43850	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SHXM_RS43860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHXM_RS43865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS43880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHXM_RS43885	COG2190	(PTS) system
SHXM_RS43915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHXM_RS43935	COG1716	ATPase activity
SHXM_RS43955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHXM_RS43970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHXM_RS43970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHXM_RS43995	COG0384	phenazine biosynthesis protein PhzF
SHXM_RS44030	COG0697	spore germination
SHXM_RS44035	COG0583	DNA-binding transcription factor activity
SHXM_RS44055	COG0488	(ABC) transporter
SHXM_RS44065	COG0477	Major facilitator Superfamily
SHXM_RS44075	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS44080	COG0583	DNA-binding transcription factor activity
SHXM_RS44095	COG4941	Belongs to the sigma-70 factor family
SHXM_RS44100	COG3795	YCII-related domain
SHXM_RS44115	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS44130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS44150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHXM_RS44155	COG0384	phenazine biosynthesis protein PhzF
SHXM_RS44170	COG0436	Aminotransferase
SHXM_RS44175	COG2050	protein possibly involved in aromatic compounds catabolism
SHXM_RS44185	COG1522	sequence-specific DNA binding
SHXM_RS44205	COG2072	flavoprotein involved in K transport
SHXM_RS44230	COG0583	DNA-binding transcription factor activity
SHXM_RS44255	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SHXM_RS44310	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHXM_RS44315	COG0596	Alpha beta hydrolase
SHXM_RS44320	COG0583	DNA-binding transcription factor activity
SHXM_RS44345	COG0477	Major facilitator Superfamily
SHXM_RS44640	COG5412	phage tail tape measure protein
SHXM_RS44640	COG3953	SLT domain
SHXM_RS44735	COG0006	proline dipeptidase activity
SHXM_RS44750	COG3012	SEC-C Motif Domain Protein
SHXM_RS44755	COG1063	alcohol dehydrogenase
SHXM_RS44760	COG2271	Major facilitator Superfamily
SHXM_RS44765	COG0246	Mannitol dehydrogenase
SHXM_RS44800	COG0789	Transcriptional regulator
SHXM_RS44840	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SHXM_RS44865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHXM_RS44910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHXM_RS44920	COG2340	Cysteine-rich secretory protein family
SHXM_RS44935	COG0531	amino acid
SHXM_RS44945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS44970	COG3290	protein histidine kinase activity
SHXM_RS45010	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SHXM_RS45020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SHXM_RS45035	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS45040	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS45055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHXM_RS45060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHXM_RS45075	COG1940	carbohydrate kinase activity
SHXM_RS45080	COG1070	Carbohydrate kinase
SHXM_RS45090	COG4677	pectinesterase activity
SHXM_RS45095	COG4279	zinc finger
SHXM_RS45100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SHXM_RS45145	COG2018	Roadblock/LC7 domain
SHXM_RS45155	COG1946	Acyl-CoA thioesterase
SHXM_RS45170	COG1132	(ABC) transporter
SHXM_RS45175	COG1132	(ABC) transporter
SHXM_RS45195	COG1132	(ABC) transporter
SHXM_RS45200	COG3629	intracellular signal transduction
SHXM_RS45200	COG3903	Transcriptional regulator
SHXM_RS45345	COG3321	synthase
SHXM_RS45345	COG0604	alcohol dehydrogenase
SHXM_RS45355	COG3321	synthase
SHXM_RS45355	COG0604	alcohol dehydrogenase
SHXM_RS45385	COG3321	synthase
SHXM_RS45385	COG0604	alcohol dehydrogenase
SHXM_RS45390	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS45400	COG1309	transcriptional regulator
SHXM_RS45405	COG1733	regulation of RNA biosynthetic process
SHXM_RS45425	COG2391	methyltransferase activity
SHXM_RS45440	COG2318	DinB family
SHXM_RS45450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHXM_RS45455	COG1113	amino acid transport
SHXM_RS45460	COG3708	Transcriptional regulator
SHXM_RS45460	COG2207	Transcriptional regulator
SHXM_RS45480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS45485	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS45490	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS45500	COG0673	inositol 2-dehydrogenase activity
SHXM_RS45505	COG0673	inositol 2-dehydrogenase activity
SHXM_RS45510	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS45520	COG1609	Transcriptional regulator
SHXM_RS45540	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS45545	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS45550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHXM_RS45555	COG0601	transmembrane transport
SHXM_RS45560	COG4166	transmembrane transport
SHXM_RS45565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHXM_RS45580	COG1733	regulation of RNA biosynthetic process
SHXM_RS45590	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS45605	COG0596	Alpha beta hydrolase
SHXM_RS45615	COG2188	Transcriptional regulator
SHXM_RS45620	COG1397	ADP-ribosylglycohydrolase
SHXM_RS45640	COG4221	oxidoreductase activity
SHXM_RS45675	COG0367	asparagine synthase
SHXM_RS45690	COG0673	inositol 2-dehydrogenase activity
SHXM_RS45695	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS45700	COG0765	amino acid transport
SHXM_RS45710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS45715	COG3250	beta-galactosidase activity
SHXM_RS45720	COG3321	synthase
SHXM_RS45720	COG0604	alcohol dehydrogenase
SHXM_RS45730	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS45740	COG0747	negative chemotaxis
SHXM_RS45750	COG0673	inositol 2-dehydrogenase activity
SHXM_RS45755	COG1940	carbohydrate kinase activity
SHXM_RS45755	COG1846	Transcriptional regulator
SHXM_RS45770	COG0492	ferredoxin-NADP+ reductase activity
SHXM_RS45775	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
SHXM_RS45795	COG3384	dioxygenase
SHXM_RS45830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS45855	COG0402	S-adenosylhomocysteine deaminase activity
SHXM_RS45860	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SHXM_RS45875	COG2423	ornithine cyclodeaminase activity
SHXM_RS45905	COG2205	protein histidine kinase activity
SHXM_RS45910	COG0745	RESPONSE REGULATOR receiver
SHXM_RS45915	COG3180	Ammonia monooxygenase
SHXM_RS45925	COG0671	phosphoesterase, PA-phosphatase related
SHXM_RS45930	COG0745	RESPONSE REGULATOR receiver
SHXM_RS45950	COG1968	undecaprenyl-diphosphatase activity
SHXM_RS45955	COG0438	transferase activity, transferring glycosyl groups
SHXM_RS45995	COG0642	Histidine kinase
SHXM_RS46005	COG4181	ATPase activity
SHXM_RS46015	COG0745	RESPONSE REGULATOR receiver
SHXM_RS46025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHXM_RS46035	COG0583	DNA-binding transcription factor activity
SHXM_RS46045	COG2197	response regulator
SHXM_RS46085	COG3458	cephalosporin-C deacetylase activity
SHXM_RS46105	COG0765	amino acid transport
SHXM_RS46110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHXM_RS46140	COG3940	Belongs to the glycosyl hydrolase 43 family
SHXM_RS46155	COG0667	Aldo Keto reductase
SHXM_RS46175	COG0667	Aldo Keto reductase
SHXM_RS46185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHXM_RS46205	COG2814	Major facilitator Superfamily
SHXM_RS46220	COG0673	inositol 2-dehydrogenase activity
SHXM_RS46235	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHXM_RS46235	COG1796	DNA polymerase
SHXM_RS46250	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS46280	COG0697	spore germination
SHXM_RS46290	COG2814	Major facilitator Superfamily
SHXM_RS46315	COG1454	alcohol dehydrogenase
SHXM_RS46325	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS46330	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS46335	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
SHXM_RS46350	COG0477	Major facilitator Superfamily
SHXM_RS46390	COG0477	Major facilitator Superfamily
SHXM_RS46415	COG0583	DNA-binding transcription factor activity
SHXM_RS46425	COG1940	carbohydrate kinase activity
SHXM_RS46425	COG1846	Transcriptional regulator
SHXM_RS46430	COG3345	alpha-galactosidase
SHXM_RS46440	COG3401	FG-GAP repeat protein
SHXM_RS46440	COG2755	lipolytic protein G-D-S-L family
SHXM_RS46445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHXM_RS46445	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
SHXM_RS46455	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHXM_RS46460	COG3842	ATPase activity
SHXM_RS46465	COG1840	ABC-type Fe3 transport system, periplasmic component
SHXM_RS46515	COG0745	RESPONSE REGULATOR receiver
SHXM_RS46525	COG0583	DNA-binding transcription factor activity
SHXM_RS46550	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS46555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHXM_RS46565	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHXM_RS46620	COG1132	(ABC) transporter
SHXM_RS46655	COG2264	protein methyltransferase activity
SHXM_RS46680	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS46685	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS46690	COG0673	inositol 2-dehydrogenase activity
SHXM_RS46700	COG1609	Transcriptional regulator
SHXM_RS46715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SHXM_RS46720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS46725	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHXM_RS46730	COG1120	ATPase activity
SHXM_RS46735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SHXM_RS46740	COG1132	(ABC) transporter
SHXM_RS46750	COG1132	(ABC) transporter
SHXM_RS46755	COG2382	esterase
SHXM_RS46780	COG0604	alcohol dehydrogenase
SHXM_RS46780	COG3321	synthase
SHXM_RS46785	COG0604	alcohol dehydrogenase
SHXM_RS46785	COG3321	synthase
SHXM_RS46800	COG3321	synthase
SHXM_RS46800	COG0604	alcohol dehydrogenase
SHXM_RS46805	COG3321	synthase
SHXM_RS46805	COG0604	alcohol dehydrogenase
SHXM_RS46855	COG1233	COG1233 Phytoene dehydrogenase and related
SHXM_RS46880	COG3458	cephalosporin-C deacetylase activity
SHXM_RS46890	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS46905	COG0604	alcohol dehydrogenase
SHXM_RS46960	COG3250	beta-galactosidase activity
SHXM_RS46965	COG0395	ABC-type sugar transport system, permease component
SHXM_RS46970	COG1175	transmembrane transport
SHXM_RS46980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHXM_RS46990	COG1486	melibiose metabolic process
SHXM_RS47015	COG1132	(ABC) transporter
SHXM_RS47035	COG2197	response regulator
SHXM_RS47055	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS47080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS47085	COG1024	Enoyl-CoA hydratase
SHXM_RS47095	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS47100	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS47110	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS47115	COG1309	transcriptional regulator
SHXM_RS47120	COG0183	Belongs to the thiolase family
SHXM_RS47140	COG1024	Enoyl-CoA hydratase
SHXM_RS47150	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS47160	COG1846	Transcriptional regulator
SHXM_RS47160	COG1940	carbohydrate kinase activity
SHXM_RS47225	COG1609	Transcriptional regulator
SHXM_RS47235	COG0395	ABC-type sugar transport system, permease component
SHXM_RS47245	COG1653	transport
SHXM_RS47260	COG1309	transcriptional regulator
SHXM_RS47275	COG4336	lyase activity
SHXM_RS47280	COG0477	Major facilitator Superfamily
SHXM_RS47290	COG1984	allophanate hydrolase subunit 2
SHXM_RS47300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHXM_RS47305	COG1802	Transcriptional regulator
SHXM_RS47310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHXM_RS47320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SHXM_RS47350	COG1733	regulation of RNA biosynthetic process
SHXM_RS47360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHXM_RS47370	COG0148	phosphopyruvate hydratase activity
SHXM_RS47390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SHXM_RS47395	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS47400	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS47405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHXM_RS47410	COG1733	regulation of RNA biosynthetic process
SHXM_RS47425	COG1733	regulation of RNA biosynthetic process
SHXM_RS47455	COG0730	response to heat
SHXM_RS47485	COG1335	isochorismatase
SHXM_RS47490	COG0477	Major facilitator Superfamily
SHXM_RS47500	COG0667	Aldo Keto reductase
SHXM_RS47510	COG1309	transcriptional regulator
SHXM_RS47530	COG0596	Alpha beta hydrolase
SHXM_RS47545	COG4221	oxidoreductase activity
SHXM_RS47555	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS47565	COG0778	Nitroreductase
SHXM_RS47585	COG0667	Aldo Keto reductase
SHXM_RS47590	COG0667	Aldo Keto reductase
SHXM_RS47595	COG4221	oxidoreductase activity
SHXM_RS47605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS47665	COG0829	nickel cation binding
SHXM_RS47670	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SHXM_RS47680	COG0804	urea catabolic process
SHXM_RS47685	COG0832	Belongs to the urease beta subunit family
SHXM_RS47695	COG2814	Major facilitator Superfamily
SHXM_RS47710	COG1309	transcriptional regulator
SHXM_RS47770	COG1609	Transcriptional regulator
SHXM_RS47805	COG0702	epimerase
SHXM_RS47825	COG1733	regulation of RNA biosynthetic process
SHXM_RS47855	COG4638	Rieske (2fe-2S)
SHXM_RS47860	COG1902	pentaerythritol trinitrate reductase activity
SHXM_RS47860	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHXM_RS47890	COG2271	Major facilitator Superfamily
SHXM_RS47895	COG1846	Transcriptional regulator
SHXM_RS47900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHXM_RS47905	COG1024	Enoyl-CoA hydratase
SHXM_RS47915	COG1024	Enoyl-CoA hydratase
SHXM_RS47920	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS47925	COG2070	2-Nitropropane dioxygenase
SHXM_RS47975	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
SHXM_RS47985	COG2080	2 iron, 2 sulfur cluster binding
SHXM_RS47990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHXM_RS47995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHXM_RS48010	COG0395	ABC-type sugar transport system, permease component
SHXM_RS48040	COG2132	Multicopper oxidase
SHXM_RS48045	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
SHXM_RS48055	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS48060	COG1082	Xylose isomerase domain protein TIM barrel
SHXM_RS48090	COG0531	amino acid
SHXM_RS48095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
SHXM_RS48100	COG3938	Belongs to the proline racemase family
SHXM_RS48140	COG4974	Belongs to the 'phage' integrase family
SHXM_RS48190	COG3507	Belongs to the glycosyl hydrolase 43 family
SHXM_RS48225	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS48240	COG3246	L-lysine catabolic process to acetate
SHXM_RS48250	COG2175	clavaminate synthase activity
SHXM_RS48255	COG2814	Major facilitator Superfamily
SHXM_RS48310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHXM_RS48325	COG0191	fructose-bisphosphate aldolase activity
SHXM_RS48340	COG1653	transport
SHXM_RS48350	COG0395	ABC-type sugar transport system, permease component
SHXM_RS48390	COG1653	transport
SHXM_RS48395	COG1175	transmembrane transport
SHXM_RS48400	COG0395	ABC-type sugar transport system, permease component
SHXM_RS48415	COG4948	Mandelate Racemase Muconate Lactonizing
SHXM_RS48420	COG0601	transmembrane transport
SHXM_RS48430	COG0444	Belongs to the ABC transporter superfamily
SHXM_RS48435	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS48475	COG3795	YCII-related domain
SHXM_RS48515	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS48520	COG1129	ABC transporter
SHXM_RS48535	COG0434	BtpA family
SHXM_RS48540	COG1609	Transcriptional regulator
SHXM_RS48565	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SHXM_RS48570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHXM_RS48575	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SHXM_RS48580	COG2814	Major facilitator Superfamily
SHXM_RS48585	COG0183	Belongs to the thiolase family
SHXM_RS48590	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS48610	COG0439	Biotin carboxylase
SHXM_RS48620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHXM_RS48635	COG0583	DNA-binding transcription factor activity
SHXM_RS48660	COG0583	DNA-binding transcription factor activity
SHXM_RS48670	COG0765	amino acid transport
SHXM_RS48700	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SHXM_RS48705	COG0477	Major facilitator Superfamily
SHXM_RS48710	COG0583	DNA-binding transcription factor activity
SHXM_RS48715	COG0454	-acetyltransferase
SHXM_RS48730	COG0395	ABC-type sugar transport system, permease component
SHXM_RS48745	COG1609	Transcriptional regulator
SHXM_RS48790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHXM_RS48815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHXM_RS48855	COG0563	adenylate kinase activity
SHXM_RS48870	COG0318	PFAM AMP-dependent synthetase and ligase
SHXM_RS48880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS48890	COG0477	Major facilitator Superfamily
SHXM_RS48895	COG1022	Amp-dependent synthetase and ligase
SHXM_RS48900	COG1309	transcriptional regulator
SHXM_RS48915	COG1024	Enoyl-CoA hydratase
SHXM_RS48920	COG1024	Enoyl-CoA hydratase
SHXM_RS48925	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHXM_RS48930	COG1022	Amp-dependent synthetase and ligase
SHXM_RS48940	COG3293	Transposase
SHXM_RS48950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS48955	COG2807	transmembrane transport
SHXM_RS48980	COG1695	Transcriptional regulator
SHXM_RS49005	COG1920	GTP binding
SHXM_RS49010	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHXM_RS49015	COG2814	Major facilitator Superfamily
SHXM_RS49020	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
SHXM_RS49025	COG2188	Transcriptional regulator
SHXM_RS49030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS49040	COG1012	belongs to the aldehyde dehydrogenase family
SHXM_RS49055	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS49065	COG4977	sequence-specific DNA binding
SHXM_RS49115	COG0477	Major facilitator Superfamily
SHXM_RS49120	COG1335	isochorismatase
SHXM_RS49140	COG0604	alcohol dehydrogenase
SHXM_RS49145	COG1309	transcriptional regulator
SHXM_RS49150	COG1609	Transcriptional regulator
SHXM_RS49165	COG1175	transmembrane transport
SHXM_RS49170	COG0395	ABC-type sugar transport system, permease component
SHXM_RS49220	COG3547	Transposase (IS116 IS110 IS902 family)
SHXM_RS49230	COG3293	Transposase
SHXM_RS49275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHXM_RS49280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHXM_RS49315	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS49330	COG0477	Major facilitator Superfamily
SHXM_RS49410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHXM_RS49420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SHXM_RS49430	COG1802	Transcriptional regulator
SHXM_RS49445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHXM_RS49455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS49465	COG3454	Phosphonate metabolism
SHXM_RS49470	COG3454	Phosphonate metabolism
SHXM_RS49475	COG1126	abc transporter atp-binding protein
SHXM_RS49480	COG4107	phosphonate C-P lyase system protein PhnK
SHXM_RS49485	COG3627	carbon phosphorus lyase activity
SHXM_RS49490	COG3626	phosphonate metabolism
SHXM_RS49520	COG3639	organic phosphonate transmembrane transporter activity
SHXM_RS49525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SHXM_RS49530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
SHXM_RS49545	COG0395	ABC-type sugar transport system, permease component
SHXM_RS49550	COG1175	transmembrane transport
SHXM_RS49570	COG1486	melibiose metabolic process
SHXM_RS49575	COG0363	glucosamine-6-phosphate deaminase activity
SHXM_RS49595	COG1349	DNA-binding transcription factor activity
SHXM_RS49600	COG0531	amino acid
SHXM_RS49605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHXM_RS49620	COG2755	lipolytic protein G-D-S-L family
SHXM_RS49640	COG1522	sequence-specific DNA binding
SHXM_RS49645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHXM_RS49680	COG1653	transport
SHXM_RS49685	COG0395	ABC-type sugar transport system, permease component
SHXM_RS49690	COG1175	transmembrane transport
SHXM_RS49695	COG3842	ATPase activity
SHXM_RS49700	COG3608	succinylglutamate desuccinylase aspartoacylase
SHXM_RS49710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHXM_RS49730	COG0559	Belongs to the binding-protein-dependent transport system permease family
SHXM_RS49765	COG1028	Short-chain dehydrogenase reductase Sdr
SHXM_RS49830	COG4608	Belongs to the ABC transporter superfamily
SHXM_RS49835	COG1737	Transcriptional regulator
SHXM_RS49845	COG2188	Transcriptional regulator
SHXM_RS49855	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
SHXM_RS49860	COG3626	phosphonate metabolism
SHXM_RS49865	COG3627	carbon phosphorus lyase activity
SHXM_RS49875	COG4778	phosphonate C-P lyase system protein PhnL
SHXM_RS49880	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
SHXM_RS49895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHXM_RS49925	COG0583	DNA-binding transcription factor activity
SHXM_RS49935	COG2814	Major facilitator Superfamily
SHXM_RS50040	COG1063	alcohol dehydrogenase
SHXM_RS50050	COG0395	ABC-type sugar transport system, permease component
SHXM_RS50055	COG1175	transmembrane transport
SHXM_RS50065	COG1609	Transcriptional regulator
SHXM_RS50100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHXM_RS50105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHXM_RS50185	COG0235	Class ii aldolase
SHXM_RS50205	COG1175	transmembrane transport
SHXM_RS50210	COG0395	ABC-type sugar transport system, permease component
SHXM_RS50215	COG0431	NADPH-dependent FMN reductase
SHXM_RS50220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS50245	COG2226	methyltransferase
SHXM_RS50250	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SHXM_RS50255	COG1737	Transcriptional regulator
SHXM_RS50265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHXM_RS50270	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SHXM_RS50280	COG3876	Protein conserved in bacteria
SHXM_RS50300	COG1126	abc transporter atp-binding protein
SHXM_RS50305	COG0765	amino acid transport
SHXM_RS50310	COG0436	Aminotransferase
SHXM_RS50315	COG1737	Transcriptional regulator
SHXM_RS50325	COG2186	Transcriptional regulator
SHXM_RS50330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHXM_RS50335	COG1116	anion transmembrane transporter activity
SHXM_RS50340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SHXM_RS50355	COG0431	NADPH-dependent FMN reductase
SHXM_RS50415	COG2814	Major facilitator Superfamily
SHXM_RS50435	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SHXM_RS50435	COG2755	lipolytic protein G-D-S-L family
SHXM_RS50465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHXM_RS50495	COG4209	transmembrane transport
SHXM_RS50500	COG0395	ABC-type sugar transport system, permease component
SHXM_RS50510	COG3250	beta-galactosidase activity
SHXM_RS50520	COG2801	Transposase and inactivated derivatives
SHXM_RS50545	COG1175	transmembrane transport
SHXM_RS50560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHXM_RS50600	COG1960	acyl-CoA dehydrogenase activity
SHXM_RS50625	COG0531	amino acid
SHXM_RS50670	COG4106	trans-aconitate 2-methyltransferase activity
SHXM_RS50790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHXM_RS50810	COG0494	nUDIX hydrolase
SHXM_RS50895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids